检索结果-南通市图书馆

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil graduate Program in Pathological Anatomy(PPgAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2020年第4期63卷 504-512页

作者： Simon Van Herck Bruno g.de geest department of Pharmaceutics Ghent UniversityGhentBelgium

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.

关键词： acetals polyacrylamides stimuli-responsive

Influence of curing conditions on the shrinkage behavior of three-dimensional printed concrete formwork

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第8期18卷 1225-1236页

作者： M.BEKAERT K.van TITTELBOOM g.de SCHUTTER Magnel-Vandepitte Laboratory for structural Engineering and Building Materials Department of Structural Engineering and Building MaterialsFaculty of Engineering and ArchitectureGhent UniversityGhent 60 B-9052Belgium

The use of three-dimensional(3D)printed concrete as formwork is becoming more widely applied within the ***,the technology is still not optimized and there are many reports of preliminary cracking during the curing of cast *** is believed to result from differential shrinkage between the printed and cast *** cracks(in the printed concrete or at the interface between the infill and printed concrete)form a preferential path for aggressive substances and can reduce the durability of the combined concrete *** ensure the desired service life of the structure,it is important that the differential shrinkage between cast and printed concrete is *** study investigated the effect of curing conditions on the differential shrinkage behavior of 3D and cast *** influence of prewetting of the dry-cured 3D printed formwork was also *** the experimental program,a vibrated and self-compacting concrete were used as cast *** 3D printed formwork was produced and combined with cast concrete to simulate a concrete *** formwork was cured for 1,7,or 28 d exposed to the air(relative humidity:60%or 95%)or submerged in *** length change of the combined elements was observed over 56 d after concrete casting and throughout the thickness of the *** show that increasing the curing period in dry conditions of the printed concrete leads to an expansion of the formwork on the first day after *** expansion leads to a non-uniform strain evolution throughout the curing period of the combined *** concrete formwork stored in wet conditions does not expand after the casting process but tends to show a decreasing linear deformation within the whole elements.

关键词： 3D concrete printing formwork shrinkage curing

Artificial equilibrium points and bi-impulsive maneuvers to observe 243 Ida

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2021年第1期34卷 410-423页

作者： Allan Kardec de almeida Jr geraldo Magela Couto OLIVEIRA antonio Fernando Bertachini de almeida PRADO National Institute for Space Research(INPE) Sao Jose dos Campos 12227-010Brazil Federal Center for Technological Education of Minas gerais(CEFET-Mg) Belo Horizonte 30421-169Brazil

In the restricted three-body problem,the traditional Lagrange points L1 and L2 are the only equilibrium points near the asteroid 243 *** thrust generated by a solar sail over a spacecraft enables the existence of new artificial equilibrium points,which depend on the position of the spacecraft with respect to the asteroid and the attitude of the solar *** equilibrium points generate new spots to observe the body from above or below the plane of *** points are very good observational locations due to their stationary *** work provides a preliminary analysis to observe Ida through the use of artificial equilibrium points as spots combined with transfer maneuvers between *** combination can be used to observe the asteroid from more different points of view in comparison to fixed *** analyses are made for a spacecraft equipped with a solar sail and capable of performing bi-impulsive *** solar radiation pressure is used both to maintain the equilibrium condition and to reduce the costs of the transfers and/or to create transfers with longer *** is a new aspect of the present research,because it combines the continuous thrust with initial and final small impulses,which are feasible for most of the spacecraft,because the magnitudes of the impulses are very *** combined maneuvers may reduce the transfer times of the maneuvers in most of the cases,compared with the maneuvers based only on continuous *** options involved in these transfers are shown,like to minimize the fuel spent(Dv)as a function of the transfer time or to extend the duration of the travel between the *** transfer times can be useful when observations are required during the transfers.

