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Anterior tibiofemoral dislocation after total knee arthroplasty:A case report and literature review

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Chinese Journal of Traumatology 2022年第4期25卷 237-241页

作者： Alejandro Almoguera-Martinez Catarina Godinho-Soares Valentín Calcedo Bernal jose-antonio Pareja Esteban Marta Garcia-Lopez Miguel Angel Plasencia Arriba Orthopaedic and Traumatology Resident at Príncipe de Asturias Hospital Alcala de HenaresMadridSpain

Anterior tibiofemoral dislocation after total knee arthroplasty is an extremely rare and serious *** English-published papers,we found only 15 relevant cases,3 of which presented vascular *** manuscript aims to present a 77-year-old woman with a TC-Plus(Smith&Nephew)cruciate-retaining type in first time of knee prosthesis,who suffered an anterior tibiofemoral dislocation and were admitted to our *** clinical management and outcome were ***,a review of literature was *** concluded that early detection and surgical intervention of vascular injury is the key in the survival of the *** there is still knee instability after acute recovery,it seems that revision surgery with constrained total knee arthroplasty can bring about good clinical and functional results.

关键词： Arthroplasty Knee dislocation Knee replacement Popliteal artery Risk factors

Photonic smart bandage for wound healing assessment

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Photonics Research 2021年第3期9卷 272-280页

作者： Arnaldo Leal-Junior Jingjing Guo Rui Min antonio jose Fernandes Anselmo Frizera Carlos Marques Telecommunications Laboratory(LABTEL) Graduate Program in Electrical EngineeringFederal University of Espi’rito SantoVitoria-ES 29075-910Brazil School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Center for Cognition and Neuroergonomics State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityZhuhai 519087China Physics Department&I3N Universidade de AveiroCampus Universitario de SantiagoAveiro 3810-193Portugal

Chronic wounds affect around 2% of the world population with an annual multi-billion dollar cost to the healthcare system. This background pushes the development of new therapies and procedures for wound healing and its assessment. Among them, the potential of hydrogen(pH) assessment is an important indicator of the wound healing stage and condition. This paper presents the development of the first optical fiber-embedded smart wound dressing for pH assessment. An intrinsically pH-sensitive optical fiber is fabricated using a polydimethylsiloxane(PDMS) precursor doped with rhodamine B dye. Raman and Fourier transform infrared(FTIR) spectroscopies are performed in order to verify the presence of rhodamine B and PDMS in the fiber samples. Then, the fiber is embedded in gauze fabric and hydrocolloid wound dressing. In addition, such low Young’s modulus of PDMS fiber enables its use as a highly sensitive pressure sensor, where the results show that the fiber-embedded bandage can measure pressures as low as 0.1 kPa with a high linearity in the range of 0 to 0.3 kPa. The smart bandage is subjected to different pH, which resulted in a wavelength shift of 0.67 nm/pH when the absorption peak at 515 nm was analyzed. Furthermore, pH increase leads to linear decrease of the transmitted optical power(R2 of 0.998), with rise and fall times below 20 s and 30 s, respectively. Therefore, the proposed optical fiber-embedded smart bandage enables the simultaneous assessment of pressure and pH on the wound region.

关键词： fiber smart healing

Reconfigurable single-shot incoherent optical signal processing system for chirped microwave signal compression

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Science Bulletin 2017年第4期62卷 242-248页

作者： Ming Li Shuqian Sun antonio Malacarne Sophie LaRochelle Jianping Yao Ninghua Zhu jose Azana Institut National de la Recherche Scientifique-Energie Materiaux et Telecommunications(INRS-EMT)VarennesQuebec J3X 1S2Canada State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China TeCIP Institute Scuolo Superiore Sant'AnnaPisa 56124Italy Center for Optics Photonics and Laser(COPL)Universite LavalQuebec G1V OA6Canada Microwave Photonics Research Laboratory University of OttawaOntario K1N 6N5Canada

We propose and demonstrate a reconfigurable and single-shot incoherent optical signal processing system for chirped microwave signal compression, using a programmable optical filter and a multiwavelength laser(MWL). The system is implemented by temporally modulating a specially shaped MWL followed by a suitable linear dispersive medium. A microwave dispersion value up to 1.33 ns/GHz over several GHz bandwidth is achieved based on this approach. Here we demonstrate a singleshot compression for different linearly chirped microwave signals over several GHz bandwidth. In addition, the robustness of the proposed system when input RF signals are largely distorted is also discussed.

关键词：信号处理系统微波信号线性啁啾非相干光信号压缩可重构多波长激光器可编程滤波器

Future for inertial-fusion energy in Europe:a roadmap

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High Power Laser Science and Engineering 2023年第6期11卷 162-192页

作者： Dimitri Batani Arnaud Colaitis Fabrizio Consoli Colin N.Danson Leonida antonio Gizzi Javier Honrubia Thomas Kühl Sebastien Le Pape Jean-Luc Miquel jose Manuel Perlado R.H.H.Scott Michael Tatarakis Vladimir Tikhonchuk Luca Volpe Centre Lasers Intenses et Applications(CELIA) Universitéde Bordeaux±CNRS±CEATalence cedexFrance ENEA Fusion and Technology for Nuclear Safety and Security DepartmentC.R.FrascatiFrascatiItaly AWE AldermastonReadingUK Centre for Inertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)PisaItaly ETSIAE Universidad Politecnica de Madrid MadridSpain GSI-Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses(LULI) CNRS±Ecole PolytechniquePalaiseau cedexFrance ALP Le BarpFrance and CEA/DAMÎle de FranceBruyères le ChâtelArpajon cedexFrance Instituto Fusión NuclearªGuillermo Velardeº(IFN-GV) Universidad Politecnica de MadridMadridSpain Central Laser Facility STFC Rutherford Appleton LaboratoryHarwell OxfordOxfordshireUK Institute of Plasma Physics and Lasers University Research and Innovation CentreHellenic Mediterranean UniversityRethymnoCreteGreece Department of Electronic Engineering School of EngineeringHellenic Mediterranean UniversityChaniaCreteGreece Extreme Light Infrastructure ERIC ELI-Beamlines FacilityDolníBÏrežanyCzech Republic Centro de Laseres Pulsados(CLPU) Parque CientificoVillamayorSalamancaSpain

The recent achievement of fusion ignition with laser-driven technologies at the National Ignition Facility sets a historic accomplishment in fusion energy *** accomplishment paves the way for using laser inertial fusion as a viable approach for future energy *** has a unique opportunity to empower research in this field internationally,and the scientific community is eager to engage in this *** propose establishing a European programme on inertial-fusion energy with the mission to demonstrate laser-driven ignition in the direct-drive scheme and to develop pathway technologies for the commercial fusion *** proposed roadmap is based on four complementary axes:(ⅰ)the physics of laser-plasma interaction and burning plasmas;(ⅱ)high-energy high repetition rate laser technology;(ⅲ)fusion reactor technology and materials;and(ⅳ)reinforcement of the laser fusion community by international education and training *** foresee collaboration with universities,research centres and industry and establishing joint activities with the private sector involved in laser *** project aims to stimulate a broad range of high-profile industrial developments in laser,plasma and radiation technologies along with the expected high-level socio-economic impact.

关键词： education and training fusion reactor technology high-energy laser high repetition rate laser inertial confinement fusion laser-plasma interaction public-private partnership radiation resistant materials

Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

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Journal of Pharmaceutical Analysis 2016年第2期6卷 117-124页

作者： antonio Martinez-Ortega Agustin Herrera antonio Salmeron-Garcia jose Cabeza Luis Cuadros-Rodriguez natalia Navas Department of Analytical Chemistry University of Granada Faculty of Science Campus Fuentenueva s/n E-18071 Granada Spain UGC intercentro Interniveles Farmacia Granada San Cecilio Hospital Biomedical Research Institute ibs. GRANADA. Hospitales Universitarios de Granada University of Granada E-18012 Granada Spain Department of Analytical Chemistry Science Faculty Biomedical Research Institute ibis. GRANADA University of Granada Campus Fuentenuevo s/n E-18071 Granada Spain

Cetuximab （CTX） is a potent chimeric mouse/human monoclonal antibody （mAb） approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses per- formed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-perfor- mance liquid chromatography with diode array detection （（RP）HPLC/DAD） is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmo- nization guidelines （ICH） for biotechnological drugs; therefore, we evaluated linearity, accuracy, preci- sion, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by compre- hensive chromatographic analysis by subjecting CTX to several informative stress conditions. As de- monstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also suc- cessfully used to quantify CTX in a long-term stability study performed under hospital conditions.

