检索结果-南通市图书馆

Enhanced protective effect of selenium-biofortified peptide RYNA(Se)MNDYT compared with its native peptide RYNAMNDYT in lipopolysaccharide-injured murine gut microbiota

引用

Food Science and Human Wellness 2024年第6期13卷 3391-3402页

作者： Shujian Wu Zhenjun Zhu Mengfei Chen aohuan huang Yizhen Xie Jiaming Chen Liang Xue Moutong Chen Jumei Zhang Juan Wang Qingping Wu Yu Ding Key Laboratory of Agricultural Microbiomics and Precision Application Ministry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Microbial Safety and HealthState Key Laboratory of Applied Microbiology Southern ChinaInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China Department of Food Science and Engineering Institute of Food Safety and NutritionCollege of Science&EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangdong Yuewei Edible Mushroom Technology Co. Ltd.Guangzhou 510530China College of Food Science South China Agricultural UniversityGuangzhou 510070China

Selenopeptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and ***,limited information is available on the utilization of selenopeptides by gut microbiota,especially Selenium(Se)*** this purpose,the present study aimed to investigate the protective effect of selenopeptide(RYNA(Se)MNDYT,Se-P2,purity of≥95%)and its original peptide(RYNAMNDYT,P2,purity of≥95%)in vivo by the microbiota-metabolite axis and further analyze the potential contribution of Se biofortification to Se-P2 *** results showed that Se-P2 exhibits a higher protective effect on lipopolysaccharide(LPS)-induced inflammation than P2,including pathology of the colon and liver,which suggested that the bioactivity of P2 was promoted by the organic combination of ***,gut microbiota composition tended to be a healthy structure by Se-P2 pretreatment in LPS-injured mice,which had a positive effect on LPS-induced gut microbiota ***,only Se-P2 promoted an increase in the relative abundance of Lactobacillus,Alistipes,and Roseburia and a decrease in the relative abundance of Akkermansia,Erysipelatoclostridium,and Bacteroides in LPS-injured *** changes in gut microbiota were obviously correlated with the changes in metabolites and affected the metabolic pathways of valine,leucine,isoleucine,phenylalanine,tyrosine,and tryptophan biosynthesis and phenylalanine *** may be one of the key reasons for Se-P2 to exert bioactivity through the microbiota-metabolite ***,Se-biofortification in Se-enriched Cordyceps militaris affected the parental proteins of Se-P2 to modulate mitogen-activated protein kinase,GPI anchored protein,and carbohydrate metabolism,translation,folding,sorting and degradation,which may contribute to the bioactivity of *** study provides information on the effect of Se on selenopeptides in vivo,which further promotes the prospective

关键词： Selenopeptide Gut microbiota Metabolites Selenium biofortification Proteomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced protective effect of selenium-biofortified peptide RYNA(Se)MNDYT compared with its native peptide RYNAMNDYT in LPS-injured murine gut microbiota

引用

Food Science and Human Wellness 2023年

作者： Shujian Wu Zhenjun Zhu Mengfei Chen aohuan huang Yizhen Xie Jiaming Chen Liang Xue Moutong Chen Jumei Zhang Juan Wang Qingping Wu Yu Ding Key Laboratory of Agricultural Microbiomics and Precision Application， Ministry of Agriculture and Rural Affairs， Guangdong Provincial Key Laboratory of Microbial Safety and Health， State Key Laboratory of Applied Microbiology Southern China， Institute of Microbiology， Guangdong Academy of Sciences Department of Food Science and Engineering， Institute of Food Safety and Nutrition， College of Science & Engineering， College of Life Science and Technology， Jinan University Guangdong Yuewei Edible Mushroom Technology Co.， Ltd. College of Food Science， South China Agricultural University

Selenium (Se)-containing peptides may be a valuable bioactive compound to promote gut microbiota-targeted therapeutic methods for intestinal disease and hepatopathy. However， limited information is available on the utilization of selenopeptides by gut microbiota， especially Se’s function. For this purpose， the present study aimed to investigate the protective effect of selenopeptide (RYNA(Se)MNDYT， Se-P2， purity of ≥95%) and its original peptide (RYNAMNDYT， P2， purity of ≥95%) in vivo by the microbiota-metabolite axis and further analyze the potential contribution of Se biofortification to Se-P2 bioactivity. The results showed that Se-P2 exhibits a higher protective effect on lipopolysaccharide (LPS)-induced inflammation than P2， including pathology of the colon and liver， which suggested that the bioactivity of P2 was promoted by the organic combination of Se. Notably， gut microbiota composition tended to be a healthy structure by Se-P2 pretreatment in LPS-injured mice， which had a positive effect on LPS-induced gut microbiota dysbacteriosis. Additionally， only Se-P2 promoted an increase in the relative abundance of Lactobacillus， Alistipes， and Roseburia and a decrease in the relative abundance of Akkermansia， Erysipelatoclostridium， and Bacteroides in LPS-injured mice. The changes in gut microbiota were obviously correlated with the changes in metabolites and affected the metabolic pathways of valine， leucine， isoleucine， phenylalanine， tyrosine， and tryptophan biosynthesis and phenylalanine metabolism. This may be one of the key reasons for Se-P2 to exert bioactivity through the microbiota-metabolite axis. Furthermore， Se-biofortification in selenium-enriched Cordyceps militaris affected the parental proteins of Se-P2 to modulate mitogen-activated protein kinase， GPI anchored protein， and carbohydrate metabolism， translation， folding， sorting and degradation， which may contribute to the bioactivity of Se-P2. Our study provides information on the effect of Se on

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

组织支持感与特殊教育教师职业倦怠的关系:职业使命感的中介作用及职称的调节作用

引用

中国特殊教育 2023年第5期 90-96页

作者：陈奕荣魏扬帆张澳环王树生黄建辉泉州师范学院教育科学学院泉州362000 泉州轻工职业学院教育学院泉州362200 江西师范大学教育学院南昌330027 澳门城市大学教育学院中国澳门999078

全面推动我国特殊教育事业的高质量发展,师资队伍建设是关键。为了系统深入了解特殊教育教师职业倦怠的影响因素,探讨组织支持感与特殊教育教师职业倦怠的关系,考察职业使命感在两者之间的中介作用,以及职称的调节作用。采用方便取样法... 详细信息

全面推动我国特殊教育事业的高质量发展,师资队伍建设是关键。为了系统深入了解特殊教育教师职业倦怠的影响因素,探讨组织支持感与特殊教育教师职业倦怠的关系,考察职业使命感在两者之间的中介作用,以及职称的调节作用。采用方便取样法抽取25所特殊教育学校289名特殊教育教师进行调查,结果发现:(1)组织支持感对特殊教育教师职业倦怠具有负向预测作用;(2)职业使命感在组织支持感与职业倦怠的关系中起着重要的中介作用;(3)职称显著调节组织支持感与特殊教育教师职业倦怠之间的关系。低职称教师组织支持感与职业倦怠的负性效应较强,高职称教师组织支持感与职业倦怠的负性效应较弱。

关键词：特殊教育教师组织支持感职业倦怠职业使命感职称

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：