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CXCL9 and CXCL10 display an agedependent profile in Chagas patients:a cohort study of aging in Bambui,Brazil

Infectious Diseases of Poverty 2020年第3期9卷 132-132页

作者： Fernanda Fortes de Araújo Karen Cecília Lima Torres Sérgio Viana Peixoto antonio luiz pinho ribeiro Juliana Vaz Melo Mambrini Vitor Bortolo Rezende Maria luiza Lima Silva Antônio Ignácio Loyola Filho Andréa Teixeira-Carvalho Maria Fernanda Lima-Costa Olindo Assis Martins-Filho Integrated Research Group in Biomarkers Rene Rachou InstituteOswaldo Cruz FoundationAvenida Augusto de Lima1715–Barro Preto–Belo HorizonteMinas Gerais 30190-002Brazil 不详

Background:Chagas disease is endemic in Latin America and still represents an important public health problem in the *** cardiomyopathy is the most significant chronic form due to its association with morbidity and *** last decade has seen increasing evidence that inflammatory cytokines and chemokines are responsible for the generation of inflammatory infiltrate and tissue damage,with chronic chagasic cardiomyopathy patients presenting a pro-inflammatory immune *** studies have evaluated the role of chemokines in experimental *** infection,few have addressed their systemic profile,especially for human infection and in aging *** present work aimed to use the data from a large population based study of older adults,conducted in an endemic area for Chagas disease,to examine the association between serum levels of cytokines and chemokines,*** infection and electrocardiogram(ECG)***:The present work evaluated serum levels of CCL2,CXCL9,CXCL10,CCL5,CXCL8,IL-1β,IL-6,TNF,IL-12 and IL-10 by Flow Cytometric Bead Array assay(CBA)and the results expressed in pg/*** baseline survey started in January 1st 1997,with 1284 participants of an aged population-based *** signed an informed consent at baseline and at each subsequent visit and authorized death certificate and medical records ***:Our results demonstrated that Chagas disease patients had higher serum levels of CXCL9,CXCL10 and IL-1βand lower serum levels of CCL5 than non-infected ***,our data demonstrated that CXCL9 and CXCL10 increased in an age-dependent profile in Chagas disease ***:Together,this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients.

关键词： Chagas disease Immune biomarkers Chemokines Cytokines Cohort

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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo antonio Marenco Saul Alfredo Antezana-Vera Daniela Pereira Dias luiz antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal luiz Fernando Alvarenga ribeiro Marco antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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The social representation of fintech from the perspective of traditional financial sector professionals:evidence from Brazil

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Financial Innovation 2022年第1期8卷 2539-2565页

作者： luiz antonio Joia Rodrigo Proença School of Public and Business Administration Getulio Vargas FoundationRio de JaneiroBrazil

This study aims to reveal the social representation of fintech from the perspective of traditional financial sector professionals in Brazil—herein used as a proxy for emerging markets—to interpret and compare it with the scientific literature on the concept of *** achieve this,we applied the social representations theory associated with the word evocation test,similarity analysis,and descending hierarchical *** analyzing the results,we perceived a partial misalignment between the existing literature on the concept of fintech and the perspective of traditional financial sector professionals concerning this *** contrast to the literature surveyed,the respondents lack perception regarding the potential of fintech to constitute disruptive technology for the traditional financial sector—radically transforming or even eliminating *** addition,traditional financial sector professionals have little insight into the potential of fintech to financially include the low-income population,owing to their lower costs and greater ease of ***,traditional financial sector professionals failed to appreciate the need to develop a legal and regulatory framework for the performance of fintech in emerging *** is a subject that has also been scantly addressed by academia.

关键词： Fintech Social representations theory Word evocation method Similarity analysis Descending hierarchical analysis Emerging markets

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Medical,ethical,and legal aspects of hematopoietic stem cell transplantation for Crohn’s disease in Brazil

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World Journal of Stem Cells 2020年第10期12卷 1113-1123页

作者： Milton Artur Ruiz Roberto luiz Kaiser Junior Lilian Piron-Ruiz Priscila Samara Saran Lilian Castiglioni luiz Gustavo de Quadros Tainara Souza pinho Richard K Burt Department of Bone Marrow Transplant Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Department of Proctology Beneficencia Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Genetics and Molecular Biology FAMERP-Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090470 Brazil Department of Endoscopy Beneficência Portuguesa HospitalABC Medical SchoolSão Bernardo 15015110Brazil Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

