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China Medical Abstracts(Internal Medicine) 2019年第3期36卷 163-164页

作者： dong aobo State Key Lab Infect Dis Prev & Contr Chin Center Dis Cont & Prev

Objective To explore HIV-1 drug resistance and influencing factors among people living with HIV/AIDS before antiretroviral therapy in Liangshan Yi Autonomous Prefecture(Liangshan).Methods Between January 1 and June 30,in both 2017 and 2018,a cross-sectional survey was conducted in Liangshan,HIV-1 pol sequences were gathered and analyzed according to WHO Guidelines on HIV drug resistance surveillance of *** HyPhy 2.2.4 and Cytoscape 3.6.1 software were used to analyze the drug resistant strains of HIV-1 transmission *** A total of 464 people living with HIV/AIDS was *** proportion of HIV-1 CRF07_BC subtype was 88.6%(411/464),with HIV-1 drug resistance rate was 9.9%(46/464).The HIV-1 drug resistance rates of non-nucleoside reverse transcriptase inhibitors(NNRTI),nucleoside reverse transcriptase inhibitors(NRTI)and protease inhibitors(PI)were 6.7%(31/464),1.9%(9/464)and 0.4%(2/464)*** recombinant strains of HIV-1 URF_01BC subtype was independently clustered according to the drug resistant mutation *** from the multivariate logistic analysis showed that injected drug users group had higher risk on HIV-1 drug resistance(aOR=3.03,95%CI:1.40-6.54)than heterosexual group among people living with HIV/*** HIV-1 drug resistance rate had already been in a high level before antiretroviral therapy was in *** newly identified recombinant strains of HIV-1 URF_01BC subtype were independently clustered according to the drug resistant mutation *** was necessary to strengthen the prevention of the HIV-1 drug resistant strains transmission.

关键词： HIV/AIDS drug prevention

Impact of HIV Pretreatment Drug Resistance on Virological Failure After One-Year Antiretroviral Therapy--China,2018-2019

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China CDC weekly 2022年第25期4卷 535-540页

作者： Miaomiao Li Chang Song aobo dong Jing Hu Ruihua Kang Hui Xing Yuhua Ruan Yiming Shao Kunxue Hong Lingjie Liao State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?While antiretroviral therapy(ART)has been rapidly scaled-up among the population living with human immunodeficiency virus or acquired immune deficiency syndrome(HIV/AIDS)... 详细信息

关键词： Therapy Impact patients

Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018

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China CDC weekly 2021年第53期3卷 1133-1138页

作者： Jingjing Hao Shan Zheng Mengze Gan aobo dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more *** study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and ***:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this *** RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)*** Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral ***:The prevalence of TDR was not significantly increased over *** prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,***:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance.

关键词： drugs Stanford HIV/AIDS

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艾滋病耐药毒株的流行传播及进化研究

中国艾滋病性病 2019年第2期25卷 197-200页

作者：董敖渤赵帅邢辉中国疾病预防控制中心性病艾滋病预防控制中心北京102206

高效抗反转录病毒治疗在全球范围内的快速展开,改善了艾滋病病毒感染者的生存时间和生活质量。艾滋病病毒传播性耐药持续的流行,对保证抗病毒治疗的效果提出了严峻的挑战。本文对艾滋病病毒的耐药传播在全球的流行现况、耐药位点的分布... 详细信息

高效抗反转录病毒治疗在全球范围内的快速展开,改善了艾滋病病毒感染者的生存时间和生活质量。艾滋病病毒传播性耐药持续的流行,对保证抗病毒治疗的效果提出了严峻的挑战。本文对艾滋病病毒的耐药传播在全球的流行现况、耐药位点的分布、耐药位点的进化和在新宿主体内的转归及相关耐药新的监测措施等方面进行综述。

关键词：艾滋病病毒传播性耐药流行现状传播网络

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

An NIR-Ⅱ-emissive Ru(Ⅱ) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2025年第1期68卷 5-7页

作者： Chonglu Li Jianbo Zhan Biao dong Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities, leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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凉山彝族自治州HIV/AIDS抗病毒治疗前HIV-1耐药情况及其影响因素分析

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中华流行病学杂志 2019年第6期40卷 648-653页

作者：董敖渤肖琳梁姝刘磊康瑞华赵帅阮玉华屈水令邢辉中国疾病预防控制中心性病艾滋病预防控制中心传染病预防控制国家重点实验室北京102206 包头市第三医院 014040 凉山彝族自治州疾病预防控制中心西昌615000 四川省疾病预防控制中心成都610041 中国疾病预防控制中心教育培训处北京102206

目的了解凉山彝族自治州(凉山州)HIV/AIDS抗病毒治疗前HIV-1耐药情况及其影响因素,为预防HIV-1耐药毒株的传播提供参考依据。方法分别于2017年1月1日至6月30日、2018年1月1日至6月30日在凉山州开展HIV/AIDS抗病毒治疗前HIV-1耐药的横断... 详细信息

目的了解凉山彝族自治州(凉山州)HIV/AIDS抗病毒治疗前HIV-1耐药情况及其影响因素,为预防HIV-1耐药毒株的传播提供参考依据。方法分别于2017年1月1日至6月30日、2018年1月1日至6月30日在凉山州开展HIV/AIDS抗病毒治疗前HIV-1耐药的横断面调查。提取获得HIV-1 pol基因区序列,根据2014年WHO耐药监测指南的推荐标准,应用HyPhy 2.2.4和Cytoscape 3.6.1软件进行HIV-1耐药毒株传播网络分析。结果研究对象464例HIV/AIDS,HIV-1毒株为CRF07_BC亚型的占88.6%(411/464),总的HIV-1耐药率为9.9%(46/464),非核苷类反转录酶抑制剂(NNRTI)、核苷类反转录酶抑制剂(NRTI)和蛋白酶抑制剂(PI)耐药率分别为6.7%(31/464)、1.9%(9/464)和0.4%(2/464);有1组HIV-1新型重组毒株URF_01BC亚型独立成簇并携带相关耐药突变位点;多因素logistic回归分析结果显示,与异性性传播人群相比,注射吸毒人群的HIV-1耐药风险较高(aOR=3.03,95%CI:1.40~6.54)。结论凉山州HIV/AIDS抗病毒治疗前的HIV-1耐药率较高,且有新型重组毒株URF_01BC亚型携带相关耐药突变位点的成簇传播,建议加强HIV-1耐药毒株传播的预防工作。

关键词： HIV-1 亚型耐药传播网络影响因素

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan dong Wenzheng An Zihu Wang dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE Jun dong Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration