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Lipoprotein (a) Cut-Off in Chronic Kidney Disease Patients with a History of Cardiovascular Disease in Center Hospital University Souro SANOU, Burkina Faso

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Advances in Biological Chemistry 2023年第6期13卷 228-235页

作者： Ollo Da aoua semde Arnaud Kouraogo Emmanuel Zongo Amidou Sawadogo Aristide Zongo Fatou Gueye Tall Souleymane Fofana Sanata Bamba Georges Anicet Ouedraogo Department of Medical Biochemistry Center Hospital University Souro SANOU Bobo-Dioulasso Burkina Faso Higher Institute of Health Sciences (INSSA) Nazi BONI University (UNB) Bobo-Dioulasso Burkina Faso Nephrology-Dialysis Department Center Hospital University Souro SANOU Bobo-Dioulasso Burkina Faso Department of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University Dakar Senegal Department of Pharmacy Center Hospital University Souro SANOU Bobo-Dioulasso Burkina Faso Laboratory of Research in Health Science and Animal Biotechnology (LARESBA) Nazi BONI University (UNB) Bobo-Dioulasso Burkina Faso

Patients living with chronic kidney disease (CKD) are at high risk of cardiovascular events. Our aim in this study was to assess the cut-off value for lipoprotein (a) (Lp(a)) in CKD patients with a history of cardiovascular disease (CVD). This was a cross-sectional study. Variables including age, sex, history of CVD, body mass index and CKD stage, were collected during CKD patient’s first admission in the nephrology dialysis department. Blood samples were collected for quantitative determination of Lp(a) by immunoturbidimetric method. They were divided into two groups: CKD patients without history of CVD and CKD patients with history of CVD. Fisher’s exact test was used to assess associations with a significance level of 0.05%. Area under the curve (AUC) and new cut-off value for Lp(a) were identified by drawing Receiver Operating Characteristic (ROC) curve. A total of seventy CKD patients with median age of 43 years [minimum-maximum = 15 - 78 years] were included. Patients with history of CVD were 65.71% (46/70). New Lp(a) cut-off point in CKD patients with history of CVD was 66.50 nmol/L [sensitivity, 87.00%;specificity, 58.30%;AUC = 0.727;p = 0.000]. ROC curve demonstrated good performance of Lp(a) to screen CKD patients with history of CVD. Further research is needed to determine an LPA gene polymorphism’s contribution to increasing risk for CVD at each kidney disease stage.

关键词： Lipoprotein (a) Cut-Off Chronic Kidney Disease Cardiovascular Disease

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Preliminary Study on Renal Ultrasound Biometry in Apparently Healthy 18 to 30-Year-Old Subjects with Normal Renal Function in Ouagadougou

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Open Journal of Nephrology 2020年第4期10卷 388-402页

作者： Gérard Coulibaly Boubakar Ouattara Gloria D. M. H. Capo-Chichi Tiéba Millogo Aïda H. Y. Lengani aoua semde Gaoussou Sanou Amidou Sawadogo Balkissa Ouattara Ousséini Diallo Nephrology and Haemodialysis Department of Yalgado Ouedraogo University Hospital Center of Ouagadougou Ouagadougou Burkina Faso Imaging Department of Yalgado Ouedraogo University Hospital Center of Ouagadougou Ouagadougou Burkina Faso Health Sciences Research Institute Ouagadougou Burkina Faso Nephrology-Dialysis Department of Sourô Sanou University Hospital Center of Bobo-Dioulasso Bobo-Dioulasso Burkina Faso Omaha Nebraska USA

Introduction: In our practice, renal measurements in patients with normal renal function usually appear to be lower compared to standards reported in reference literature. The standards are probably different in our context. Given the importance of renal biometrics in nephrological practice, we felt it necessary to carry out this preliminary study in order to identify an order of reference measurements appropriate to our context. Methods: This was a cross-sectional study that took place from 18 August to 04 November 2018 at the Yalgado Ouedrarogo University Hospital Center. The first 100 subjects aged between 18 and 30 years who met the following inclusion criteria were selected: to be black african Burkinabe and to have normal renal function. The height, width and thickness of each kidney were measured using ultra-sound scanners. For statistical tests, a value of p Results: The average age was 23.9 ± 6.1 years and the sex ratio was 2.2. Mean heights, widths and renal thicknesses were 94.5 ± 14.5, 38.7 ± 10.7 and 36.3 ± 10.3 mm, and 96.7 ± 16.7, 42.7 ± 16.7 and 36.8 ± 10.8 mm respectively for right and left kidneys. The distribution of the different renal dimensions in our sample followed a normal distribution. In the particular case of the right kidney, the probability that its height was between 79.2 and 109.7 mm was 0.95 and the probability that it was less than 79.2 mm or greater than 109.7 mm was 0.05. Renal height was significantly higher in subjects with height greater than 1.70 m (p ≤ 0.02). The left kidneys were on average significantly larger than the right kidneys (p = 0.0001). Conclusions: Our study is not extrapolable to the general population of Burkina Faso. It suggests, however, that the kidneys of the apparently healthy Burkinabe subject are smaller than what is reported in anatomy reference books. Our work, which is preliminary, should be deepened through a national survey. In the

关键词： Black African Burkina Faso Renal Biometrics Ultrasounds Scanner

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