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昆布多糖的复合酶法提取工艺优化及其对α-葡萄糖苷酶的抑制活性

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食品工业科技 2024年第3期45卷 197-206页

作者：张涵殷澳张会佳侯相竹高阳徐多多长春中医药大学人参科学研究院吉林长春130117 长春中医药大学药学院吉林长春130117

优化复合酶提取昆布多糖的工艺参数,并考察其抑制α-葡萄糖苷酶的能力。以昆布多糖得率为评价指标,通过正交试验确定复合酶配比,采用响应面法评价酶解时间、pH、液料比和温度对昆布多糖得率的影响。采用体外酶抑制实验测定昆布多糖对α... 详细信息

优化复合酶提取昆布多糖的工艺参数,并考察其抑制α-葡萄糖苷酶的能力。以昆布多糖得率为评价指标,通过正交试验确定复合酶配比,采用响应面法评价酶解时间、pH、液料比和温度对昆布多糖得率的影响。采用体外酶抑制实验测定昆布多糖对α-葡萄糖苷酶的抑制活性。结果表明,复合酶最佳添加量为纤维素酶100 mg、果胶酶90 mg、木瓜蛋白酶55 mg,最佳酶法提取工艺为酶解时间1.8 h、酶解温度49.4℃、pH6.1、液料比59:1 mL/g,最佳工艺条件下昆布多糖预测得率18.183%,实测多糖得率18.19%±1.04%,其中性糖、酸性糖、蛋白质及硫酸根含量分别52.72%、11.76%、2.66%、19.49%;在1~5 mg/mL范围内其对α-葡萄糖苷酶的抑制作用随浓度增加而升高,最大抑制率为79.04%±3.17%,IC50为1.443 mg/mL。复合酶法提取的昆布多糖得率高,其对α-葡萄糖苷酶具有明显的抑制作用。

关键词：昆布多糖复合酶提取工艺 α-葡萄糖苷酶活性

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黄芪多糖复合酶提取工艺优化及其α-葡萄糖苷酶抑制活性

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食品工业科技 2024年第17期45卷 181-189页

作者：张会佳侯相竹张涵殷澳高阳徐多多长春中医药大学人参科学研究院吉林长春130117 长春中医药大学药学院吉林长春130117

目的:以黄芪为原料,采用复合酶法(木瓜蛋白酶、果胶酶、纤维素酶)提取黄芪多糖(Astragalus polysaccharides,APS),并分析工艺条件对多糖提取的影响。方法:在正交试验确定复合酶比例的基础上,采用响应面法对复合酶提取APS的提取条件进行... 详细信息

目的:以黄芪为原料,采用复合酶法(木瓜蛋白酶、果胶酶、纤维素酶)提取黄芪多糖(Astragalus polysaccharides,APS),并分析工艺条件对多糖提取的影响。方法:在正交试验确定复合酶比例的基础上,采用响应面法对复合酶提取APS的提取条件进行优化,得到最优工艺条件,采用pNPG法评价其α-葡萄糖苷酶抑制活性。结果:5 g黄芪药材粉末,最佳复合酶配比为:木瓜蛋白酶88000 U、果胶酶65000 U、纤维素酶6000 U;最佳酶解提取条件为:酶解处理时间、温度、pH和料液比分别为2.82 h、60.34℃、5.11和1:34.46 g/mL,APS的得率最高可达22.79%±0.14%;APS对α-葡萄糖苷酶的半数抑制浓度(IC50)为7.42μg/mL。结论:复合酶提取APS的得率较单酶得率显著提高,APS对α-葡萄糖苷酶表现出较强的抑制作用。

关键词：黄芪多糖复合酶提取工艺响应面 α-葡萄糖苷酶活性

朝鲜淫羊藿多糖复合酶提工艺优化及抗氧化活性研究

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食品科技 2024年第1期49卷 191-200页

作者：殷澳张涵侯相竹张会佳徐多多高阳长春中医药大学吉林长春130117

目的:优化复合酶法提取淫羊藿多糖的工艺,同时评价淫羊藿多糖的抗氧化活性。方法:以朝鲜淫羊藿为原料,多糖提取率为指标,利用纤维素酶、果胶酶、木瓜蛋白酶协同作用提取淫羊藿多糖,基于正交试验和响应面试验优化复合酶提取工艺条件,利用... 详细信息

