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Reinforced tissue matrix to strengthen the abdominal wall following reversal of temporary ostomies or to treat incisional hernias

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 823-832页

作者： Spencer P Lake Corey R Deeken Amit K agarwal Mechanical Engineering&Materials Science Washington University in St.LouisSt.LouisMO 63130United States Covalent Bio LLCSt.LouisMO 63025United States Department of Surgery McGovern Medical School at UTHealthHoustonTX 77026United States

BACKGROUND Abdominal wall deficiencies or weakness are a common complication of tem-porary ostomies,and incisional hernias frequently develop after colostomy or ileostomy takedown.The use of synthetic meshes to reinforce the abdominal wall has reduced hernia occurrence.Biologic meshes have also been used to enhance healing,particularly in contaminated conditions.Reinforced tissue matrices(R-TMs),which include a biologic scaffold of native extracellular matrix and a syn-thetic component for added strength/durability,are designed to take advantage of aspects of both synthetic and biologic materials.To date,RTMs have not been reported to reinforce the abdominal wall following stoma reversal.METHODS Twenty-eight patients were selected with a parastomal and/or incisional hernia who had received a temporary ileostomy or colostomy for fecal diversion after rectal cancer treatment or trauma.Following hernia repair and proximal stoma closure,RTM(OviTex®1S permanent or OviTex®LPR)was placed to reinforce the abdominal wall using a laparoscopic,robotic,or open surgical approach.Post-operative follow-up was performed at 1 month and 1 year.Hernia recurrence was determined by physical examination and,when necessary,via computed tomo-graphy scan.Secondary endpoints included length of hospital stay,time to return to work,and hospital readmissions.Evaluated complications of the wound/repair site included presence of surgical site infection,seroma,hematoma,wound dehiscence,or fistula formation.RESULTS The observational study cohort included 16 male and 12 female patients with average age of 58.5 years±16.3 years and average body mass index of 26.2 kg/m^(2)±4.1 kg/m^(2).Patients presented with a parastomal hernia(75.0%),in-cisional hernia(14.3%),or combined parastomal/incisional hernia(10.7%).Using a laparoscopic(53.6%),robotic(35.7%),or open(10.7%)technique,RTMs(OviTex®LPR:82.1%,OviTex®1S:17.9%)were placed using sublay(82.1%)or intraperitoneal onlay(IPOM;17.9%)mesh positioning.At 1-month and 1-year follow-ups,there were no hernia r

关键词： Reinforced tissue matrix Reinforced forestomach matrix Ileostomy Colostomy Ostomy takedown Incisional hernia Abdominal wall

Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek agarwal Sujita Kumar Kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCS)is proven to be safe in treating various neurological conditions in children and adolescents.It is also an effective method in the treatment of OCD in adults.AIM To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with OCD.METHODS We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCS)scale to assess their condition.Both active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 sessions.Reassessment occurred at 2,6,and 12 wk using CY-BOCS.RESULTS Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group only.The mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were comparable.CONCLUSION tDCS is safe and well tolerated for the treatment of OCD in adolescents.However,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder Safety Transcranial direct current stimulation

Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 794-805页

作者： Muhammad Zulfiqah Sadikan Nurul Alimah Abdul Nasir Mohammad Johari Ibahim Igor Iezhitsa Renu agarwal Department of Pharmacology Faculty of MedicineManipal University College Malaysia(MUCM)Bukit BaruMelaka 75150Malaysia Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Medical Education Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Biochemistry and Molecular Medicine Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgograd 400131Russia

AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat model.METHODS:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic rats.The stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)algorithms.RESULTS:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic retinas.The 18s gene was expressed consistently in both normal control and diabetic rats’retinal tissue.That this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic rats.Furthermore,there was no ideal gene stably expressed for use in all experimental settings.CONCLUSION:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.

