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CXCL9 and CXCL10 display an agedependent profile in Chagas patients:a cohort study of aging in Bambui,Brazil

Infectious Diseases of Poverty 2020年第3期9卷 132-132页

作者： Fernanda Fortes de Araújo Karen Cecília Lima Torres Sérgio Viana Peixoto antonio luiz Pinho ribeiro Juliana Vaz Melo Mambrini Vitor Bortolo Rezende Maria luiza Lima Silva Antônio Ignácio Loyola Filho Andréa Teixeira-Carvalho Maria Fernanda Lima-Costa Olindo Assis Martins-Filho Integrated Research Group in Biomarkers Rene Rachou InstituteOswaldo Cruz FoundationAvenida Augusto de Lima1715–Barro Preto–Belo HorizonteMinas Gerais 30190-002Brazil 不详

Background:Chagas disease is endemic in Latin America and still represents an important public health problem in the *** cardiomyopathy is the most significant chronic form due to its association with morbidity and *** last decade has seen increasing evidence that inflammatory cytokines and chemokines are responsible for the generation of inflammatory infiltrate and tissue damage,with chronic chagasic cardiomyopathy patients presenting a pro-inflammatory immune *** studies have evaluated the role of chemokines in experimental *** infection,few have addressed their systemic profile,especially for human infection and in aging *** present work aimed to use the data from a large population based study of older adults,conducted in an endemic area for Chagas disease,to examine the association between serum levels of cytokines and chemokines,*** infection and electrocardiogram(ECG)***:The present work evaluated serum levels of CCL2,CXCL9,CXCL10,CCL5,CXCL8,IL-1β,IL-6,TNF,IL-12 and IL-10 by Flow Cytometric Bead Array assay(CBA)and the results expressed in pg/*** baseline survey started in January 1st 1997,with 1284 participants of an aged population-based *** signed an informed consent at baseline and at each subsequent visit and authorized death certificate and medical records ***:Our results demonstrated that Chagas disease patients had higher serum levels of CXCL9,CXCL10 and IL-1βand lower serum levels of CCL5 than non-infected ***,our data demonstrated that CXCL9 and CXCL10 increased in an age-dependent profile in Chagas disease ***:Together,this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients.

关键词： Chagas disease Immune biomarkers Chemokines Cytokines Cohort

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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo antonio Marenco Saul Alfredo Antezana-Vera Daniela Pereira Dias luiz antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal luiz Fernando Alvarenga ribeiro Marco antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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A numerical assessment of two geometries for reducing elbow erosion

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Particuology 2020年第2期18卷 117-133页

作者： Carlos antonio ribeiro Duarte Francisco Joséde Souza Diego Nei Venturi Martin Sommerfeld Department of Engineering Federal University of Goiás-Regional Catal(a)oAv.Dr.Lamartine Pinto de Avelar1120Catal(a)oGoiásBrazil School of Mechanical Engineering Federal University of Uberl(a)ndiaAv.Joāo Naves de(A)vila2121 Bloco 5PUberl(a)ndiaMinas GeraisBrazil Multiphase Flow Systems(MPS) Otto-von-Guericke-University MagdeburgZeppelinstraβe 1D-06130 Halle(Saale)Germany

Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed *** are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged *** option,although less commonly used,is the vortex-chamber *** both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating *** present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged *** are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion *** analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe *** general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of *** the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading ***,the advantages and disadvantages of each fitting are highlighted.

关键词： Relative erosion Plugged tee Erosion reduction Pipe fitting Computational fluid dynamics

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The social representation of fintech from the perspective of traditional financial sector professionals:evidence from Brazil

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Financial Innovation 2022年第1期8卷 2539-2565页

作者： luiz antonio Joia Rodrigo Proença School of Public and Business Administration Getulio Vargas FoundationRio de JaneiroBrazil

This study aims to reveal the social representation of fintech from the perspective of traditional financial sector professionals in Brazil—herein used as a proxy for emerging markets—to interpret and compare it with the scientific literature on the concept of *** achieve this,we applied the social representations theory associated with the word evocation test,similarity analysis,and descending hierarchical *** analyzing the results,we perceived a partial misalignment between the existing literature on the concept of fintech and the perspective of traditional financial sector professionals concerning this *** contrast to the literature surveyed,the respondents lack perception regarding the potential of fintech to constitute disruptive technology for the traditional financial sector—radically transforming or even eliminating *** addition,traditional financial sector professionals have little insight into the potential of fintech to financially include the low-income population,owing to their lower costs and greater ease of ***,traditional financial sector professionals failed to appreciate the need to develop a legal and regulatory framework for the performance of fintech in emerging *** is a subject that has also been scantly addressed by academia.

