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The Journal of Biomedical Research 2018年第4期32卷 288-297页

作者： Muyi Yang Zhenyu Diao Zhiyin Wang Guijun Yan Guangfeng Zhao Mingming Zheng anyi dai Yimin dai Yali Hu Drum Tower Clinical Medical College Nanjing Medical University Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalNanjing University Medical School

Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4（TLR4） plays an essential *** their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains ***,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide（LPS）-induced rat preeclampsia model,through targeting the TLR4/NF-κB *** results showed that pravastatin reduced the blood pressure [maximum decline on gestational day（GD） 12,（101.33±2.49） mmHg vs.（118.3±1.37） mmHg,P〈0.05] and urine protein level [maximum decline on GD9,（3,726.23± 1,572.86） μg vs.（1,991.03 ±609.37）μg,P〈 0.05],which were elevated following LPS *** also significantly reduced the rate of fetal growth restriction in LPS-treated rats（34.10% vs.8.99%,P〈0.05）.Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin *** effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in ***,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of *** results provide supportive evidence for use of pravastatin in preventing preeclampsia.

关键词： preeclampsia arteriole remodeling pravastatin toll-like receptor 4 fetal development

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《公司法》公司社会责任条款实施的应对路径

河南财经政法大学学报 2025年第1期40卷 156-166页

作者：庞宝峰张安毅河南省高级人民法院河南郑州450008 河南财经政法大学民商法学院/知识产权学院河南郑州450046

2023年我国《公司法》修订后出台了“升级版”的公司社会责任条款,其第二十条立法规定用了“应当”“充分考虑”等用语,带来了理解上的歧义与实施上的难题。但这个条款不是强制公司主动追求利益相关者利益和社会公共利益,而是为了防止... 详细信息

2023年我国《公司法》修订后出台了“升级版”的公司社会责任条款,其第二十条立法规定用了“应当”“充分考虑”等用语,带来了理解上的歧义与实施上的难题。但这个条款不是强制公司主动追求利益相关者利益和社会公共利益,而是为了防止公司在逐利过程中损害利益相关者利益、社会公共利益,立法目的是保障公司承担法律责任、引导公司承担道德责任。董事等经营层要对公司利益负责,但维护利益相关者利益和社会公共利益才能促进公司长期营利,这是对董事等经营层合理决策的要求,属于董事等经营层勤勉义务的一部分。判断董事等经营层在治理公司过程中是否尽到了合理考虑利益相关者利益、社会公共利益的勤勉义务,应适用商业判断规则。在公司股东会、董事会决议违法侵害利益相关者利益或公共利益时,要赋予权益受损害的主体提起确认决议无效诉讼的权利,将法律层面的社会责任纳入司法审查。

关键词：公司社会责任公司目标董事义务司法化

不同肥胖症诊断标准的肥胖与绝经后子宫内膜样腺癌患者病理指标的相关性分析

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江苏医药 2021年第11期47卷 1097-1100页

作者：肖镇冬周航戴安怡徐晓峰李荣汤晓秋朱湘虹凌静娴周怀君李强南京大学医学院附属鼓楼医院妇科江苏210008

目的探讨不同肥胖诊断标准的肥胖与绝经后子宫内膜样腺癌患者病理结果的相关性。方法收集手术治疗的146例绝经后子宫内膜样腺癌患者的临床资料,分析不同肥胖诊断标准的肥胖与子宫内膜样腺癌患者临床病理学特征的相关性。结果单因素分析... 详细信息

目的探讨不同肥胖诊断标准的肥胖与绝经后子宫内膜样腺癌患者病理结果的相关性。方法收集手术治疗的146例绝经后子宫内膜样腺癌患者的临床资料,分析不同肥胖诊断标准的肥胖与子宫内膜样腺癌患者临床病理学特征的相关性。结果单因素分析显示,按照中国成年人肥胖标准,肥胖患者腹水脱落细胞学阳性比例高于非肥胖患者(7.3%vs.1.0%)(P0.05);而按照WHO制定的肥胖诊断标准,子宫内膜样腺癌病理因素在肥胖与非肥胖组间分布差异无统计学意义(P>0.05)。结论基于BMI制定的肥胖诊断标准,肥胖与绝经后患者子宫内膜样腺癌病理因素无明显相关性。

