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Present and future of metastatic colorectal cancer treatment: A review of new candidate targets

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World Journal of Gastroenterology 2017年第26期23卷 4675-4688页

作者： Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria della corte Floriana Morgillo antonio Raucci antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli Department of Internal and Experimental Medicine“F.Magrassi e A.Lanzara” Institute of Medical OncologyUniversitàdegli studi della Campania Luigi Vanvitelli Department of Internal and Experimental Medicine Magrassi-LanzaraInstitute of RadiologyUniversitàdegli studi della Campania Luigi Vanvitelli Gastroenterology Unit Ospedale Umberto I Unit of Colorectal Surgery Department of MedicalSurgicalNeurologicalMetabolic and Ageing SciencesUniversità degli studi della Campania Luigi Vanvitelli

In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon.

关键词： Novel biomarkers Monoclonal antibodies Resistance Mutation RAS Target therapy Metastatic colorectal cancer

When sepsis affects the heart: A case report and literature review

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World Journal of Clinical Cases 2015年第8期3卷 743-750页

作者： Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano della corte Carlo Maida Irene Simonetta antonio Pinto U.O.C.di Medicina Interna e Cardioangiologia University of Palermo

A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient.

关键词： Sepsis Shock Hypotension Troponin Myocardial dysfunction

Efficient Techniques and Algorithms for Improving Indoor Localization Precision on WLAN Networks Applications

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International Journal of Communications, Network and System Sciences 2009年第7期2卷 645-651页

作者： antonio del corte-VALIENTE Jose Manuel GóMEZ-PULIDO Oscar GUTIéRREZ-BLANCO 不详

This paper proposes efficient techniques that allow the deploying of high precision location applications for indoor scenarios over Wireless Local Area Networks (WLAN). Firstly, we compare the use of radio frequency (RF) power levels and relative time delays based on ray-tracing as detection methods to estimate the localization of a set of mobile station using the fingerprint technique. Detection method play an important role in applications of high frequencies techniques for locations systems based on current and emerging standards such as Wi-Fi (802.11x) and Wi-Max (802.16x). The localization algorithm computes the Eucli- dean distance between the samples of signals received from each unknown position and each fingerprint stored in the database or radio-map obtained using the FASPRI simulation tool. Experimental results show that more precision can be obtained in the localization process by means of relative delay instead of RF power detection method. Secondly, the Euclidean distance has been compared with others similarity distance measures. Finally, an interpolation algorithm between the fingerprinting weighing based on the distances has been implemented in order to eliminate those fingerprints that do not contribute to the improvement in the accuracy. These techniques allow obtaining more precision in the localization of indoor mobile devices over WLAN networks.

关键词： Localization Euclidean Distance Interpolation Mahalanobis Distance Faspri Fingerprinting GTD

The Essential Oil of Ocimum americanum from Senegal and Gambia as a Source of Methyleugenol for the Control of Bactrocera dorsalis, Fruit Fly

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 133-141页

作者： Yoro Tine antonio Alain Coffi Sinzogan Ousmane Ndiaye Cebastiana Sambou Alioune Diallo Ismaila Mbenga Kemo Badji El Hadji Omar Dieng Assa Balayara Jeanne Diatta Cheikhouna Gaye Julien Paolini Jean Costa Alassane Wele Saliou Ngom Laboratoire de Chimie Organique et Thérapeutique Faculté de Médecine Pharmacie et Odontologie Université Cheikh Anta Diop Dakar Sénégal Faculte des Sciences Agronomiques Universite d’Abomey Calavi Cotonou Benin Ecole Nationale Supérieure d’Agriculture (ENSA) Université Iba Der Thiam de Thiès Thiès Sénégal Direction de la Protection des Végétaux Rufisque Sénégal Laboratoire de Chimie des Produits Naturels Université de Corse Corte France National Agricultural Research Institute (NARI) Sere Kunda Gambia Institut Sénégalais de Recherches Agricoles (ISRA) Dakar Sénégal

The fruit fly, Bactrocera dorsalis (Diptera: Tephritidae) is one of the most important pests in all mango-producing areas, particularly in West Africa. In Senegal, O. americanum leaves have been used for several years to control this fly. However, to our knowledge, no chemical studies have been carried out. Thus, the aim of this study is to determine the chemical composition of the essential oil of O. americanum leaves collected in Senegal and Gambia. The essential oil obtained by hydrodistillation of these leaves is analyzed by GC/FID and GC/MS. Yields of essential oils from O. americanum leaves are 3.84% and 2.13%, respectively. Analysis of these essential oils by GC/FID and GC/MS allowed the identification of 23 compounds representing almost 100% of the total compositions. These essential oils are mainly dominated by methyleugenol (72.0% and 75.8%, respectively). Other components in significant percent are trans-β-caryophyllene (13.9% and 13.0%, respectively), germacrene D (4.1% and 3.7%, respectively), β-elemene (3.3% and 0.9%, respectively). Due to the high methyleugenol content, this study explains the attractive potential of O. americanum towards B. dorsalis. In perspective, we plan to evaluate the attractive effect of the essential oil and leaf powder of O. americanum against B. dorsalis, a real pest of mango orchards in Senegal.

关键词： Ocimum americanum Essential Oils Methyleugenol Bactrocera dorsalis GC/MS