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Constructing long-cycling crystalline C_(3)N_(4)-based carbonaceous anodes for sodium-ion battery via N configuration control

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Carbon Energy 2024年第1期6卷 159-171页

作者： Ying Wang Hongguan Li Shuanlong Di Boyin Zhai Ping Niu antonios Kelarakis Shulan Wang Li Li School of Metallurgy Northeastern UniversityShenyangLiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoningChina Department of Chemistry College of ScienceNortheastern UniversityShenyangLiaoningChina School of Natural Sciences UCLan Research Centre for Smart MaterialsUniversity of Central LancashirePrestonUK Foshan Graduate School of Innovation Northeastern UniversityFoshanGuangdongChina

Carbon nitrides with two-dimensional layered structures and high theoretical capacities are attractive as anode materials for sodium-ion batteries while their low crystallinity and insufficient structural stability strongly restrict their practical *** carbon nitrides with conductive carbon may relieve these ***,little is known about the influence of nitrogen(N)configurations on the interactions between carbon and C_(3)N_(4),which is fundamentally critical for guiding the precise design of advanced C_(3)N_(4)-related ***,highly crystalline C_(3)N_(4)(poly(triazine imide),PTI)based all-carbon composites were developed by molten salt *** importantly,the vital role of pyrrolic-N for enhancing charge transfer and boosting Na+storage of C_(3)N_(4)-based composites,which was confirmed by both theoretical and experimental evidence,was spot-highlighted for the first *** elaborately controlling the salt composition,the composite with high pyrrolic-N and minimized graphitic-N content was *** from the formation of highly crystalline PTI and electrochemically favorable pyrrolic-N configurations,the composite delivered an unusual reverse growth and record-level cycling stability even after 5000 cycles along with high reversible capacity and outstanding full-cell capacity *** work broadens the energy storage applications of C_(3)N_(4) and provides new prospects for the design of advanced all-carbon electrodes.

关键词： anode highly crystalline C_(3)N_(4) N configuration sodium-ion batteries ultra-long cyclic stability

A simulation study for a cost-effective PET-like detector system intended to track particles in granular assemblies

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Particuology 2024年第1期84卷 117-125页

作者： Josephine Oppotsch antonios Athanassiadis Miriam Fritsch Fritz-Herbert Heinsius Thomas Held Nikoline Hilse Viktor Scherer Matthias Steinke Ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

Since many industrial applications rely on the processing of densely packed and moving granular ma-terial,obtaining bulk internal information on the particle movement inside the reactors is of great *** information can be delivered by Positron Emission Particle Tracking(PEPT).By marking pellets with a positron-emitting radioisotope,the position of these tracer particles can be determined via the time-of-flight differences of the emitted gamma-ray *** current paper proposes a PET-like detector system based on cost-effective organic plastic scintillators instead of the more common but expensive inorganic *** system is currently under construction and was tested for its resolution and efficiency in this simulation *** Monte Carlo simulations and the software toolkit Geant4,three different geometries(an empty glass box,a generic grate system,and a cubic box of 1 m3 completely filled with pellets)were investigated,leading to a spatial resolution in the millimeter range and an efficiency,defined as the ratio of reconstructed decay locations to simulated decays,of 2.7%,1.4%,and 0.3%.

关键词： Positron emission particle tracking Geant4 Monte Carlo method Time-of-flight Plastic scintillators Silicon photomultipliers(SiPMs)

Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine

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World Journal of Gastroenterology 2005年第13期11卷 1922-1928页

作者： Ioannis S.Elefsiniotis antonios moulakakis Konstantinos D.Pantazis Irene Glynou Ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos Department of Internal Medicine Department of Microbiology Department of Hepatogastroenterology

AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and ***: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB.

关键词： b2-微球蛋白血清 HBeAg 慢性乙型肝炎拉米夫定药物治疗

Quantitative assessment of the impact of a triage physician on the Accreditation Council for Graduate Medical Education resident milestones in the emergency department

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World Journal of Emergency Medicine 2024年第3期15卷 220-222页

作者： Julie Cueva Duncan Grossman Vishnu Muppala Arlene Chung Mahlaqa Butt Jefferson Drapkin antonios Likourezos Errel Khordipour Department of Emergency Medicine Maimonides Medical CenterNew York 11219USA

The “door-to-doctor” time for patients to be seen by a physician is an increasingly studied *** may shorten this time by implementing a triage physician (TP).The exact role of a TP may vary across *** put in preliminary orders for lab work,imaging,and treatment,and decide treatment location for further *** the prevalence of TPs grows,its effect on resident education in academic emergency departments (EDs) remains *** implemented a TP in the spring of 2016 and assessed resident physicians before and after implementation.