关键词：肥胖体重指数子宫内膜样腺癌

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The Troupe(Excerpt)

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2018年第4期12卷 645-673页

作者： WANG anyi Todd Foley 不详 Department of East Asian Studies & Comparative Literature New York UniversityNew YorkNY 10003USA

*** OperaIn its previous life,this regional Cultural Workers' Troupe of ours had been a Liuzi opera *** being displaced by the 'new culture,' Liuzi opera seemed to be in full decline—an ancient and rare dramatic form that had become *** had never seen it ourselves,or even heard a line of it *** said it had its origins as palace entertainment,possessing a subtle richness and lofty style that made it a truly elite form,though too elite to gain the popularity needed to withstand the test of *** explanation always sounded a little overblown.

关键词：

Cloud Foren:A Novel Framework for Digital Forensics in Cloud Computing

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Journal of Harbin Institute of Technology(New Series) 2014年第6期21卷 39-45页

作者： Mathew Nyamagwa Jigang Liu anyi Liu Tetsutaro Uehara Dept.of Information and Computer Sciences Metropolitan State UniversitySaint Paul 55106USA Dept.of Computer Science Indiana University Purdue University Fort WayneFort Wayne 46805IndiananUSA Dept.of Computer Science College of Information Science & EngineeringRitsumeikan UniversityKusatsu 525875 5ShigaJapan

Since its birth in the early 90 's,digital forensics has been mainly focused on collecting and examining digital evidence from computers and networks that are controlled and owned by individuals or *** cloud computing has recently emerged as a dominant platform for running applications and storing data,digital forensics faces well-known challenges in the cloud,such as data inaccessibility,data and service volatility,and law enforcement lacks control over the *** date,very little research has been done to develop efficient theory and practice for digital forensics in the *** this paper,we present a novel framework,Cloud Foren,which systematically addresses the challenges of forensics in cloud *** Foren covers the entire process of digital forensics,from the initial point of complaint to the final point where the evidence is *** key components of Cloud Foren address some challenges,which are unique to the *** proposed forensic process allows cloud forensic examiner,cloud provider,and cloud customer collaborate *** use two case studies to demonstrate the applicability of Cloud *** believe Cloud Foren holds great promise for more precise and automatic digital forensics in a cloud computing environment.

关键词： digital forensics cloud computing framework

A carbon nanofiber network for stable lithium metal anodes with high Coulombic efficiency and long cycle life

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Nano Research 2016年第11期9卷 3428-3436页

作者： anyi Zhang Xin Fang Chenfei Shen Yihang Liu Chongwu Zhou Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los Angeles 90089 USA Ming Hsieh Departmen t of Electrical Engineering University of Southern California Los Angeles 90089 USA

Li metal is considered one of the most promising candidates for the anode material in high-energy-density Li-ion batteries. However, the dendritic growth of Li metal during the plating/stripping process can severely reduce Coulombic efficiency and cause safety problems, which is a key issue limiting the application of Li metal anodes. Herein, we present a novel strategy for dendrite-free deposition of Li by modifying the Cu current collector with a three-dimensional carbon nanofiber （CNF） network. Owing to the large surface area and high conductivity of the CNF network, Li metal is inserted into and deposited onto the CNF directly, and no dendritic Li metal is observed, leaving a flat Li metal surface. With Li metal as the counter electrode for Li deposition, an average Coulombic efficiency of 99.9% was achieved for more than 300 cycles, at large current densities of 1.0 and 2.0 mA·cm^-2, and with a high Li loading of 1 mAh·cm^-2. The scalability of the preparation method and the impressive results achieved here demonstrate the potential for the application of our design to the future development of dendrite-free Li metal anodes.

