检索结果-南通市图书馆

Liquid-phase 3D bioprinting of gelatin alginate hydrogels:influence of printing parameters on hydrogel line width and layer height

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2019年第3期2卷 172-180页

作者： Maha Alruwaili jose A.Lopez Kevin mccarthy Emmanuel G.Reynaud Brian j.Rodriguez Conway Institute of Biomolecular and Biomedical Research University College DublinDublinIreland School of Physics University College DublinDublinIreland School of Biomolecular and Biomedical Science University College DublinDublinIreland

Extrusion-based 3D bioprinting is a direct deposition approach used to create three-dimensional(3D)tissue scaffolds typically comprising *** are hydrated polymer networks that are chemically or physically ***,3D bioprinting is performed in air,despite the hydrated nature of hydrogels and the potential advantage of using a liquid phase to provide cross-linking and otherwise functionalize the *** this work,we print gelatin alginate hydrogels directly into a cross-linking solution of calcium chloride and investigate the influence of nozzle diameter,distance between nozzle and surface,calcium chloride concentration,and extrusion rate on the dimensions of the printed *** hydrogel layer height was generally found to increase with increasing extrusion rate and nozzle distance,according to the increased volume extruded and the available space,*** addition,the hydrogel width was generally found to increase with decreasing nozzle distance and cross-linking concentration corresponding to confinement-induced spreading and low crosslinking regimes,***/height ratios of^1 were generally achieved when the nozzle diameter and distance were comparable above a certain cross-linking *** these relationships,biocompatible 3D multilayer structures were successfully printed directly into calcium chloride cross-linking solution.

关键词： Gelatin alginate Hydrogel Additive manufacturing 3D printing 3D bioprinting Biomaterials Extrusion Bioplotting

在线全文

学校读者我要写书评

暂无评论

《音系学中的优选论读本》述评

当代语言学 2007年第2期9卷 176-181页

作者： j.mccarthy 张璐天津师范大学主校区外国语学院

《音系学中的优选论读本》（Optimality Theory in Phonology：A Reader）于2004年由B1ackwell出版社出版。美国马萨诸塞州大学语言学系教授john ***任该书主编。mccarthy于1979年在麻省理工学院获得语言学博士学位，长期以来一直致力... 详细信息

《音系学中的优选论读本》（Optimality Theory in Phonology：A Reader）于2004年由B1ackwell出版社出版。美国马萨诸塞州大学语言学系教授john ***任该书主编。mccarthy于1979年在麻省理工学院获得语言学博士学位，长期以来一直致力于音系学理论的研究及教学，目前主要研究优选论的理论及应用。

关键词：优选论音系学读本述评麻省理工学院马萨诸塞州博士学位出版社

Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis ***-j378

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2018年第4期3卷 246-251页

作者： Dongbo Xu Keshav K.Nepal jing Chen Dedra Harmody Haining Zhu Peter j.mccarthy Amy E.Wright Guojun Wang Harbor Branch Oceanographic Institute Florida Atlantic University5600 US 1 NorthFort PierceFL34946United States Department of Molecular and Cellular Biochemistry University of Kentucky741 South LimestoneLexingtonKY40536United States

Marine natural products have become an increasingly important source of new drug leads during recent *** an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis *** ***,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-j378 significantly increased the yield of these *** structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS *** A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,*** analysis of the draft genome of HB-j378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins.

关键词： Nocardiopsis Nocardiopsistins Angucycline Anti-MRSA Actinobacteria LaCl_(3)

《隐含的归纳:优选论中的音系不透明现象》介绍

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代语言学 2010年第2期12卷 182-185页

作者： j.mccarthy 郭中子美国马萨诸塞州大学语言学系同济大学外国语学院上海市200092 天津外国语学院英语学院天津市300204

1．引言

关键词：优选论音系归纳隐含 Equinox 2007年马萨诸塞州系列丛书

Galaxy formation in the reionization epoch as hinted by WideField Camera 3 observations of the Hubble Ultra Deep Field

