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Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice

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World Journal of Gastroenterology 2008年第13期14卷 2003-2009页

作者： Pornprom Yoysungnoen Ponthip Wirachwong Chatchawan Changtam apichart Suksamrarn Suthiluk Patumraj Department of Physiology Faculty of Medical Science Naresuan University Phitsanulok 65000 Thailand The Government Pharmaceutical Organization Rama VI Rajtevi Bangkok 10300 Thailand Department of Chemistry Faculty of Science Ramkhamhaeng University Bangkok 10240 Thailand Department of Physiology Faculty of Medicine Chulalongkorn University Bangkok 10300 Thailand

AIM: To determine the effect of tetrahydrocurcumin (THC) on tumor angiogenesis compared with curcumin (CUR) by using both in vitro and in vivo models of human hepatocellular carcinoma cell line (HepG2). METHODS: The 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay was used for testing the anti-proliferating activities of CUR and THC. In male BALB/c nude mice, 2 × 106 human HepG2 cells were inoculated onto a dorsal skin-fold chamber. One day after HepG2 inoculation, the experimental groups were fed oral daily with CUR or THC (300 mg/kg or 3000 mg/kg). On d 7, 14 and 21, the tumor microvasculature was observed using fluorescence videomicroscopy and capillary vascularity (CV) was measured. RESULTS: Pathological angiogenic features including microvascular dilatation, tortuosity, and hyper-permeability were observed. CUR and THC could attenuate these pathologic features. In HepG2-groups, the CV were significantly increased on d 7 (52.43%), 14 (69.17%), and 21 (74.08%), as compared to controls (33.04%,P < 0.001). Treatment with CUR and THC resulted in significant decrease in the CV (P < 0.005 and P < 0.001, respectively). In particular, the anti-angiogenic effects of CUR and THC were dose-dependent manner. However, the beneficial effect of THC treatment than CUR was observed, in particular, from the 21 d CV (44.96% and 52.86%, P < 0.05). CONCLUSION: THC expressed its anti-angiogenesis without any cytotoxic activities to HepG2 cells even at the highest doses. It is suggested that anti-angiogenic properties of CUR and THC represent a common potential mechanism for their anti-cancer actions.

关键词： Tumor angiogenesis HepG2 Curcumin Tetrahydrocurcumin Intravital fluorescence videomicroscopy

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Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats

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World Journal of Gastroenterology 2012年第47期18卷 6951-6959页

作者： Khanitta Srimuangwong Chainarong Tocharus Jiraporn Tocharus apichart Suksamrarn Pornphorm Yoysungnoen Chintana Department of Anatomy Faculty of Medical ScienceNaresuan UniversityPhitsanulok 65000Thailand Department of Anatomy Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Physiology Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry Faculty of ScienceRamkhamhaeng UniversityBangkok 10240Thailand Division of Physiology Faculty of MedicineThammasat UniversityRangsit CampusPathumthani 12120Thailand

AIM:To investigate the effects of hexahydrocurcumin(HHC),and its combination with 5-fluorouracil(5-FU) on dimethylhydrazine(DMH)-induced colon cancer in ***:Male Wistar rats weighing 100-120 g were used as subject *** crypt foci(ACF),early preneoplastic lesions of colon cancer,were induced by subcutaneous injection of DHM(40 mg/kg) twice a week for two *** the first DMH injection,rats were treated daily with vehicle(n = 12),curcumin(CUR)(50 mg/kg)(n = 12),HHC(50 mg/kg) orally(n = 12),and treated weekly with an intraperitoneal injection of 5-FU(50 mg/kg)(n = 12),or a combination of 5-FU plus CUR(n = 12) and HHC(n = 12) at the same dosage(s) for 16 *** total number of ACF and large ACF were ***(COX)-1 and COX-2 expression were detected by immunohistochemistry in colon *** quantitative data of both COX-1 and COX-2 expression were presented as the percentage of number of positive-stained cells to the total number of cells *** cells in colon tissues were also visualized using the dUTP-biotin nick end labeling *** index(AI) was determined as the percentage of labeled nuclei with respect to the total number of nuclei ***:The total number of ACF was highest in the DMH-vehicle group(1558.20 ± 17.37),however,the number of ACF was significantly reduced by all treatments,5-FU(1231.20 ± 25.62 vs 1558.20 ± 17.37,P < 0.001),CUR(1284.20 ± 25.47 vs 1558.20 ± 17.37,P < 0.001),HHC(1086.80 ± 53.47 vs 1558.20 ± 17.37,P < 0.001),DMH-5-FU + CUR(880.20 ± 13.67 vs 1558.20 ± 17.37,P < 0.001) and DMH-5-FU + HHC(665.80 ± 16.64 vs 1558.20 ± 17.37,P < 0.001).Interestingly,the total number of ACF in the combined treatment groups,the DMH-5-FU + CUR group(880.20 ± 13.67 vs 1231.20 ± 25.62,P < 0.001;880.20 ± 13.67 vs 1284.20 ± 25.47,P < 0.001) and the DMH-5-FU + HHC group(665.80 ± 16.64 vs 1231.20 ± 25.62,P < 0.001;665.80 ± 16.64 vs 1086.80 ± 53.47,P < 0.001) were significantly reduced as compared to 5