关键词： housekeeping genes stability real-time reverse transcription polymerase chain reaction retinal tissue streptozotocin-induced diabetic rats

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发挥CRM最大效益的支点在哪里

IT时代周刊 2005年第9期15卷 58-58页

作者： anupam agarwal David Harding Jeffrey R.Schumacher 麦肯锡旧金山分公司波士顿分公司

企业应将CRM解决方案视作一项针对内部用户推出的产品或服务,通过合理地定价,充分宣传并提供良好的售后服务。

关键词： CRM 最大效益支点解决方案实施效果企业投资

Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in BCS-HCC.METHODS A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were included.The prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were evaluated.RESULTS In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular obstruction.The median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver transplantation.CONCLUSION HCC is not uncommon in patients with BCS.Radiological interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

Advancements in nanotechnology for the delivery of phytochemicals

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Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan K.Yadav Nazneen Sultana Arun agarwal Saurabh Verma Manish K.Chourasia Jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research Institute Council of Scientific and Industrial Research Academy of Scientific and Innovative Research

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Bioavailability Drug delivery system Phytochemical Phytosome Plant extracts

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减销售成本，但不减收入

经济管理文摘 2009年第10期 48-50页

作者： anupam agarwal Eric Harmon Michael Viertler

企业害怕对销售队伍动大手术是有道理的：这可是实现收入的发动机啊。不论对这架发动机做了多少修补工作，侗只要一想起来要对它进行大修，高管们就怕得要命。为了让销售工作能够进行下去，只要还能对付，企业就会继续零敲碎打地对其进... 详细信息

企业害怕对销售队伍动大手术是有道理的：这可是实现收入的发动机啊。不论对这架发动机做了多少修补工作，侗只要一想起来要对它进行大修，高管们就怕得要命。为了让销售工作能够进行下去，只要还能对付，企业就会继续零敲碎打地对其进行修修补补。

关键词：销售成本收入修补工作销售队伍销售工作发动机企业高管

***: SAR Deforestation Classification of Amazon Forest for Land Use Land Cover Application

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Journal of Computer and Communications 2024年第3期12卷 68-83页

作者： Priyanka Darbari Ankush agarwal Manoj Kumar Computer Engineering and Application GLA University Mathura India Department of Information Technology GGV Bilaspur India

The process of turning forest area into land is known as deforestation or forest degradation. Reforestation as a fraction of deforestation is extremely low. For improved qualitative and quantitative classification, we used Sentinel-1 dataset of State of Para, Brazil to precisely and closely monitor deforestation between June 2019 and June 2023. This research aimed to find out suitable model for classification called Satellite Imaging analysis by Transpose deep neural transformation network (SIT-net) using mathematical model based on Band math approach to classify deforestation applying transpose deep neural network. The main advantage of proposed model is easy to handle SAR images. The study concludes that SAR satellite gives high-resolution images to improve deforestation monitoring and proposed model takes less computational time compared to other techniques.

关键词： Brazilian Amazon Sentinel-1 Band Math Transpose CNN Transformation Network

Deep Learning-Based Speech Emotion Recognition: Leveraging Diverse Datasets and Augmentation Techniques for Robust Modeling

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ayush Porwal Praveen Kumar Tyagi Ajay Sharma Dheeraj Kumar agarwal Department of Electronics and Instrumentation Engineering Shri G.S.Institute of Technology and Science Department of Electronics and Communication Engineering Maulana Azad National Institute of Technology School of Computing Science and Engineering VIT Bhopal University

In recent years， Speech Emotion Recognition (SER) has developed into an essential instrument for interpreting human emotions from auditory data. The proposed research focused on the development of a SER system employing deep learning and multiple datasets containing samples of emotive speech. The primary objective of this research endeavor is to investigate the utilization of Convolutional Neural Networks (CNNs) in the process of sound feature extraction. Stretching， pitch manipulation， and noise injection are a few of the techniques utilized in this study to improve the data quality. The investigation includes coverage of these methods. Feature extraction methods including Zero Crossing Rate， Chroma＿stft， MFCC， RMS， and MelSpectogram are used to train a model. By using these techniques， audio signals can be transformed into recognized features that can be utilized to train the model. Ultimately， the study will produce a thorough evaluation of the model’s performance. When this method was applied， the model achieved an impressive accuracy of 94.57% on the test dataset. Proposed work also validated on EMO-BD and IEMOCAP dataset. These consist of further data augmentation， feature engineering， and hyperparameter optimization. By following these development paths， SER systems will be able to be implemented in real-world scenarios with greater accuracy and resilience.

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