目的:优化复合酶法提取淫羊藿多糖的工艺,同时评价淫羊藿多糖的抗氧化活性。方法:以朝鲜淫羊藿为原料,多糖提取率为指标,利用纤维素酶、果胶酶、木瓜蛋白酶协同作用提取淫羊藿多糖,基于正交试验和响应面试验优化复合酶提取工艺条件,利用DPPH法、ABTS法评价淫羊藿多糖的体外抗氧化活性。结果:朝鲜淫羊藿多糖最佳酶提取工艺为酶添加量(果胶酶8000U/g、纤维素酶17600 U/g、木瓜蛋白酶900 U/g)、提取时间2 h、p H6.0、液料比53 mL/g、提取温度50℃,在此条件下,淫羊藿多糖的得率为(16.95±0.15)%,比水提法高3.86%。且酶提多糖具有更强的体外抗氧化活性。结论:复合酶提的优化工艺条件温和、操作简单,多糖得率和抗氧化活性均较传统水提取法更高。

关键词：朝鲜淫羊藿多糖酶提取响应面优化抗氧化活性

Integration of flexible,recyclable,and transient gelatin hydrogels toward multifunctional electronics

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Journal of Materials Science & Technology 2023年第14期145卷 83-92页

作者： Rui yin Chen Zhang Jian Shao Youyou Chen ao yin Qiang Feng Shuqin Chen Fei Peng Xing Ma Cheng-Yan Xu Feihua Liu Weiwei Zhao Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding&Joining Harbin Institute of TechnologyHarbin 150001China

Facing the challenges posed by exponentially increasing e-waste,the development of recyclable and tran-sient electronics has paved the way to an environmentally-friendly progression strategy,where electron-ics can disintegrate and/or degrade into eco-friendly end products in a controlled *** polymers possess cost and energy efficiency,easy modification,and fast degradation,all of which are ideal prop-erties for transient *** is especially attractive due to its unique thermoreversible gelation processes,yet its huge potential as a multifunctional electronic material has not been well-researched due to its limited mechanical strength and low ***,we explored versatile applications of gelatin-based hydrogels through the assistance of multifunctional additives like carbon nanotubes to enhance their electromechanical *** optimized gelatin hydrogel displays not only a high conductivity of 0.93 S/m,electromagnetic shielding effectiveness of 39.6 dB,and tensile stress tolerance of 263 kPa,but also shows a negative permittivity phenomenon,which may find versatile applications in novel *** a proof of concept,hydrogels were assembled as wearable sensors to sensitively de-tect static and dynamic pressures and strains generated by solids,liquids,and airflow,as well as diverse body ***,the recyclability,biocompatibility,and degradability of gelatin-based hy-drogels were well studied and *** work outlines a facile method to design multifunctional transient materials for wearable,sustainable,and eco-friendly electronics.

关键词： Gelatin hydrogels Carbon nanotubes Negative permittivity Electromagnetic interference shielding Wearable sensor

Spray pyrolysis-derived W-doped MoSe2/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang Jun-Yu Chen Jie Ouyang Hong yin ao-Jie Li Liang Chen Jun-Lin Huang Yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Chemistry and Chemical Engineering Hunan Institute of Science and Technology Hunan Province Key Laboratory of Materials Surface & Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and Technology International Iberian Nanotechnology Laboratory (INL)

Two-dimensional MoSe2is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe2/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe2and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe2（0.73 nm）,thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory（DFT） calculations confirm that W-doped MoSe2/rGO exhibits the narrowest bandgap（0.892 eV）.Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g-1after 300 cycles at a current density of 1 A·g-1.

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen Feng yin yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang ao Shen Xi-Yong Yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

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超短波治疗结合运动疗法对脑梗死偏瘫的疗效

临床神经病学杂志 2023年第1期36卷 60-63页

作者：尹傲冉亳州市人民医院康复科 236800

目的探讨超短波治疗结合运动疗法对脑梗死偏瘫的疗效。方法采用简单随机分组将60例脑梗死偏瘫患者分为超短波治疗组(n=30)和对照组(n=30)。对照组采用运动疗法,超短波治疗组在对照组基础上结合超短波治疗。连续治疗3周,比较两组患者的... 详细信息

