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Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

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World Journal of Gastroenterology 2006年第19期12卷 3031-3037页

作者： Kazuhiro Fukushima Yoko aoi Shinichi Kato Koji Takeuchi Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University MisasagiYamashinaKyoto 607-8414Japan

AIM： Lafutidine, a histamine H2 receptor antagonist, exhibits gastro-protective action mediated by capsaicinsensitive afferent neurons （CSN）. We compared the effect between lafutidine and capsaicin, with respect to the interaction with endogenous prostaglandins （PG）, nitric oxide （NO） and the afferent neurons, including transient receptor potential vanilloid subtype 1 （TRPV1）. METHODS： Male SD rats and C57BL/6 mice, both wildtype and prostacyclin IP receptor knockout animals, were used after 18 h of fasting. Gastric lesions were induced by the po administration of HCl/ethanol （60% in 150 mmol/L HCl） in a volume of 1 mL for rats or 0.3 mL for mice. RESULTS： Both lafutidine and capsaicin （1-10 mg/kg, po） afforded dose-dependent protection against HCI/ ethanol in rats and mice. The effects were attenuated by both the ablation of CSN and pretreatment with NG-nitro- L-arginine methyl ester, yet only the effect of capsaicin was mitigated by prior administration of capsazepine, the TRPV1 antagonist, as well as indomethacin. Lafutidine protected the stomach against HCl/ethanol in IP receptor knockout mice, similar to wild-type animals, while capsaicin failed to afford protection in the animals lacking IP receptors. Neither of these agents affected the mucosal PGE2 or 6-keto PGF1α contents in rat stomachs. Capsaicin evoked an increase in [Ca^2＋]i in rat TRPV1-transfected HEK293 cells while lafutidine did not. CONCLUSION： These results suggest that although both lafutidine and capsaicin exhibit gastro-protective action mediated by CSN, the mode of their effects differs regarding the dependency on endogenous PGs/IP receptors and TRPV1. It is assumed that lafutidine interacts with CSN at yet unidentified sites other than TRPV1.

关键词： Lafutidine A histamine H2-receptor antagonist Gastric protection Prostaglandin Capsaicin-sensirive afferent neuron TRPVt

Integrated biological–physical process for biogas purification effluent treatment

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Journal of Environmental Sciences 2019年第9期31卷 110-122页

作者： Roslan Noorain Tomonori Kindaichi Noriatsu Ozaki Yoshiteru aoi Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of Engineering Hiroshima University 1-4-1 Kagamiyama Higashihiroshima Hiroshima 739-8527 Japan Section of Environmental Engineering Technology Malaysia Institute of Chemical & Bioengineering Technology University Kuala Lumpur Lot 1988 Kawasan Perindustrian Bandar Vendor Taboh Naning 78000 Alor Gajah Melaka Malaysia Department of Molecular Biotechnology Graduate School of Advanced Sciences of Matter Hiroshima University 1-3-1 Kagamiyama Higashihiroshima 739-8530 Japan

Biogas purification via water scrubbing produces effluent containing dissolved CH4, H2S,and CO2, which should be removed to reduce greenhouse gas emissions and increase its potential for water regeneration. In this study, a reactor built with air supplies at the top and bottom was utilized for the treatment of biogas purification effluent through biological oxidation and physical stripping processes. Up to 98% of CH4 was removed through biological treatment at a hydraulic retention time of 2 hr and an upper airflow rate of 2.02 L/day. Additionally, a minimum CH4 concentration of 0.04% with no trace of H2S gas was detected in the off gas. Meanwhile, a white precipitate was captured on the carrier showing the formation of sulfur. According to the developed mathematical model, an upper airflow rate of greater than 2.02 L/day showed a small deterioration in CH4 removal performance after reaching the maximum value, whereas a 50 L/day bottom airflow rate was required to strip the CO2 efficiently and raise the effluent p H from 5.64 to 7.3. Microbiological analysis confirmed the presence of type 1 methanotroph communities dominated by Methylobacter and Methylocaldum. However, bacterial communities promoting sulfide oxidation were dominated by Hyphomicrobium.

关键词： Biogas purification effluent Dissolved methane pH elevation Biological oxidation CO2 stripping

Origins of short gamma-ray bursts deduced from offsets in their host galaxies revisited

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Research in Astronomy and Astrophysics 2012年第9期12卷 1255-1268页

作者： Xiao-Hong Cui Shigehiro Nagataki Junichi aoi Ren-Xin Xu National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China xhcui@ bao.ac cn Yukawa Institute for Theoretical Physics Oiwake-cho Kitashirakawa Sakyo-ku Kyoto606-8502 Japan School of Physics and State Key Laboratory of Nuclear Physics and Technology PekingUniversity Beijing 100871 China

The spatial distribution of short Gamma-ray bursts (GRBs) in their host galaxies provides us with an opportunity to investigate their origins. Based on the currently observed distribution of short GRBs relative to their host galaxies, we obtain the fraction of the component that traces the mergers of binary compact objects and the one that traces star formation rate (such as massive stars) in earlyand late-type host galaxies. From the analysis of projected offset distribution and only based on population synthesis and massive star models, we find that the fraction of massive stars is 0.37+-00..4327 with an error at the 1σ level for a sample with 22 short GRBs in the literature. From these results, it is hard to accept that the origin of short GRBs with observed statistics is well described by current models using only the offset distribution. The uncertainties in observational localizations of short GRBs also strongly affect the resulting fraction.