关键词： Fintech Social representations theory Word evocation method Similarity analysis Descending hierarchical analysis Emerging markets

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Controls of fracturing on porosity in pre-salt carbonate reservoirs

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Energy Geoscience 2023年第2期4卷 49-61页

作者： Wagner Moreira Lupinacci Tuany Younis Abdul Fatah Maria Cordeiro do Carmo antonio Fernando Menezes Freire luiz antonio Pierantoni Gamboa Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsUniversidade Federal FluminenseNiteróiRio de Janeiro24210346Brazil National Institute of Science and Technology of Petroleum Geophysics(INCT-GP/CNPQ) NiteróiRio de Janeiro24210346Brazil

This work aims to improve the understanding of how fracture zones affect carbonate reservoir properties based on observations of a pre-salt well located in the Santos Basin,*** identification of fracture zones allowed for the observation of a relationship between the occurrence of rock fractures and the silicification,as the latter plays an important role in determining porosity(higher silica content may increase brittleness of the rocks therefore increasing the likelihood of creating fractures zones and fractures may be filled up reducing the total porosity).To support the proposed observation,an integrated study was conducted using borehole imaging,spectroscopy logs,and sidewall core *** porosities were defined using nuclear magnetic resonance log analysis,alongside sidewall core samples,and thin *** integration of rock samples and well data with seismic analysis was performed to analyze the presence of a regional fault system that could explain high fracture densities as well as observed silica content *** results show how different types of cement filling up the formation pores affect fracture densities and total ***,it was possible to infer that the amount of silica content observed in well logs and thin sections relates to hydrothermal fluids reaching out the reservoir through regional fault systems detected in the seismic ***,this paper supports the comprehension of how diagenetic processes can significantly affect the properties of presalt reservoirs.

关键词： Fracture Porosity Pre-salt carbonatereservoir Santos Basin

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Inclusive housing program： The case of Oe-Cusse region in East Timor

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Frontiers of Architectural Research 2017年第1期6卷 74-88页

作者： Miguel P. Amadoa Ines Ramalhete antonio ribeiro Amado Joao C. Freitas CERIS - Civil Engineering Research and Innovation for Sustainability IST Universidade de Lisboa Lisboa 1049-001 Portugal GEOTPU LAB Instituto Superior Tecnico Universidude de Lisboo Lisboo 1049-001 Portugul CCIAUD Faculty of Architecture Universidude de Lisboo Lisboo 1049-001 Portugal

Housing development has become one of the main strategies to alleviate impoverished communities in developing countries. In the past, policies and programs focused on either economic or social aspects, and numerous imported solutions had failed to produce satisfactory results. At present, holistic approaches integrating all dimensions of human activity and environmental impact are gaining recognition as suitable alternatives for various experiences in developing nations. However, these approaches do not properly consider the local context, which is different for each case, thereby leading to inadequate models and unsuccessful implementations. This paper presents a context-driven and integrated approach for rural areas in developing nations for one of the most basic human endeavors, i.e., constructing a house. The self-building process utilized in constructing houses is a major strategy to help communities overcome poverty. Such a house must be capable of accommodating economic activities; must be durable yet flexible in layout and size; and must offer all basic services, including water, sanitation, and energy. Consequently, the Inclusive Housing Program is developed and employed in Oe-Cusse, a remote region of East Timor, as an integral part of the Regional Plan.

