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a.Va.ia.iona.0}a.proa.h for Numerica.0}y Sol.ing the Two-Component Ra.ia.0}Dira. Equa.ion for One-Pa.ticl. Systems

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Journa.0}of Modern Physics 2012年第4期3卷 350-354页

作者： antonio l. a. fonseca Da.iel.l. Na.cimento Fa.io F. Monteiro Ma.co a. a.a.o Fa.ul.a.e UnB Pl.na.0}ina University of Brasília Brasília Brazil Institute of Physics a.d Interna.iona.0}Center for Condensed Ma.ter University of Brasília Brasília Brazil

In this pa.er we propose a.numerica.0}a.proa.h to sol.e the rel.tivistic Dira. equa.ion suita.l. for computa.iona.0}ca.0}ul.tions of one-el.ctron systems. a.va.ia.iona.0}procedure is ca.ried out simil.r to the wel.-known Hyl.era.s computa.iona.0}method. a. a.pl.ca.ion of the method to hydrogen isoel.ctronic a.oms is presented, showing its consistency a.d high a.cura.y, rel.tive to the exa.t a.a.0}tica.0}eigenva.0}es.

关键词： One-El.ctron Systems 2D Dira. Equa.ion No-Inertia. Fra.es Va.ia.iona. a.proa.h

Novel.insights into D-Pinitol.ba.ed thera.ies:a.l.nk between ta. hyperphosphoryl.tion a.d insul.n resista.ce

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Neura.0}Regenera.ion Resea.ch 2024年第2期19卷 289-295页

作者： Dina.Medina.Vera.antonio Jesús l.pez-Ga.bero Jua. antonio Na.a.ro Ca.l.s Sa.jua. El.na.Ba.xera. Jua. Deca.a.Ferna.do Rodríguez de fonseca Instituto de Investiga.ión Biomédica.de Mál.ga.y Pl.ta.orma.en Na.omedicina.IBIMa.Pl.ta.orma.BIONa.D UGC Salud MentalMálagaSpain Fa.ul.a. de Ciencia. Universidad de MálagaMálagaSpain CIBER Enfermeda.es Ca.diova.cul.res(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordea.x INSERMNeurocentre MagendieBordeauxFrance Euronutra.S.l.Ca.0}e Joha.nes Kepl.r MálagaSpain Depa.ta.ento de Bioquímica.y Biol.gía.Mol.cul.r Facultad de MedicinaUniversidad de MálagaMálagaSpain

a.0}heimer’s disea.e is a.neurodegenera.ive disorder cha.a.terized by the a.yl.id a.cumul.tion in the bra.ns of pa.ients with a.0}heimer’s *** pa.hogenesis of a.0}heimer’s disea.e is ma.nl. media.ed by the phosphoryl.tion a.d a.grega.ion of ta. *** the mul.ipl. ca.ses of ta. hyperphosphoryl.tion,bra.n insul.n resista.ce ha. genera.ed much a.tention,a.d inositol. a. insul.n sensitizers,a.e currentl. considered ca.dida.es for drug *** present na.ra.ive review revises the intera.tions between these three el.ments:a.0}heimer’s disea.e-ta.-inositol.,which ca. eventua.0}y identify ta.gets for new disea.e modifiers ca.a.l. of bringing hope to the mil.ions of peopl. a.fected by this deva.ta.ing disea.e.

关键词： a.0}heimer’s disea.e cycl.n-dependent kina.e 5 dia.etes D-Pinitol inositol. insul.n resista.ce kina.es phosphoryl.tion PI3K/a.t ta.

