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Role of the advanced glycation end products receptor in Crohn's disease inflammation

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World Journal of Gastroenterology 2013年第45期19卷 8269-8281页

作者： Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio antonio rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo University of Pavia 27100 Pavia Italy Department of Human Pathology Fondazione IRCCS Policlinico San Matteo University of Pavia 27100 Pavia Italy Biometry and Clinical Epidemiology Unit Fondazione IRCCS Policlinico San Matteo 27100 Pavia Italy Endoscopy Unit Fondazione IRCCS Policlinico San Matteo 27100 Pavia Italy Department of Molecular Medicine University of Pavia 27100 Pavia Italy Center of Research in Molecular Medicine-CIRMC University of Pavia 27100 Pavia Italy IBD Unit Chair and Division of Gastroenterology Luigi Sacco Hospital University of Milan 20157 Milan Italy Department of Pathology Luigi Sacco HospitalUniversity of Milan 20157 Milan Italy Department of Surgery Luigi Sacco Hospital University of Milan 20157 Milan Italy

AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting *** tissues from 21 control subjects were used for *** same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental *** staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also *** effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic *** analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered ***:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative *** results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse *** evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a si

关键词： Apoptosis Crohn’s disease Chronic inflammation Immunohistochemistry Receptor for advanced glycation end products Tumor necrosis factor-α

Erratum to:Superlubricity of epitaxial monolayer WS_(2)on graphene

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Nano Research 2024年第6期17卷 5754-5754页

作者： Holger Büch antonio rossi Stiven Forti Domenica Convertino Valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation@NEST Istituto Italiano di TecnologiaPiazza S.Silvestro 1256127 PisaItaly NEST Istituto Nanoscienze–CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Graphene Labs Istituto Italiano di TecnologiaVia Morego 3016163 GenovaItaly

The article"Superlubricity of epitaxial monolayer WS2 on graphene",written by Holger Büch,antonio rossi,Stiven Forti,Domenica Convertino,Valentina Tozzini,and Camilla Coletti,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on June 18th 2018 without open *** the author(s)’decision to opt for Open Choice the copyright of the article changed in August 2018 to©The Author(s)2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License(http://***/licenses/by/4.0/),which permits use,duplication,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license and indicate if changes were made.

关键词： monolayer epitaxial license

Autonomous scanning probe microscopy investigations over WS_(2)and Au{111}

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npj Computational Materials 2022年第1期8卷 916-922页

作者： John C.Thomas antonio rossi Darian Smalley Luca Francaviglia Zhuohang Yu Tianyi Zhang Shalini Kumari Joshua A.Robinson Mauricio Terrones Masahiro Ishigami Eli Rotenberg Edward S.Barnard Archana Raja Ed Wong D.Frank Ogletree Marcus M.Noack Alexander Weber-Bargioni Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Department of Physics and NanoScience Technology Center University of Central FloridaOrlandoFL32816United States Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16082United States Center for Two-Dimensional and Layered Materials The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Physics and Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802United States Center for Advanced Mathematics for Energy Research Applications Lawrence Berkeley National LaboratoryBerkeleyCA94720United States

Individual atomic defects in 2D materials impact their macroscopic *** the interplay is challenging,however,intelligent hyperspectral scanning tunneling spectroscopy(STS)mapping provides a feasible solution to this technically difficult and time consuming ***,dense spectroscopic volume is collected autonomously via Gaussian process regression,where convolutional neural networks are used in tandem for spectral *** data enable defect segmentation,and a workflow is provided for machine-driven decision making during experimentation with capability for user *** provide a means towards autonomous experimentation for the benefit of both enhanced reproducibility and *** investigations on WS_(2)sulfur vacancy sites are explored,which is combined with local density of states confirmation on the Au{111}herringbone *** vacancies,pristine WS_(2),Au face-centered cubic,and Au hexagonal close-packed regions are examined and detected by machine learning methods to demonstrate the potential of artificial intelligence for hyperspectral STS mapping.

