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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W M Lemlijn-Slenter Karolina ap Wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P value<0.05 was considered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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Voice Recognition by Neuro-Heuristic Method

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Tsinghua Science and Technology 2019年第1期24卷 9-17页

作者： Dawid Po?ap Marcin Wozniak Institute of Mathematics Silesian University of Technology

The amount of digital data is increasing every day. At every step of our daily lives, we deal with technologies in which our data are stored(e.g., mobile phones and laptops), and this is one of the main reasons for the design of various types of encryption and user identity verification algorithms. These algorithms are meant not only to fulfill the desire of protecting data but also to address the possibility of granting access of specific digital data to selected individuals. This process brings with it the problem of identity verification. This paper discusses the problem of voice verification and presents a voice verification method based on artificial intelligence *** tests are performed herein to demonstrate the effectiveness of the presented solution. The research results are shown and discussed in terms of the advantages and disadvantages of the solution.

关键词： neural network heuristic algorithms Discrete Fourier Transform(DFT) image processing

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张雷、雷晓华：在南京，去南京，回到南京

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建筑实践 2024年第Z1期 262-271页

作者：艾侠戴伯威《建筑实践》编辑部

张雷（右），张·雷设计研究azLa联合创始人、主持建筑师，南京大学建筑与城市规划学院教授，江苏省设计大师，江苏省建筑与历史文化研究会副会长。雷晓华（左），张·雷设计研究azLa联合创始人、主持建筑师，云夕精品民宿品牌创始人。...

张雷（右），张·雷设计研究azLa联合创始人、主持建筑师，南京大学建筑与城市规划学院教授，江苏省设计大师，江苏省建筑与历史文化研究会副会长。雷晓华（左），张·雷设计研究azLa联合创始人、主持建筑师，云夕精品民宿品牌创始人。全面领导并主持张·雷设计研究建筑、室内、景观、生活美学产品设计研究工作。张·雷设计研究azLa是根植南京面向全国的知名建筑设计机构，二十年来完成了二百余项设计，项目包括了多种类型和尺度，始终保持国内领先的学术水准和专业设计品质。

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Caustic Failure of Thermal Insulated Tubing in Steam Flooding

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Journal of Materials Science & Technology 1997年第1期13卷 27-36页

作者： Xian, ap San, YY Zhang, D Wang, YK Sun, HP LIAOHE OIL FIELD MACHINERY PLANT PANJIN 124209PEOPLES R CHINA

The coupling of the pre-stressed thermal insulated tubing string broke down inside the steam flooding welts, after the tubing were used in high temperature and high pressure steam for about two years. With further check, it was found that most of the weld joints between the inner and outer tubing also cracked. The failure analysis for the accidents has been carried out by the analysis of chemical composition for the steels, microstructure observation, mechanical property tests, and the investigation of the service environment etc.. The results show that the early damage of the pre-stressed thermal insulated tubing string is mainly induced by the caustic stress corrosion, which can be strengthened by an unstable microstructure of the coupling serviced at high temperature for a long time. Moreover, the high pre-stress design on the thermal insulated pipe for the cyclic steam injection may be not suitable to the situation of steam flooding, which would result in the weld joint cracking.

关键词： Steel pipe

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Propylthiouracyl-induced severe liver toxicity:An indication for alanine aminotransferase monitoring?

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World Journal of Gastroenterology 2006年第38期12卷 6232-6234页

作者： M Benyounes C Sempoux C Daumerie J Rahier ap Geubel Departments of Gastroenterology Endocrinology and Pathology St Luc University Hospital Université Catholique de Louvain Brussels 1200 Belgium

Propylthiouracyl (PTU)-related liver toxicity is likely to oc- cur in about 1% of treated patients. In case of acute or subacute hepatitis, liver failure may occur in about one third. We report two further cases of PTU-induced sub- acute hepatitis, in whom the delay between occurrence of liver damage after the initiation of treatment, the un- derestimation of its severity and the delayed withdrawal of the drug were all likely responsible for liver failure. The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotrans- ferase monitoring, at least during the first six months of therapy.

关键词： Hepatitis Drug-induced liver toxicity Propylthiouracil Alanine aminotransferase

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俄罗斯阿尔泰-Sayan地区Aksug斑岩Cu-Mo体系的地质与地球化学特征(英文)

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岩石学报 2008年第12期24卷 2657-2668页

作者： Berzina AN Berzina ap Institute of Geology and Mineralogy Koptyug Avenue 3 Novosibirsk 630090 Russia

The Aksug deposit,located in Altay-Sayan region of Russia,is one of the largest porphyry Cu-Mo deposits in *** ore-bearing porphyries of the Aksug porphyry Cu-Mo system were formed in post-collisional *** belong to calk-alkaline and high K-calk-alkaline *** are characterized by enrichment of LILE and depletion of HSFE andHREE,showing the importance of subduction-related components in magma *** plutonic intrusions that host porphyrysystems have been formed during *** origin of porphyritic rocks is dominantly the mantle with lower crustal *** economically important Cu-Mo mineralization is closely related to a porphyry series in time and space,being emplaced towardsthe end of magmatic *** the emplacement of plutonic and ore-bearing porphyry complexes took place in differentgeodynamic environments,both complexes are characterized by certain similarity in geochemical composition,alkalinity,trace elementcontent,Sr isotopic *** fact evidently indicates a common deep-seated magmatic source(at the lower crust-uppermantle level).Low initial ^(87)Sr/^(86)St,sulfur isotopic characteristics and presence of PGE-Co-Ni mineralization in associated pyrite-chalcopyrite ores suggest that mantle source of chalcophile elements was of high importance in porphyry Cu-Mo mineralization of theAksug deposit.