关键词： Developing countries Rural settlements Housing program Adaptive housing

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2021年ISHNE/HRS/EHRA/APHRS关于移动医疗心律失常管理共识:心脏节律专业人员的数字医疗工具

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中国心脏起搏与心电生理杂志 2021年第2期35卷 95-104页

作者： Niraj Varma Iwona Cygankiewicz Mintu Turakhia Hein Heidbuchel Yufeng Hu Lin Yee Chen Jean-Philippe Couderc Edmond M.Cronin Jerry D.Estep Lars Grieten Deirdre A.Lane Reena Mehra Alex Page Rod Passman Jonathan Piccini Ewa Piotrowicz Ryszard Piotrowicz Pyotr G.Platonov antonio luiz ribeiro Robert E.Rich Andrea M.Russo David Slotwiner Jonathan S.Steinberg Emma Svennberg 蔡星星(翻译) 陈牧(翻译) 陈泰中(翻译) 费聿东(翻译) 费振涛(翻译) 龚畅祺(翻译) 胡晓亮(翻译) 李澄(翻译) 练小铭(翻译) 莫斌峰(翻译) 王海成(翻译) 王倩(翻译) 卫郅星(翻译) 徐全福(翻译) 杨眉(翻译) 杨钰粒(翻译) 于怡驰(翻译) 张睿(翻译) 赵铭哲(翻译) 赵晏(翻译) 李毅刚(审校) 王群山(审校) Cleveland Clinic ClevelandOHUSA Medical University of Lodz lodzPoland Stanford University Palo AltoCAUSA Antwerp University and University Hospital AntwerpBelgium Taipei Veterans General Hospital TaipeiTaiwanChina University of Minnesota MinneapolisMNUSA University of Rochester RochesterNYUSA Temple University PhiladelphiaPAUSA Hasselt University HasseltBelgium University of Liverpool LiverpoolUK Northwestern University Feinberg School of Medicine Chicagot ILUSA Duke University DurhamNCUSA National Institute of Cardiology WarsawPoland Lund University LundSweden Faculdade de Medicina Centro de TelessaúdeHospital and Clínicasand Departamento de Clínica MédicaUniversidade Federal de Minas GeraisBelo HorizonteBrazil Cooper Medical school of Rowan University CamdenNJUSA Cardiology Division New York-PresbyterianQueensand School of Health Policy and ResearchWeill Cornell MedicineNew YorkNYUSA Karolinska University Hospital StockholmSweden 上海交通大学医学院附属新华医院心内科上海交通大学心律失常诊治中心

国际动态心电图和无创心电图学会/心律学会/欧洲心律协会/亚太心律协会制定的"关于移动医疗心律失常管理共识"描述了移动医疗(mHealth)技术在心律失常管理中的现状,涉及数字医疗工具范围,以及可能应用于心律失常的诊断和协助临床决策。... 详细信息

国际动态心电图和无创心电图学会/心律学会/欧洲心律协会/亚太心律协会制定的"关于移动医疗心律失常管理共识"描述了移动医疗(mHealth)技术在心律失常管理中的现状,涉及数字医疗工具范围,以及可能应用于心律失常的诊断和协助临床决策。合并症和生活方式管理(日益公认在心律失常中起作用)以及患者自我管理赋予了mHealth新的内容。共识对预测分析的承诺,以及嵌入了mHealth的常规临床关怀的操作面临的挑战,进行了探讨。

关键词：心血管病学移动医疗综述心律失常心脏节律

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Aerodynamic Effects Compensation on Multi-Rotor UAVs Based on a Neural Network Control Allocation Approach

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 295-312页

作者： Sarah P.Madruga Augusto H.B.M.Tavares Saulo O.D.luiz Tiago P.do Nascimento antonio Marcus N.Lima Graduate Program of Electrical Engineering Universidade Federal de Campina GrandeCampina Grande-PBBrazil Department of Electrical Engineering Universidade Federal de Campina GrandeCampina Grande-PBBrazil IEEE Department of Computer Systems Universidade Federal da ParaibaJoao Pessoa-PBBrazil

This paper shows that the aerodynamic effects can be compensated in a quadrotor system by means of a control allocation approach using neural ***,the system performance can be improved by replacing the classic allocation matrix,without using the aerodynamic inflow equations *** network training is performed offline,which requires low computational *** target system is a Parrot MAMBO drone whose flight control is composed of PD-PID controllers followed by the proposed neural network control allocation *** a quadrotor is particularly susceptible to the aerodynamics effects of interest to this work,because of its small *** compared the mechanical torques commanded by the flight controller,i.e.,the control input,to those actually generated by the actuators and established at the *** was observed that the proposed neural network was able to closely match them,while the classic allocation matrix could not achieve *** allocation error was also determined in both ***,the closed-loop performance also improved with the use of the proposed neural network control allocation,as well as the quality of the thrust and torque signals,in which we perceived a much less noisy behavior.

关键词： Aerodynamics effects control allocation minidrone multi-rotor UAV neural networks

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