关键词： autonomous consuming packed

Development of a Synbiotic Low-Calorie Beverage Made from Soy and Yacon Extracts

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Food and Nutrition Sciences 2012年第11期3卷 1500-1508页

作者： Marla Simone Jovenasso Manzoni Daniela Cardoso Umbelino Cavallini Nadiége Dourado Pauly-Silveira Mariana Nougalli Roselino Elizeu antonio rossi Department of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University Department of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University

The objective of this study was to develop a new low-calorie symbiotic beverage made from yacon (prebiotic source) and soy extracts, containing probiotic Bifidobacterium animalis ssp. lactis BB-12. The synbiotic beverage was first produced with a range of sucrose concentrations in order to determine ideal sweetness by an acceptance test using a “just-about-right scale”. Sucrose was then replaced by sucralose or aspartame to produce sugar-free beverages. Characteristics including viable cell numbers, physicochemical properties, sensorial characteristics and fructoo-ligosaccharides content were investigated. The ideal sweetness of the beverages with sucrose, aspartame and sucralose were 7.28%, 0.0486% and 0.0167%, respectively. Sucralose exhibited higher scores in acceptance test and was used to replace sucrose in the low-calorie symbiotic beverage. The synbiotic beverage exhibited counts of Bifidobacterium spp. of 108 ***-1, sufficient condition to be considered probiotic. The chemical composition of the product was (g/100g): 2.91 of protein, 1.41 of fat, 2.41 of total carbohydrate;0.82 of FOS and 148.22 Kj of energy value. The synbiotic beverage developed in this study may be successful in health applications, due to their functional ingredients (soy, probiotic bacteria and yacon prebiotics) that can afford benefits to health or can present disease-preventing properties, beyond their inherent nutritional value. In addition this low-calorie beverage can be consumed by diabetic individuals and people concerned about the ingestion of calories.

关键词： Fructooligosaccharides Physicochemical Properties Prebiotics Probiotic Strain Sensory Properties

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阿尔卑斯山的重生:依山而居

世界建筑 2015年第9期 124-127页

作者：安东尼奥.德罗西罗伯托.迪尼辛梦瑶山地建筑学院(IAM)

记忆与再生栏目主持：米凯利·博尼诺，皮埃尔-阿拉因·克罗塞特本栏目的第二期围绕阿尔卑斯山的人类环境再生展开。在《世界建筑》“山地建设的可持续性”这一期的框架内，我们邀请了两位来自意大利都灵理工大学山体建筑学院（IAM）的... 详细信息

记忆与再生栏目主持：米凯利·博尼诺，皮埃尔-阿拉因·克罗塞特本栏目的第二期围绕阿尔卑斯山的人类环境再生展开。在《世界建筑》“山地建设的可持续性”这一期的框架内，我们邀请了两位来自意大利都灵理工大学山体建筑学院（IAM）的学者，

关键词：阿尔卑斯山《世界建筑》人类环境可持续性建筑学院意大利栏目再生

Estrogens in males: what have we learned in the last 10 years?

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Asian Journal of Andrology 2005年第1期7卷 3-20,页

作者： Vincenzo Rochira antonio R. M. Granata Bruno Madeo Lucia Zirilli Giuseppina rossi Cesare Carani Integrated Department of Medicine and Medical Specialties University of Modena and Reggio Emilia Modena 41100 Italy

This review focuses on the role of estrogen in men, mainly in male reproduction. The continuing increase in data obtained, and recent discoveries in this area will enable a better understanding of male physiology; the... 详细信息

关键词： estrogen male sexual behavior male infertility gonadotropin feedback

Unravelling the protracted U-Pb zircon geochronological record of high to ultrahigh temperature metamorphic rocks:Implications for provenance investigations

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Geoscience Frontiers 2023年第2期14卷 116-132页

作者： Mahyra Tedeschi Pedro Leonardo rossi Vieira Matheus Kuchenbecker Bruno VRibeiro Vitor Barrote Humberto Reis Laura Stutenbecker Cristiano Lana antonio Pedrosa-Soares Ivo Dussin Programa de Pós-graduação em Geologia da Universidade Federal de Minerais Centro de Pesquisas Manoel Teixeira da CostaInstitute of GeosciencesFederal University of Minas GeraisAv.Antônio Carlos6627Belo Horizonte 31270-901Brazil Institute of Geological Sciences University of Bern3012 BernSwitzerland Laboratório de Estudos Tectônicos Universidade Federal dos Vales do Jequitinhonha e MucuriRodovia MGT 367Km 583-Diamantina 39100-000Brazil School of Earth Atmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6845Australia Freie Universität Berlin Institut für Geologische WissenschaftenGeochemieMalteserstr.1074-10012249 BerlinGermany Departamento de Geologia-Escola de Minas Universidade Federal de Ouro Preto 35400-000Brazil Department of Materials and Earth Sciences Institute of Applied GeosciencesTU DarmstadtSchnittspahnstr.964287 DarmstadtGermany TEKTOS Geotectonic Research Group Geology InstituteRio de Janeiro State UniversitySão Francisco Xavier Street524/4030-AMaracanãRio de Janeiro 20550-900Brazil

