检索结果-南通市图书馆

Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway

引用

Cellular & Molecular Immunology 2013年第4期10卷 330-337页

作者： Yuejuan zheng Yang Yang Yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo aoxiang zheng Ping Li Yan Zhang Guang Ji Yizhi Yu Department of Immunology and Microbiology Shanghai University of Traditional Chinese Medicine Shanghai 201203 China National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University Shanghai 200433 China Institute of Digestive Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride （EH） is a compound that is widely used in cardiovascular diseases, especially to treat hypotension caused by either anesthesia or overdose of antihypertensive drugs. In this study, we reported that EH also plays an important role in the control of the inflammatory response. EH increased IL-IO and decreased proinflammatory cytokine （IL-6, tumor-necrosis factor （TNF）-a, IL-12 and IL-11~） expression in primary peritoneal macrophages and Raw264.7 cells treated with peptidoglycan （PGN）, a Gram-positive cell wall component. The anti-inflammatory role of EH was also demonstrated in an experimental mouse model of peritonitis induced by intraperitoneal PGN injection. The phosphatidylinositol 3-kinase （PI3K）/Akt pathway was found to be responsible for the EH-mediated increase in IL-IO production and decrease in IL-6 expression. Therefore, our results illustrated that EH can help maintain immune equilibrium and diminish host damage by balancing the production of pro- and anti-inflammatory cytokines after PGN challenge. EH may be a new potential anti-inflammatory drug that can be useful for treating severe invasive Gram-positive bacterial infection.

关键词： anti-i nflammation EH ephedrine hydroch Ioride I L- 10 peptidoglycan PG N phosphatidylinositol 3-ki nase PI3K

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inorganic Nanotube/Organic Nanoparticle Hybrids for Enhanced Photoelectrochemical Properties

引用

Journal of Materials Science & Technology 2017年第7期33卷 728-733页

作者： Yingzhi Chen aoxiang Li Ming Jin Lu-Ning Wang zheng-Hong Huang School of Materials Science and Engineering University of Science and Technology Beijing Key Laboratory of Advanced Materials (MOE) School of Materials Science and Engineering Tsinghua University

Inorganic/organic nanohybrids composed of arrayed TiO_2 nanotubes（Ti NTs）/porphyrin nanoparticles（NPs） have been fabricated via a wet chemical approach. The inorganic component, particularly the arrayed one-dimensional（1D） nanostructures, provides high charge-carrier mobility and rapid charge transport. The organic component exhibits extensive visible light absorption and good solution processability. Additionally, the geometric restraint by supramolecular assembly renders an improved photostability. A combination of these two components could thus allow for an efficient solar energy conversion. In this work, a colloid of porphyrin NPs prepared by a solvent exchange method is coated on anodic Ti NTs by means of a dip-coating treatment to form inorganic/organic hybrids. The hybrids exhibit an improvement on solar absorption and a significant enhancement on photocurrent generation at a small bias compared with individual component. Herein, the inorganic/organic nanohybrids are proved to be excellent photoanodes highly responsive to visible light and thus pave a way to discover new inorganic/organic assemblies for high-performance optoelectronic applications, as well as for device integration.

关键词： Anodic TiO_2 nanotubes Porphyrin nanoparticles Inorganic/organic nanohybrid Photoelectrochemical water splitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Facile fabrication of three-dimensional interconnected nanoporous N-TiO_2 for efficient photoelectrochemical water splitting

引用

Journal of Materials Science & Technology 2018年第6期34卷 955-960页

作者： Yingzhi Chen aoxiang Li Qun Li Xinmei Hou Lu-Ning Wang zheng-Hong Huang School of Materials Science and Engineering University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Key Laboratory of Advanced Materials (MOE) School of Materials Science and Engineering Tsinghua University

Three-dimensional （3D） interconnected porous architectures are expected to perform well in photoelectrochemical （PEC） water splitting due to their high specific surface area as well as favourable porous properties and interconnections. In this work, we demonstrated the facile fabrication of 3D interconnected nanoporous N-doped TiO2 （N-TiO2 network） by annealing the anodized 3D interconnected nanoporous TiO2 （TiO2 network） in ammonia atmosphere. The obtained N-TiO2 network exhibited broadened light absorption, and abundant, interconnected pores for improving charge separation, which was supported by the reduced charge transfer resistance. With these merits, a remarkably high photocurrent density at 1.23 V vs. reversible hydrogen electrode （RHE） was realized for the N-TiO2 network without any co-catalysts or sacrificial reagents, and the photostability can be assured after long term illumination. In view of its simplicity and efficiency, this structure promises for perspective PEC applications.

