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Management of erectile dysfunction in hypertension:Tips and tricks

World Journal of Cardiology 2014年第9期6卷 908-915页

作者： Margus Viigimaa Charalambos Vlachopoulos antonios lazaridis Michael Doumas Tallinn University of Technology Institute of Biomedical Engineering North Estonia Medical Centre 1st Department of Cardiology Kapodestrian University 2nd Propedeutic Department of Internal Medicine Aristotle University

Arterial hypertension is a major risk factor for cardiovascular disease and affects approximately one third of the adult population worldwide. The vascular origin of erectile dysfunction is now widely accepted in the vast majority of cases. Erectile dysfunction is frequently encountered in patients with arterial hypertension and greatly affects their quality of life of hypertensive patients and their sexual partners. Therefore, the management of erectile dysfunction in hypertensive patients is of paramount importance. Unfortunately, erectile dysfunction remains under-reported, under-recognized, and under-treated in hypertensive patients, mainly due to the lack of familiarity with this clinical entity by treating physicians. This review aims to discuss the more frequent problems in the management of hypertensive patients with erectile dysfunction and propose ways to overcome these problems in everyday clinical practice.

关键词： Erectile dysfunction Hypertension Antihy-pertensive drugs Management Phosphodiesterase-5 inhibitors Cardiovascular risk

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Erectile dysfunction in chronic kidney disease:From pathophysiology to management

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World Journal of Nephrology 2015年第3期4卷 379-387页

作者： Eirini Papadopoulou Anna Varouktsi antonios lazaridis Chrysoula Boutari Michael Doumas 2nd Propaedeutic Department of Internal Medicine Aristotle University

Chronic kidney disease(CKD) is encountered in millions of people worldwide,with continuously rising incidence during the past decades,affecting their quality of life despite the increase of life expectancy in these *** of sexual function is common among men with CKD,as both conditions share common pathophysiological causes,such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease,hypertension and diabetes *** estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease ***,sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients,a fact which should raise awareness among clinicians.A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes.

关键词： Chronic kidney disease Erectile dysfunction Management Quality of life Hypertension Diabetes mellitus Phosphodiesterase-5 inhibitors

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Non-interventional management of resistant hypertension

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World Journal of Cardiology 2014年第10期6卷 1080-1090页

作者： Michael Doumas Costas Tsioufis Charles Faselis antonios lazaridis Haris Grassos Vasilios Papademetriou 2nd Propedeutic Department of Internal Medicine Aristotle University 54643 Thessaloniki Greecest 1st Cardiology Department Kapodestrian University 11527 Athens Greece Department of Internal Medicine Veterans Af-fairs Medical Center and George Washington University Department of Cardiology KAT Hospital 14561 Athens Greece Department of Cardiology Veterans Affairs Medical Center and Georgetown University

Hypertension is one of the most popular fields of re-search in modern medicine due to its high prevalence and its major impact on cardiovascular risk and con-sequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or cardiovascular death. On the other hand, resistant hypertension, the "uncontrollable" part of arterial hy-pertension despite appropriate therapy, comprises a much greater menace since long-standing, high levels of blood pressure along with concomitant debilitating entities such as chronic kidney disease and diabetes mellitus create a prominent high cardiovascular risk milieu. However, despite the alarming consequences, resistant hypertension and its effective management still have not received proper scientific attention. As-pects like the exact prevalence and prognosis are yet tobe clarified. In an effort to manage patients with resis-tant hypertension appropriately, clinical doctors are still racking their brains in order to find the best therapeutic algorithm and surmount the substantial difficulties in controlling this clinical entity. This review aims to shed light on the effective management of resistant hyper-tension and provide practical recommendations for cli-nicians dealing with such patients.

关键词： Resistant hypertension Antihypertensive drugs Adherence White coat hypertension Secondary hypertension

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