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Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil

World Journal of Gastroenterology 2019年第38期25卷 5862-5882页

作者： Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari Department of Surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSP 14049-900Brazil Hospital Universitario da Universidade Federal do Piaui TeresinaPI 64049-550Brazil Carolina D Gonclves Isabella M GuimaraesUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Universidade do Estado da Bahia -SalvadorBA 41150-000Brazil Department of Internal Medicine Botucatu Medical School at Sao Paulo State University(UNESP)BotucatuSP 18618-687Brazil Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda GoianiaGO 74535-170Brazil Kaiser Clinica Sao Jose do Rio PretoSP 15015-110Brazil Escola Paulista de Medicina Sao PauloSP 04023-900Brazil UNIFESP Disciplina de GastroenterologiaSao PauloSP 04040-002Brazil Faculdade de Medicina do ABC Santo AndreSP 09060-870Brazil Faculdade de Medicina UFMG Belo HorizonteMG30130-100Brazil Inflammatory Bowel Disease Center Federal University of Juiz de ForaJuiz de ForaMG 36036-247Brazil Takeda Pharmaceuticals Brazil Sao PauloSP 04709-011Brazil 不详 Hospital de Clinicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil Hospital de Clinicas de Porto Alegre Porto Alegre-RS 90035-007Brazil Universidade Federal do Piaui TeresinaPI 64073-500Brazil Hospital de Clínicas da Universidade Federal do Parana CuritibaPR 80060-900Brazil CTI Clinical Trial&Consulting Services Lisbon 1070-274Portugal CMIP Centro Mineiro de Pesquisa Juiz de ForaMG 36010-570Brazil Hospital Nossa Senhora das Gracas CuritibaPR 80810-040Brazil

BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general *** about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD *** To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in *** A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,*** PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI *** about healthcare resources and treatment during the previous 3 years was collected from medical ***-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at *** in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/*** to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,re

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Quality of life Healthcare resources

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Designing Artemisinins with Antimalarial Potential, Combining Molecular Electrostatic Potential, Ligand-Heme Interaction and Multivariate Models

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Computational Chemistry 2023年第1期11卷 1-23页

作者： Josué de Jesus Oliveira Araújo Ricardo Morais de Miranda Jeferson Stiver Oliveira de Castro antonio Florêncio de Figueiredo Ana Cecília Barbosa Pinheiro Sílvia Simone dos Santos Morais Marcos antonio Barros dos Santos Andréia de Lourdes Ribeiro Pinheiro Andréia de Lourdes Ribeiro Pinheiro Fábio dos Santos Gil Heriberto Rodrigues Bitencourt Gustavo Nery ramos Alves José Ciríaco Pinheiro Laboratório de Química Teórica e Computacional Universidade Federal do Pará Belém PA Brasil Instituto Federal de Educaç ã o Ciência e Tecnologia do Pará Belém PA Brasil Universidade do Estado do Amapá Macapá AP Brasil Fundaç ã o Santa Casa de Misericórdia do Pará Belém PA Brasil Universidade do Estado do Pará Barcarena PA Brasil Departamento de Biologia Universidade do Estado do Maranh&atilde o S&atilde o Luís MA Brasil Laboratório de Síntese Organica Universidade Federal do Pará Belém PA Brasil

Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activities, as well as to investigate likely interactions with the receptor in a biological process and to use that information to propose new molecules. In order to discover the best geometry involving the ligand-receptor complexes (heme) studied and help in the proposition of the new derivatives, molecular simulations of interactions between the most negative charged region around the peroxide and heme locates (the ones around the Fe2+ ion) were carried out. In addition, PCA (principal components analysis), HCA (hierarchical cluster analysis), SDA (stepwise discriminant analysis), and KNN (K-nearest neighbor) multivariate models were employed to investigate which descriptors are responsible for the classification between the higher and lower antimalarial activity of the compounds, and also this information was used to propose new potentially active molecules. The information accumulated in studies of MEP, molecular docking, and multivariate analysis supported the proposal of new structures with potential antimalarial activities. The multivariate models constructed were applied to the new structures and indicated numbers 19 and 20 as the most prominent for syntheses and biological assays.

关键词： Artemisinins Antimalarial Potential Molecular Electrostatic Potential Ligand-Heme Interaction Multivariate Models

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Terpinolene inhibits acute responses triggered by different inflammatory agents in vivo models of mouse

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Food Bioscience 2023年第3期53卷 3038-3046页

作者： Isis Oliveira Menezes Lucas Yure Santos da Silva Renata Torres Pessoa Andreza Guedes Barbosa ramos Francisco Assis Bezerra da Cunha Jaime Ribeiro-Filho Anita Oliveira Brito Pereira Bezerra Martins Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Laboratory of Pharmacology and Molecular Chemistry(LFQM) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Semi-arid Bioprospecting Laboratory(LABSEMA) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Research Laboratory in Genetics and Translational Hematology(LIGHT) Gonçalo Moniz Institute(IGM)Oswaldo Cruz Foundation(FIOCRUZ)Rua Waldemar Falcão121Candeal40296-710SalvadorBABrazil Gonçalo Moniz Institute–IGM Fiocruz-BASalvador40296-710BABrazil Department of Biological Chemistry Regional University of CaririAv.Cel.Antonio Luiz1161.PimentaCratoCE63105-000Brazil