关键词： Reverse-phase high performance liquidchromatography Diode detector Stress study Biopharmaceuticals Cetuximab

Profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1046-1050页

作者： jose antonio Trigueros David P Pinero Mahmoud M Ismail Department of Financial Economic and Accounting Miguel Hernandez University Elche 03202 Alicante Spain Department of Optics Pharmacology and AnatomyUniversity of Alicante Crta San Vicente del RaspeigAlicante 03690 Spain Al-Azhar University Cairo 11651 Egypt

AIM：To define the financial and management conditions required to introduce a femtosecond laser system for cataract surgery in a clinic using a fuzzy logic ***：In the simulation performed in the current study,the costs associated to the acquisition and use of a commercially available femtosecond laser platform for cataract surgery（VICTUS,TECHNOLAS Perfect Vision GmbH,Bausch ＆ Lomb,Munich,Germany） during a period of 5y were considered.A sensitivity analysis was performed considering such costs and the countable amortization of the system during this 5y ***,a fuzzy logic analysis was used to obtain an estimation of the money income associated to each femtosecond laser-assisted cataract surgery（G）. RESULTS：According to the sensitivity analysis,the femtosecond laser system under evaluation can be profitable if 1400 cataract surgeries are performed per year and if each surgery can be invoiced more than $*** contrast,the fuzzy logic analysis confirmed that the patient had to pay more per surgery,between $661.8 and $667.4 per surgery,without considering the cost of the intraocular lens（IOL）.CONCLUSION：A profitability of femtosecond laser systems for cataract surgery can be obtained after a detailed financial analysis,especially in those centers with large volumes of *** cost of the surgery for patients should be adapted to the real flow of patients with the ability of paying a reasonable range of cost.

关键词： cataract surgery femtosecond laser fuzzy logic femto-cataract victus profitability analysis

Unraveling the Biochemical and Molecular Networks Involved in Maize Cell Habituation to the Cellulose Biosynthesis Inhibitor Dichlobenil

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Molecular Plant 2010年第5期3卷 842-853页

作者： Hugo Melida antonio Encina Jesus Alvarez jose Luis Acebes David Caparros-Ruiz Area de Fisiologia Vegetal Facultad de CC. Biologicas y Ambientales Universidad de Leon E-24071 Leon Spain Centre de Recerca en AgriGen6mica (Consorci CSIC-IRTA-UAB) Jordi Girona 18-26 E-08034 Barcelona Spain

The biochemical and molecular processes involved in the habituation of maize cells to growth in the presence of the cellulose biosynthesis inhibitor dichlobenil （DCB） were investigated. DCB affects the synthesis of cellulose both in active and stationary growth phases and alters the expression of several CesA genes. Of these, ZmCesA5 and ZmCesA7 seem to play a major role in habituating cells to growth in the presence of DCB. As a consequence of the reduction in cellulose, the expression of several genes involved in the synthesis of hydroxycinnamates is increased, resulting in cell walls with higher levels of ferulic and p-coumaric acids. A proteomic analysis revealed that habituation to DCB is linked to modifications in several metabolic pathways. Finally, habituated cells present a reduction in glutathione S-transferase detoxifying activity and antioxidant activities. Plant cell adaptation to the disturbance of such a crucial process as cellulose biosynthesis requires changes in several metabolic networks, in order to modify cell wall architecture and metabolism, and survive in the presence of the inhibitor. Some of these modifications are described in this paper.

关键词： Abiotic/environmental stress acclimation--physiological cell walls maize cellulose dichlobenil phenylpropanoid.

