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Agricultural Sciences 2014年第11期5卷 1015-1024页

作者： Margarita Miranda José Delatorre-Herrera antonio Vega-Gálvez Evelyn Jorquera Issis Quispe-Fuentes enrique A. Martínez Department of Food Engineering Universidad de La Serena La Serena Chile Department of Agriculture of Desert and Biotechnology Facultad de Recursos Naturales Renovables Universidad Arturo Prat Iquique Chile Centro de Estudios Avanzados en Zonas áridas (CEAZA) Facultad de Ciencias del Mar Universidad Católica del Norte Coquimbo and La Serena Chile

Antimicrobial potential of quinoa seeds from six diverse seeds, grown in three distinctive geo-graphical zones of Chile, was correlated with their total phenolic content (TPC), total flavonoid content (TFC) and total saponin content (TSC). The six seeds were Ancovinto, Cancosa, Cahuil, Faro, Regalona and Villarrica. A significant influence of quinoa source on chemical composition of seeds was observed. Extracts of all quinoa samples showed antimicrobial activity in the range of 8.3 - 14.8 mm inhibition zone for E. coli and 8.5 - 15.0 mm inhibition zone for S. aureus. Cancosa seeds had the highest antimicrobial action. The TPC and TFC ranged from 3.71 to 16.55 mg GA/100 g d.m. and 7.77 to 14.37 mg QE/100 g d.m., respectively. TSC varied from 1.78 to 3.08 g/100 g d.m. A cor-relation between TFC and antimicrobial activity was found. In conclusion, the six types of quinoa seeds were identified as potential sources of antioxidant compounds and antimicrobial activity.

关键词： Quinoa Antimicrobial Activity Phenols Flavonoids Saponin

Could Low Hdl-Cholesterol Levels Be an Unvalued Predictor of Cancer Risk?: A Retrospective Case Study

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International Journal of Clinical Medicine 2015年第12期6卷 984-992页

作者： Juan antonio Vílchez Natalia Sancho-Rodríguez Ana Martínez-Ruiz enrique Martínez-Sánchez Francisco Ruiz-Espejo Isabel Tovar-Zapata Jose antonio Noguera-Velasco Clinical Analysis Department Virgen de la Arrixaca Clinic University Hospital Murcia Spain Cardiology Department Virgen de la Arrixaca Clinic University Hospital Murcia Spain Laboratorios Unilabs S. L. Murcia Spain

Background: The relationship between serum lipid profile levels and cancer risk remained uncertain. Recently, it had been reported a significant inverse association between high-density lipoprotein cholesterol (HDL) and the risk of incident cancer that was independent of low-density lipoprotein cholesterol (LDL), age or sex. Objective: The aim of our study was to evaluate the behavior of HDL in cancer patients and in healthy population. Methods: We created a retrospectively search strategy in the laboratory information system (LIS). We filtered and searched those patients with CEA within 5 - 20 ng/ml and any value of HDL and corroborated the presence of cancer (Group 1 (G1)) or not (Group 2 (G2)). Moreover, we searched a control group (patients in outpatient oncology clinic) to observe the values of HDL. Comparisons and statistical logistic regression models were applied to link the levels of this biomarkers and cancer risk. Results: We examined 852 valid patients, median age 62 (50 - 73) years. Within the search strategy group, G2 showed highest levels of HDL (54 (43 - 67) mg/dl) and lowest CEA levels (6.7 (5.7 - 8.4) ng/ml) comparing with G1: HDL (47 (37 - 60) mg/dl) and the CEA (7.9 (6.2 - 10.9) ng/ml);p p r2: 0.092;p p = 0.001)] and CEA [OR: 1.115 (1.060 - 1.174), (p < 0.001)] and they were confirmed as independent predictors of cancer. Conclusion: Our findings confirmed the inverse association of HDL levels between healthy populations and were diagnosed with cancer. Moreover, in a random population, patients with cancer presented lower HDL values compared to those without cancer. Therefore, it could demonstrate the possible positive predictive value of low HDL related to cancer risk.

关键词： High-Density Lipoprotein Cholesterol (HDL) Cancer Risk Lipid Profile Carcinoembryonic Antigen (CEA)

Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice

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World Journal of Gastroenterology 2006年第40期12卷 6464-6472页

作者： Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré antonio Salas Marek W Radomski enrique Quintero Gastroenterology Department and Research Unit Hospital Universitario de Canarias Tenerife Spain Reumathology Department Hospital Universitario de Canrias Tenerife Spain Pathology Department Hospital Mutua de Terrassa Barcelona Spain Institute of Molecular Medicine University of Texas Houston-Texas United States

AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in ***: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation.