关键词： gamma-rays: bursts — cosmology: galaxy — methods: statistical

Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature

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World Journal of Gastroenterology 2021年第1期27卷 129-142页

作者： Takeshi Okamoto Takaaki Yoshimoto Nobuyuki Ohike aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda Department of Gastroenterology St.Luke's International HospitalTokyo 104-8560Japan Department of Pathology Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Surgery St.Luke’s International HospitalTokyo 104-8560Japan Department of Cardiology St.Luke’s International HospitalTokyo 104-8560Japan

BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely *** report the first case of spontaneous regression of gastric *** SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed *** tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle *** esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 *** removal of the abdominal mass confirmed it to be a metastatic gastrinoma *** gastric lesion was subsequently diagnosed as primary gastric *** months later,the gastric lesion had disappeared without *** patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of *** Gastric gastrinoma may arise as a polypoid lesion in the gastric *** regression can rarely occur after biopsy.

关键词： Neuroendocrine neoplasm Functional tumor Biopsy Gastrin Stomach Case report

Biological methane production coupled with sulfur oxidation in a microbial electrosynthesis system without organic substrates

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Journal of Environmental Sciences 2022年第6期34卷 68-78页

作者： Ha T.T.Dinh Hiromi Kambara Shuji Matsushita Yoshiteru aoi Tomonori Kindaichi Noriatsu Ozaki Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of Advanced Science and EngineeringHiroshima University1-4-1KagamiyamaHigashihiroshimaHiroshima 739-8527Japan Faculty of Environment Ho Chi Minh City University of Natural Resources and Environment236 Le Van Sy1 WardTan Binh DistrictHo Chi Minh CityViet Nam Agricultural Technology Research Center Hiroshima Prefectural Technology Research Institute6869HaraHachihonmatsuHigashihiroshimaHiroshima 739-0151Japan Program of Biotechnology Graduate School of Integrated Sciences for LifeHiroshima University1-3-1KagamiyamaHigashihiroshimaHiroshima 739-8530Japan

Methane is produced in a microbial electrosynthesis system(MES) without organic substrates. However, a relatively high applied voltage is required for the bioelectrical *** this study, we demonstrated that electrotrophic methane production at the biocathode was achieved even at a very low voltage of 0.1 V in an MES, in which abiotic HS-oxidized to SO_(4)^(2-) at the anodic carbon-cloth surface coated with platinum powder. In addition, microbial community analysis revealed the most probable pathway for methane production from electrons. First, electrotrophic H_(2) was produced by syntrophic bacteria, such as Syntrophorhabdus, Syntrophobacter, Syntrophus, Leptolinea, and Aminicenantales, with the direct acceptance of electrons at the biocathode. Subsequently, most of the produced H_(2) was converted to acetate by homoacetogens, such as Clostridium and Spirochaeta 2. In conclusion,the majority of the methane was indirectly produced by a large population of acetoclastic methanogens, namely Methanosaeta, via acetate. Further, hydrogenotrophic methanogens,including Methanobacterium and Methanolinea, produced methane via H_(2).

关键词： Bioelectricity Homoacetogens Methane production Microbial electrosynthesis system Sulfur oxidation

New microbial electrosynthesis system for methane production from carbon dioxide coupled with oxidation of sulfide to sulfate

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Journal of Environmental Sciences 2023年第3期125卷 786-797页

作者： Hiromi Kambara Ha T.T.Dinh Shuji Matsushita Yoshiteru aoi Tomonori Kindaichi Noriatsu Ozaki Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan Faculty of Environment Ho Chi Minh City University of Natural Resources and Environment236 Le Van Sy1 WardTan Binh DistrictHo Chi Minh CityVietnam Agricultural Technology Research Center Hiroshima Prefectural Technology Research Institute6869HaraHachihonmatsuHigashihiroshimaHiroshima 739–0151Japan Program of Biotechnology Graduate School of Integrated Sciences for LifeHiroshima University1–3–1KagamiyamaHigashi-HiroshimaHiroshima 739–8530Japan Department of Civil and Environmental Engineering Graduate School of Advanced Science and EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan

Microbial electrosynthesis system (MES) is a promising method that can use carbon dioxide,which is a greenhouse gas,to produce methane which acts as an energy source,without using organic ***,this bioelectrical reduction reaction can proceed at a certain high applied voltage when coupled with water oxidation in the anode coated with metallic *** coupled with the oxidation of HS–to SO_(4)^(2-),methane production is thermodynamically more feasible,thus implying its production at a considerably lower applied *** this study,we demonstrated the possibility of electrotrophic methane production coupled with HS–oxidation in a cost-effective bioanode chamber in the MES without organic substrates at a low applied voltage of 0.2 *** addition,microbial community analyses of biomass enriched in the bioanode and biocathode were used to reveal the most probable pathway for methane production from HS–*** the bioanode,electroautotrophic SO_(4)^(2-)production accompanied with electron donation to the electrode is performed mainly by the following two steps:first,incomplete sulfide oxidation to sulfur cycle intermediates (SCI) is performed;then the produced SCI are disproportionated to HS^(–)and SO_(4)^(2-).In the biocathode,methane is produced mainly via H_(2)and acetate by electronaccepting syntrophic bacteria,homoacetogens,and acetoclastic ***,a new ecofriendly MES with biological H_(2)S removal is established.