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2010年第9期10卷 867-904页

作者： Hao-jing Yan Rogier A. Windhorst Nimish E Hathi Seth H. Cohen Russell E.Ryan Robert W. O＇Connell Patrick j. mccarthy Center for Cosmology and AstroParticle Physics The Ohio State University 191 West Woodruff Avenue Columbus OH 43210 USA School of Earth and Space Exploration Arizona State University Tempe AZ 85287 USA Department of Physics ＆ Astronomy University of California Riverside CA 92521 USA Department of Physics University of California One Shields Avenue Davis CA 95616 USA Astronomy Department University of Virginia P.O. Box 3818 Charlottesville VA 22903 USA Observatories of the Carnegie Institution of Washington 813 Santa Barbara Street Pasadena CA 91101 USA

We present a large sample of candidate galaxies at z ≈ 7 - 10, selected in the Hubble Ultra Deep Field using the new observations of the Wide Field Camera 3 that was recently installed on the Hubble Space Telescope. Our sample is composed of 20 z850-dropouts （four new discoveries）, 15 Y105-dropouts （nine new discoveries） and 20 j125-dropouts （all new discoveries）. The surface densities of the Z850-dropouts are close to what was predicted by earlier studies, however, those of the Y105- and j125-dropouts are quite unexpected. While no Y105- or j125-dropouts have been found at AB ≤ 28.0 mag, their surface densities seem to increase sharply at fainter levels. While some of these candidates seem to be close to foreground galaxies and thus could possibly be gravitationally lensed, the overall surface densities after excluding such cases are still much higher than what would be expected if the luminosity function does not evolve from z ～ 7 to 10. Motivated by such steep increases, we tentatively propose a set of Schechter function parameters to describe the luminosity functions at z ≈8 and 10. As compared to their counterpart at z ≈ 7, here L^＊ decreases by a factor of ～ 6.5 and Ф^＊ increases by a factor of 17-90. Although such parameters are not yet demanded by the existing observations, they are allowed and seem to agree with the data better than other alternatives. If these luminosity functions are still valid beyond our current detection limit, this would imply a sudden emergence of a large number of low-luminosity galaxies when looking back in time to z ≈ 10, which, while seemingly exotic, would naturally fit in the picture of the cosmic hydrogen reionization. These early galaxies could easily account for the ionizing photon budget required by the reionization, and they would imply that the global star formation rate density might start from a very high value at z ≈ 10, rapidly reach the minimum at z≈ 7, and start to rise again towards z ≈ 6. In this scenario, the maj

关键词： cosmology observations -- cosmology early universe -- galaxies evolution -- galaxies luminosity function, mass function -- infrared galaxies

The impact of storage conditions upon gentamicin coated antimicrobial implants

在线全文

学校读者我要写书评

暂无评论

journal of Pharmaceutical Analysis 2016年第6期6卷 374-381页

作者： Nicholas D. Mullins Benjamin j. Deadman Humphrey A. Moynihan Florence O. mccarthy Simon E. Lawrence jonathan Thompson Anita R. Maguirea Department of Chemistry Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University CollegeCork Ireland DePuy Synthes (Ireland) Loughbeg Ringaskiddy Co. Cork Ireland School of Pharmacy Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University College CorkIreland

A systematic approach was developed to investigate the stability of gentamicin sulfate(GS) and GS/poly(lacticco-glycolic acid)(PLGA) coatings on hydroxyapatite *** influence of environmental factors(light,humidity,oxidation and heat) upon degradation of the drug in the coatings was investigated using liquid chromatography with evaporative light scattering detection and mass *** coated rods were found to be stable across the range of environments assessed,with only an oxidizing atmosphere resulting in significant changes to the gentamicin *** contrast,rods coated with GS/PLGA were more sensitive to storage conditions with compositional changes being detected after storage at 60 °C,75% relative humidity or exposure to *** effect of γ-irradiation on the coated rods was also investigated and found to have no significant ***,liquid chromatography–mass spectrometry analysis revealed that known gentamines C_1,C_1 aand C_2were the major degradants *** degradation of gentamicin coatings did not produce any unexpected degradants or impurities.