Crohn's disease(CD)is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal *** etiology of CD is unknown;however,genetic,epigenetic,environmental,and lifestyle factors could play an essential role in the onset and establishment of the *** results from immune dysregulation due to loss of the healthy symbiotic relationship between host and intestinal flora and or its *** affects both sexes equally with a male to female ratio of 1.0,and its onset can occur at any age,but the diagnosis is most commonly observed in the range of 20 to 40 years of *** diminishes quality of life,interferes with social activities,traumatizes due to the stigma of incontinence,fistulae,strictures,and colostomies,and in severe cases,affects survival when compared to the general *** fluctuate between periods of remission and activity in which complications such as fistulas,strictures,and the need for bowel resection,surgery,and colostomy implantation make up the most severe aspects of the *** can be progressive and the complications recurrent despite treatment with anti-inflammatory drugs,corticosteroids,immunosuppressants,and biological ***,over time many patients become refractory without treatment alternatives,and in this scenario,hematopoietic stem cell transplantation(HSCT)has emerged as a potential treatment *** rationale for the use of HSCT for CD is anchored in animal studies and human clinical trials where HSCT could reset a patient's immune system by eliminating disease-causing effector cells and upon immune recovery increase regulatory and suppressive immune *** HSCT using a non-myeloablative regimen of cyclophosphamide and anti-thymocyte globulin without CD34+selection has been to date the most common transplant conditioning regimen *** this review we will address the current situation regarding CD treatment with HSCT and emphasize the medical,ethical,and legal aspect

关键词： Crohn disease Hematopoietic stem cell transplant Stem cell therapy Autologous transplant Ethics Treatment

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Controls of fracturing on porosity in pre-salt carbonate reservoirs

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Energy Geoscience 2023年第2期4卷 49-61页

作者： Wagner Moreira Lupinacci Tuany Younis Abdul Fatah Maria Cordeiro do Carmo antonio Fernando Menezes Freire luiz antonio Pierantoni Gamboa Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsUniversidade Federal FluminenseNiteróiRio de Janeiro24210346Brazil National Institute of Science and Technology of Petroleum Geophysics(INCT-GP/CNPQ) NiteróiRio de Janeiro24210346Brazil

This work aims to improve the understanding of how fracture zones affect carbonate reservoir properties based on observations of a pre-salt well located in the Santos Basin,*** identification of fracture zones allowed for the observation of a relationship between the occurrence of rock fractures and the silicification,as the latter plays an important role in determining porosity(higher silica content may increase brittleness of the rocks therefore increasing the likelihood of creating fractures zones and fractures may be filled up reducing the total porosity).To support the proposed observation,an integrated study was conducted using borehole imaging,spectroscopy logs,and sidewall core *** porosities were defined using nuclear magnetic resonance log analysis,alongside sidewall core samples,and thin *** integration of rock samples and well data with seismic analysis was performed to analyze the presence of a regional fault system that could explain high fracture densities as well as observed silica content *** results show how different types of cement filling up the formation pores affect fracture densities and total ***,it was possible to infer that the amount of silica content observed in well logs and thin sections relates to hydrothermal fluids reaching out the reservoir through regional fault systems detected in the seismic ***,this paper supports the comprehension of how diagenetic processes can significantly affect the properties of presalt reservoirs.

关键词： Fracture Porosity Pre-salt carbonatereservoir Santos Basin

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Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa(Jacq.) Raf.(Cleomaceae)

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 12-17页

作者： Francisca Samara Muniz dos Santos Jose Weverton Almeida Bezerra Jean Paul Kamdem Aline Augusti Boligon Marli Matiko Anraku Ana Raquel Pereira da Silva Kleber ribeiro Fidelis Nadghia Figueiredo Leite antonio Ivanildo pinho Henrique Douglas Melo Coutinho Jose Edilson Goncalves dos Santos Microscopy Laboratory Regional University of Cariri (URCA) Program Post graduate in Plant Biology (UFPE) Phytochemical Laboratory Department of Industrial Pharmacy Federal University of Santa Maria (UFSM) Microbiology and Molecular Biology Laboratory Regional University of Cariri (URCA)

Objective: To evaluate the antibacterial activity and neuroprotective capacity of the ethanolic and aqueous extracts of Tarenaya spinosa(T. spinosa) as well as to determine and quantify some of its polyphenols by high performance liquid chromatography with diode-array detection(HPLC-DAD). Methods: The bacterial Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. The drugs gentamicin, norfloxacin and imipenem were used to evaluate the modulating or antagonistic capacity of the T. spinosa extracts. The extract was analysed by HPLC-DAD to determine the main phenolic compounds. For the cell viability tests, individual heads of the Nauphoeta cinerea arthropod model were removed, homogenized in Trifluoromethyl ketone and centrifuged afterwards. Subsequently, 20 μL of NaN O2 were added to the biological material, except in the control group, to evaluate the protection capacity of the extracts. The homogenate of the insect heads was incubated for 2 h in tubes containing tetrazolium bromide. Results: HPLC-DAD demonstrated that the ethanolic extract of T. spinosa presented caffeic acid as the major compound. The ethanolic extract also showed neuroprotective effects at concentrations ≥ 10 μg/mL, while aqueous extract was shown to have a protective effect only at the concentration of 100 μg/mL. The aqueous extract demonstrated a clinically relevant antibacterial activity against the Staphylococcus aureus multidrug resistant strain-MDR, with MIC 512 μg/m L. However, when the extracts were associated with gentamicin and imipenem, a synergism was detected against Staphylococcus aureus and Escherichia coli MDR strains. Conclusions: Although it does not present an antibacterial action, the extracts of T. spinosa can be used in the pharmaceutical industries since its extracts show modulating action of drugs. Besides, these natural products have neuroprotective capacity.