关键词： 3D interconnected nanoporous N-TiO2 N-TiO2 nanotube arrays Anodization Photoelectrochemical water splitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High IL-23^(+)cells infiltration correlates with worse clinical outcomes and abiraterone effectiveness in patients with prostate cancer

引用

Asian Journal of Andrology 2022年第2期24卷 147-153页

作者： zheng Liu Jun-Yu Zhang Yun-Jie Yang Kun Chang Qi-Feng Wang Yun-Yi Kong Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

Individualized treatment of prostate cancer depends on an accurate stratification of patients who are sensitive to various treatments.Interleukin-23(IL-23)was reported to play a significant role in prostate cancer.Here,we aimed to explore the clinical value of IL-23-secreting(IL-23^(+))cells in prostate cancer patients.We evaluated interleukin-23A(IL-23A)expression in The Cancer Genome Atlas database and retrospectively enrolled 179 treatment-naive metastatic prostate cancer patients diagnosed in our institute between June 2012 and December 2014.IL-23^(+)cells were stained and evaluated via immunohistochemistry.Further,survival and multivariate Cox regression analyses were conducted to explore the prognostic value of IL-23^(+)cells.We found that IL-23A expression correlated with disease progression,while IL-23^(+)cells were clearly stained within prostate cancer tissue.Patients with higher Gleason scores and multiple metastatic lesions tended to have more IL-23^(+)cell infiltration.Further analyses showed that patients with higher levels of IL-23^(+)cells had significantly worse overall survival(hazard ratio[HR]=2.996,95%confidence interval[95%CI]:1.812–4.955;P=0.001)and a higher risk of developing castration resistance(HR=2.725,95%CI:1.865–3.981;P=0.001).Moreover,subgroup analyses showed that when patients progressed to a castration-resistant status,the prognostic value of IL-23^(+)cells was observed only in patients treated with abiraterone instead of docetaxel.Therefore,we showed that high IL-23^(+)cell infiltration is an independent prognosticator in patients with metastatic prostate cancer.IL-23^(+)cell infiltration may correlate with abiraterone effectiveness in castration-resistant prostate cancer patients.

关键词： abiraterone acetate interleukin-23 prognosis prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prognostic value of PTEN in de novo diagnosed metastatic prostate cancer

引用

Asian Journal of Andrology 2022年第1期24卷 50-55页

作者： Jun-Yu Zhang Yun-Yi Kong Qi-Feng Wang Yun-Jie Yang zheng Liu Nan Lin Ding-Wei Ye Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

The purpose of our study is to investigate the prognostic value of phosphatase and tensin homolog on chromosome 10(PTEN)expression in patients with de novo metastatic castration naive prostate cancer(mCNPC).A total of 205 patients with mCNPC at Fudan University Shanghai Cancer Center(Shanghai,China)were retrospectively examined.Immunohistochemical staining of PTEN was performed on prostate biopsy samples of these patients.Associations among clinicopathological features,patient survival and PTEN protein expression were analyzed.PTEN loss occurred in 58 of 205(28.3%)patients.Loss of PTEN was significantly correlated with high metastatic volume(P=0.017).No association between PTEN expression and Gleason score was observed.Patients with PTEN loss had significantly shorter progression-free survival(PFS,P<0.001)and overall survival(OS,P<0.001)compared with patients with intact PTEN expression.Multivariate analysis showed that elevated alkaline phosphatase,high metastatic volume and PTEN loss were independent poor prognostic factors for PFS.The Eastern Cooperative Oncology Group performance status(ECOG PS)≥2 and PTEN loss were independent poor prognostic factors for OS.The adjusted hazard ratio of PTEN loss for PFS and OS was 1.67(95%confidence interval[CI]:1.14–2.43,P=0.008)and 1.95(95%CI:1.23–3.10,P=0.005),respectively.PTEN loss was also significantly associated with shorter PFS(P=0.025)and OS(P<0.001)in patients with low-volume metastatic disease.Our data showed that PTEN loss is an independent predictor for shorter PFS and OS in patients with de novo mCNPC.