关键词： Gentamicin Coatings Storage stability testing LC–ELSD

Nociceptive and Neuropathic Pain Qualities in Men and Women with Acute Coronary Syndromes: A Complex Pain Presentation

在线全文

学校读者我要写书评

暂无评论

Open journal of Nursing 2017年第3期7卷 331-344页

作者： Sheila O’Keefe-mccarthy Michael McGillion Charles j. Victor Sheila Rizza judith McFetridge-Durdle Brock University St. Catharines Ontario Canada Heart and Stroke Foundation/Michael G. De Groote Endowed Chair in Cardiovascular Nursing Research School of Nursing Faculty of Health Sciences Hamilton Ontario Canada University of Toronto Toronto Ontario Canada Nurse Practitioner Heart Failure Clinic Trillium Health Partners-Credit Valley Site Mississauga Ontario Canada Florida State University College of Nursing Tallahassee Florida US

Background: Cardiac pain arising from acute coronary syndrome (ACS) is a multi-factorial phenomenon. Historically, episodes of cardiac pain have been captured using a one-dimensional numeric pain rating scale. Lacking in clinical practice are acute pain assessments that employ a comprehensive evaluation of an emergent ACS episode. Aim: To examine the sensory-discriminative, motivational-affective and cognitive-evaluative dimensions of ACS-related pain. Methods: A descriptive-correlational, repeated-measure design was used to collect data on 121 ACS patients of their cardiac pain intensity. The (numeric rating scale-NRS 0-10 scale) measured chest pain “Now” and “Worst pain in the previous 2 hours over 8 hours” and the McGill Pain Questionnaire Short-Form (MPQ-SF) measured pain at 4 hours. Results: Mean age was 67.6 ± 13, 50% were male, 60% had unstable angina and 40% had Non-ST-elevation myocardial infarction. Cardiac pain intensity scores remained in the mild range from 1.1 ± 2.2 to 2.4 ± 2.7. MPQ-SF: 66% described pain as distressing and 26% reported pain was horrible or excruciating. Participants described ACS pain quality as acute injury (nociceptive pain: heavy, cramping, stabbing), as nerve damage (neuropathic: gnawing, hot-burning, shooting) and as a mixture of acute and chronic pain qualities (aching, tender and throbbing). Conclusions: Patients reported both nociceptive and neuropathic cardiac pain. It is unclear if pain perceptions are due to: i) pathophysiology of clot formation, ii) occurrence of a first or repeated ACS episode, or iii) complex co-morbidities. Pain arising from ACS requires an understanding of the interplay of ischemic, metabolic and neuropathophysiological mechanisms that contribute to complex cardiac pain experiences.

关键词： Acute Coronary Syndromes Nociceptive Pain Neuropathic Pain Pain Descriptors Emergency Department

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

剑桥标准英语教程 3A 学生用书 2

CONTROLLING TOPOGRAPHY AND PROPERTIES OF POLYMER SURFACES USING MAGIC

丛书名：新东方大愚文化

2016年

作者： Michael mccarthy jeanne McCarten Helen Sandiford

本书以庞大的剑桥英语语料库为基石，结合英语的实际应用情况，向学生展示真实语境中的语言和明确的会话策略，帮助学生流利、自信地说出英语。本教程除了讲授听说读写技巧外，还包含大量练习，另配有MP3光盘和网站支持，帮助全面提高... 详细信息

ISBN: (纸本)9787561944837

本书以庞大的剑桥英语语料库为基石，结合英语的实际应用情况，向学生展示真实语境中的语言和明确的会话策略，帮助学生流利、自信地说出英语。本教程除了讲授听说读写技巧外，还包含大量练习，另配有MP3光盘和网站支持，帮助全面提高学生的英语应用能力。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

CONTROLLING TOPOGRAPHY AND PROPERTIES OF POLYMER SURFACES US...