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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 183-190页

作者： Cristhianne Moraes Jorge L.V.Anjos Monica Maruno antonio Alonso Pedro Rocha-Filho Department of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences of Ribeirão PretoUniversidade de São PauloRibeirão Preto 14040-903SPBrazil Physics Department Universidade Federal de Goiás(UFG)Campus Catalão-Av.Dr.Lamartine Pinto de Velar1120St.Universitário75704-020Catalão-GOBrazil Pharmacy Course Coordination Centro Uni.Barão de MauáR.Ramos de Azevedo423Jardim PaulistaRibeirão PretoSP 14090-180Brazil Biophysics Laboratory Physics InstituteUniversidade Federal de Goiás(UFG)Goiânia 74.690-900GOBrazil

The rational design of emulsions requires study of the main factors that influence their formation, physicochemical properties and, consequently, stability and performance. The use of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive. Dipteryx alata Vogel(D. alata) is an oleaginous species native to Brazil. The seeds of this species contain highly unsaturated oil with significant amounts of tocopherols and phytosterols, representing an important source of agents capable of combatting oxidative processes. In this work, a lamellar gel phase emulsion using oil extracted from the seeds of D. alata(baru) was developed. The steps involved in the development of this research were as follows: 1) development of formulations and 2) in vitro assays by simulating the evaporation of the final product after application to the skin and Electron paramagnetic resonance spectroscopy(EPR) of fatty acid spin labels was used to investigate the profile of interaction of the dispersed systems with stratum corneum(SC) lipids. The results indicate that the developed system shows no signs of instability during the storage period. Moreover, EPR studies indicated that D. alata oil and especially the developed formulation were able to increase SC lipid fluidity and extract a fatty-acid spin label from the lipid domain structures of SC, demonstrating its potential to act as a drug or skin care vehicle.

关键词： Stratum corneum O/W emulsions Baru oil EPR spectroscopy

3-D AVO分析和模拟用于煤层气储层的裂缝探测

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国外油气勘探 1999年第1期11卷 72-86页

作者： antonio C. B. ramos Thomas L. Davis 赵岩石油地球物理勘探局石油物探学校

近几年来,振幅随炮检距变化(AVO)分析已经成功地用于预测储层性质和流体含量,在某些情况下,能提供气—水界面、气—油界面的空间位置。在这篇文章中,我们证明,3-D,AVO方法也可用于描述裂缝性储层的性质。给出裂缝密度变化的空间位置。... 详细信息

近几年来,振幅随炮检距变化(AVO)分析已经成功地用于预测储层性质和流体含量,在某些情况下,能提供气—水界面、气—油界面的空间位置。在这篇文章中,我们证明,3-D,AVO方法也可用于描述裂缝性储层的性质。给出裂缝密度变化的空间位置。在新墨西哥州San Juan盆地的Cedar Hill矿区Fruitland组地层的裂缝性煤层中生产甲烷气因为煤层缺乏原生渗透率,裂缝的存在则是生产甲烷气的决定性因素。为了有助于描述煤层的储层性质,在这块地区采用的是3-D多分量地震勘探。本次研究中,多分量数据体的叠前F波振幅资料用来圈定煤层气储层中大泊松比差异(或高裂缝密度)的区域边界。而震源-接收点方位分选则用于检测煤层裂缝系统引起的方位各向异性的优选方向、两种模拟方法(使用射线追踪和反射率)预测裂缝性煤层带对角度有关的P波反射率的影响对水平层状地层模型建立了合成共中心点(CMP)道集,模型所用的弹性参数取自声波测井和密度测井。由各向异性模拟方法模拟煤层中裂缝密度的变化。与砂岩—煤层界面有关的大声阻抗差异决定了P波反射率响应。对于计算模型来说,这些差异的影响远远超过各向异性差异的影响。由3—D数据体得到的9个大面元的地震AVO分析证实了模型的预测,具有AVO截距的范围指示低速煤层可能与应力释放带有关。具有AVO梯度的范围辨别大泊松比差异的煤层带,并因而识别煤层气储层中的高密度裂缝带。3-D AVO成果和储层泊松比变化图结合这些响应生成包括断裂程度和其可能的应力条件的储层图件。震源接收点方位分选被用于测定煤层裂缝系统引起的方位各向异性的优选方向。

关键词： AVO 煤层气模拟储集层地震勘探裂缝探测

CD36 genetic variation, fat intake and liver fibrosis in chronic hepatitis C virus infection

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World Journal of Hepatology 2016年第25期8卷 1067-1074页

作者： Omar ramos-Lopez Sonia Roman Erika Martinez-Lopez Nora A Fierro Karina Gonzalez-Aldaco Alexis Jose-Abrego Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Health Sciences University Center University of Guadalajara

AIM To analyze the association of the CD36 polymorphism(rs1761667) with dietary intake and liver fibrosis(LF) in chronic hepatitis C(CHC) patients. METHODS In this study, 73 patients with CHC were recruited. The CD36 genotype(G > A) was determined by a TaqM an real-time PCR system. Dietary assessment was carried out using a three-day food record to register the daily intake of macronutrients. Serum lipids and liver enzymes were measured by a dry chemistry assay. LF evaluated by transient elastography(Fibroscan~)and APRI score was classified as mild LF(F1-F2) and advanced LF(F3-F4).RESULTS Overall, the CD36 genotypic frequencies were AA(30.1%), AG(54.8%), and GG(15.1%), whereas the allelic A and G frequencies were 57.5% and 42.5%, respectively. CHC patients who were carriers of the CD36 AA genotype had a higher intake of calories attributable to total fat and saturated fatty acids than those with the non-AA genotypes. Additionally, aspartate aminotransferase(AST) serum values were higher in AA genotype carriers compared to non-AA carriers(91.7 IU/L vs 69.8 IU/L, P = 0.02). Moreover, the AA genotype was associated with an increase of 30.23 IU/L of AST(β = 30.23, 95%CI: 9.0-51.46, P = 0.006). Likewise, the AA genotype was associated with advanced LF compared to the AG(OR = 3.60, 95%CI: 1.16-11.15, P = 0.02) or AG + GG genotypes(OR = 3.52, 95%CI: 1.18-10.45, P = 0.02).CONCLUSION This study suggests that the CD36(rs1761667) AA genotype is associated with higher fat intake and more instances of advanced LF in CHC patients.

关键词： Hepatitis C virus infection CD36 receptor Lipids Liver fibrosis Mexico

Self-reported dietary supplement use in deployed United States service members pre-deployment *** deployment,Afghanistan,2013-2014

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Military Medical Research 2018年第3期5卷 207-215页

作者： Shawn M.Varney Patrick C.Ng Crystal A.Perez Allyson A.Arana Edwin R.Austin Rosemarie G.ramos Vikhyat S.Bebartas University of Texas Health Science Center San antonio 7709Floyd Curl DrSan AntonioTX 78229USA San antonio Military Medical Center 3551Roger Brooke DriveSan AntonioTX 78234USA Rocky Mountain Poison and Drug Center Denver Health and Hospital AuthorityDenverCOUSA U.S.Army Institute of Surgical Research USAF En Route Care Research Center3698Chambers Pass STE BJBSA Ft Sam HoustonSan AntonioTX 78234USA Department of Emergency Medicine University of Colorado School of Medicine13001E 17th PlaceAuroraCO 80045USA

Background: Dietary supplement use(protein/amino acids, weight-loss supplements, performance enhancers) is common among U.S. military members. Reported dietary supplement use in deployed troops is limited and is of concern in settings where troops are exposed to high ambient temperatures, increased physical demands, and dehydration. Our objective was to describe dietary supplement use and adverse events(AEs) among deployed U.S. service members compared with their pre-deployment ***: We conducted an institutional review board(IRB) approved, descriptive study in Afghanistan using a written questionnaire and collected demographic information, dietary supplement use before and during deployment, AEs associated with supplement use, and physical workout routines. Participants were U.S. military personnel of all branches of service deployed to Afghanistan. They were recruited in high-traffic areas in the combat theater. We analyzed the data with descriptive statistics. Paired t-test/Wilcoxon signed-rank test was conducted to examine the before/during deployment changes for continuous data, and Mc Nemar's chi-square test was conducted for categorical data. We constructed separate logistic regression models to determine the best predictors of increases or decreases in dietary supplement use, with demographic information, reasons for using supplements, and education requested/received as covariates in each model. All statistical tests were two-sided at a significance level of 5%(P<0.05).Results: Data were collected on 1685 participants. Ninety-seven of the participants were in the Army or Air Force. The participants were more likely to work out daily or more than once a day during deployment. Thirty-five percent of the participants reported no supplement use before or during deployment. The remaining 65% of participants reported increased use and increased frequency of use of supplements(e.g., daily) during deployment compared with predeployment. Additionally, more pe

关键词： Military Dietary supplement Workout Exercise Adverse events

Taphonomic characterisation of tooth marks of extinct Eurasian carnivores through geometric morphometrics

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Science Bulletin 2022年第16期67卷 1644-1648,M0003,M0004页

作者： José Yravedra Lloyd Austin Courtenay Darío Herranz-Rodrigo Gonzalo Linares-Matás Juan JoséRodríguez-Alba Verónica Estaca-Gómez Carmen Luzón Alexia Serrano-ramos MiguelÁngel Maté-González Joséantonio Solano Diego González-Aguilera Juan Manuel Jiménez-Arenas Department of Prehistory Ancient History and ArchaeologyComplutense University of MadridMadrid 28040Spain C.A.I.Archaeometry and Archaeological Analysis Complutense UniversityMadrid 28040Spain Grupo de Investigación Ecosistemas Cuaternarios Complutense UniversityMadrid 28040Spain Grupo de Investigación Arqueología Prehistórica Complutense UniversityMadrid 28040Spain Museo Primeros Pobladores de Europa‘Josep Gibert’ Orce 18858Spain Department of Cartographic and Land Engineering Higher Polytechnic School of AvilaUniversity of SalamancaAvila 05003Spain School of Archaeology St.Hugh’s CollegeUniversity of OxfordOxford 01865United Kingdom History and Arts Doctoral Program University of GranadaGranada 18071Spain Escuela Técnica Superior de Ingenieros en Topografía Geodesia y Cartografía.Universidad Politécnica de MadridMadrid 28031Spain Department of Prehistory and Archaeology University of GranadaGranada 18071Spain

Determining the cause and nature of the postmortem processes that living organisms experience is one of the main common issues faced by forensic experts,zooarchaeologists,palaeontologists,and other *** are among the most destructive agents that can interact with a corpse,since their feeding behaviour can lead to very extensive alterations,complicating the diagnostic identification of which carnivore species was responsible for the death of an individual,a livestock unit,or the formation of a fossil *** though some currently available techniques enable forensic experts to undertake a differential diagnosis of carnivore agency from corpse examination.

关键词：几何形态测量学埋藏特征有蹄类动物齿痕几何形态学机器学习分类预测多变量分析

Hybrid Duodenal Transit Bipartition: An Endoscopic and Laparoscopic Metabolic Procedure

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Surgical Science 2024年第10期15卷 547-564页

作者： Paulo Reis Rizzo Esselin de Melo Anna Carolina Hoff Ricardo Zorron Victor ramos Mussa Dib Carlos Augusto Scussel Madalosso Rui Ribeiro Thonya Cruz Braga Fernando Reis Esselin Melo Paula Volpe Carlos Eduardo Domene antonio Torres Paulo Reis Institute Goinia Brazil Alfredo Nasser University Center (UNIFAN) Goinia Brazil Angioskope International Interventional Endoscopy Training Center So Paulo Brazil Department of Bariatric and Metabolic Surgery CUF Descobertas Hospital Lisbon Portugal Victor Dib Institute Manaus Brazil Gastrobese Clinic Passo Fundo Brazil Lusadas Amadora Hospital Lisboa Portugal Clianest Group Renaissance Hospital Goinia Brazil IOM-Intraoperative Medical Services Paulo Reis Institute Braslia Brazil Integrated Center for Advanced Medicine (CIMAMED) So Paulo Brazil Department of Surgery Hospital Clnico San Carlos Madrid Spain Department of Surgery School of Medicine Complutense University Madrid Spain San Carlos Health Research Institute (IdISSC) Madrid Spain

Obesity has been increasing significantly in Brazil and worldwide, becoming a major public health issue. Traditional prevention and treatment strategies, including behavioral interventions, nutritional modifications, physical activity, pharmacotherapy, and metabolic/bariatric procedures, have proven insufficient to reverse this trend. Bariatric surgery is recognized as the most effective treatment for obesity and its comorbidities, but it carries potential long-term risks. Hybrid Duodenal Transit Bipartition is proposed as a minimally invasive “endobariatric” procedure combining endoscopic sleeve gastroplasty (ESG) with laparoscopic duodenoileal or distal duodenojejunal anastomosis. The main objective of this study is to demonstrate the importance of the intestinal metabolic component of hybrid duodenal transit bipartition. This intestinal component is responsible for optimizing and attempting to maintain weight loss and control comorbidities from an ESG through the incretin stimulus generated by the early arrival of food in the ileum or distal jejunum (duodenoileal or distal duodenojejunal anastomosis). Additionally, it is a minimally invasive procedure that preserves the entire digestive system and does not involve gastrointestinal exclusion, allowing for endoscopic and nutritional access. To date, only one patient has undergone the hybrid duodenal bipartition procedure, with satisfactory early postoperative results at 60 days and weight loss exceeding the scientific literature on patients who underwent isolated endoscopic sleeve gastroplasty. Further studies are needed to validate these results and assess the long-term metabolic benefits of this new approach.

关键词： Duodenal Switch Duodenal Transit Bipartition Bariatric Surgery Metabolic Surgery Endoscopic Gastroplasty Endobariatric

Emergency medicine providers＇ opioid prescribing practices stratified by gender, age, and years in practice

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World Journal of Emergency Medicine 2016年第2期7卷 106-110页

作者： Shawn M. Varney Vikhyat S. Bebarta Lisa M. Mannina Rosemarie G. ramos Victoria J. Ganem Katherine R. Carey Department of Emergency Medicine University of Texas Health Science Center San Antonio 78229 USA Department of Emergency Medicine University of Colorado School of Medicine Aurora 80045 USA Department of Emergency Medicine Mike O'Callaghan Federal Medical Center Nellis 89191 USA Air Force Enroute Care Research Center Fort Sam Houston 78208 USA The Geneva Foundation Tacoma 98402 USA

BACKGROUND: Emergency medicine providers(EMPs) prescribe about 25% of opioids, but the effect of EMP risk perception on decisions to prescribe opioids is unknown. This study was undertaken to identify factors that infl uence EMP risk and opioid prescribing ***: We distributed an anonymous questionnaire to EMPs at a military trauma and referral center. Response frequencies and distributions were assessed for independence using the Chi-square ***: Eighty-nine EMPs completed the questionnaire(100% response). Respondents were primarily younger male physicians(80%) in practice under fi ve years(55%). Male EMPs were more likely to prescribe more opioid tablets than female ones both when and when not concerned for opioid misuse(P<0.001, P<0.007, respectively). Of the providers, 70% stated that patient age would inf luence their prescribing decisions. Hydrocodone and oxycodone were the opioids prescribed most frequently. About 60% of the providers reported changing their prescribing behavior would not prevent opioid misuse. Additionally, 40% of the providers believed at least 10% of patients seen at this military ED misused ***: Female EM providers reported prescribing fewer opioid tablets. Patient age infl uenced prescribing behavior, but the effect is unknown. Finally, EM providers reported that altering their prescribing behavior would not prevent prescription opioid misuse.