关键词：病理治疗临床肠炎

Renal function and choroidal thickness using swept-source optical coherence tomography in diabetic patients

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 985-989页

作者： antonio Manuel Garrido-Hermosilla Mariola Méndez-Muros Estanislao Gutiérrez-Sánchez Cristóbal Morales-Portillo María Jesús Díaz-GrANDa Eduardo Esteban-González Isabel Relimpio-López María Asunción Martínez-Brocca enrique Rodríguez-de-la-Rúa-Franch Department of Ophthalmology Virgen Macarena University HospitalSeville 41009Spain OftaRed Institute of Health Carlos IIIMadridSpain Department of Endocrinology and Nutrition Virgen Macarena University HospitalSeville 41009Spain

AIM: To assess the relationship between choroidal thickness and renal function in diabetic patients. METHODS: Cross-sectional retrospective clinical study of 42 eyes of 21 ocular treatment-na?ve diabetic patients. Demographic data included: age, sex, type and course of diabetes. Ocular data included: severity of diabetic retinopathy;retinal thickness at the central macular region, as well as choroidal thickness at the central and paracentral quadrants, using automatically generated maps by swept-source optical coherence tomography;presence of cystic macular edema;and ocular axial length(AXL). Lab-test parameters included: glycated hemoglobin(HbA1c), albuminuria, albumin/creatinine ratio in urine, and glomerular filtration rate. RESULTS: A significant negative correlation was mainly observed between several choroidal thicknesses, age(P<0.020) and ocular AXL(P<0.030). On the contrary, a significant positive correlation was found between all choroidal thicknesses, HbA1 c(P<0.035) and albuminuria(P<0.040). CONCLUSION: Choroidal thickness can represent an additional tool to help clinicians predicting the renal status in ocular treatment-na?ve diabetic patients.

关键词： choroidal thickness renal function swept-source optical coherence tomography spectral-domain optical coherence tomography diabetes mellitus

Antitumor effects of electrochemical treatment

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Chinese Journal of Cancer Research 2013年第2期25卷 223-234页

作者： Héctor Manuel Camué Ciria Maraelys Morales González Lisset Ortíz Zamora Luis enrique Bergues Cabrales Gustavo Victoriano Sierra González Luciana Oliveira de Oliveira Rodrigo Zanella antonio Carlos Buzaid Orlando Parise Luciana Macedo Brito Cesar Augusto Antunes Teixeira Marina das Neves Gomes Gleyce Moreno Venicio Feo da Veiga Marcos Telló Carla Holandino Research Department National Centre of Applied Electromagnetism Oriente University Pharmacy Department Oriente University Finlay Institute La lisa. La Habana Cuba Veterinary Teaching Hospital Federal University of Rio Grande do Sul. Porto Alegre Sírio e Libanês Hospital Faculty of Pharmacy Medicine Department Federal University of Rio de Janeiro Professor Paulo de Góes Institute of Microbiology Federal University of Rio de Janeiro Pontifical Catholic University of Rio Grande do Sul. Porto Alegre

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the anfitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor ceils. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods.

关键词： Direct electric current electrochemical treatment antimmoral treatment tumor tumor electrolysis rumor entropy dissipative structure

Management of the Prosthetic Valve Thrombosis: This Time Is Different

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Case Reports in Clinical Medicine 2021年第7期10卷 185-190页

作者： Zineb Kounka Benjamín Roque-Rodríguez Luis enrique Lezcano-Gort David antonio Chipayo-Gonzáles Elena Gallego-Curto Cecilio Raúl Rodríguez-Carreras Department of Cardiology Complejo Hospitalario Universitario de C&aacute ceres C&aacute ceres Spain Intensive Care Unit Complejo Hospitalario Universitario de C&aacute ceres C&aacute ceres Spain

Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, whose physical examination and echocardioscopy suggested PVT confirmed with fluoroscopy. Intra-aortic fibrinolysis was the treatment chosen with successful results.

关键词： Prosthetic Valve Thrombosis Intra-Aortic Fibrinolysis Low-Dose Slow Infusion

rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study

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World Journal of Gastroenterology 2017年第47期23卷 8405-8414页

作者： Henry Córdova Lidia Argüello Carme Loras antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach Endoscopy Unit.Institut de Malalties Digestives Hospital ClínicIDIBAPSCIBERehdUniversitat de Barcelona Digestive Endoscopy Unit Digestive Diseases DepartmentGastrointestinal Endoscopy Research GroupIISLa Fe Polytechnic University Hospital Hospital Universitari Mútua de Terrassa CIBERehd Hospital Reina Sofía Hospital Del Mar Hospital Universitari de Bellvitge IDIBELLUniversitat de BarcelonaHospitalet de Llobregat Hospital Universitario de Canarias Hospital Santos Reyes Aranda de Duero Hospital San Jorge Consorci Hospitalari de Vic Universitat de Vic Hospital de Viladecans Hospital Morales Meseguer Hospital Moisès Broggi Sant Joan Despí Hospital Joan XXIII Complejo Hospitalario de Pontevedra

AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of *** Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location.