The aim of this work was evaluate the effects of terpinolene on acute inflammatory responses in *** vivo preclinical research using different inflammatory agents to induce acute responses and evaluate the effects of terpinolene in orally treated *** acute inflammatory responses were induced by injecting phlogistic agents in the mice paw to observe the development of pain responses(formalin test)or edema(carrageenan,dextran,histamine,arachidonic acid,and prostaglandin).The antiedematogenic activity was also evaluated using a croton oil-induced ear edema ***,cotton pellet-induced granuloma was used to carry out a pre-liminary evaluation of terpinolene in a chronic inflammatory *** administered terpinolene(5,10,and 20 mg/mL)significantly inhibited ear edema development(by 33.82%,29.63%,and 33,30%,respectively).Following an oral administration,only the highest dose of the monoterpene(200 mg/kg)reduced the licking time of the formalin test in both phases 1(73.55%)and 2(96.61%).The carrageenan-induced edema signifi-cantly inhibited over time following the oral administration of terpinolene at 50 mg/kg(T1:47.74%,T2:54.67%,T3:48.63%,and T4:62.99%),100 mg/kg(T1:72.86%,T2:71.03%,T3:48.63%,and T4:57.83%),and 200 mg/kg(T1:43.22%,T2:34.11%,T3:36.47%,and T4:45.20%).On the other hand,only the dose of 200 (mg/kg)caused a significant reduction of the dextran-induced paw edema(T1:51.18%,T2:60%,T3:50.92%,and T4:65.15%).Regarding the participation of inflammatory pathways,the monoterpene(200 mg/kg,p.o.)had little impact on histamine-induced edema,while the edema induced by arachidonic acid was significantly reduced at all time-points(T1:37.04%,T2:24.32%,and T3:35.13%,and T4:35.53%),which was corroborated by the observation that the compound inhibited the response triggered by prostaglandin E2(PGE2),suggesting inter-ference with downstream signaling ***,terpinolene(200 mg/kg,p.o.)reduced both the weight(21.43%)and total protein content(36.21%)

关键词： Terpinolene Antiedematogenic Inflammation In vivo study Inflammatory pathways

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How Growth Ability of Multidrug-Resistant Escherichia coli Is Affected by Abiotic Stress Factors

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Open Journal of Preventive Medicine 2014年第5期4卷 250-256页

作者： Lucinda Janete Bessa Vania Filipa Dias Angelo Mendes Paula Martins-Costa Helena ramos Paulo Martins da Costa CIIMAR—Interdisciplinary Center for Marine and Environmental Research University of PortoPortoPortugal ICBAS—Institute Abel Salazar for the Biomedical Sciences University of PortoPortoPortugal FCUP—Faculty of Sciences University of PortoPortoPortugal Servico de Microbiologia Centro Hospitalar do PortoHospital Geral de Santo AntonioPortoPortugal

The ability of multidrug-resistant Escherichia coli to adapt and grow in a wide range of different environmental conditions may be crucial to the global spread of antimicrobial resistance. The aim of this study was to evaluate the survival ability of 54 multidrug-resistant E. coli strains, isolated from three different biotopes (clinical setting, gull intestine, river water) when subjected to variations in pH (from 3 to 11) and salinity (from 0.5% to 6% of NaCl) and to nutrient deprivation. The growth of each isolate as well as of a reference strain was assessed during 168 h in every varying condition. Slight variations in the growth ability under some abiotic stress factors were recorded among the isolates from the different biotopes. Multidrug-resistant isolates from gull feces were found to be the more tolerant to environmental abiotic changes, while isolates from river water were the less tolerant. In addition, it was notorious that the carriage of antimicrobial resistance has a clear fitness cost in comparison with the susceptible (reference) strain, highlighting the necessity of reducing the selective pressure exerted by antibiotics. This study underlines the ecological hardness of multidrug-resistant E. coli isolates with a consequent ability to reach and colonize new host and environments.

