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An open-label pilot study with high-dose thiamine in Parkinson's disease

Neural Regeneration Research 2016年第3期11卷 406-407页

作者： antonio costantini Roberto Fancellu Department of Neurological Rehabilitation "Villa Immacolata" Clinic Unit of Neurology IRCCS San Martino University Hospital IST

Parkinson’s disease（PD）is a progressive neurodegenerative disorder clinically characterized by motor symptoms（bradykinesia,tremor,rigidity,postural instability）and non-motor symptoms（hyposmia,sleep disorders,aut... 详细信息

关键词： label tremor autonomic instability pilot fatigue rigidity progressive paired dopamine

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Can long-term thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1？

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Neural Regeneration Research 2016年第9期11卷 1487-1491页

作者： antonio costantini Erika Trevi Maria Immacolata Pala Roberto Fancellu Department of Neurological Rehabilitation "Villa Immacolata" Clinic Viterbo Italy School of Physiotherapy Catholic University of Rome Rome Italy Neurology Unit IRCCS San Martino University Hospital IST Genoa Italy

Myotonic dystrophy type 1, also known as Steinert＇s disease, is an autosomal dominant disorder with multisystemic clinical features affecting the skeletal and cardiac muscles, the eyes, and the endocrine system. Thiamine （vitamin B1） is a cofactor of fundamental enzymes involved in the energetic cell me- tabolism; recent studies described its role in oxidative stress, protein processing, peroxisomal function, and gene expression. Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells. Our aim was to investigate the potential therapeutical effects of long-term treatment with thiamine in myotonic dystrophy type 1 in an observational open-label pilot study. We de- scribed two patients with myotonic dystrophy type 1 treated with intramuscular thiamine 100 mg twice a week for 12 or 11 months. We evaluated the patients using the grading of muscle strength according to Medical Research Council （MRC）, the Muscular Impairment Rating Scale （MIRS）, and the Modified Barthel index. High-dose thiamine treatment was well tolerated and effective in improving the motor symptomatology, particularly the muscle strength evaluated with the MRC scale, and the patients＇ activi- ties of daily living using the Modified Barthel Index. At the end of treatment, the MRC score was 5 in the proximal muscles and 2-4 in the distal muscles （the MRG score before the treatment was 3-4 and 1-3, re- spectively）. The MIRS grade improved by 25% compared to baseline for both patients. In patient #1, the Modified Barthel Index improved by 44%, and in patient #2 by 29%. These findings suggest that clinical outcomes are improved by long-term thiamine treatment.

关键词： nerve regeneration myotonic dystrophy type I thiamine Steinert's disease muscular strength activity of daily living neural regeneration

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Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation： long-term outcomes

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Asian Journal of Andrology 2018年第6期20卷 572-575页

作者： antonio Luigi Pastore Giovanni Palleschi Andrea Fuschi Yazan AI Salhi Alessandro Zucchi Giorgio Bozzini Ester IUiano Elisabetta costantini antonio Carbone Uroiogy Unit Department of Medico-Surgical Sciences and Biotechnologies ICOT Faculty of Pharmacy and Medicine 'Sapienza' University of Rome Latina (LT) 04100 Italy Uroresearch Nonprofit Association for Research in Urology Latina 04100 Italy Department of Urology and Andrology University of Perugia Perugia 05156 Italy Department of Urology MATER DOMINI Humanitas Castellanza (VA) 21053 Italy

The aim of the study was to evaluate the long-term outcomes of pelvic floor muscle （PFM） rehabilitation in males with lifelong premature ejaculation （PE）, using intravaginal ejaculatory latency time （IELT） and the self-report Premature Ejaculation Diagnostic Tool （PEDT） as primary outcomes. A total of 154 participants were retrospectively reviewed in this study, with 122 completing the training protocol. At baseline, all participants had an IELT 〈60 s and PEDT score 〉11. Participants completed a 12-week program of PFM rehabilitation, including physio-kinesiotherapy treatment, electrostimulation, and biofeedback, with three sessions per week, with 20 min for each component completed at each session. The effectiveness of intervention was evaluated by comparing the change in the geometric mean of IELT and PEDT values, from baseline, at 3, 6, and 12 months during the intervention, and at 24 and 36 months postintervention, using a paired sample 2-tailed t-test, including the associated 95% confidence intervals. Of the 122 participants who completed PFM rehabilitation, 111 gained control of their ejaculation reflex, with a mean IELT of 161.6 s and PEDT score of 2.3 at the 12-week endpoint of the intervention, representing an increase from baseline of 40.4 s and 17.0 scores, respectively, for IELT and PEDT （P 〈 0.0001）. Of the 95 participants who completed the 36-month follow-up, 64% and 56% maintained satisfactory eiaculation control at 24 and 36 months oostintervention, respectively.

关键词： biofeedback electrostimulation intravaginal ejaculatory latency time pelvic floor rehabilitation premature ejaculation premature ejaculation diagnostic tool

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