关键词： immunohistochemistry metastatic prostate cancer metastatic volume phosphatase and tensin homolog on chromosome 10 prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

溶蚀粉煤灰混凝土抗压强度试验与理论预测

引用

建筑结构学报 2018年第S1期39卷 392-396页

作者：周欣竹陈翱翔郑建军张坚浙江工业大学建筑工程学院浙江杭州310023 浙江工业大学浙江省工程结构与防灾减灾技术研究重点实验室浙江杭州310023

钙溶蚀是水环境中混凝土结构耐久性失效的主要原因,通过硝酸铵溶液加速溶蚀试验和损伤力学研究了溶蚀粉煤灰混凝土抗压强度随溶蚀时间的退化规律。在该试验中,水胶比为0.5,粉煤灰掺量分别为0%、10%、20%和30%。试验结果表明,溶蚀深度近... 详细信息

钙溶蚀是水环境中混凝土结构耐久性失效的主要原因,通过硝酸铵溶液加速溶蚀试验和损伤力学研究了溶蚀粉煤灰混凝土抗压强度随溶蚀时间的退化规律。在该试验中,水胶比为0.5,粉煤灰掺量分别为0%、10%、20%和30%。试验结果表明,溶蚀深度近似与溶蚀时间的平方根成正比;溶蚀粉煤灰混凝土的抗压强度随着溶蚀时间的增加而下降,掺加粉煤灰可以降低溶蚀混凝土抗压强度的下降率。基于试验结果,把溶蚀粉煤灰混凝土的溶蚀深度和弹性模量表示成粉煤灰掺量和溶蚀时间的函数。再引入峰值应力时未溶蚀和已溶蚀粉煤灰混凝土力学损伤变量相等的假设,利用损伤力学讨论并提出了溶蚀粉煤灰混凝土抗压强度的解析预测方法。经与试验结果比较,初步证实了该预测方法的有效性,为混凝土结构的耐久性评估和设计提供理论依据。

关键词：溶蚀粉煤灰混凝土溶蚀深度溶蚀时间抗压强度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一株海洋真菌与细菌共培养次级代谢产物的研究

引用

扬州大学学报（农业与生命科学版） 2023年第4期44卷 84-89页

作者：朱夏濠郝宝聪郑杨李申奥徐奥翔王梦如陈敏扬州大学环境科学与工程学院江苏扬州225127

对海洋真菌Penicillium janthinellum HK1-6与耐甲氧西林金黄色葡萄球菌(Staphylococcus aureus)ATCC 43300共培养的次级代谢产物进行分离纯化与结构鉴定,综合运用多种色谱方法从共培养发酵产物中分离得到5个化合物,采用NMR等光谱方法... 详细信息

对海洋真菌Penicillium janthinellum HK1-6与耐甲氧西林金黄色葡萄球菌(Staphylococcus aureus)ATCC 43300共培养的次级代谢产物进行分离纯化与结构鉴定,综合运用多种色谱方法从共培养发酵产物中分离得到5个化合物,采用NMR等光谱方法并参照文献将其分别鉴定为吲哚-3-乙酸(1)、青霉酸(2)、diorcinol(3)、orcinol(4)和paraherquanide N(5)。同时采用质谱-分子网络及GNPS平台技术鉴定了3个吲哚生物碱类化合物notoamide B(6)、paraherquanide F(7)和paraherquamide E(8)。该研究表明,共培养是激活微生物沉默基因簇,发现抗生素类化合物的一种有效方法。

关键词：海洋真菌细菌共培养次级代谢产物分子网络吲哚生物碱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

翼缘宽度对预期损伤部位采用FRC增强的梁柱组合件破坏机制影响的试验研究及数值模拟

引用

土木工程学报 2016年第12期49卷 52-64页

作者：陆婷婷梁兴文胡翱翔邓明科张正西安建筑科技大学陕西西安710055

为研究现浇板翼缘宽度和纤维增强混凝土(FRC)材料对框架结构破坏机制的影响,设计制作一组纵梁腹板两侧各6倍和8倍板厚翼缘宽度,且带有横交梁的梁柱组合件,试件的预期损伤部位采用FRC材料,柱梁抗弯承载力比分别取1.2和1.4;对试件进行拟... 详细信息

