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Photo-Physical Properties of Stilbine-3 (STB-3) Laser Dyes Embedded in Sol-Gel Glasses

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New Journal of Glass and Ceramics 2016年第4期6卷 64-74页

作者： Laxman V. Jathar Dilip G. Achalawat Jayraj R. Rane aparna V. Deshpande Shaila M. Wagle Department of Physics R. D. National College Mumbai University Mumbai India Department of Physics Institute of Chemical Technology Mumbai University Mumbai India Department of Physics Kishinchand Chellaram College Mumbai India

Solid-state tunable dye laser materials developed by incorporation of stable laser dye molecules into solid host matrices like polymers, organically modified silicates (ORMOSILS) and porous sol-gel glasses. These materials have technical advantages such as compactness, better manageability and suitability for field measurement. The recent research work with highly porous sol-gel glasses having good transparency in UV-Near UV region used as solid host for solid-state dye laser materials has attracted a great deal of attention because of its high potential utility than polymers. Two different procedure’s are used for incorpoerating the Stilbine-3 (STB-3) laser dyes into porous sol-gel matrices such as dope or dip methods. In dope method dye is mixed at the sol state and drying is carried out afterward;while in dip method matrix is first prepared and the matrix is dipped in desired dye solution. After preparation of these dye embedded sol-gel glasses we studied their spectroscopic properties of using absorption and fluorescence spectroscopy. Along with spectroscopy properties, the studies for longevity or the shelf life and lasing action of these materials were carried out. Laser dye STB-3 incorporated in sol-gel glass samples shows the same result as in methanolic solution.

关键词： Sol-Gel Glass Laser Dye Stilbine-3 (STB-3)

Novel 1,3,4-(thiadiazol-2-ylamino) methyl-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-thiones: synthesis, docking and antimycobacterial testing

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Advances in Biological Chemistry 2011年第2期1卷 7-14页

作者： Trupti S. Chitre Santosh Panda Shital M Patil aparna S. Chothe G Vignesh M. K. Kathiravan Dept.of Pharmaceutical Chemistry (PGwing) AISSMS College of Pharmacy Kennedy Road Near RTO Pune-411001 Maharashtra India.

In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions between the synthesized com-pounds and active site of 14DM. The test compounds were screened for antimycobacterial activity using Middlebrook 7H9 medium against M. tuberculosis H37Rv (ATCC 27294) as well as Isoniazid (INH) resistant clinical strain. Among the series 5c and 5a are found to be most potent (susceptible) while the compound 5f did not show activity against M. tuberculosis H37Rv (resistant). The SAR study reveals the importance of substitutions at para position for good activity.

关键词： Mannich Base Oxadiazole Thiadiazole Antimycobacterial Docking

Sensori-Neural Hearing Loss Client’s Performance with Receiver-In-Canal (RIC) Hearing Aids

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第2期2卷 68-73页

作者： S. G. R. Prakash Ravichandran aparna S. B. Rathna Kumar Tamsekar Madhav Kaki Ashritha Kande Navyatha Ali Yavar Jung National Institute for the Hearing Handicapped Department of Disability Affairs Ministry of Social Justice and Empowerment Goverment of India Mumbai India Ali Yavar Jung National Institute for the Hearing Handicapped Southern Regional Centre Department of Disability Affairs Ministry of Social Justice and Empowerment Goverment of India Secunderabad India

Background: Individuals fitted with hearing aids complain of the unnatural sound quality of their voice, other internally generated sounds such as chewing and swallowing sounds “hollow”, “muffled” sounds. Receiver-In-Canal hearing aids are favored due to small size, discrete appearance and ability to minimize occlusion. Aim: To compare the performance of Receiver-In-Canal (RIC) to traditional ear tip (ET), ear moulds (EM) fittings using Functional gain measures. Method: Ten subjects with flat moderately severe sensori neural hearing loss participated in the study. Subjective unaided and aided measures for digital BTE hearing aids with ear tip, ear mould or Receiver-In-Canal for pure tones of 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz were obtained. Results and Discussion: Higher scores were obtained with Receiver-In-Canal fitting on Functional gain measures. No significant difference between all the three conditions was obtained at low frequencies especially at 500 Hz, as Receiver-In-Canal hearing aids attenuate low frequency sounds automatically when the ear is left open (up to 30 dB less amplification at 500 Hz) especially for hearing in noisy situations. Conclusion: The results suggest that Receiver-In-Canal fittings are an effective means of overcoming the major barriers to the acceptance of amplification and further suggest the clinical importance of subjective measures in measuring aided benefit of open-fit devices in the rehabilitation of person’s with moderately severe to severe SN hearing loss.