关键词： lithium-ion batteries lithium metal anode carbon nanofiber three-dimensionalconductive network

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A Girls' Trip

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2019年第2期13卷 262-297页

作者： WANG anyi Todd Foley(Translated) 不详 Departments of East Asian Studies and Comparative Literature New York University New York NY 10003 USA

When Fentian and Shui first set out, no one in the village thought it was a good idea. These two girls were too wild, prone to bold actions without really thin king them through, and if they weren't careful, they'd be... 详细信息

关键词： Cirlsf Trip Fentian set out

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The Rescue Truck

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2019年第2期13卷 298-311页

作者： WANG anyi Todd Foley(Translated) 不详 Departments of East Asian Studies and Comparative Literature New York University New York NY 10003 USA

There was a period of time that was completely hidden from his memory. The last thing he remembered was racing through the longtang alleyways, a mighty army following close on his heels-a "mighty army” that consisted... 详细信息

关键词： There other that his time from of on

APTAnet: an atom-level peptide-TCR interaction affinity prediction model

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Biophysics Reports 2024年第1期10卷 1-14页

作者： Peng Xiong anyi Liang Xunhui Cai Tian Xia School of Artificial Intelligence and Automation Huazhong University of Science and Technology Institute of Pathology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The prediction of affinity between TCRs and peptides is crucial for the further development of TIL(Tumor-Infiltrating Lymphocytes) immunotherapy. Inspired by the broader research of drug-protein interaction(DPI), we propose an atom-level peptide-TCR interaction(PTI) affinity prediction model APTAnet using natural language processing methods. APTAnet model achieved an average ROC-AUC and PR-AUC of 0.893 and 0.877, respectively, in ten-fold cross-validation on 25,675 pairs of PTI ***, experimental results on an independent test set from the McPAS database showed that APTAnet outperformed the current mainstream models. Finally, through the validation on 11 cases of real tumor patient data, we found that the APTAnet model can effectively identify tumor peptides and screen tumor-specific TCRs.

关键词： Immunotherapy TCR Antigen Natural language processing Transfer learning

Elevational patterns of abundant and rare bacterial diversity and composition in mountain streams in the southeast of the Tibetan Plateau

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Science China Earth Sciences 2019年第5期62卷 853-862页

作者： Keshao LIU TANDong YAO Yongqin LIU Baiqing XU anyi HU Yuying CHEN Key Laboratory of Tibetan Environment Changes and Land Surface Processes Chinese Academy of Sciences University of Chinese Academy of Sciences CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences Key Laboratory of Alpine Ecology and Biodiversity Chinese Academy of Sciences Key Laboratory of Urban Pollutant Conversion Institute of Urban Environment Chinese Academy of Sciences

Elevational gradients are powerful ‘natural laboratory' for testing the responses of microbes to geophysical influences. Microbial communities are normally composed of a few abundant and many rare taxa. Abundant and rare taxa play different ecological roles in kinds of environments, but how their diversity and composition patterns response to elevation gradients is still poorly elucidated. In this study, we investigated the elevational patterns of abundant and rare bacterial diversity and composition in a mountain stream from 712 to 3435 m at Gangrigabu Mountain on the Tibetan Plateau, China. Our results revealed abundant and rare bacteria had similar decreasing elevation trend of alpha diversity, and both of them showed a significant elevational distance-decay relationship. However, the turnover rate of the elevational distance-decay of rare bacteria was higher than that of abundant bacteria. The species-abundance distribution patterns of rare taxonomic composition were associated with the elevational gradient, while most of abundant bacterial clades did not display any relationships with *** results suggested that rare bacteria were more sensitive to changes in elevation gradient.

关键词： Rare bacteria Diversity patterns Elevation gradients Mountain stream