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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： anuradha kumari Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

Anticancer Activities of Plant Secondary Metabolites:Rice Callus Suspension Culture as a New Paradigm

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Rice science 2021年第1期28卷 13-30页

作者： Wusirika Ramakrishna anuradha kumari Nafeesa Rahman Pallavi Mandave Department of Biochemistry Central University of PunjabBathindaPunjab 151001India Department of Biological Sciences Michigan Technological University1400 Townsend Drive HoughtonMichigan 49931USA Interactive Research School for Health Affairs Bharati VidyapeethPuneMaharashtra 411043India

Plant natural products including alkaloids,polyphenols,terpenoids and flavonoids have been reported to exert anticancer activity by targeting various metabolic *** biological pathways regulated by plant products can serve as novel drug *** natural compounds or their derivatives used for cancer treatment and some novel plant-based compounds which are used in clinical trials were *** suspension culture with secondary metabolites can provide a continuous source of plant pharmaceuticals without time and space *** research has shown that rice callus suspension culture can kill>95%cancer cells with no significant effect on the growth of normal *** role of candidate genes and metabolites which are likely to be involved in the process and their potential to serve as anticancer and anti-inflammatory agents were *** scale production of plant callus suspension culture and its constituents can be achieved using elicitors which enhance specific secondary metabolites combined with bioprocess technology.

关键词： plant metabolite cancer metabolism rice callus suspension culture cytotoxicity anticancer agent

Change in Mass of Spinning Black Holes w.r.t. the Angular Momentum

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Journal of Modern Physics 2018年第5期9卷 1037-1042页

作者： Dipo Mahto anuradha kumari Department of Physics Marwari College T. M. B. University Bhagalpur India Department of Physics T. M. B. University Bhagalpur India

Mahto et al. have shown δS≥0 and M2=a*J by using the first law of the black hole mechanics in the vacuum and Einstein mass-energy equivalence relation specially for spinning black holes. In the present paper, this work is extended to propose a model for the change in mass of the spinning black holes due to corresponding change in the angular momentum for maximum & half spin parameter of black holes (a* = 1 & 1/2) and calculated their values for different test black holes in XRBs and AGN. We have also shown that the change in mass of the spinning black holes due to corresponding change in the angular momentum for maximum spinning rate of black holes (a* = 1) is double to that of the spinning black holes having spinning parameter (a* = 1/2).

关键词： Spinning Black Holes Angular Momentum Spinning Parameter

Change in Entropy of Spinning Black Holes Due to Corresponding Change in Mass in AGN

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Journal of Applied Mathematics and Physics 2018年第8期6卷 1686-1691页

作者： anuradha kumari Supriya kumari Dipo Mahto Department of Physics T. M. B. University Bhagalpur India Department of Physics Marwari College T. M. B. University Bhagalpur India

The present paper discusses the change in entropy of spinning black holes due to change in mass for AGN black holes on the basis of the model as proposed in the case of XRBs under condition that the black holes spin with unit spinning parameter and angular momentum and this model gives slightly some different nature of the super-massive spinning black holes in AGN as specified for XRBs.

关键词： Entropy Change Angular Velocity Spin Parameter

Change in Entropy of Spinning Black Holes Due to Corresponding Change in Mass in XRBs

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International Journal of Astronomy and Astrophysics 2018年第2期8卷 171-177页

作者： Dipo Mahto anuradha kumari Department of Physics Marwari College T. M. B. University Bhagalpur India Department of Physics T. M. B. University Bhagalpur India

The present paper gives a theoretical model for the change in entropy of spinning black holes due to change in mass to use the first law of black hole mechanics for unit spinning parameter and angular momentum in XRBs. This shows that the entropy change with respect to the mass of uncharged spinning black holes is essentially the function of mass and their surface gravity are lesser than to that of the non-spinning black holes.

关键词： Entropy Change Spinning Parameters and Angular Momentum

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

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Neural Regeneration Research 2025年第10期20卷 2862-2871页

作者： Prajakta Deshpande anuradha Venkatakrishnan Chimata Amit Singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and *** acetylation is a common post-translational modification pivotal to basic cellular *** to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and *** this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in ***,we have focused on N-acetyltransferase 9 and its role in microtubule *** have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative *** have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

关键词： acetyl-coenzyme A Alzheimer’s disease animal models cell death drosophila eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 neurodegeneration

OKRA (HIBISCUS ESCULENTUS) AND FENUGREEK (TRIGONELLA FOENUM GRACEUM) MUCILAGE:CHARACTERIZATION AND APPLICATION AS FLOCCULANTS FOR TEXTILE EFFLUENT TREATMENTS

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Chinese Journal of Polymer Science 2008年第6期26卷 679-687页

作者： Rajani Srinivasan anuradha Mishra Blackland Research and Extension Centre Texas A&M University System720East Blackland RoadTempleTX76502USA Department of Chemistry University Institute of Engineering and TechnologyCSJM UniversityKanpur-208 024India

The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was *** polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic *** of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...

