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Two decades of fire activity over the PEEX domain:a look from space,with contribution from models and ground-based measurements

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Big Earth Data 2024年第2期8卷 350-396页

作者： Larisa Sogacheva Timo H.Virtanen anu-maija sundström Pekka Kolmonen mikhail Sofiev Hanna K.Lappalainen Antti Arola Finnish meteorological Institute Climate Research ProgrammeHelsinkiFinland Finnish meteorological Institute Space and Earth Observation CentreHelsinkiFinland Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland

It has been suggested that forest fires will become more frequent/intense with changing climate,which would increase aerosol/gas emissions into the atmosphere.A better under-standing of the relations between meteorological conditions,fires,and fire emissions will help estimate the climate response via forest *** this study,we use ERA5 meteor-ological products,including temperature,precipitation,and soil moisture,to explain the frequency of forest fires and the amount of radiant energy released per time unit by burning vegetation(fire radiative power,FRP).We explore the relation-ships between satellite-retrieved fire products and aerosol properties(aerosol optical depth,AOD),carbon monoxide(CO),formaldehyde(HCHO),and nitrogen dioxide(NO_(2))con-centrations over the PEEX domain,which covers different vegetation zones(***/grasslands,forest,arctic tun-dra)of Pan-Eurasia and *** analyse the concentrations of black carbon and absorbing organic carbon using groundbased AErosol RObotic *** analysis covers the months of may to August from 2002 to *** show posi-tive temperature trends in the Northern zone(>65°N)in June and August(1.56°C and 0.64°C,respectively);all statistically significant trends for precipitation and soil moisture are *** can explain increased fire activity in Siberia over the recent years(2019-2022).Over the whole PEEX domain,FC and FRP trends remain insignificant or negative;a decrease in AOD may address those negative *** show that intrasummer variations exist for cropland/grassland fires,which occur most often in may and August,while Siberian forest fires occur more often in July and *** show that CO concentration has been gradually decreasing in the last two decades in may and *** trends are negative in may,June,and over summer for all regions,in July in Europe,China,the Southern zone(may and

关键词： PEEX wild fires satellite trend enhancement ratios

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Analysis of human brain tissue derived from DBS surgery

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Translational Neurodegeneration 2022年第1期11卷 625-640页

作者： Salla m.Kangas Jaakko Teppo maija J.Lahtinen anu Suoranta Bishwa Ghimire Pirkko mattila Johanna Uusimaa markku Varjosalo Jani Katisko Reetta Hinttala PEDEGO Research Unit University of OuluOuluFinland medical Research Center Oulu University HospitalUniversity of OuluOuluFinland Biocenter Oulu University of OuluOuluFinland Institute of Biotechnology HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Drug Research Program Faculty of PharmacyUniversity of HelsinkiHelsinkiFin-land Neurosurgery Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland Oulu Research Group of Advanced Surgical Technologies and Physics(ORGASTP) Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland Institute for molecular medicine Finland(FImm) HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Clinic for Children and Adolescents Division of Pediatric NeurologyOulu University HospitalOuluFinland

Background:Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living *** samples usually represent the advanced disease stage of the ***-thermore,the postmortem interval can affect the transcriptomic and proteomic ***,fresh brain tissue samples from living patients represent a valuable resource of metabolically intact *** of deep brain stimulation(DBS)electrodes into the human brain is a neurosurgical treatment for,e.g.,movement ***,we describe an improved approach to collecting brain tissues from surgical instruments used in implantation of DBS device for transcriptomics and proteomics ***:Samples were extracted from guide tubes and recording electrodes used in routine DBS implantation procedure to treat patients with Parkinson’s disease,genetic dystonia and *** sequencing was performed in tissues extracted from the recording microelectrodes and liquid chromatography-mass spectrometry(LC-mS)per-formed in tissues from guide *** assess the performance of the current approach,the obtained datasets were compared with previously published datasets representing brain ***:Altogether,32,034 RNA transcripts representing the unique Ensembl gene identifiers were detected from eight samples representing both hemispheres of four *** using LC-mS,we identified 734 unique proteins from 31 samples collected from 14 *** datasets are available in the BioStudies database(accession number S-BSST667).Our results indicate that surgical instruments used in DBS installation retain brain material sufficient for protein and gene expression *** with previously published datasets obtained with similar approach proved the robustness and reproducibility of the ***:The instruments used during routine DBS surgery are a useful source for obtaining fresh brain tis-sues from living patien

关键词： Deep brain stimulation movement disorders Brain Proteomics Transcriptomics RNA sequencing LC-mS Personalized medicine

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