关键词： Polypectomy Bleeding Adverse events Protruded polyps Gastroduodenal Foregut

Few-mode fibre-optic microwave photonic links

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Light(Science & Applications) 2017年第1期6卷 684-691页

作者： He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose enrique antonio Lopez Rodrigo Amezcua Correa Guifang Li CREOL The College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA The College of Precision Instruments and Opto-Electronics Engineering Tianjin UniversityTianjin 300072China School of Physics Science and Information Technology Shandong Provincial Key Lab of Optical Communication Science and TechnologyLiaocheng UniversityShandong 252059China State Key Laboratory of Optical Communication Technologies and Networks FiberHome Telecommunication Technologies Co.LtdWuhan Research Institute of Posts and TelecommunicationsNo.88 Youkeyuan RoadHongshan DistrictWuhan 430074China Prysmian Group Parc des Industries Artois FlandresHaisnes 62092France

The fibre-optic microwave photonic link has become one of the basic building blocks for microwave *** the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic *** though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude *** this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial *** specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed *** work represents the first step in few-mode microwave *** spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics.

关键词： analogue optic-fibre link few-mode fibre fibre nonlinearity microwave photonics space-division multiplexing

Clinical features and radiological manifestations of COVID-19 disease

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World Journal of Radiology 2020年第11期12卷 247-260页

作者： Pedro Landete Carlos Andres Quezada Loaiza Beatriz Aldave-Orzaiz Susana Hernandez Muniz antonio Maldonado enrique Zamora Allan Charles Sam Cerna Elia del Cerro Raquel Cano Alonso Felipe Counago Department of Pulmonology H.U.La PrincesaMadrid 28006Spain Department of Pulmonology H.12 de OctubreMadrid 28041Spain Department of Radiologist H.U.La PrincesaMadrid 28006Spain Department of Radiation Oncology Hospital Universitario Quironsalud MadridMadrid 28223Spain Department of Pulmonology Hospital MD Anderson Madrid.EspanaMadrid 28033Spain Department of Diagnostic Imaging Hospital Universitario Quiron MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzUniversidad Europea de MadridMadrid 28028Spain

Coronavirus disease 2019(COVID-19)was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province(China).Coronavirus is a family of single-stranded RNA *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted from person to *** asymptomatic individuals can transmit the virus,symptomatic patients are more *** incubation period ranges from 3-7 d and symptoms are mainly respiratory,including pneumonia or pulmonary embolism in severe *** serum levels of interleukins(IL)-2,IL-6,IL-7 indicate the presence of cytokine release syndrome,which is associated with disease *** disease has three main phases:Viral infection,pulmonary involvement,and *** date,no treatment has proved to be safe or *** X-ray and computed tomography(CT)are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia,follow-up,and detection of *** main radiological findings are ground-glass opacification and areas of *** long-term clinical course is unknown,although some patients may develop pulmonary *** emission tomography-computed tomography(PETCT)is useful to assess pulmonary involvement,to define the affected areas,and to assess treatment *** pathophysiology and clinical course of COVID-19 infection remain poorly ***,patterns detected on CT and PETCT may help to diagnose and guide *** this mini review,we analyze the clinical manifestations and radiological findings of COVID-19 infection.

关键词： COVID-19 Coronavirus Natural history Clinical features Pathogenesis Radiology images

An overview of the endogenous and environmental factors related to the Coffea arabica flowering process

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Beverage Plant Research 2021年第1期1卷 106-121页

作者： Marlon enrique López Iasminy Silva Santos Raphael Ricon de Oliveira AndréAlmeida Lima Carlos HenriqueCardon antonio Chalfun-Junior Laboratory of Plant Molecular Physiology Plant Physiology SectorDepartment of BiologyFederal University of LavrasLavras-Minas GeraisBrazil37200-900

The transition of vegetative meristems to a reproductive state followed by floral development and flowering is a complex process regulated by many regulatory pathways that integrate(epi)genetic and environmental factors to guarantee the reproductive success in *** woody and perennial species,such as coffee trees,the extended life cycle reflects adaptive strategies,i.e.,two-year cycle,sequential flowering and bud latency during the winter,that ensure reproductive success in a variable *** dynamics of coffee flowering integrate multiple stimuli to induce morpho-physiological changes,especially during the reproductive *** discussed diverse stimuli which are directly and indirectly associated with molecular pathways related to the reproductive meristem transition and floral development until ***,we propose to redefine some concepts regarding coffee floral development,such as:i)a summary of genes possibly involved in the flowering pathways;ii)a new classification of buds by position in the node(B1-B4)to avoid misunderstandings with the uneven developmental stages;iii)comparative ABC model to Arabidopsis and tomato to allow evolutionary discussions of whorls development in Coffea *** this,we expect to collaborate to drive future studies towards coffee breeding and production,for example,improving floral bud activation,controlling the flowering time,anthesis synchronization to produce more homogeneous ripening fruits,reducing abortion or early flower openings,and increasing ***,we think that the explored relationship between physiological and molecular approaches during the coffee flowering may be extended to understand other tropical perennial species,especially those with asynchronous flowering behavior,and to understand evolutive aspects in Rubiaceae.

关键词： breeding process flowering