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Rationales and uncertainties for aspirin use in COViD-19:a narrative review

Family Medicine and Community Health 2021年第2期9卷 15-23页

作者： Hazem A Sayed Ahmed Eric Merrell Mansoura ismail anwar i joudeh Jeffrey B Riley Ahmed Shawkat Hanan Habeb Edward Darling Reda A Goweda Mohamed H Shehata Hossam Amin Gary F Nieman Hani Aiash Department of Family Medicine Suez Canal University Faculty of MedicineIsmailiaEgypt Department of Medicine State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Department of internal Medicine The University of JordanAmmanJordan Department of Cardiovascular Perfusion State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Department of Critical Care State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Egypt Ministry of Health and Population CairoEgypt Department of Community Medicine Umm Al-Qura University College of MedicineMakkahSaudi Arabia Department of Family and Community Medicine Arabian Gulf University College of Medicine and Medical ScienceManamaBahrain Department of Critical Care New York Medical CollegeValhallaNew YorkUSA Department of Surgery State University of New York Upstate Medical UniversitySyracuseNew YorkUSA

Objectives To review the pathophysiology of COViD-19 disease,potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with *** Narrative *** The online databases PubMed,OViD Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January *** guidelines from relevant societies,journals and forums were also assessed for *** Not *** A review of the selected literature revealed that clinical deterioration in COViD-19 is attributed to the interplay between endothelial dysfunction,coagulopathy and dysregulated *** has anti-inflammatory effects,antiplatelet aggregation,anticoagulant properties as well as pleiotropic effects on endothelial *** the COViD-19 pandemic,low-dose aspirin is used effectively in secondary prevention of atherosclerotic cardiovascular disease,prevention of venous thromboembolism after total hip or knee replacement,prevention of pre-eclampsia and postdischarge treatment for multisystem inflammatory syndrome in *** low-dose aspirin therapy may reduce the risk of intensive care unit admission and mechanical ventilation in hospitalised patients with COViD-19,whereas aspirin association with mortality is still *** The authors recommend a low-dose aspirin regimen for primary prevention of arterial thromboembolism in patients aged 40-70 years who are at high atherosclerotic cardiovascular disease risk,or an intermediate risk with a risk-enhancer and have a low risk of ***’s protective roles in COViD-19 associated with acute lung injury,vascular thrombosis without previous cardiovascular disease and mortality need further randomised controlled trials to establish causal conclusions.

关键词： prevention aspirin mortality

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