为研究现浇板翼缘宽度和纤维增强混凝土(FRC)材料对框架结构破坏机制的影响,设计制作一组纵梁腹板两侧各6倍和8倍板厚翼缘宽度,且带有横交梁的梁柱组合件,试件的预期损伤部位采用FRC材料,柱梁抗弯承载力比分别取1.2和1.4;对试件进行拟静力试验,考察试件的破坏过程和破坏形态,分析其破坏机制和翼缘板内钢筋的应变分布,研究试件的变形和耗能能力、强度和刚度退化等抗震性能。在试验研究基础上,对试件原型破坏过程进行数值模拟,并进行了参数分析。结果表明,预期损伤部位范围内的梁、柱和板采用FRC材料,在一定程度上可以减小板对梁抗弯承载力影响的范围,易于实现"强柱弱梁"的破坏机制;考虑8倍板厚翼缘宽度的梁柱组合件更易于实现"强柱弱梁"的破坏机制,并且能显著降低其强度退化系数,提高其耗能能力。

关键词：梁柱组合件纤维增强混凝土(FRC) 强柱弱梁翼缘宽度柱梁抗弯承载力比

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柱梁端受弯承载力比对局部FRC增强的梁柱组合体破坏机制影响的试验研究

引用

建筑结构学报 2015年第11期36卷 56-63页

作者：梁兴文陆婷婷张正邓明科胡翱翔西安建筑科技大学土木工程学院陕西西安710055

为研究在预期损伤部位采用纤维增强混凝土(FRC)和柱梁端受弯承载力比对框架结构破坏机制的影响,设计了5个带有翼缘板的不同柱梁端受弯承载力比值的梁柱组合体,其中4个试件的预期损伤部位采用FRC材料增强,1个试件全部采用普通混凝土。通... 详细信息

为研究在预期损伤部位采用纤维增强混凝土(FRC)和柱梁端受弯承载力比对框架结构破坏机制的影响,设计了5个带有翼缘板的不同柱梁端受弯承载力比值的梁柱组合体,其中4个试件的预期损伤部位采用FRC材料增强,1个试件全部采用普通混凝土。通过对试件进行拟静力试验,分析其破坏机理、变形和耗能性能以及承载力等。研究结果表明,与普通钢筋混凝土梁柱组合体相比,预期损伤部位采用FRC梁柱组合体的峰值荷载提高了13%,极限层间侧移角增大了17%,总耗能提高了40%,抗损伤能力明显提高;考虑梁两侧各6倍板厚翼缘宽度内钢筋对梁端弯矩的影响,当柱梁端受弯承载力比为1.2时,可基本实现强柱弱梁破坏机制,当比值为1.4时,可完全实现强柱弱梁破坏机制。

关键词：梁柱组合体纤维增强混凝土强柱弱梁柱梁端受弯承载力比翼缘宽度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

不同柱梁抗弯承载力比对框架结构抗倒塌性能的影响

引用

地震工程学报 2017年第5期39卷 859-869页

作者：张正梁兴文陆婷婷胡翱翔西安建筑科技大学土木工程学院陕西西安710055 中国建材国际工程集团有限公司安徽蚌埠233000

设计不同柱梁抗弯承载力比(ηc-bua)的5个纤维增强混凝土(FRC)框架结构及3个钢筋混凝土(RC)框架结构,利用性能评估软件Perform-3D进行Pushover及IDA计算分析,得出其破坏机制及易损性曲线。结果表明,柱、梁端部局部采用FRC后,承载力有一... 详细信息

设计不同柱梁抗弯承载力比(ηc-bua)的5个纤维增强混凝土(FRC)框架结构及3个钢筋混凝土(RC)框架结构,利用性能评估软件Perform-3D进行Pushover及IDA计算分析,得出其破坏机制及易损性曲线。结果表明,柱、梁端部局部采用FRC后,承载力有一定提高,峰值位移有较大提高;ηc-bua对FRC框架结构的破坏机制影响很大;ηc-bua对FRC框架结构地震反应也有一定的影响,其比值越大,超越概率越小,且随期望破坏程度的加重,这种影响也趋于明显,当ηc-bua在1.2以上时,结构的倒塌概率均小于10%,满足大震不倒的概率要求。

关键词：柱梁抗弯承载力比纤维增强混凝土(FRC) 抗倒塌性能推覆分析增量动力分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：