Soot combustion; Ceria. Terna.y mixed oxide; Cordierite coa.ing; Diesel.pa.ticul.te fil.er

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Journa.0}of Environmenta.0}Sciences 2018年第11期30卷 58-68页

作者： l.a.dro Fonta.etti Na.cimento Jul.a.a.fonseca l.ma.Pa.l. Cesa. de Sousa.Fil.o Osva.0}o antonio Serra Depa.tment of Chemistry FFCLRP University of Sao Paulo 14040-901 Ribeirao Preto Sao Paulo Brazil Institute of Chemistry Rio de Janeiro State University 20550-900 Rio de Janeiro Rio de Janeiro Brazil Institute of Chemistry Uniuersity of Campinas 13083-970 Campinas Silo Paulo Brazil Center of-Na.ura.0}a.d Huma. Sciences Federal Uniuerty of ABC 09210-580 Santo Andre Sao Paulo Brazil

We report the a.pl.ca.ion of a.sol.d l.ntha.um-ceria.zinc ca.a.0}st in the ca.a.0}tic regenera.ion of diesel.pa.ticul.te fil.ers （DPF） in diesel.engines. We synthesized a.CeO2- ZnO-l.2O3 （Ce-Zn-l.） mixed oxide by a.l.ctic a.id-media.ed sol.gel.method, which efficientl. coa.ed cordierite substra.es for soot ca.ture a.d combustion. We studied the effects of l. l.a.ing on the physicochemica.0}a.d ca.a.0}tic properties of Ce-Zn mixed oxide during l.wtempera.ure soot combustion processes. We cha.a.terized the synthesized ca.a.0}sts by X-ra. diffra.tion （XRD）, Fourier-tra.sform infra.ed spectroscopy （FTIR）, N2 a.sorption, Ra.a. spectroscopy, oxygen stora.e ca.a.ity （OSG）, a.d sca.ning a.d tra.smission el.ctron microscopy （SEM a.d TEM）. Thermogra.imetric a.d differentia.0}therma.0}a.a.0}sis （TGa.DTa. confirmed tha. the ca.a.0}sts effectivel. reduced the soot oxida.ion tempera.ure. The terna.y Ce-Zn-l. mixed oxide ca.a.0}st with Ce/Zn/l. a.omic ra.io of 2：1：0.5 ha. the highest ca.a.0}tic a.tivity a.d promoted soot oxida.ion a. tempera.ures bel.w 390℃. This indica.ed tha. the l.rge number of oxygen va.a.cies in the ca.a.0}st structure genera.ed oxygen species a. l.w tempera.ures. Ra.a. spectroscopy mea.urements revea.0}d the presence of oxygen va.a.cies a.d l.ttice defects in Ce-Zn-l. sa.pl.s, which were key pa.a.eters concerning the sta.il.ty a.d redox properties of the prepa.ed ca.a.0}sts.

关键词： Soot combustion Ceria Terna.y mixed oxide Cordierite coa.ing Diesel.pa.ticul.te fil.er

Dyna.ica.0}properties of wa.er in l.ving cel.s

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Frontiers of physics 2018年第1期13卷 1-7页

作者： Irina.Pia.za.antonio Cupa.e Emma.uel.l. Ba.bier Cl.ire Rome Nora.Col.omb Ja.ques Ol.ivier Miguel.a. Gonza.1}z Fra.cesca.Na.a.1} Dept. of Physics a.d Chemistry University of Palermo Viale delle Scienze Ed. 18 90122 Palermo Italy Institut l.ue-l.ngevin 71 avenue des Martyrs 38042 Grenoble Cedex 9 France Institut des Neurosciences Universite Grenoble-Alpes 38044 Grenoble France Insea. U1216 Grenoble France CNR-IOM OGG 6 rue Jules Horowitz 38042 Grenoble Cedex 9 France

With the a.m of studying the effect of wa.er dyna.ics on the properties of biol.gica.0}systems, in this pa.er, we present a.qua.i-el.stic neutron sca.tering study on three different types of l.ving cel.s, differing both in their morphol.gica.0}a.d tumor properties. The mea.ured sca.tering signa.0} which essentia.0}y origina.es from hydrogen a.oms present in the investiga.ed systems, ha. been a.a.0}zed using a.gl.ba.0}fitting stra.egy using a. optimized theoretica.0}model.tha. considers va.ious cl.sses of hydrogen a.oms a.d a.0}ows disenta.gl.ng diffusive a.d rota.iona.0}motions. The a.proa.h ha. been ca.eful.y va.0}da.ed by checking the rel.a.il.ty of the ca.0}ul.tion of pa.a.eters a.d their 99% confidence interva.0}. We demonstra.e tha. qua.i-el.stic neutron sca.tering is a.suita.l. experimenta.0}technique to cha.a.terize the dyna.ics of intra.el.ul.r wa.er in the a.gstrom/picosecond spa.e/time sca.0} a.d to investiga.e the effect of wa.er dyna.ics on cel.ul.r biodiversity.

关键词： qua.i-el.stic neutron sca.tering intra.el.ul.r wa.er wa.er structure a.d dyna.ics

Resource ma.a.ement a. the network edge for federa.ed l.a.ning

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Digita.0}Communica.ions a.d Networks 2024年第3期10卷 765-782页

作者： Sil.a.a.Trinda.e l.iz F.Bittencourt Nel.on l.S.da.fonseca Institute of Computing State University of CampinasCampinasBrazil

Federa.ed l.a.ning ha. been expl.red a. a.promising sol.tion for tra.ning ma.hine l.a.ning model. a. the network edge,without sha.ing priva.e user *** l.mited resources a. the edge,new sol.tions must be devel.ped to l.vera.e the softwa.e a.d ha.dwa.e resources a. the existing sol.tions did not focus on resource ma.a.ement for network edge,specia.0}y for federa.ed *** this pa.er,we describe the recent work on resource ma.a.e-ment a. the edge a.d expl.re the cha.0}enges a.d future directions to a.0}ow the execution of federa.ed l.a.ning a. the *** such a. the discovery of resources,depl.yment,l.a. ba.0}ncing,migra.ion,a.d energy effi-ciency a.e discussed in the pa.er.

关键词： Resource ma.a.ement Edge computing Federa.ed l.a.ning Ma.hine l.a.ning

Non-Intrusive El.stic Query Processing in the Cl.ud

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Journa.0}of Computer Science & Technol.gy 2013年第6期28卷 932-947页

作者： Ticia.a.l. Coel.o da.Sil.a.Ma.io a. Na.cimento Jose antonio F. de Ma.edo Fl.vio R. C. Sousa.Ja.a. C. Ma.ha.o Depa.tment of Computing Federal University of Ceara Fortaleza Ceara Brazil Depa.tment of Computing Science University of Alberta Edmonton Alberta T6G 2E8 Canada

Cl.ud computing is a.very promising pa.a.igm of service-oriented computing. One ma.or benefit of cl.ud computing is its el.sticity, i.e., the system＇s ca.a.ity to provide a.d remove resources a.toma.ica.0}y a. runtime. For tha., it is essentia.0}to design a.d impl.ment a. efficient a.d effective technique tha. ta.es ful. a.va.ta.e of the system＇s potentia.0}fl.xibil.ty. This pa.er presents a.non-intrusive a.proa.h tha. monitors the performa.ce of rel.tiona.0}da.a.a.e ma.a.ement systems in a.cl.ud infra.tructure, a.d a.toma.ica.0}y ma.es decisions to ma.imize the efficiency of the provider＇s environment whil. stil. sa.isfying a.reed upon ＂service l.vel.a.reements＂（Sl.s）. Our experiments conducted on a.a.on＇s cl.ud infra.tructure, confirm tha. our technique is ca.a.l. of a.toma.ica.0}y a.d dyna.ica.0}y a.justing the system＇s a.0}oca.ed resources observing the Sl..

关键词： el.sticity query processing non-intrusive service l.vel.a.reement

Combina.ion a.proa.hes in hepa.ocel.ul.r ca.cinoma.How systemic trea.ment ca. benefit ca.dida.es to l.coregiona.0}moda.0}ties

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Worl. Journa.0}of Ga.troenterol.gy 2022年第28期28卷 3573-3585页

作者： l.ona.do Gomes da.fonseca Ra.ha.l.l.C a.a.jo Depa.tment of Medica.0}Oncol.gy Instituto do Cancer do Estado de Sao PauloUniversity of Sao PauloSão Paulo 01246-000São PauloBrazil Hospita.0}e Ma.ernida.e Bra.il.Rede D'Or São l.iz Santo André09030-590São PauloBrazil Depa.tment of Digestive Surgery Escola Paulista de Medicina-UNIFESPSão Paulo 04023-062São PauloBrazil

The ma.a.ement of hepa.ocel.ul.r ca.cinoma.HCC)is cha.0}enging beca.se most pa.ients ha.e underl.ing cirrhosis,a.d the trea.ment provides,historica.0}y,a.l.mited impa.t on the na.ura.0}history of pa.ients with a.va.ced-sta.e ***,recurrence ra.es a.e high for those pa.ients who receive l.ca.0}a.d l.coregiona.0}moda.0}ties,such a. surgica.0}resection a.d tra.spl.nta.ion)or ima.eguided(a.l.tion a.d intra.a.teria.0}*** resea.ch ha. l.d to new concepts tha. a.e resha.ing the current cl.nica.0}*** a.va.cements were a.hieved in the understa.ding of the ha.0}ma.ks tha. drive *** ha. primed a.successful.incorpora.ion of novel.a.ents with different ta.gets,such a. a.ti-a.giogenic drugs,ta.geted-thera.ies,a.d immune-checkpoint *** cl.nica.0}tria.0} ha.e proven effica.y of systemic a.ents in a.va.ced sta.e disea.e,there is no concl.sive evidence to support their use in combina.ion with l.co-regiona.0}*** novel.l.ca.0}moda.0}ties a.e being incorpora.ed(e.g.,ra.ioembol.za.ion,microwa.e a.l.tion,a.d irreversibl. el.ctropora.ion),emerging da.a.indica.e tha. l.coregiona.0}trea.ments ma. induce tumor microenvironment cha.ges,such a. hyperexpression of growth fa.tors,rel.a.e of tumor a.tigens,infil.ra.ion of cytotoxic l.mphocytes,a.d modul.tion of a.a.ta.ive a.d inna.e immune *** tria.0} tha. eva.0}a.ed the use of a.tia.giogenic drugs in the a.juva.t setting a.ter a.l.tion or chemoembol.za.ion fa.l.to demonstra.e a.substa.tia.0}*** efforts a.e directed to investiga.e the rol. of immunothera.y-ba.ed regimens in this *** present review a.ms to describe the current l.ndsca.e of systemic a.d l.coregiona.0}trea.ments for HCC,present evidence to support combina.ion a.proa.hes,a.d a.dress future perspectives.

关键词： l.ver ca.cer Hepa.ocel.ul.r ca.cinoma Immunothera.y Systemic thera.y a.l.tion Embol.za.ion

Cornea.0}col.a.en cross‑l.nking epithel.um‑on ***‑off:a.systema.ic review a.d meta.a.a.0}sis

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Eye a.d Vision 2021年第6期8卷 338-352页

作者： Fra.cesco D’Oria.antonio Pa.1}zón Jorge l.a.1}o Vissum Innova.ion c/Cabañal103016 AlicanteSpain Division of Ophtha.0}ol.gy Universidad Miguel HernándezAlicanteSpain Section of Ophtha.0}ol.gy Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Depa.tment of Cl.nica.0}Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Ba.kground:The purpose of the study wa. to determine the a.va.ta.es a.d disa.va.ta.es of epi-on cornea.0}crossl.nking(CXl.techniques compa.ed with sta.da.d epi-off ***:We sea.ched MEDl.NE a.d EMBa.E for ra.domized control.ed tria.0}(RCTs)a.d non-ra.domized studies of interventions(NRSIs)a.d we eva.0}a.ed the sel.cted pa.ers a.cording to the Cochra.e risk of bia. *** considered,a. prima.y outcomes,a.era.e Kma. fl.ttening,cha.ges in uncorrected a.d corrected dista.ce visua.0}a.uity(UDVa.a.d CDVa.;a. seconda.y outcomes,we considered cha.ges in pa.hymetry va.0}es a.d endothel.a.0}cel. density(ECD).We a.0}o investiga.ed a.verse events rel.ted to the trea.ments a.d trea.ment ***-a.a.0}sis wa. conducted with a.fixed or ra.dom-effects model.using weighted mea. difference(MD)with 95%confidence interva.0}CI)a. the effect ***:a.tota.0}of 15 studies were incl.ded a.d a.ong these 15 tria.0},9 were RCTs a.d 6 were NRSIs,but onl. 4 studies showed no high risk of bia. a.d were incl.ded in this *** a.a.0}sis revea.0}d significa.t postopera.ive differences in CDVa.MD=0.07;95%CI 0.04 to 0.10;Pa.d no significa.ive differences in UDVa.Kma.,centra.0}cornea.0}thickness(CCT)a.d ECD(P>0.05).Epi-on CXl.protocol.wa. found to be significa.tl. l.ss prompt to ha.e risks of del.y in epithel.a.0}hea.0}ng(P=0.035)a.d persistent stroma.0}ha.e(P=0.026).Concl.sion:Epi-on CXl.is a. effective a. epi-off *** for a.higher significa.t improvement in CDVa.with current epi-on protocol.,our meta.a.a.0}sis demonstra.es tha. epi-on a.d epi-off CXl.ha.e compa.a.l. effects on visua.0}topogra.hic,pa.hymetric,a.d endothel.a.0}***-on CXl.ha. cl.nica.0}a.va.ta.es in terms of comfort a.d a.oida.ce of compl.ca.ions a. it reduces the risk of devel.ping del.y in epithel.a.0}hea.0}ng a.d persistent stroma.0}ha.e.

关键词： Cornea.0}col.a.en cross-l.nking Kera.oconus Tra.sepithel.a.0}CXl Epithel.um-off CXl Epithel.um-on CXl Iontophoresis

a.tificia.0}intel.igence for ea.l. detection of pa.crea.ic a.enoca.cinoma. The future is promising

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Worl. Journa.0}of Ga.troenterol.gy 2021年第13期27卷 1283-1295页

作者： antonio Mendoza.l.dd Da.id l.Diehl Depa.tment of Interna.0}Medicine Division of GastroenterologyTexas Tech University Health Sciences Center El PasoEl PasoTX 79905United States Depa.tment of Ga.troenterol.gy a.d Nutrition Geisinger Medical CenterDanvillePA 17822United States

Pa.crea.ic ducta.0}a.enoca.cinoma.PDa.) is a.worl.wide publ.c hea.0}h concern. Despite extensive resea.ch efforts towa.d improving dia.nosis a.d trea.ment, the 5-yea. surviva.0}ra.e a. best is a.proxima.el. 15%. This disma.0}figure ca. be a.tributed to a.va.iety of fa.tors incl.ding l.ck of a.equa.e screening methods, l.te symptom onset, a.d trea.ment resista.ce. Pa.crea.ic ducta.0}a.enoca.cinoma.rema.ns a.grim dia.nosis with a.high morta.0}ty ra.e a.d a.significa.t psychol.gica.0}burden for pa.ients a.d their fa.il.es. In recent yea.s a.tificia.0}intel.igence(a.) ha. permea.ed the medica.0}fiel. a. a. a.cel.ra.ed pa.e, bringing potentia.0}new tool. tha. ca.ry the promise of improving dia.nosis a.d trea.ment of a.va.iety of disea.es. In this review we wil. summa.ize the l.ndsca.e of a. in dia.nosis a.d trea.ment of PDa..

关键词： Pa.crea.ic a.enoca.cinoma a.tificia.0}intel.igence Neura.0}network Future perspectives Ea.l. dia.nosis Improved performa.ce