关键词： Escherichia coli Multidrug Resistance Nutrient Deprivation pH Salinity

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旧元素,新物件

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现代装饰 2020年第12期 82-91页

作者： Sergio Prieto Helios Collection Christina Z antonio Marc Wood Qeeboo Marcantonio VIBIA ramos&Bassols Arik Levy Martin Azua Ichiro Iwasaki Stefano Giovannoni 舒禹(编译) Dovain Studio Forge Creative Nichetto Studio Studio Job Lievore Altherr Molina Emiliana Design Studio

美国当代影响力最深远的广告创意大师之一James Webb Young在他的巅峰之作《A Technique for Producing Ideas》中提到:"创意,就是旧元素的新组合。"旧元素于情理之中带给我们熟悉感,新组合又于意料之外催生出陌生感,熟悉与陌生的奇妙组... 详细信息

美国当代影响力最深远的广告创意大师之一James Webb Young在他的巅峰之作《A Technique for Producing Ideas》中提到:"创意,就是旧元素的新组合。"旧元素于情理之中带给我们熟悉感,新组合又于意料之外催生出陌生感,熟悉与陌生的奇妙组合,自然而然创造出令人眼前一亮的新事物。本期设计物料馆精心挑选了一系列的产品,打破常规台灯比例的Pin灯具,将椅背与霓虹灯管混搭的Helios,让"乌龟"成为生活用具一部分的Turtle Carry,展现天然大理石不透明之美的Rosa Rings,玻璃遇上木材的Waney Glass Table……这些产品都以旧元素为出发点进行设计,或是将看似不相干的物件跨界搭配,或是在细节处进行差异化改动组合,但都成功地让旧元素摇身一变,成为别具一格的新物件。

关键词：天然大理石生活用具广告创意打破常规差异化意料之外熟悉感

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The Laughter of Ticklishness Is a Darwinian Feature Related to Empathy in Both Genders: Self-Esteem in Men and Sexism in Women

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Open Journal of Medical Psychology 2014年第1期3卷 18-23页

作者： Verónica Juárez-ramos Elvira Salazar-López María ángeles Rodríguez Artacho K. Chmielowiec A. Riquelme J. Fernández-Gómez A. I. Fernández-Ramirez A. Vicente de Haro A. Miranda M. Caballero B. Machado antonio González Hernández Emilio Gómez Milán Departamento de Psicología Experimental Universidad de Granada Granada Spain

The theory of false alarm for laughter could explain the involuntary laugh when someone is tickled. To put this hypothesis to the test, we handed out a questionnaire (180 items) with two hundred university students. Our main results are: In women who like being tickled, we discover components related to pleasure, erotism, feeling of affection, arousal, uncontrollability, domination, sexism and Darwinian (golden ratio) and psychological traits (empathy, low schizotypy and external locus of control) that are not present in the laughter at a stumble. The relation of both types of laughter with sense of humor is also differential. In men who like being tickled, we discover components related to masturbation, sexual fantasies, erotism, arousal, domination, sexist humour and Darwinian (square chin, feeling of masculinity) and psychological traits (empathic stress, low schizotypy, external locus of control and overall self-esteem). The relationship between being tickled and self-esteem shows a double aspect in men: It is positive in men who like being tickled and negative in men who do not like being tickled. For women there is not a relationship between self-esteem and tickling. Our conclusion is that laughter of ticklishness is a Darwinian feature related to empathy.

关键词： Tickling Gender Empathy Self-Esteem False Alarm

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Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel antonio Quintero-ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

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Meningoencephalitis due to Listeria monocytogenes in a Young Immunocompetent Patient: Case Report with Literature Review

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Advances in Infectious Diseases 2024年第1期14卷 213-219页

作者： Janette Alejandra Gamiño Gutierrez Gustavo Adolfo Hernández Valdez Arleth Anahí Montaño Gómez Jorge Morales Rojas Graciela Gaddy Robles Martinez Anahi Herrera Ruelas Alin Kaori Ferreyra Gudiño Jocelin Celeste Jurado Cardona Jimena Jexabeth Ibáñez Núñez Anahí Fierros ramos Departmento de Neurocirugia Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara México Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic México

Meningoencephalitis secondary to Listeria monocytogenes (L. monocytogenes) mainly affects newborns, the elderly and immunocompromised people;there are extremely rare cases in which said infection occurs in immunocompetent individuals. We present the case of a young adult patient without immunocompromise, who developed meningoencephalitis due to L. monocytogenes;This case is exceptional, since it occurred in an individual outside the classic age group, in addition to not having risk factors, which is why it should be considered an atypical causal agent.

关键词： Meningitis Encephalitis Rhombencephalitis Listeria monocytogenes Immunocompetent

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雌性红颊獴昼夜活动模式与天气的关系

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动物学研究 1990年第4期11卷 355-357页

作者： Steven W. Buskirk(Department of Zoology and Physiology, University of Wyoming, Box 3166, Laramie, WY 82071 U. S. A.)WU Delin (Kunming Institute of Ecology, Acadcmia Sinica, Kunming)Arthur Cleveland(Department of Biology, Incarnate Word College, 4301 Broadway, San antonio, TX 78209-6397 U. S. A) Department of Zoology and Physiology University of Wyoming 中科院昆明生态所云南昆明 Department Biology Incarnate Word

The small Indian mongoose (Herpester ouropurciatus) is notable for the high degree of diurrality of its *** and ramos(1975)

关键词：獴昼夜活动模式昼行性

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