关键词： Fenugreek Okra Natural polysaccharides Flocculation Wastewater treatment Textile effluent Bridging Hibiscus esculentus Trigonella foenum graceum.

Asymptotic and Partial Asymptotic Hankel Operators on H^2(D^n)

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1729-1740页

作者： anuradha GUPTA Bhawna GUPTA Department of Mathematics Delhi College of Arts and CommerceNetaji NagarUniversity of DelhiDelhiIndia Department of Mathematics University of DelhiDelhiIndia

In this paper,we generalize the concept of asymptotic Hankel operators on H2(D)to the Hardy space H2(Dn)(over polydisk)in terms of asymptotic Hankel and partial asymptotic Hankel operators and investigate some properties in case of its weak and strong ***,we introduce ith-partial Hankel operators on H2(Dn)and obtain a characterization of its compactness for n>*** main results include the containment of Toeplitz algebra in the collection of all strong partial asymptotic Hankel operators on H2(Dn).It is also shown that a Toeplitz operator with symbolφis asymptotic Hankel if and only if φ is holomorphic function in L∞(Tn).

关键词： Hankel operator Asymptotic Hankel operator partial asymptotic Hankel operator i(th)-partial Hankel operator i(th)-partial big Hankel operator

Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

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Neural Regeneration Research 2015年第10期10卷 1565-1567页

作者： anuradha Kalani Neetu Tyagi Department of Physiology and Biophysics School of Medicine University of Louisville

Exosomes：Exosomes are a sub-population of micro-vesicles ranging from 40–100 nm that were earlier thought as artefacts under electron *** recently came into attention for their storage of biological information,cell-to-cell communication,serving as biomarkers and potential use in neural protection and regeneration （Kalani et al., 2013, 2014a）.

关键词： Exosomes in neurological disease neuroprotection problems and perspectives repair and therapeutics

Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis

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Chinese Journal of Integrative Medicine 2023年第9期29卷 818-824页

作者： Sahar Idris anuradha Mishra Mohammad Khushtar Faculty of Pharmacy Integral UniversityDasauliLucknow226026Uttar PradeshIndia Amity Institute of Pharmacy LucknowAmity University Uttar PradeshNoida201313India

Objective To quantify phytochemicals using liquid chromatography and mass spectroscopy(LCMS)analysis and explore the therapeutic effect of Aesculus hippocastanum L.(AH)seeds ethanolic extract against gastric ulcers in *** Preliminary phytochemical testing and LCMS analysis were performed according to standard *** treatment,the animals were divided into 7 groups including normal control,ulcer control,self-healing,AH seeds low and high doses,ranitidine and per se *** were orally administered with 10 mg/kg of indomethacin,excluding the normal control group(which received 1%carboxy methyl cellulose)and the per se group(received 200 mg/kg AH seeds extract).The test group rats were then given 2 doses of AH seeds extract(100 and 200 mg/kg,respectively),while the standard group was given ranitidine(50 mg/kg).On the 11th day,rats in all groups were sacrificed,and their stomach was isolated to calculate the ulcer index,and other parameters such as blood prostaglandin(PGE2),tissue superoxide dismutase(SOD),catalase(CAT),malonyldialdehyde(MDA),and glutathione(GSH).All isolated stomach tissues were analyzed for histopathological *** The phytochemical examination shows that the AH seeds contain alkaloids,flavonoids,saponins,phenolic components,and *** analysis confirms the presence of quercetin and *** AH seeds extract showed significant improvement in gastric mucosa conditions after indomethacin-induced gastric lesions(P<0.01).Further marked improvement in blood PGE2 and antioxidant enzymes,SOD,CAT,MDA and GSH,were observed compared with self-healing and untreated ulcer-induced groups(P<0.01).Histopathology results confirmed that AH seeds extract improved the mucosal layer and gastric epithelial membrane in treated groups compared to untreated ulcer-induced *** LCMS report confirms the presence of quercetin and rutin in AH seeds ethanolic *** therapeutic effect of AH seeds extract against indomethacin

关键词： Aesculus hippocastanum L. pharmacological action phytochemical physicochemical analysis liquid chromatography and mass spectroscopy analysis gastro-protective activity