关键词： Artificial equilibrium points Astrodynamics Orbital transfers Solar radiation pressure Solar sail

The Colider and Roosevelt olcanic rocks (sw amazonian craton): geochemistry and sm-nd isotope characteristics of a silicic large igneous province

在线全文

学校读者我要写书评

暂无评论

Acta geochimica 2021年第6期40卷 1023-1049页

作者： Bruna Saar de almeida Mauro César geraldes carlos Augusto Sommer Felipe Corrales antonio Joāo Paes de Barros Universidade do Estado do Rio de Janeiro Rio de JaneiroBrazil University of geneva GenevaSwitzerland Universidade Federal do Rio grande do Sul Rio Grande do SulBrazil METAMAT(Mato grosso State geological Survey) CuiabaBrazil

The volcanic rocks of the Colíder and Roosevelt formations are extensively exposed in the south-central portion of the Amazonian Craton where effusive and pyroclastic rocks have been *** units,topped by chemical sediments and oceanic facies as rhyolite and andesite lavas,rhyodacite,and porphyritic dacite,with frequent intercalations of pyroclastic and epiclastic ***-rock geochemistry for 55 samples of rhyolitic to andesitic composition suggests the involvement of fertile mantle-derived components with E-MORB to OIB *** analyzed rocks display calc-alkaline to shoshonitic affinity consistent with generation related to an active continental *** whole-rock Sm-Nd isotope data from selected felsic volcanic rocks of the Colíder and Roosevelt formations yield negative initial eNd values between–3 and–9,indicating the predominantly crustal nature of the parental magmas with early Archean to late Paleoproterozoic(ca.2.5–2.0 ga)depleted mantle model ages.

关键词： Amazonian craton geochemistry Sm-Nd isotopes Paleoproterozoic Volcanism

Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第6期24卷 524-534页

作者： Meike N.Leiske Bruno g.de geest Richard Hoogenboom Supramolecular Chemistry group Centre of Macromolecular Chemistry(CMaC)Department of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281 S4B-9000GhentBelgium department of Pharmaceutics and Cancer Research Institute ghent(CRIg) Ghent UniversityOttergemsesteenweg 460B-9000GhentBelgium Faculty of Biology Chemistry&Earth SciencesUniversity of BayreuthUniversitätsstraße 3095447 BayreuthGermany

Zwitterionic polymers are known to interact with cells and have been shown to reveal cancer cell *** this work,the importance of the chemistry of the polymer backbone for the cellular specificity of amino-acid-derived polyzwitterions is demonstrated.A series of glutamic acid(glu)-based vinyl monomers(i.e.,an acrylate,a methacrylate,an acrylamide,and a methacrylamide)were prepared and used for reversible addition-fragmentation chain-transfer(RAFT)polymerisation,yielding.defined polymers with narrow size distribution(Ðglu-functionalised,zwitterionic polymers revealed high cytocompatibility;however,differences in cellular association and specificity were *** particular,the methacrylamide-derived polymers showed high association with both,breast cancer cells and non-cancerous dendritic cells and,consequently,lack *** contrast,high specificity to only breast cancer cells was observed for polyacrylates,-methacrylates,*** analysis of the polymers revealed differences in hydrophobicity,zeta potential,and potential side chain hydrolysis,which are impacted by the polymer backbone and might be responsible for the altered the cell association of these *** is shown that a slightly negative net charge is preferred over a neutral charge to retain cell *** was also confirmed by association experiments in the presence of competitive amino acid transporter *** affinity of slightly negatively charged glu-derived polymers to the xCT glu/cystine cell membrane antiporter was found to be higher than that of neutrally charged *** results emphasise the importance of the polymer backbone for the design of cell-specific *** study further highlights the potential to tailor amino-acid-derived zwitterionic materials beyond their side chain functionality.

关键词： Amino-acid-functionalised polymer Zwitterionic polymer Cell-specific polymer Cancer-targeting RAFT-Polymerisation

Brent *** Texas Intermediate in the US petro derivatives price formation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 729-739页

作者： Alejandro almeida antonio A.golpe Juan Manuel Martín-Alvarez Jose carlos Vides Universidad Internacional de La Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over *** the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the refined ***,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate ***,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined *** results possess important considerations to policymakers and the market participants and the price formation.

关键词： Crude oil prices Spatial panel model Refined products Price formation

Olig.dendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter Lies de groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the olig.dendroglial lineage comprises two cell types:olig.dendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the olig.dendroglial lineage should be delineated into five distinct cell states:olig.dendrocyte precursor cells,committed olig.dendrocyte precursor cells,newly formed olig.dendrocytes,myelin-forming olig.dendrocytes,and mature *** new classification system enables a deeper understanding of the olig.dendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve olig.dendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration olig.dendrocytes olig.dendroglial lineage remyelination

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos M Ardila department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors