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Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： Ana M.GARCÍA-l.pez Ramiro RECENA antonio DElGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(HS)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnSO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-HS complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source

Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer

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Chinese Journal of Cancer 2015年第1期34卷 41-49页

作者： José antonio l.pez-Guerrero Ignacio Romero Andrés Poveda laboratory of Molecular Biology Fundación Instituto Valenciano de Oncología Clinical Area of Gynecological Cancer Fundación Instituto Valenciano de Oncología

Epithelial ovarian cancer(OC) is a common gynecologic malignancy in women. The standard treatment for OC is maximal cytoreductive surgical debulking followed by platinum-based chemotherapy. Despite the high response rate to primary therapy, approximately 85% of patients will develop recurrent ovarian cancer(ROC). This review identifies the clinical use of trabectedin in the treatment algorithm for ROC, with specific emphasis on platinum-sensitive ROC, for which trabectedin in combination with pegylated liposomal doxorubicin has been approved as a treatment protocol. The main mechanisms of action of trabectedin at the cellular level and in the tumor microenvironment is also discussed as bases for identifying biomarkers for selecting patients who may largely benefit from trabectedin-based therapies.

关键词：治疗方案卵巢癌敏感复发铂疗法恶性肿瘤聚乙二醇化

The 2.7 K black-body radiation background reference frame

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Chinese Physics B 2010年第4期19卷 16-20页

作者： l.pez-Carrera Benjamín Rosales Marco antonio Ares de Parga Gonzalo Departamento de Física Escuela Superior de Física y MatemticasInstituto Politécnico NacionalU.P.A.López MateosZacatenco 07738México DFMéxico Departamento de Física Universidad de las AméricasSanta Catarina MrtirC.P.72820CholulaPuebla.México

This paper reports that the directional temperature is used to present a scheme for deducing the velocity of the reference frame where the black-body which produces the 2.7 K radiation background is at rest. The new r... 详细信息

关键词： relativistic transformations thermodynamics covariance black-body radiation

Effect of aging on behaviour of mesenchymal stem cells

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World Journal of Stem Cells 2019年第6期11卷 337-346页

作者： Juan antonio Fafián-labora Miriam Morente-l.pez María C Arufe Grupo de Terapia Celular y Medicina Regenerativa Departamento de Fisioterapia Ciencias Biomédicas y MedicinaUniversidade da Coru?a

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.

关键词： Mesenchymal stem cells Aging Autophagy Mitochondrial stress Extracellular vesicles

Potential seed germination-enhancing plant growth-promoting rhizobacteria for restoration of Pinus chiapensis ecosystems

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Journal of Forestry Research 2021年第5期32卷 2143-2153页

作者： Cristina Domínguez-Castillo Julia María Alatorre-Cruz Dolores Castañeda-antonio Jose antonio Munive Xianwu Guo Jesús Francisco l.pez-Olguín luis Ernesto Fuentes-Ramírez Ricardo Carreño-l.pez Centro de Investigaciones en Ciencias Microbiológicas Instituto de CienciasBenemérita Universidad Autónoma de PueblaPueblaMéxico Universidad Autónoma de Querétaro QuerétaroMéxico Centro de Biotecnología Genómica Instituto Politécnico NacionalReynosaTamaulipasMéxico

Rhizosphere soil samples of three Pinus chiapensis sites were analyzed for their physicochemical properties,soil bacteria isolated and screened in vitro for growthpromoting *** isolates that showed promise were identified to five genera Dyella,luteimonas,Euterobacter,Paraburkholderia and Bacillus based on the sequences of16 S rRNA *** the strains were isolated from nondisturbed *** bacteria significantly decreased germination time and increased sprout *** acetic acid and gibberellin production and phosphate solubilisation were *** indicate that these biochemicals could be essential for *** distribution and suggest the possibility that PGPR inoculation on *** seeds prior to planting could improve germination and possibly seedling development.

关键词： Pinus chiapensis Plant growth-promoting rhizobacteria Dyella luteimonas Enterobacter

Twenty-four-hour movement guidelines during middle adolescence and their association with glucose outcomes and type 2 diabetes mellitus in adulthood

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Journal of Sport and Health Science 2023年第2期12卷 167-174页

作者： antonio García-Hermoso JoséFrancisco l.pez-Gil Yasmin Ezzatvar Robinson Ramírez-Vélez Mikel Izquierdo Navarrabiomed Hospital Universitario de Navarra(HUN)Universidad Publica de Navarra(UPNA)IdiSNAPamplona 31008Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 16007Spain Department of Nursing Universitat de ValenciaValencia 46010Spain

Purpose:The aim of the present study was to determine the association between adherence to the 24-h movement guidelines during middle adolescence and glucose outcomes(glycated hemoglobin and fasting glucose)and type 2 diabetes mellitus(T2DM)in adulthood,14 and 22 years ***:We analyzed data from apparently healthy adolescents aged 12-18 years who participated in WavesⅠandⅡ(1994-1996,n=14,738),WaveⅣ(2008-2009,n=8913),and Wave V(2016-2018,n=3457)of the National longitudinal Study of Adolescent to Adult Health(Add Health)in the United *** activity,screen time,and sleep duration were measured using questionnaires,and the 24-h guidelines were defined as:5 or more times moderate-to-vigorous physical activity per week,≤2 h per day of screen time,and 9-11 h of sleep for 12-13 years and 8-10 h for 14-17 *** and venous whole blood was collected and analyzed to determine glycated hemoglobin and fasting glucose for WavesⅣandⅤ,***:Only 2.1%of the adolescents met all the 3 guidelines,and 37.8%met none of *** both wavesⅣandⅤ,adolescents who met physical activity and screen time guidelines had lower odds of T2DM in adulthood than those who did not meet any of these guidelines(WaveⅣ;prevalence ratio(PR)=0.57,95%confidence interval(95%CI):0.21-0.89;Wave V:PR=0.43,95%CI:0.32-0.74).Only for Wave V did adolescents who met all 3 guidelines have lower odds of T2DM at follow-up compared with those who did not meet any of these guidelines(PR=0.47,95%CI:0.24-0.91).Also,for each increase in meeting one of the 24-h recommendations,the odds of T2DM decreased by 18%(PR=0.82,95%CI:0.61-0.99)and 15%(PR=0.85,95%CI:0.65-0.98)in adulthood for WavesⅣandⅤ,***:Promoting all 24-h movement guidelines in adolescence,especially physical activity and screen time,is important for lowering the potential risk of T2DM in adulthood.

关键词： Glucose metabolism Glycated hemoglobin Physical activity Screen time Sleep duration

Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation

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World Journal of Gastroenterology 2015年第39期21卷 11016-11026页

作者： antonio Cuadrado David San Segundo Marcos l.pez-Hoyos Javier Crespo Emilio Fábrega Gastro- enterology and Hepatology Unit Marqués de Valdecilla University Hospital Instituto de Investigación Marqués de Valdecilla Immunology Unit Marqués de Valdecilla University Hospital. Instituto de Investigación Marqués de Valdecilla

Antibody-mediated rejection(AMR) caused by donorspecific anti-human leukocyte antigen antibodies(DSA) is widely accepted to be a risk factor for decreased graft survival after kidney transplantation. This entity also plays a pathogenic role in other solid organ transplants as it appears to be an increasingly common cause of heart graft dysfunction and an emerging issue in lung transplantation. In contrast, the liver appears relatively resistant to DSA-mediated injury. This "immune-tolerance" liver property has been sustained by a low rate of liver graft loss in patients with preformed DSA and by the intrinsic liver characteristics that favor the absorption and elimination of DSA; however, alloantibody-mediated adverse consequences are increasingly being recognized, and several cases of acute AMR after ABO-compatible liver transplant(lT) have been reported. Furthermore, the availability of new solid-phase assays, allowing the detection of low titers of DSA and the refinement of objective diagnostic criteria for AMR in solid organ transplants and particularly in lT, have improved the recognition and management of this entity. A cost-effective strategy of DSA monitoring, avoidance of class Ⅱ human leukocyte antigen mismatching, judicious immunosuppression attached to a higher level of clinical suspicion of AMR, particularly in cases unresponsive to conventional antirejection therapy, can allow a rational approach to this threat.

关键词： Donor-specific anti-human leukocyte antigen antibo

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera antonio Jesús l.pez-Gambero Juan antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.l.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Study of reverse osmosis membranes fouling by inorganic salts and colloidal particles during seawater desalination

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Chinese Journal of Chemical Engineering 2020年第3期28卷 733-742页

作者： Santiago Gutiérrez Ruiz Juan antonio l.pez-Ramírez Mohammed Hassani Zerrouk Agata Egea-Corbacho lopera JoséMaría Quiroga Alonso Department of Environmental Technologies Faculty of Marine and Environmental SciencesUniversity of Cadiz11510Puerto RealCadizSpain

Fouling phenomenon is considered among the major reasons that cause significant increase of operating cost of desalination plants equipped with reverse osmosis(RO)*** phenomenon is studied in the present work in the case of RO polyamide aromatic membranes using model seawater containing inorganic salts and colloidal *** solubility conditions of CaCO3 and CaSO4 were applied to study RO performances with and without colloid *** experiments,the membrane permeate fluxes were continuously ***,studies of chemical composition,structure,and morphology of the materials deposited on the membrane surface were conducted using energy dispersive microanalysis(EDS)X-ray diffraction and scanning electronic microscopy(SEM).Results show that in conditions of calcium carbonate oversaturation there is a reduction in the permeate flow of 11.2%due to fouling of the membrane by the precipitation of this *** in the same conditions of calcium sulphate oversaturation the reduction of the flow is 5%,so we can conclude that in conditions of oversaturation of both salts,calcium carbonate produces a greater fouling of the membrane that in its view causes greater decrease in the flow of *** this based on the results of the test with both salts in oversaturated *** in the formation of calcite and gypsum crystals onto the membranes as XRD analyses *** presence of colloidal silica in those conditions intensifies strongly the fouling,leading until to 24.1%of permeate flux decrease.

关键词： Reverse osmosis Desalination Fouling Seawater Scaling