目的探讨超短波治疗结合运动疗法对脑梗死偏瘫的疗效。方法采用简单随机分组将60例脑梗死偏瘫患者分为超短波治疗组(n=30)和对照组(n=30)。对照组采用运动疗法,超短波治疗组在对照组基础上结合超短波治疗。连续治疗3周,比较两组患者的临床疗效、NIHSS评分、肢体运动功能评分(FMA)、Berg平衡量表评分(BBS)、日常生活活动能力评分(BI)。结果治疗3周后,超短波治疗组的总有效率显著高于对照组(χ^(2)=4.320,P=0.038)。病程≤5个月、病程4~9个月、病程≥10个月患者总有效率差异无统计学意义(χ^(2)=3.690,P=0.158)。与对照组比较,超短波治疗组治疗前FMA评分差异无统计学意义(P>0.05),治疗后各时间点FMA评分均显著升高(均P0.05),治疗后各时间点BBS评分均显著升高(均P0.05),治疗3周时NIHSS评分显著降低,BI评分显著升高(均P<0.001)。两组患者均未出现严重不良反应。结论超短波治疗结合运动疗法能够改善患者平衡功能、运功功能,提高日常生活活动能力。

关键词：偏瘫脑梗死运动疗法超短波治疗仪康复

Intelligent Reflecting Surface Assisted Transmission Optimization Strategies in Wireless Networks

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China Communications 2024年第4期21卷 120-135页

作者： He Xinxin Qi Xuan Meng Wei Liu Wei yin Changchuan School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Wireless Power Transfer(WPT)technology can provide real-time power for many terminal devices in Internet of Things(IoT)through millimeterWave(mmWave)to support applications with large capacity and low *** the intelligent reflecting surface(IRS)can be adopted to create effective virtual links to address the mmWave blockage problem,the conventional solutions only adopt IRS in the downlink from the Base Station(BS)to the users to enhance the received signal *** practice,the reflection of IRS is also applicable to the uplink to improve the spectral *** is a challenging to jointly optimize IRS beamforming and system resource allocation for wireless energy acquisition and information *** this paper,we first design a Low-Energy Adaptive Clustering Hierarchy(LEACH)clustering protocol for clustering and data ***,the problem of maximizing the minimum system spectral efficiency is constructed by jointly optimizing the transmit power of sensor devices,the uplink and downlink transmission times,the active beamforming at the BS,and the IRS dynamic *** solve this non-convex optimization problem,we propose an alternating optimization(ao)-based joint solution *** results show that the use of IRS dynamic beamforming can significantly improve the spectral efficiency of the system,and ensure the reliability of equipment communication and the sustainability of energy supply under NLOS link.

关键词： intelligent reflecting surface(IRS) joint optimization millimeter wave wireless information transmission(WIT) wireless power transfer(WPT)

事件层组合特征限定软沉积变形的地震成因——在青岛灵山岛的应用

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地球科学进展 2024年第1期39卷 96-107页

作者：张济东梁超操应长陈奥卢银中国石油大学(华东)地球科学与技术学院山东青岛266580 中国石油大学(华东)深层油气全国重点实验室山东青岛266580 同济大学海洋地质国家重点实验室上海200092

对软沉积物变形构造的形成过程解析和触发因素识别一直是国内外事件沉积学研究的重点和难点。国内外学者常将地层中保存的软沉积物变形构造的形成归因于地震作用,但缺乏足够的证据来支撑地震震动触发相应的沉积过程与变形机制。由于软... 详细信息

对软沉积物变形构造的形成过程解析和触发因素识别一直是国内外事件沉积学研究的重点和难点。国内外学者常将地层中保存的软沉积物变形构造的形成归因于地震作用,但缺乏足够的证据来支撑地震震动触发相应的沉积过程与变形机制。由于软沉积物变形构造可以由地震、风暴和非地震参与的液化作用、重力作用及滑坡等因素触发,且可能受瑞利—泰勒不稳定性(因密度差异沿垂向变形)或开尔文—亥姆获兹不稳定性(沿水平方向变形)机制的控制,软沉积物变形构造本身并不能作为特定触发因素的判别标志。此前,通过解析事件层组合特征来揭示与软沉积物变形构造形成相关的沉积过程和变形机制,进而限定变形构造触发因素的方法已成功应用于中东地区死海盆地(死海断裂带)的事件沉积研究中。尝试应用此方法来解析灵山岛灯塔剖面底部软沉积物变形构造的变形机制与触发因素,研究发现灯塔剖面底部的软沉积物变形构造是原位形成与保存的,并被浊流沉积层上覆,且二者之间无背景沉积物。这种独特的事件层组合指示原位变形和异地搬运两种水下沉积过程准同期发生,而能够同时激发这两类物质来源与沉积过程迥异的事件沉积响应的最可能因素是区域强震震动。结合灵山岛研究案例认为,前人所做的模式化的事件沉积成因判别标志不宜直接套用,而控制事件沉积的沉积过程与物理机制具有一定的普适性,应该是事件沉积学研究的关键。

关键词：软沉积变形浊流沉积地震震动沉积响应