关键词： Sensori Neural Hearing Loss RIC Hearing Aids Functional Gain Measures

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全球化进入第四纪企业需重思跨国战略

中国工业评论 2017年第5期 20-25页

作者： Arindam Bhattacharya Hans-Paul Bürkner aparna Bijapurkar 波士顿咨询公司新德里办公室波士顿咨询公司

全球化并未终结，只是表现形式与以往不同。企业只有洞悉变革背后的推动力，打造能够适应多极世界格局的业务形态，才能在全球化第四个阶段成为赢家。

关键词：全球化企业第四纪

Immune checkpoint blockade therapies for HCC: current status and future implications

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Hepatoma Research 2019年第9期5卷 1-17页

作者： Ritu Shrestha Kim R.Bridle Darrell H.G.Crawford aparna Jayachandran The University of Queensland Faculty of MedicineBrisbaneQueensland 4120Australia Gallipoli Medical Research Institute Greenslopes Private HospitalBrisbaneQueensland 4120Australia

Hepatocellular carcinoma(HCC)is the most lethal and common type of liver cancer with limited treatment options at the advanced *** use of immune checkpoint inhibitor(ICI)based immunotherapy is exponentially increasing in the treatment of patients with advanced solid *** expression of immune checkpoints on tumor cells leading to lower activity of T-cells is one of the major mechanisms of immune *** blockade immunotherapies with antibodies against PD-1,PD-L1 or CTLA-4 are being investigated in clinical trials in HCC *** have improved survival in patients with inoperable advanced stage HCC where other curative treatments are not ***,the response rates remain low with only a small subset of patients responding to this *** is an unmet need to identify predictive markers to select those HCC patients who would benefit from ICI ***,epithelial-to-mesenchymal transition(EMT),a major process driving HCC invasion and metastasis by regulating the phenotypic cellular switching from epithelial to mesenchymal state,has been implicated as a resistance mechanism associated with ICI *** role of EMT as a regulator of immune checkpoint molecule in HCC is just ***,the consequence of EMT as a resistance mechanism in HCC patients undergoing ICI treatments remains *** this review,we summarize the recent clinical studies with ICIs in HCC and highlight the trials underway featuring novel monotherapies and combinatorial approaches based on immune and non-immune *** will discuss the ongoing efforts to discover new immune checkpoint molecules in HCC as potential drug *** also highlight the role of EMT in facilitating therapy resistance in HCC treated with ICIs and discuss potential strategies to circumvent resistance in ICI treated HCC patients.

关键词： Hepatocellular carcinoma immunotherapy immune checkpoint inhibitors epithelial-to-mesenchymal transition programmed cell death protein-1 programmed death-ligand 1 resistance

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垂体腺瘤

英国医学杂志中文版 2020年第5期23卷 285-290页

作者： aparna Pal Laurence Leaver John Wass 彭浩(译) Oxford Centre for Diabetes Endocrinology and MetabolismOxford University Hospitals NHS Foundation TrustOxfordUK Green Templeton College University of OxfordOxfordUK 应急总医院肿瘤科

一名58岁男子,描述说他在过去的一年中感到越来越疲劳,做事没有积极性。血液常规检查正常。他正在经历离婚,他和他的家庭医生都认为这些症状可能与压力有关。在一次眼科常规检查中,发现他有双颞侧偏盲。垂体磁共振成像(MRI)显示一2.5 c... 详细信息

一名58岁男子,描述说他在过去的一年中感到越来越疲劳,做事没有积极性。血液常规检查正常。他正在经历离婚,他和他的家庭医生都认为这些症状可能与压力有关。在一次眼科常规检查中,发现他有双颞侧偏盲。垂体磁共振成像(MRI)显示一2.5 cm垂体腺瘤,瘤体抬高压迫视神经交叉。经进一步询问,患者说他勃起功能障碍已有4年。

关键词：血液常规检查家庭医生双颞侧偏盲勃起功能障碍眼科常规检查垂体腺瘤视神经交叉瘤体

不同时间脓毒症核转录因子-κB对细胞因子表达调节的实验研究

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中国现代医学杂志 2005年第15期15卷 2260-2263页

作者：苏建荣张正孙东旭 aparna Krishan Gabriel Fernandas 首都医科大学附属北京友谊医院临床检验中心北京大学人民医院 Department of Medicine University of Texas Health Science Center TX78229-3900USA