关键词： physician doctor treatment

Immunogenicity of recombinant hepatitis B vaccine in treatment-nave and treatment-experienced chronic hepatitis C patients: The effect of pegylated interferon plus ribavirin treatment

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World Journal of Gastroenterology 2006年第27期12卷 4420-4424页

作者： Ioannis S Elefsiniotis Elena Vezali Konstantinos Kamposioras Konstantinos D Pantazis Radostina Tontorova Ioannis Ketikoglou antonios moulakakis George Saroglou Department of Internal Medicine Hepatology UnitHippokration Hospital of AthensAthensGreeceDepartment of Internal MedicineFaculty of NursingUniversity of AthensAthensGreece Department of Internal Medicine Hepatology UnitHippokration Hospital of AthensAthensGreece Department of Internal Medicine Faculty of NursingUniversity of AthensAthensGreece

瞄准：为了回顾地评估导致种痘的 anti-HBs seroconversion，评价在处理天真并且处理富有经验长期的丙肝(CHC ) 病人。另外， seroconversion 加 ribavirin (肋骨) 在 pegylated 干扰素(木钉) 期间在 CHC 评估病人有希望地评估治疗。方... 详细信息

瞄准：为了回顾地评估导致种痘的 anti-HBs seroconversion，评价在处理天真并且处理富有经验长期的丙肝(CHC ) 病人。另外， seroconversion 加 ribavirin (肋骨) 在 pegylated 干扰素(木钉) 期间在 CHC 评估病人有希望地评估治疗。方法：七十个处理天真的 CHC 病人(组 A ) ，加肋骨治疗 CHC 病人(组 B ) 的 22 持续 virological responders-SVR 追随者干扰素(IFN ) 和 121 个健康题目(组 C ) 被参予了一样的 HBV 种痘时间表(20 microg， 0-1-6 瞬间) 。如果 anti-HBs 层次在在跟随疫苗的第三剂量的 3 瞬间以内的 10 mIU/mL 上面， Seroconversion 被考虑。而且，我们有希望地选择了 30 个非肝脏硬化症的 CHC 病人并且为使随机化的一样的疫苗的时间表的功效评估了他们他们在二个组：Group-1， 15 个 CHC 病人加肋骨治疗和 Group-2 与木钉的开始同时收到了疫苗的第一剂量，没有伴随物治疗， 15 个病人收到了一样的种痘时间表。anti-HBs 的决心在瞬间 1， 2，和 7 点被执行。数据的统计分析基于 ANOVA 学生的 t 测试和 chi 平方分析(P < 0.05 ) 。结果：70 个组 A 病人(82.85%) 中的 58 个， 20/22 组 B (90.9%) 和 112/121 健康题目(92.56%) 是 seroconverted。seroconversion 率比在处理天真的 CHC 病人在控制组是显著地更高的(P = 0.04 ) 。相应的率在组 A 和组 B CHC 病人之间是可比较的(P = 0.38 ) 。绝大多数非应答者(10/14， 71.43%) 被 HCV 的 genotype-1 感染了。seroconversion 率在在瞬间 1 点的组 1 和 2 CHC 病人之间是可比较的(20% 对 26.7% ， P = 0.67 ) ，瞬间 2 (46.7% 对 60% ， P = 0.46 ) 并且瞬间 7 (86.7% 对 93.3% ， P = 0.54 ) 后续。结论：HBV 疫苗的 immunogenicity 似乎在与健康题目相比的 CHC 病人更低。SVR 后面的 IFN 正肋骨治疗不影响抗体反应到 HBV 疫苗。由 genotype-1 的感染似乎否定地影响 seroconversion 率。对 HBV 的种痘不以 anti-HBs seroconversion 率在加肋骨联合治疗的木钉期间是有益的。

关键词：免疫原性重组体乙型肝炎治疗

Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme:a systematic review going beyond pathologic implications

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Oncology Research 2024年第8期32卷 1239-1256页

作者： DIMITRA P.VAGELI PANAGIOTIS G.DOUKAS KERASIA GOUPOU antonios D.BENOS KYRIAKI ASTARA KONSTANTINA ZACHAROULI SOTIRIS SOTIRIOU MARIA IOANNOU Department of Surgery Yale UniversityNew HavenCT 06510USA Department of Pathology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece Department of Medicine Rutgers/Saint Peter’s University HospitalNew BrunswickNJ 08901USA Department of Neurology Army Share Fund Hospital(NIMTS)Athens11521Greece Laboratory of Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece

Glioblastoma multiforme(GBM)is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular *** conditions in the tissue microenvironment are considered a pivotal player leading tumor ***,hypoxia is known to activate inducible factors,such as hypoxia-inducible factor 1alpha(HIF-1α),which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators,such as the vascular endothelial growth factor(VEGF).Here,we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data,as potential biomarkers of GBM prognosis and treatment *** performed a systematic review(Medline/Embase,and Pubmed database search was completed by 16th of April 2024 by two independent teams;PRISMA 2020).We evaluated methods of immunoassays,cell viability,or animal or patient survival methods of the retrieved studies to assess unbiased *** used inclusion criteria,such as the evaluation of GBM prognosis based on HIF-1α/VEGF expression,other biomarkers or clinical and imaging manifestations in GBM related to HIF-1α/VEGF expression,application of immunoassays for protein expression,and evaluation of the effectiveness of GBM therapeutic strategies based on HIF-1α/VEGF *** used exclusion criteria,such as data not reporting both HIF-1αand VEGF or *** included 50 studies investigating in total 1319 GBM human specimens,18 different cell lines or GBM-derived stem cells,and 6 different animal models,to identify the association of HIF-1α/VEGF immunophenotypes,and with other prognostic factors,clinical and macroscopic data in GBM prognosis and therapeutic *** found that increased HIF-1α/VEGF expression in GBM correlates with oncogenic factors,such as miR-210-3p,Oct4,AKT,COX-2,PDGF-C,PLDO3,M2 polarization,or ALK,leading to unfavorable *** HIF-1α/VEGF expression correlates with F

关键词： Glioblastoma multiforme(GBM) Astrocytoma Grade III Astrocytoma Grade IV Hypoxia-inducible factor 1alpha(HIF-1α) Vascular endothelial growth factor(VEGF)

Crystallinity engineering of carbon nitride protective coating for ultra-stable Zn metal anodes

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Electron 2024年第1期2卷 177-187页

作者： Chen Liu Yuxin Zhu Shuanlong Di Jiarui He Ping Niu antonios Kelarakis Marta Krysmann Shulan Wang Li Li School of Metallurgy Northeastern UniversityShenyangChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangChina Foshan Graduate School of Innovation Northeastern UniversityFoshanChina Department of Chemistry College of ScienceNortheastern UniversityShenyangChina UCLan Research Centre for Smart Materials School of Natural SciencesUniversity of Central LancashirePrestonUK School of Dentistry University of Central LancashirePrestonUK

Ineffective control of dendrite growth and side reactions on Zn anodes significantly retards commercialization of aqueous Zn-ion *** conventional interfacial modification strategies that are primarily focused on component optimization or microstructural tuning,herein,we propose a crystallinity engineering strategy by developing highly crystalline carbon nitride protective layers for Zn anodes through molten salt ***,the highly ordered structure along with sufficient functional polar groups and pre-intercalated Kþendows the coating with high ionic conductivity,strong hydrophilicity,and accelerated ion diffusion *** calculations also confirm its enhanced Zn adsorption capability compared to commonly reported carbon nitride with amorphous or semi-crystalline structure and bare *** from the aforementioned features,the as-synthesized protective layer enables a calendar lifespan of symmetric cells for 1100 h and outstanding stability of full cells with capacity retention of 91.5%after 1500 *** work proposes a new conceptual strategy for Zn anode protection.

关键词： crystalline carbon nitride crystallinity engineering long cycling life uniform Zn deposition Zn metal anode

3D micropattern force regulates stem cell function

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National Science Review 2023年第8期10卷 69-70页

作者： antonios G. Mikos Department of Bioengineering Rice University

Biophysical cues of the cellular microenvironment significantly influence cell behaviors by mechanotransduction [1,2].For example, the mechanical properties of the extracellular matrix modulate human mesenchymal stem ...

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A numerical case study on the long-term seismic assessment of reinforced concrete tunnels in corrosive environments

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 551-572页

作者： Maria Antoniou antonios Mantakas Nikolaos Nikitas Raul Fuentes ETH Zurich ZurichSwitzerland National Technical University of Athens AthensGreece University of Leeds LeedsUK RWTH Aachen University AachenGermany

The paper investigates the long-term seismic behaviour of an underground reinforced concrete(RC)metro tunnel in Santiago,Chile,considering the combined effects of chloride-induced corrosion and cumulative,low-amplitude seismic shaking on the structure’s *** soil-tunnel response is evaluated with the aid of transient,nonlinear finite element analysis using a two-dimensional(2D)plane strain numerical model that adopts advanced nonlinear models for the simulation of soil and concrete plasticity and the dynamic stiffness *** effects of corrosion deterioration are demonstrated in terms of time-dependent loss of rebar area and cover concrete stiffness and *** study illustrates the influence of ageing and repeated seismic shaking on lining deformation,crack development,and the modal characteristics of the intact and degrading *** results indicate that multiple lowamplitude events drive the non-degrading RC tunnel beyond its elastic regime without significant structural response consequences.A noticeable impact of corrosion deterioration on the structure’s seismic performance is revealed,increasing with the number and intensity of earthquake *** different tunnel embedment depths are comparatively *** analyses demonstrate larger coseismic section convergence in the case of the deeper tunnel,yet a less pronounced effect of ageing and successive seismic loading compared to the shallow section,which is evident in the RC lining cracks at the end of shaking.

关键词： Tunnels Reinforcement corrosion Ageing Earthquakes Numerical modelling Long-term performance Concrete cracking behaviour