关键词： Prescription opioid misuse Emergency medicine provider Prescribing practices

Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques(Macaca mulatta)

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Animal Models and Experimental Medicine 2019年第4期2卷 326-333页

作者： Jose J.Rosado-Franco Marcos J.ramos-Benitez Laura M.Parodi Derick Rosario Nicole Compo Luis D.Giavedoni Ana M.Espino Department of Microbiology and Medical Zoology Medical Sciences CampusUniversity of Puerto RicoSan JuanPuerto Rico Southwest National Primate Research Center Texas Biomedical Research InstituteSan AntonioTXUSA Chemistry Department Rio Piedras CampusUniversity of Puerto RicoSan JuanPuerto Rico Medical Sciences Campus Caribbean Primate Research Center University of Puerto RicoToa BajaPuerto Rico

The aim of this study was to identify inflammation-associated markers during the early phase of sepsis in rhesus macaque. Four rhesus macaques were given an intravenous dose of 1010 CFU/kg of E. coli. Blood samples were collected before, or 30 minutes, 2, 4, 6 and 8 hours after E. coli infusion. Physiological parameters, bacteremia, endotoxemia, C-reactive protein(CRP), procalcitonin(PCT), and plasma cytokines/chemokines were determined for each animal. Bacteremia was present in all animals from 30 minutes to 3 hours after E. coli infusion whereas endotoxin was detected during the full-time course. CRP and PCT levels remained at detectable levels during the whole experimental window suggesting an ongoing inflammatory process. Signature cytokines and chemokines such as TNF-α, MIP-1α, and MIP-1β peaked about 2 hours after E. coli infusion and decreased thereafter. Plasma IL-6, IL-12 p40, IFN-γ, and IL-1 Ra, as well as I-TAC, MIG, IP-10 and MCP-1, remained at detectable levels after 4 hours of E. coli infusion. This nonhuman primate model could be useful for the assessment of new therapeutics aiming to suppress key inflammatory markers throughout sepsis early phases.

关键词： chemokines cytokines Macaca mulatta sepsis

Determination of Paraquat in Several Commercially Available Types of Rice

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Food and Nutrition Sciences 2018年第12期9卷 1368-1375页

作者： Thais Lopes Lima Maria Aparecida Nicoletti Camila Munhoz Gabriel ramos De Abreu Julia Zaccarelli Magalhaes Esther Lopes Ricci Ricci Paula A.Faria Waziry Júlia Nathalia Alves da Costa Ana Carolina Nascimento antonio AndréRinaldi Fukushima Universidade Sao Judas Tadeu-R.Taquari Sao Paulo/SPBrazil Departamento de Farmacia.Faculdade de Ciencias Farmaceuticas.Universidade de Sao Paulo Sao Paulo/SPBrazil Instituto de Ciencias da Saude Universidade Presbiteriana MackenzieRua da ConsolacaoSao Paulo/SPBrazil Departamento de Patologia Faculdade de Medicina Veterinaria e ZootecniaUniversidade de Sao PauloSao Paulo/SPBrazil New Southeastern University Fort LauderdaleFloridaUnited States of America Veterans Affairs Medical CenterMiamiFloridaUSA Faculdade Sao Bento-Largo de Sao Bento s/no-CentroSao Paulo-SPSao Paulo/SPBrazil

Introduction: Paraquat (1,1’-dimethyl-4,4’-bipyridine-dichloride) is a herbicide used to combat weeds and improve crop productivity. Its acute toxicity can cause fatal poisoning in humans and animals and several studies have shown a strong correlation between paraquat and Parkinson’s disease. Objective: To determine the concentration of paraquat in different types of rice in Brazil. Method: Paraquat quantification is based on a complexation reaction with sodium dithionite, which generates a blueish color compound, whose absorbance was read in a spectrophotometer at the 600 nm wavelength. Results: Five samples were found to be above the maximum allowed limit, while one sample had a concentration in the upper allowed limit. The method employed did not allow quantification of black rice. Conclusion: There is a need for identification of the type of pesticide used in each examined crop as well as their respective dates of remission in order to improve the safety of agricultural practices.

关键词： Paraquat Herbicide Rice