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Ultrastructural Aspects of Apoptosis in Systemic Sclerosis Inflammatory Myopathy

Microscopy Research 2018年第1期6卷 1-7页

作者： Héctor J. Finol Héctor Luis Osorio-Vega Radharani Dorta-Ledezma antonio roschman-gonzález Blanca Muller Israel Montes de Oca Center for Electron Microscopy Sciences Faculty Caracas Venezuela Laboratory of Cellular and Molecular Pathology Center for Experimental Medicine Venezuelan Institute for Scientific Research Miranda Venezuela Dentistry Faculty Central University of Venezuela Caracas Venezuela Medicine Service No. 2 Caracas University Hospital Caracas Venezuela

Muscle biopsies from two female patients with systemic sclerosis (SS) and an inflammatory myopathy were studied ultrastructurally in relation to the possible presence of apoptosis in skeletal muscle fibers. Undergoing apoptosis showed characteristic morphological features of this process, including chromatin aggregation as well as nuclear and sarcoplasmic partition into membrane bound-vacuoles (apoptotic bodies) which contained autophagosomes, mitochondria, isolated myofilaments and nuclear material. Vacuoles exhibited different diameters and were covered by single membranes, appearing beneath basement membrane. Apoptosis occurred in some fiber segments as in necrosis or included whole atrophied fibers. These results indicate that apoptosis coexists with necrosis in the inflammatory myopathy of SS.

关键词： Apoptosis Skeletal Muscle Fiber Systemic Sclerosis Inflammatory Myopathy Ultrastructure

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<i>Trypanosoma evansi</i>: A Qualitative and Quantitative Ultrastructural Analysis of the Spleen during Experimental Murine Infections

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Microscopy Research 2020年第3期8卷 31-42页

作者： Lucia Proietti d’Empaire Félix Tejero Hector J. Finol Pedro M. Aso antonio roschman-gonzalez Centro de Biología Estructural Instituto Venezolano de Investigaciones Científicas Caracas Venezuela Instituto de Zoología y Ecología Tropical Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Centro de Microscopía Electrónica Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Departamento de Biología Celular Universidad Simón Bolívar Caracas Venezuela

A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two Trypanosoma evansi strains derived from naturally infected local equine hosts (Equusasinus and E. caballus);T. evansi causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from E. caballus strain.

关键词： Trypanosoma evansi Spleen Ultrastructure Mouse

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