关键词： Microbial electrosynthesis system Low applied voltage Organic substrates Methane production Sulfur oxidation

Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4377-4383页

作者： Akio Sato Kazuhiro Saito Koichiro Abe Katsutoshi Sugimoto Toshitaka Nagao aoi Sukeda Daisuke Yunaiyama Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Gastroenterology and Hepatology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Anatomic Pathology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan

BACKGROUND As hepatic myelolipoma is rarely encountered,its radiological diagnosis using ultrasonography(US),computed tomography(CT),and magnetic resonance imaging(MRI)is *** myelolipoma is similar to fat-contained hepatic lesions seen in hepatocellular carcinoma and ***,further development of techniques to diagnose hepatic myelolipoma is *** SUMMARY A 44-year-old obese man was found to have a hepatic lesion during his medical *** lesion was 50 mm×57 mm in size and was detected in segment 8(S8)of the liver by *** patient was diagnosed with hepatic lesion 20 years ago,but it was left *** patient had no symptoms,liver dysfunction,hepatitis virus antibody,or tumor marker *** CT showed a welldefined lesion in S8 of the *** central and peripheral areas of the lesion primarily exhibited fat density and hypodensity,*** revealed a capsule-like *** was performed to address the probability of hepatocellular *** lesion was pathologically confirmed as a *** marrow scintigraphy performed using 111InCl3 revealed accumulation of the radiopharmaceutical in the soft tissue component,except in the fat-dominant part of the tumor,as well as in the surrounding liver parenchyma due to the presence of reticuloendothelial cells in the *** This is the first report on the diagnosis of hepatic myelolipoma using 111InCl3 *** effectiveness of bone marrow scintigraphy for diagnosing hepatic myelolipoma might be *** radiopharmaceuticals accumulate in both hematopoietic and reticuloendothelial cells,the accumulation of radiopharmaceuticals in the lesion is obscure.

关键词： Liver 111InCl3 Myelolipoma Magnetic resonance imaging Benign tumor Case report

Two homologous INDOLE-3-ACETAIVHDE (IAM) HYDROLASE genes are required for the auxin effects of IAM in Arabidopsis

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Journal of Genetics and Genomics 2020年第3期47卷 157-165页

作者： Yangbin Gao Xinhua Dai Yuki aoi Yumiko Takebayashi Liping Yang Xiaorui Guo Qiwei Zeng Hanchuanzhi Yu Hiroyuki Kasahara Yunde Zhao Section of Cell and Developmental Biology University of California San DiegoLa JollaCA92093-0116USA RIKEN Center for Sustainable Resource Science Kanagawa230-0045Japan School of Life Sciences Jilin Normal UniversitySiping136000China Key Laboratory of Plant Ecology Northeast Forestry UniversityHarbin150040China State Key Laboratory of Silkworm Genome Biology Institute of Sericulture and Systems BiologySouthwest UniversityChongqing400716China Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyTokyo183-8509Japan Department of Bioregulation and Biointeraction Graduate School of AgricultureTokyo University of Agriculture and TechnologyFuchu183-8509Japan

Indole-3-acetamide(IAM)is the first confirmed auxin biosynthetic intermediate in some plant pathogenic *** applied IAM or production of IAM by overexpressing the bacterial iaaM gene in Arabidopsis causes auxin overproduction ***,it is still inconclusive whether plants use IAM as a key precursor for auxin ***,we reported the isolation IAM HYDROLASE 1(IAMH1)gene in Arabidopsis from a forward genetic screen for IAM-insensitive mutants that display normal auxin ***1 has a close homolog named IAMH2 that is located right next to IAMH1on chromosomeⅣin *** generated iamh1 iamh2 double mutants using our CRISPR/Cas9gene editing *** showed that disruption of the IAMH genes rendered Arabidopsis plants resistant to IAM treatments and also suppressed the iaaM overexpression phenotypes,suggesting that IAMH1 and IAMH2 are the main enzymes responsible for converting IAM into indole-3-acetic acid(IAA)in *** iamh double mutants did not display obvious developmental defects,indicating that IAM does not play a major role in auxin biosynthesis under normal growth *** findings provide a solid foundation for clarifying the roles of IAM in auxin biosynthesis and plant development.

关键词： Auxin Auxin biosynthesis Indole-3-acetamide Arabidopsis CRISPR IAMH1 IAMH2

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