目的探讨在不同时间段内脓毒症核转录因子-κB(NuclearTranscriptionFactor,NF-κB)对细胞因子表达的调节及其临床意义。方法将30只小鼠分为正常对照组、假手术(sham)组和盲肠结扎(CLP)组,采用酶联免疫吸附法(ELISA)和RT-PCR法分别检测... 详细信息

目的探讨在不同时间段内脓毒症核转录因子-κB(NuclearTranscriptionFactor,NF-κB)对细胞因子表达的调节及其临床意义。方法将30只小鼠分为正常对照组、假手术(sham)组和盲肠结扎(CLP)组,采用酶联免疫吸附法(ELISA)和RT-PCR法分别检测血清细胞因子(TNFα、IL-6和IL-10)总量和脾细胞相应细胞因子基因表达量。同时采用电泳迁移率滞后分析法检测核转录因子NF-κBDNA结合活性。结果CLP组细胞因子TNFα、IL-6和IL-10高于正常对照组和sham组;CLP组有活性的NF-κB增多,以正调节促炎细胞因子TNFα和IL-6表达为主,TNFα和IL-6基因表达增高,且在4～18h调节IL-6(P0.05)。结论随着脓毒症时间的推移,活性NF-κB增多,对促炎因子的正调节作用高于抗炎因子,是造成促炎因子与抗炎因子不平衡的重要原因。不同时间脓毒症细胞因子失衡程度不同,脓毒症的发展趋势亦不同。

关键词：脓毒症细胞因子核转录因子时间

Facebook发布人工智能引擎Deep Text

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商业观察 2016年第6期 55-56页

作者： Ahmad Abdulkader aparna Lakshmiratan Joy Zhang 机器之心

Facebook推出一款文本理解引擎DeepText,试图让它理解用户贴出的每篇文章。媒体预测,这款人工智能引擎将会深刻变革公司核心产品体验。Facebook的搜索世界比不上谷歌的大,不过,其规模仍然蔚为可观。有超过十亿用户每天都会刷Facebook,... 详细信息

Facebook推出一款文本理解引擎DeepText,试图让它理解用户贴出的每篇文章。媒体预测,这款人工智能引擎将会深刻变革公司核心产品体验。Facebook的搜索世界比不上谷歌的大,不过,其规模仍然蔚为可观。有超过十亿用户每天都会刷Facebook,网络服务器上每天有数万亿的状态更新、活动邀请、

关键词： Deep Text Facebook 文本理解产品体验谷歌 Messenger 自然语言理解自然语言处理语言文本使用深度

不同器官细胞因子在多细菌感染性炎症时的基因表达和临床意义

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北京医学 2005年第10期27卷 577-579页

作者：苏建荣张正孙东旭 aparna Krishan Gabriel Fernandas 北京大学人民医院检验科首都医科大学附属北京友谊医院检验科 University of Texas Health Science Center Department of MedicineTX78229-3900USA

目的探讨肝、肺细胞因子基因表达与腹腔吞噬细胞上清液、循环血中细胞因子含量的关系,为临床诊治多细菌感染引发的炎症提供实验依据。方法将30只小鼠分为假手术对照组(sham组)和盲肠结扎组(CLP组)。采用RT!PCR法检测肝脏和肺脏肿瘤坏死... 详细信息

目的探讨肝、肺细胞因子基因表达与腹腔吞噬细胞上清液、循环血中细胞因子含量的关系,为临床诊治多细菌感染引发的炎症提供实验依据。方法将30只小鼠分为假手术对照组(sham组)和盲肠结扎组(CLP组)。采用RT!PCR法检测肝脏和肺脏肿瘤坏死因子α(TNF!α)和白细胞介素10(IL!10)的基因表达情况,采用ELISA法检测腹腔巨噬细胞上清液和循环血液中相应细胞因子含量。结果CLP组的TNF"α、IL!10基因表达和腹腔巨噬细胞上清液、循环血液中的相应细胞因子含量均高于sham组。CLP后18h组与4h组比较,TNF"α在腹腔巨噬细胞上清液、循环血液中的活性均有显著性差异(P<0.05),在肝、肺中基因表达有非常显著性差异(P<0.01);IL!10在腹腔巨噬细胞上清液和循环血液中的含量无显著性差异,而在肝、肺中基因表达有显著性差异。结论发生多细菌感染性炎症时,肝、肺参与细胞因子的表达;血液中细胞因子含量不能完全代表组织器官内的基因表达情况;多细菌感染性炎症治疗应考虑靶器官细胞因子的表达状态。

关键词：多细菌感染细胞因子基因表达细胞因子含量细菌感染性感染性炎症肿瘤坏死因子-α(TNF-α) 组织器官临床意义腹腔巨噬细胞