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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 45-46页

作者： aoki c.a. Rossaro L. Ramsamooj R. c.L. Bowlus 徐瑞 Division of Gastroenterology Univ. of California Davis Med. Ctr. PSSB 3500 4150 V Street Sacramento CA 95817 United States Dr.

Purpose: Liver iron is frequently elevated in chronic hepatitis c.a.d may con tribute to liver injury. The pathophysiology behind this phenomenon may involve hepcidin, a gene that is up- regulated in the liver by inflammation and iron. I nappropriately low hepcidin is important to the pathophysiology of hereditary he mochromatosis. However, the role of hepcidin in the iron loading of patients wit h hepatitis c is unknown. Subjects and Methods: To determine whether liver hepci din mRNA correlates with markers of hepatic inflammation and iron status in pati ents with hepatitis c, we extracted total RNA from liver biopsy specimens of pat ients with chronic hepatitis c.a.d quantified hepcidin mRNA. Liver hepcidin mRNA levels were then correlated with aspartate aminotransferase, alanine aminotrans ferase, ferritin, viral load, fibrosis, hepatic iron concentration, and Hepatic.a.tivity Index (HAI). Results: Among patients with hepatitis c, there was a sign ificant correlation of hepcidin mRNA expression in the liver with hepatic iron c oncentration and serum ferritin (r = 0.72, P = 0.006, and r = 0.60, P = 0.01, re spectively). Hepcidin mRNA expression in the liver did not correlate with aspart ate aminotransferase, alanine aminotransferase, HAI, or viral load. No differenc es in hepcidin mRNA were found based on viral genotype or the presence of fibros is. conclusion: In contrast to other inflammatory states, hepcidin mRNA expressi on in the liver was independent of markers of inflammation in hepatitis c. Inste ad, our results suggest that iron stores in patients with hepatitis c regulate h epcidin expression and that iron loading in chronic hepatitis c is not due to in appropriate hepcidin expression.

关键词：丙型肝炎患者帕西慢性丙型肝炎肝活检标本丙肝患者遗传性血色病氨基转移酶病毒载量血清铁蛋白病理生理

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.a.am Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct c.a.ses of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance c.a.acteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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collaborative multi-agent reinforcement learning based on experience propagation

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Journal of Systems Engineering and Electronics 2013年第4期24卷 683-689页

作者： Min Fang Frans c.a. Groen School of computer Science and Technology Xidian University Informatics Institute University of Amsterdam

For multi-agent reinforcement learning in Markov games, knowledge extraction and sharing are key research problems. State list extracting means to calculate the optimal shared state path from state trajectories with cycles. A state list extracting algorithm checks cyclic state lists of a current state in the state trajectory, condensing the optimal action set of the current state. By reinforcing the optimal action selected, the action policy of cyclic states is optimized gradually. The state list extracting is repeatedly learned and used as the experience knowledge which is shared by teams. Agents speed up the rate of convergence by experience sharing. competition games of preys and predators are used for the experiments. The results of experiments prove that the proposed algorithms overcome the lack of experience in the initial stage, speed up learning and improve the performance.

关键词： multi-agent Q learning state list extracting experience sharing.

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic.a.d idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic.a.d environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma c.a.tivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Amarts on Riesz Spaces

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Ac.a.Mathematica Sinica,English Series 2008年第2期24卷 329-342页

作者： coenraad c.a. LABUSc.a.NE Bruce A.WATSON School of Mathematics University of the Witwatersrand Private Bag 3 P O WITS 2050 South Africa

The concepts of conditional expec.a.ions, martingales and stopping times were extended to the Riesz space context by Kuo, Labusc.a.ne and Watson （Discrete time stoc.a.tic processes on Riesz spaces, Indag. Math.,15（2004）, 435-451）. Here we extend the definition of an asymptotic martingale （amart） to the Riesz spaces context, and prove that Riesz space amarts can be decomposed into the sum of a martingale and an adapted sequence convergent to zero. consequently an amart convergence theorem is deduced.

关键词： amart martingale Riesz space Banach lattice

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Fisher Information and complexity Measure of Generalized Morse Potential Model

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communications in Theoretical Physics 2016年第9期65卷 275-279页

作者： c.a. Onate J.O.A. Idiodi Physics Department University of Benin Nigeria

The spreading of the quantum-mec.a.ical probability distribution density of the three-dimensional system is quantitatively determined by means of the local information-theoretic quantity of the Shannon information and information energy in both position and momentum spaces. The complexity measure which is equivalent to c.a.er–Rao uncertainty product is determined. We have obtained the information content stored, the concentration of quantum system and complexity measure numerically for n = 0, 1, 2 and 3 respectively.