关键词： Tarenaya spinosa Cleome spinose Nauphoeta cinerea Synergism Antibiotic resistance

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Aerodynamic Effects Compensation on Multi-Rotor UAVs Based on a Neural Network Control Allocation Approach

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 295-312页

作者： Sarah P.Madruga Augusto H.B.M.Tavares Saulo O.D.luiz Tiago P.do Nascimento antonio Marcus N.Lima Graduate Program of Electrical Engineering Universidade Federal de Campina GrandeCampina Grande-PBBrazil Department of Electrical Engineering Universidade Federal de Campina GrandeCampina Grande-PBBrazil IEEE Department of Computer Systems Universidade Federal da ParaibaJoao Pessoa-PBBrazil

This paper shows that the aerodynamic effects can be compensated in a quadrotor system by means of a control allocation approach using neural ***,the system performance can be improved by replacing the classic allocation matrix,without using the aerodynamic inflow equations *** network training is performed offline,which requires low computational *** target system is a Parrot MAMBO drone whose flight control is composed of PD-PID controllers followed by the proposed neural network control allocation *** a quadrotor is particularly susceptible to the aerodynamics effects of interest to this work,because of its small *** compared the mechanical torques commanded by the flight controller,i.e.,the control input,to those actually generated by the actuators and established at the *** was observed that the proposed neural network was able to closely match them,while the classic allocation matrix could not achieve *** allocation error was also determined in both ***,the closed-loop performance also improved with the use of the proposed neural network control allocation,as well as the quality of the thrust and torque signals,in which we perceived a much less noisy behavior.

关键词： Aerodynamics effects control allocation minidrone multi-rotor UAV neural networks

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The Effects of Different Titanium Surfaces on the Behaviour of Osteoblast-Like Cells

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Journal of Biomedical Science and Engineering 2015年第6期8卷 380-388页

作者： Fabiano ribeiro Cirano Adriane Yaeko Togashi Marcia Martins Marques Francisco Emílio Pustiglioni luiz antonio Pugliesi Alves Lima Department of Periodontology Paulista University(UNIP)Sao PauloBrazil Department of Dental Implantology State University of Western Parana(UNIOESTE)CascavelBrazil Department of Dentistry University of Sao PauloSao PauloBrazil Department of Periodontology University of Sao PauloSao PauloBrazil

This study investigated the influence of different titanium surfaces on the differentiation of rat osteoblast-like cells (osteo-1). Osteo-1 cells were cultured on the following titanium surfaces: 1) pretreated, smooth surface (PT);2) sandblasted and acid etched surface (SLA);and 3) sandblasted and acid-etched surface rinsed under nitrogen protection to prevent exposure to air and preserved in isotonic saline solution (modSLA). Cell metabolism, total protein content, collagen content and alkaline phosphatase (AP) activity and the formation of calcified nodules were analyzed. The titanium surface did not influence cell metabolism, total protein content and collagen content. The SLA surface influenced cell differentiation, with the observation of a significant reduction of AP activity and formation of calcified nodules after 21 days compared to the PT surface. No difference was observed between the PT and modSLA surfaces. All titanium surfaces tested permitted the full expression of the osteoblast phenotype by osteo-1 cells, including matrix mineralization.

关键词： Titanium Dental Implants Osteoblasts

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Lameness prediction in broiler chicken using a machine learning technique

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Information Processing in Agriculture 2021年第3期8卷 409-418页

作者： Irenilza de Alencar Naas Nilsa Duarte da Silva Lima Rodrigo Franco Gonc¸alves luiz antonio de Lima Henry Ungaro Jair Minoro Abe Paulista University-Graduate Program in Production Engineering Sao PauloBrazil

Broiler flock welfare is usually assessed through mortality,physiology,behavior,and walk-ing *** possibility of assessing broiler chicken lameness using the bird walking abil-ity was investigated using the machine learning approach for the first *** on broiler walking speed and acceleration,genetic strain,and sex were recorded and input in a *** were classified according to the 6-point gait score(GS0 is a sound bird,and GS5 is a severely lame bird).Decision trees were built initially using all *** confusion matrix of each developed model was *** pruning technique was used,removing from the dataset the variables that did not infer in the classification *** reorganized the dataset and re-arranged the data by grouping the intermediate target class of gait score using the Borda Count ***-processing data,we obtained a new set of decision *** the 3-point gait score(GS0 is a sound bird,and GS2 is a lame bird),we obtained a new model with better accuracy(78%);however,the model had a lower accuracy for classifying lame broilers(GS2,5%).The final decision tree was selected for classifying broilers,either sound or lame,according to their walking *** developed model presented good accuracy(91%),and it ordered properly sound(86%)and lame birds(92%).The novel model might be used to assess broiler lameness on-farm by registering the bird displacement *** developments using the model might allow flock lameness detection automatically.

关键词： Broiler welfare Broiler walking speed Decision tree Confusion matrix Gait score

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