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Allograft tissue irradiation and failure rate after anterior cruciate ligament reconstruction:A systematic review

World Journal of Orthopedics 2016年第6期7卷 392-400页

作者： Jesse Dashe Robert L Parisien antonio cusano Emily J Curry Asheesh Bedi Xinning Li Depatment of Orthopaedic Surgery Boston University School of Medicine-Boston Medical Center Depatment of Orthopaedic Surgery University of Michigan School of Medicine

AIM:To evaluate whether anterior cruciate ligament(ACL) allograft irradiation is effective for sterility without compromising graft integrity and increasing failure ***:A literature search was conducted using Pub Med,Cochrane,and *** following search terms were used:"Gamma irradiation AND anterior cruciate ligament AND allograft" with a return of 30 *** used included:English language,years *** were 6 hits that were not reviewed,as there were only abstracts *** 5 hits were discarded,as they did not pertain to the topic of *** were 9 more articles that were excluded:Three studies were performed on animals and 6 studies were ***,a total of 10 articles were applicable to ***:There is a delicate dosing crossover where gamma irradiation is both effective for sterility without catastrophically compromising the structural integrity of the *** note,low dose irradiation is considered less than 2.0 Mrad,moderate dose is between 2.1-2.4 Mrad,and high dose is greater than or equal to 2.5 *** upon the results of the literature search,the optimal threshold for sterilization was found to be sterilization at less than 2.2 Mrad of gamma irradiation with the important caveat of being performed at low *** graft selection process also must include thorough donor screening and testing as well as harvesting the tissue in a sterile *** of higher dose(≥ 2.5 Mrad) of irradiation causes greater allograft tissue laxity that results in greater graft failure rate clinically in patients after ACL ***:Allograft ACL graft gamma irradiatedwith less than 2.2 Mrad appears to be a reasonable alternative to autograft for patients above 25 years of age.

关键词： Anterior cruciate ligament reconstruction Graft choice Allograft Gamma irradiation Anterior cruciate ligament graft failure rate

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