关键词： fisher information Shannon entropy complexity measures

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Existence of aromatic sp^2 c-H…O = c intramolecular interaction similar to hydrogen bond

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Science china chemistry 1996年第3期39卷 285-291页

作者： Zeper Abliz Hiroshi Moriyama Junji aoki Toyotoshi Ueda Department of chemistry Xin Jiang University Urumchi 830046ChinaDepartment of Chemistry Toho University Funabashi Chiba 274 JapanDepartment of Chemistry Toho University Funabashi Chiba 274 JapanDepartment of ChemistryMeisei UniversityHino Tokyo 191 Japan

A ’H NMR signal shifted drastically to down field (δ - 10.0) at the bay area and in dose proximity to c = O group for H-1 was observed through complete assignments of 1H NMR spectra for pyridino- and benzobenzanthrones. It is concluded that this phenomenon is due not only to the anisotropy effect of c=O plus aromatic ring current effect, but also to the electrostatic.a.traction of c-H (δ+)…O(δ-)=c interaction. The evidence for the sp2c-H…O = c intramolecular interaction similar to hydrogen bond has also been given by EI-MS and MS/MS (cID) spectroscopy and IR spectroscopy, as well as MNDO-PM3 calculations. This new kind of interaction might be called ’quasi-hydrogen bond’.

关键词： polycyclic aromatic ketone pyridinobenzanthrone intramolecular interaction hydrogen bond quasl-hydrogen bond.

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U-Pb provenance fingerprints of metavolcanic-sedimentary successions of the Mineiro belt:Proxies for the continuity of plate tectonics through the Paleoproterozoic

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Geoscience Frontiers 2022年第5期13卷 309-335页

作者： W.Teixeira c.a.Ávila I.A.Dussin E.Bongiolo Instituto de Geociênc.a. Universidade de São PauloBrazil Museu Nacional Universidade Federal do Rio de JaneiroBrazil Faculdade de Geologia Universidade do Estado do Rio de JaneiroBrazil Programa de Pós-graduação em Geociênc.a. Instituto de GeociênciasUniversidade Federal do Rio Grande do SulBrazil

We document new U-Pb detrital zircon LA-Mc-IcP-MS data for seven metavolcanic-sedimentary successions and metasedimentary sequences and reassess additional dates of five silicic.a.tic samples toward their tectonic significance in the context of the Mineiro belt,Southern São Francisco *** belt represents a crustal segment of the 2.47–2.00 Ga Minas Orogen,c.a.sically known by its Siderian and Rhyac.a. juvenile rocks with important implications in the Earth’s *** new and compiled detrital provenance constraints unravel the long-lived magmatic.a.d sedimentary history of the studied basins,lasting ca.230–220 *** maximum depositional dates around 2.1 Ga reflect the renewed sediment budget with the subsequent metamorphic episode ca.2.0 *** of the unmixed relative probability diagrams are consistent with sourcing from the Siderian and Rhyac.a. arcs of the Mineiro belt,determining a detrital provenance c.a.ge in time and space for the precursor *** potential sources could be the youngest rocks of the Mantiqueira and Juiz de Fora terranes that constitute the other segments of the Minas Orogen,given the age *** overall detrital fingerprints determine the study basins resumed mainly in Rhyac.a. fore-arc.a.d/or back-arc settings,i.e.,akin to a subductionrelated system that evolved to a collisional(foreland)*** samples show fingerprints of primary extensional settings,determined by major Archean detrital populations sourced from areas outside the Mineiro belt beside the Paleoproterozoic *** working model considers the collage between the Mineiro belt and the ancient foreland around 2.10 Ga and eventual interaction with other crustal segments of the Minas Orogen,generating the ca.2.0 Ga metamorphism over the metasedimentary *** more complete isotopic repository in detrital and igneous zircon grains for the studied supracrustal successions and the assoc.a.ed rocks allows new insights into the Rhyac.a.–Oro

关键词： Paleoproterozoic São Francisco c.a.on Detrital zircon geochronology Metavolcanic-sedimentary basin

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MnO/N—c.a.ode materials for lithium-ion batteries prepared by cotton-templated combustion synthesis

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Green Energy & Environment 2017年第4期2卷 377-386页

作者： cheng-Gong Han chunyu Zhu Yoshitaka aoki Hiroki Habazaki Tomohiro Akiyama Faculty of Engineering Hokkaido University

We herein report a facile one-pot synthesis of MnO/N-doped carbon(N—c) composites via a sustainable cotton-template glycineenitrate combustion synthesis to yield superior anode materials for Li ion batteries. MnO nanoparticles with several nanometers were well-embedded in a porous N-doped carbon matrix. It displays the unique c.a.acteristics, including the shortened Li^+-ion transport path, increased contact areas with the electrolyte solution, inhibited volume c.a.ges and agglomeration of nanoparticles, as well as good conductivity and structural stability during the cycling process, thereby benefiting the superior cycling performance and rate capability. This favorable electrochemical performance of obtained MnO/N—c composites via a one-pot biomass-templated glycine/nitrate combustion synthesis renders the suitability as anode materials for Li-ion batteries.

关键词： Biomass cotton Manganese oxide Lithium ion battery Porous carbon

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