The assessment of detrital zircon age records is a key method in basin analysis,but it is prone to several biases that may compromise accurate sedimentary provenance *** to ultrahigh temperature(HT-UHT)metamorphism(especially if T>850℃)is herein presented as a natural cause of bias in provenance studies based on U-Pb detrital zircon ages,since zircon from rocks submitted to these extreme and often prolonged conditions frequently yield protracted,apparently concordant,geochronological *** age spreading can result from disturbance of the primary U-Pb zircon system,likewise from(re)crystallization processes during multiple and/or prolonged metamorphic *** this contribution,available geochronological data on Archean,Neoproterozoic and Palaeozoic HT-UHT metamorphic rocks,acquired by different techniques(SIMS and LA-ICP-MS)and showing distinct compositions,are reassessed to demonstrate HT-UHT metamorphism may result in modes and age distributions of unclear geological *** a consequence,it may induce misinterpretations on UPb detrital zircon provenance analyses,particularly in sedimentary rocks metamorphosed under such extreme temperature *** evaluate the presence of HT-UHT metamorphism-related bias in the detrital zircon record,we suggest a workflow for data acquisition and interpretation,combining a multi-proxy approach with:(i)in situ U-Pb dating coupled with Hf analyses to retrieve the isotopic composition of the sources,and(ii)the integration of a petrochronological investigation to typify fingerprints of the HT-UHT metamorphic *** proposed workflow is validated in the investigation of one theoretical and one natural example allowing a better characterization of the sedimentary sources,maximum depositional ages,and the tectonic setting of the *** workflow allows to the appraisal of biases imposed by HT-UHT metamorphism and resulting disturbances in the U-Pb detrital zircon record,particularly for sedimentary

关键词： Detrital zircon Protracted zircon record Sedimentary basins UHT metamorphism Prolonged metamorphism Bias in detrital zircon

Benign intratesticular schwannoma:a rare finding

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Asian Journal of Andrology 2006年第1期8卷 101-103页

作者： Maria Chiara Sighinolfi Alessandro Mofferdin Stefano S.De Stefani antonio Celia Salvatore Micali Giovanni Saredi Giulio rossi Riccardo Valli Giampaolo Bianchi Division of Urology Department of Pathology Section of Anatomic Pathology University of Modena 41100 ModenaItaly

Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）

关键词： schwannoma Schwann cells testicular neoplasm S 100 protein

Active surveillance of adverse drug reactions in children in five Italian paediatric wards

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Open Journal of Pediatrics 2012年第2期2卷 111-117页

作者： Mariapina Gallo antonio Clavenna Maurizio Bonati Paolo Siani antonio Irpino Francesco rossi Annalisa Capuano Department of European and Mediterranean Studies Faculty of Political Studies and Higher European Education Jean Monnet Second University of Naples Naples Italy Department of Experimental Medicine Section of Pharmacology “Leonardo Donatelli” Center of Pharmacosurveillance and Phar-macoepidemiology Faculty of Medicine and Surgery Second University of Naples Naples Italy Laboratory for Mother and Child Health Department of Public Health Mario Negri Institute for Pharmacological Research Milan Italy Pediatric Department AORN A. Santobono-Pausillipon Hospital Naples Italy

Adverse drug reactions (ADRs) are an important clinical problem and contribute significantly to mortality and morbidity. Scant data on the safety of drug use in children are usually available at the time of marketing authorization, due to the limited number of trials performed in the paediatric population. Few studies monitored the incidence of ADRs in Italian hospitalized children, that cannot be compared for methodological reasons. A 6-month prospective observational study was, therefore, conducted on the paediatric wards of five hospitals in the Campania Region, Italy. Data were collected on all patients admitted to the wards during the study period through a structured questionnaire administered to the mothers and through a hospital chart review. Of the 752 patients enrolled, 86.2% were exposed to one or more drugs during hospitalization. The therapeutic class most prescribed was systemic antibacterial agents (47%). Six ADRs occurred during hospitalization (incidence 0.9%;95% CI 0.2% - 1.7%). In addition, one child was admitted to a hospital for an ADR. Five out of seven ADRs occurred in girls. The skin was the most affected organ. The medications implicated were amoxicillin, acyclovir, ibuprofen, ceftriaxone, paracetamol, and ranitidine. According to the Naranjo probability criteria, six ADRs were probably, and one possibly, related to the suspected drug. In conclusion, this study reveals that ADRs may be under-reported in children hospitalized in the Campania Region. Consequently, healthcare personnel should be alert to the possibility of ADRs. More accurate reporting of ADRs in children would result in safer use of drugs in such patients.

关键词： Child Prospective Studies Drug Therapy/Adverse Effects Adverse Drug ReactionReporting System Hospital