关键词： Hexahydrocurcumin Curcumin analog Colon cancer Combination treatment Cyclooxygenase-2 Apoptosis

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Synthesis and structure-activity relationship of rhodomyrtone derivatives as antibacterial agent

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Chinese Chemical Letters 2012年第9期23卷 1011-1014页

作者： Sukanlaya Leejae Boon-ek Yingyongnarongkul apichart Suksamrarn Supayang Piyawan Voravuthikunchai Department of Microbiology and Natural Products Research Center Faculty of SciencePrince of Songkla UniversitySongkhla 90112Thailand Department of Chemistry and Center of Excellent ofInnovation in Chemistry Faculty of ScienceRamkhamhaeng UniversityBangkok 10240Thailand

To study structure-activity relationship of rhodomyrtone against Gram-positive bacteria, structural modification of rhodo- myrtone was carded out to afford its 10 analogues. All compounds were assayed for their antibacterial potency using broth microdilution method. The results indicated that rhodomyrtone exhibited higher antibacterial activity against al! Gram-positive bacteria than its analogues, with the exception of rhodomyrtone 6,8-diacetate （3） and oxime analogues 6 and 7 which demonstrated similar activity as the parent compound against Bacillus subtilis and Staphylococcus epidermidis with minimum inhibitory concentration and minimum bactericidal concentration ranged from 1 to 4 ~g/mL and 2 to 4 ~g/mL, respectively. In contrast, all analogues displayed no activity against Acinetobacter baumannii. Hydroxyl and ketone groups of rhodomyrtone were elucidated to be essential for the antibacterial property.

关键词： Rhodomyrtone Structure-activity relationship Oxime analogues Antibacterial activity

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Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells

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World Journal of Gastroenterology 2012年第19期18卷 2383-2389页

作者： Khanitta Srimuangwong Chainarong Tocharus Pornphrom Yoysungnoen Chintana apichart Suksamrarn Jiraporn Tocharus Department of Anatomy Faculty of Medical ScienceNaresuan UniversityPhitsanulok 65000Thailand Department of Anatomy Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Division of Physiology Faculty of MedicineThammasat UniversityRangsit CampusPathumthani 12120Thailand Department of Chemistry Faculty of ScienceRamkhamhaeng UniversityBangkok 10240Thailand Department of Physiology Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand

AIM： To investigate the ability of hexahydrocurcumin （HHC） to enhance 5-fluorouracil （5-FU） in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase （COX）-2 expression.METHODS： Antiproliferative effects of HHC and 5-FU, alone and in combination, on growth of HT-29 human colon cancer cells were assessed using 5-diphenyltetrazolium bromide （MTT） reduction assay. In combinationtreatment, low doses of 5-FU were used combined with various concentrations of HHC to minimize the toxic- ity and side effects of 5-FU. The therapeutic effects of these drugs on down-regulation of COX-2 mRNA and protein expression were examined using semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR） and Western blotting analysis.RESULTS： Ml-I- reduction assay indicated that HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. Semi-quantitative RT-PCR analysis indicated that HHC is a selective COX-2 inhibitor. This finding was supported by the ob- servation that HHC significantly down-regulates COX-2 mRNA expression compared to the control （control： 100.05% ± 0.03% vs HHC： 61.01% ± 0.35%, P 〈 0.05） but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy. Semi-quantitative RT-PCR indicated that 5-FU at the concentration of 5 pmol/L in combina- tion with HHC at the concentration of 25 pmol/L signifi- cantly down-regulates COX-2 mRNA expression when compared with values in cells treated with 5-FU or HHC alone （HHC ＋ 5-FU： 31.93% ± 5.69%, 5-FU： 100.66% ± 4.52% vs HHC： 61.01% ±0.35%, P 〈 0.05）.CONCLUSION： HHC together with 5-FU exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer.

关键词： Colon cancer Hexahydrocurcumin 5-Fluo-rouracil Combination treatment Cyclooxygenase-2 Synergistic effect

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Enhanced dissolution of sildenafil dry foam tablets

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 191-192页

作者： Somchai Sawatdee apichart Atipairin Attawadee Sae Yoon Teerapol Srichana Drug and Cosmetic Research and Development Unit School of PharmacyWalailak UniversityNakhon Si Thammarat 80161Thailand Department of Pharmaceutical Technology Faculty of Pharmaceutical SciencesPrince of Songkla UniversitySongkhla 90112Thailand

Sildenafil citrate is a highly selective phosphodiesterase-5(PDE-5)*** is used for treatment of erectile dysfunction and pulmonary hypertension[1].Sildenafil citrate is categorized in BCS class 2 so it is developed as a citrate salt to increase water solubility(4.1 mg/mL)[2].The conventional product has been developed as a tablet dosage *** is rapidly absorbed after oral administration,but gives a relatively low oral bioavailability of about 40%and late onset of action[2].Dry foam formulation technology is an alternative approach to overcome such a problem.

关键词： Sildenafil citrate Dry foam tablet Dissolution

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Thailand Experience in Developing Wellness-driven Rice as the Key to Fight NCDs and Farmer Poverty

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粮油食品科技 2020年第5期28卷 57-63页

作者： apichart Vanavichi Siriphat Ruangpayak Rice Science Center and Agronomy Department Faculty of Agriculture KamphangsaenKasetsart UniversityKamphangsaenNakhonpathom73140Thailand

Prevalence of chronic noncommunicable diseases(NCDs)is rapidly increasing and has become a global problem in modern *** consumption of simple,processed carbohydrate foods is considered one of the main causes of NCD in young and elderly *** grain rice is an important source of a complex carbohydrate,dietary fiber,enriched with vitamins,minerals,and ***,palatability of brown rice is the key success factor among white-rice-addicted *** the initial phase,we successfully breed rice strains with aromatic,soft-whole grain,white rice contains high grain-Fe/Zn density and intermediate glycemic index(GI).The most successful variety was uniquely soft-textured black purple rice named Riceberry,depicting rice enriched with blueberry nutritional *** development for fiber-rich,high antioxidant has been extremely active from academia,real sectors,and *** total,39 patent applications(18 granted patents),12 international publications,and 18,700 Youtubes related to *** 2017,Riceberry has become the most popular choice for product development surpassing Thai Hommali *** than 200 food and non-food products were commercialized as dairy replacement,side dishes,meals,hot beverages,bakery,and breakfast *** the second phase,we successfully breed low GI rice strains named Pink+4 equipped with farmers’preferred resistance to flash flooding,bacterial leaf blight,leaf blast,and devastating brown planthopper adapted to organic rice *** products combined of low GI rice flour with purple Riceberry have been the next trend for functional ingredients and *** healthy rice products have high potential globally as healthy foods,gluten-free,fiber-rich,complex carbohydrate,and nutrient-dense from sustainable organic farming.

关键词： whole-grain rice non-communicable diseases(NCDs) glycemic Index(GI) riceberry Thai Hommali Rice organic farming flash flooding bacterial leaf blight leaf blast brown planthopper gluten-free foods

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A Multi-Mode Public Transportation System Using Vehicular to Network Architecture

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Computers, Materials & Continua 2022年第12期73卷 5845-5862页

作者： Settawit Poochaya Peerapong Uthansakul Monthippa Uthansakul Patikorn Anchuen Kontorn Thammakul Arfat Ahmad Khan Niwat Punanwarakorn Pech Sirivoratum Aranya Kaewkrad Panrawee Kanpan apichart Wantamee School of Telecommunication Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand Office of Graduate Studies Navaminda Kasatriyadhiraj Royal Air Force AcademyBangkok10220Thailand School of Mechanical Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand School of Manufacturing Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand Thaicom Public Company Limited Patumthani12140Thailand

The number of accidents in the campus of Suranaree University of Technology(SUT)has increased due to increasing number of personal *** this paper,we focus on the development of public transportation system using Intelligent Transportation System(ITS)along with the limitation of personal vehicles using sharing economy *** SUT Smart Transit is utilized as a major public transportation system,while MoreSai@SUT(electric motorcycle services)is a minor public transportation system in this *** are called Multi-Mode Transportation system as a ***,a Vehicle toNetwork(V2N)is used for developing theMulti-Mode Transportation system in the *** to equipping vehicles with On Board Unit(OBU)and 4G LTE modules,the real time speed and locations are transmitted to the *** data is then applied in the proposed mathematical model for the estimation of Estimated Time of Arrival(ETA).In terms of vehicle classifications and counts,we deployed CCTV cameras,and the recorded videos are analyzed by using You Only Look Once(YOLO)*** simulation and measurement results of SUT Smart Transit and MoreSai@SUT before the covid-19 pandemic are *** to the existing researches,the proposed system is implemented in the real *** final results unveil the attractiveness and satisfaction of ***,due to the proposed system,the CO_(2) gas gets reduced when Multi-Mode Transportation is implemented practically in the campus.

关键词： Smart transit intelligent transportation system(ITS) dedicated short range communication(DSRC) vehicle to network(V2N) vehicle to everything(V2X) electric vehicle(EV) you only look once(YOLO)

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Radiation effects and radioprotection by Thai medicinal plants in mouse macrophage cell line

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Asian Pacific Journal of Tropical Medicine 2009年第1期2卷 35-41页

作者： Cheeraratana Cheeramakara Kriyapom Songmueng Wanyarat Nakosiri Montri Chairojana Arag Vitittheeranon Nopchai Suthisai Nongnuch Jangsawang Channarong Sanghiran apichart Nontprasert Department of Tropical Radioisotopes Hospital for Tropical DiseasesFaculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand Bangkok X-ray Unit Hospital for Tropical DiseasesFaculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand Bangkok Office of Atomic Energy for Peace Ministry of Science and TechnologyBangkok 10900Thailand Department of Clinical Tropical Medicine Faculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand

Objective:To investigate the effects of radiation on growth-arrested(GA) and micronucleus-production(MP) rates,and the radioprotective properties of Thai medicinal plants in mouse macrophage cell line RAW264.7 in ***:Mouse macrophage cell line(RAW264.7) was cultured in *** radiation exposures, growth-arrested rate assay,micronucleus production assay,and radioprotection by Thai medicinal plants were ***:The results showed that GA and MP rates forγ-rays and UV were dose-dependent. The 50%-affected dose ofγand UV radiation for the GA rate was 10 Gy and 159 microwatt/cm for 0.5 seconds, *** X-ray exposure,there was no apparent effect on RAW264.7 cells,even with a fortyfold human diagnostic *** exposures toγradiation at 20 Gy resulted in a significantly higher MP rate than 20 Gy single exposure or control(P<0.05).The Thai medicinal plants(Kamin-chun capsules,Curcuma longa Linn;Hed lingeu,Ganoderma lucidum;Ya Pakking capsule,Murdannia loriformis) could not prevent cell damage,but epigallocatechin gallate and L-cysteine could provide protection from 2 Gyγ-ray exposure. Conclusion:γradiation caused chromosomal damage during cell division and UV caused cell death, while X-ray radiation was *** radioprotective effects of Thai medicinal plants,Kamin-chun,Hed lingeu, and Ya Pakking,could not prevent cell damage in this study.

关键词： Radiation RAW264.7 Growth-arrested rate Micronucleus production Radioprotection Thai medicinal plants

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Management and Agricultural Technology Affecting to Longan Security in Thailand

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World Journal of Engineering and Technology 2018年第4期6卷 738-751页

作者： apichart Sudswang Sudawan Somjai Sriparinya Toopgrajank Suan Sunandha Rajabhat University Bangkok Thailand

The objectives of this research are to study the management influences on Longan product, the value of Longan product with agricultural science and technology, and the public policy that affects on Longan product security. This study employs quantitative methods in analyzing the data collected from 400 Longan farmers in 3 provinces located in the northern region of Thailand: Chiang Mai, Chiang Rai, and Lamphun. The models were tested via Structural Equation Modeling or SEM and results indicate that Longan product management and public policy have positive effects on Longan security. Results also show that agricultural technology has a negative effect while the value of Longan product has no influence on the Longan security.

关键词： Agricultural Technology Longan Management

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PDE5 vs PDE6 Inhibitory Activities of Curcumin And Its Analogues

PDE5 vs PDE6 Inhibitory Activities of Curcumin And Its Analo...

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第十四届全国中药和天然药物学术研讨会

作者： Kanokwan Changwichit Prapapan Temkitthawon Nantaka Khorana Oraya Khruangthip Krongkarn Chootip Thipphawan Chuprajob Chatchawan Changtam apichart Suksamrarn C.Norman Scholfield Kornkanok Ingkaninan Naresuan University PhitsanulokThailand

＜正＞Erectile Dysfunction（ED）is a common public health problem affecting millions of men ***（PDE5）inhibitors can be used for the treatment of ED and more recently,for Pulmonary Hypertension（PAH）.However,most of PDE5 inhibitors show some undesirable side *** aim of the study is to search for new PDE5 inhibitors from

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