关键词：斑岩铜钼矿床岩石化学分析微量元素碱度

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Analysis of Growth and Productivity of Green Chickpea Using Nitrogen and Phosphorus Fertilization

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1193-1203页

作者： Maricela apáez-Barrios JoséAlberto Salvador Escalante-Estrada Patricio apáez-Barrios Yurixhi Atenea Raya-Montaño Juan CarlosÁlvarez-Hernández Facultad de Ciencias Agropecuarias-Universidad Michoacana de San Nicolás de Hidalgo Apatzingán60670México Colegio de Postgraduados-Campus Montecillo Texcoco56230México Facultad de Agrobiología“Presidente Juárez” Universidad Michoacana de San Nicolás de HidalgoUruapan60190México

Chickpea contains high levels of protein,vitamins and *** chickpea yield is the result of meeting nitrogen and phosphorus *** effect of appropriately meeting such requirements reflects on growth and can easily be evaluated using growth *** research determined:(a)The effect of nitrogen and phosphorus fertilization on phenology,net assimilation rate,number of green leaves,leaf area,leaf area index and leaf area duration;(b)Green chickpea yield and number of pods due to fertilization;and(c)The combination of nitrogen and phosphorus fertilization that yields the most net *** and phosphorus fertilization was evaluated;each at the doses of 0,75 and 150 kg ha–1(N0,N75,N150;P0,P75 and P150,respectively).The combination of the levels of both nutrients generated nine combinations of treatments which were distributed in the field in a randomized complete block design in an arrangement of divided plots with four *** of phenological phases were similar among *** and phosphorus fertilization increased number of leaves,leaf area index,and leaf area duration that translated into increased green chickpea yield(GCY).Combinations N150-P75 and N150-P150 produced the highest *** highest net revenue and revenue per peso invested was obtained with N150-P75.

关键词： Cicer arietinum economic analysis leaf area number of leaves yield

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Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer

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World Journal of Gastrointestinal Oncology 2014年第4期6卷 83-97页

作者： Ganepola ap Ganepola Joel Nizin John R Rutledge David H Chang Center for Cancer Research and Genomic Medicine The Daniel and Gloria Blumenthal Cancer Center Department of Surgery The Valley Hospital

Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design.

关键词： Colorectal neoplasms Early detection of cancer Colonoscopy Biological markers Blood Messenger RNA MicroRNA Long non-coding RNA DNA methylation Microsatellite instability Loss of heterozygosity High-throughput nucleotide sequencing Mass spectrometry Real-time polymerase chain reaction Microarray analysis

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Retrieval of Elastic Green’s Tensor near a Cylindrical Inhomogeneity from Vector Correlations

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Communications in Computational Physics 2008年第1期3卷 250-270页

作者： Juan ap´erez-Ruiz Francisco Luzon Francisco J.Sanchez-Sesma Grupo de Geof´ısica aplicada Departamento de F´ısica AplicadaUniversidad de Almer´ıaCa˜nada de San Urbano s/n04120-Almer´ıaSpain Departamento de Sismolog´ıa Instituto de IngenieriaUniversidad Nacional Aut´onoma de M´exicoCd.UniversitariaCircuito Escolar s/nCoyoac´an 04510M´exico D.F.Mexico.

Multiple scattering of elastic waves in realistic media makes that averagefield intensities or energy densities follow diffusive processes. In such regime the successiveP to S energy conversions by distributed random inhomogeneities give rise toequipartition which means that in the phase space the available elastic energy is distributedin averagewith equal amounts among the possible states of P and S waves. Insuch diffusive regime the P to S energy ratio equilibrates in an universal way independentof the particular details of the scattering. It has been demonstrated that averagingthe cross correlations at any two points of an elastic medium subjected to diffuse elasticwavefields leads to the emergence of the Green function, which is the wave fieldthat would be observed at one position if an impulsive load is applied at the other. Inthis work we study the problem of the retrieval of the 2D tensor elastodynamic Greenfunction in an infinite elastic space containing a circular cylinder inclusion. We illuminateisotropically the elastic spacewith plane waves. We assume the spectra for both Pand S waves uniform but such that the energy ratio ES/EP=(a/b)2, which is the onepredicted by equipartition theory in two-dimensions. We then show that the Fouriertransform of azimuthal average of the cross-correlation of motion between two pointswithin an elastic medium is proportional to the imaginary part of the exact Green tensorfunction between these points. The numerical results presented here point out thepossibility of detection and imaging of diffractors and resonant diffractors by crosscorrelation even in presence of attenuation exists.

关键词： Multiple scattering elastic waves elastic Green’s tensor

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Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2014年第1期6卷 22-33页

作者： Ganepola ap Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang Center for Cancer Research and Genomic Medicine The Valley Hospital Department of Surgery The Valley Hospital

AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early ***:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published *** selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic *** three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA ***:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published *** microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and *** three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although

关键词： MicroRNA Diagnosis Biomarkers Pancreatic cancer Blood plasma Circulating

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