Changes in Cinnamic Acid Derivatives Associated with the Habituation of Maize Cells to Dichlobenil

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Molecular Plant 2011年第5期4卷 869-878页

作者： Hugo Melida Jesus Alvarez jose Luis Acebes antonio Encina Stephen C. Fry Area de Fisiologia Vegetal Facultad de CC Biologicas y Ambientales Universidad de Leon E-24071 Leon Spain Edinburgh Cell Wall Group Institute of Molecular Plant Sciences School of Biological Sciences University of Edinburgh Daniel Rutherford Building The King＇s Buildings Edinburgh EH9 3JH UK

The habituation of cell cultures to cellulose biosynthesis inhibitors such as dichlobenil （DCB） represents a valu- able tool to improve our knowledge of the mechanisms involved in plant cell wall structural plasticity. Maize cell lines habituated to lethal concentrations of DCB were able to grow through the acquisition of a modified cell wall in which cellulose was partially replaced by a more extensive network of arabinoxylans. The aim of this work was to investigate the phenolic metabolism of non-habituated and DCB-habituated maize cell cultures. Maize cell cultures were fed [14C]cinnamate and the fate of the radioactivity in different intra-protoplasmic and wall-localized fractions throughout the culture cycle was analyzed by autoradiography and scintillation counting. Non-habituated and habituated cultures did not markedly differ in their ability to uptake exogenous [14C]cinnamic acid. However, interesting differences were found in the radiolabeling of low- and high-Mr metabolites. Habituated cultures displayed a higher number and amount of radiola-beled low-Mr compounds, which could act as reserves later used for polysaccharide feruloylation. DCB-habituated cultures were highly enriched in esterified [14C]dehydrodiferulates and larger coupling products. In conclusion, an extensive and early cross-linking of hydroxycinnamates was observed in DCB-habituated cultures, probably strengthening their cellulose-deficient walls.

关键词： Cell wall Zea mays maize dichlobenil DCB dehydrodiferulate ferulate cinnamic acid.

Rethinking de novo immune hepatitis,an old concept for liver allograft rejection:relevance of glutathione S-transferase T1 mismatch

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World Journal of Gastroenterology 2018年第29期24卷 3239-3249页

作者： Isabel Aguilera Elena Aguado-Dominguez jose Manuel Sousa antonio Nunez-Roldan Department of Immunology Instituto de Biomedicina de Sevilla(IBIS)Hospital Universitario Virgen del RocíoSevilla 41013Spain Digestive and Liver Diseases Service Hospital Universitario Virgen del RocíoSevilla 41013Spain

Antibody-mediated rejection(AMR) in liver transplantation has long been underestimated. The concept of the liver as an organ susceptible to AMR has emerged in recent years, not only in the context of the major histocompatibility complex with the presence of HLA donor-specific antibodies, but also with antigens regarded as "minor", whose role in AMR has been demonstrated. Among them, antibodies against glutathione S-transferase T1 have been found in 100% of patients with de novo autoimmune hepatitis(dn AIH) when studied. In its latest update, the Banff Working Group for liver allograft pathology proposed replacing the term dn AIH with plasma cell(PC)-rich rejection. Antibodies to glutathione S-transferase T1(GSTT1) in null recipients of GSTT1 positive donors have been included as a contributory but nonessential feature of the diagnosis of PC-rich rejection. Also in this update, non-organ-specific anti-nuclear or smooth muscle autoantibodies are no longer included as diagnostic criteria. Although initially found in a proportion of patients with PC-rich rejection, the presence of autoantibodies is misleading since they are not diseasespecific and appear in many different contexts as bystanders. The cellular types and proportions of the inflammatory infiltrates in diagnostic biopsies have been studied in detail very recently. PC-rich rejection biopsies present a characteristic cellular profile with a predominance of T lymphocytes and a high proportion of PCs, close to 30%, of which 16.48% are Ig G4+. New data on the relevance of GSTT1-specific T lymphocytes to PC-rich rejection will be discussed in this review.

关键词： glutathione S-transferase T1 mismatch liver allograft rejection plasma cell-rich rejection de novo autoimmune hepatitis donor-specific antibodies newCAST cell quantification IgG4+plasma cell T lymphocytes