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Mitochondrial tRNA Glutamic Acid Variant 14709T〉C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers

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Chinese Medical Journal 2018年第20期131卷 2518-2519页

作者： Josef Finsterer Fulvio A Scorza Ana C Fiorini Carla A Scorza antonio carlos de almeida department of Neurology City Hospital Rudolfstiftung Vienna Austria department of Neuroscience University of Sao Paolo Sao Paolo Brazil department of Audiology University of Sao Paolo Sao Paolo Brazil department of Biosystems Engineering Laboratory of Experimental and Computational Neuroscience Sao Paolo Brazi

We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.

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Influence of Testing Temperature on the Corrosion Behavior of API 5L X70 Pipeline Steel

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Journal of Mechanics Engineering and Automation 2014年第6期4卷 528-532页

作者： carlos antonio Vieira de almeida Machado Renato Altobelli Antunes Elisabete Jorge Pessine Olandir Vercino Correa Centro de Engenharia Modelagem e Ci~ncias Sociais Aplicadas (CECS) Universidade Federal do ABC Santo Andre 09210-580Brazil Centro de Ciencia e Tecnologia de Materiais (CCTM) Instituto de Pesquisas Energeticas e Nucleares(IPEN/CNEN-SP) Cidade Universitaria Sao Paulo 05508-000 Brazil

It is known that localized corrosion attack takes a preponderant role in the onset of stress corrosion cracking of pipeline steels in high pH conditions. Carbonate/bicarbonate solutions can be employed to study the localized corrosion behavior of these materials. In addition to the presence of chloride ions in the electrolyte, the solution temperature is also of prime importance to the onset of pitting corrosion. The aim of this work is to evaluate the influence of the testing temperature on the corrosion behavior of the API 5L X70 pipeline steel which is a standard material for gas pipelines in Brazil. Samples were exposed to a solution consisting of Na2CO3, NaHCO3 and NaCl at three different temperatures： RT （room temperature）, 40 ℃ and 60 ℃. The corrosion morphology was observed using SEM （scanning electron microscopy）. The results showed that pitting corrosion became facilitated when the steel was immersed at higher temperatures.

关键词： API 50 X70 pipeline steel corrosion temperature

Increased basal plasma brain-derived neurotrophic factor levels in sprint runners

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Neuroscience Bulletin 2011年第5期27卷 325-329页

作者： Paulo Roberto Correia Fulvio Alexandre Scorza Sérgio Gomes da Silva Aline Pansani Michelle Toscano-Silva antonio carlos de almeida Ricardo Mario Arida 圣保罗联邦大学生理学系圣保罗联邦大学神经内外科系 So Joo del-Rei联邦大学实验与计算神经生物学实验室

Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters （100 m） at either the international （Olympics and Outdoor World Championships）（n = 14） or the domestic level （n = 8）, and sedentary subjects （n = 15）, were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.

关键词： brain-derived neurotrophic factor physical exercise sprint plasma brain human

The Colider and Roosevelt olcanic rocks (sw amazonian craton): geochemistry and sm-nd isotope characteristics of a silicic large igneous province

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Acta Geochimica 2021年第6期40卷 1023-1049页

作者： Bruna Saar de almeida Mauro César Geraldes carlos Augusto Sommer Felipe Corrales antonio Joāo Paes de Barros Universidade do Estado do Rio de Janeiro Rio de JaneiroBrazil University of Geneva GenevaSwitzerland Universidade Federal do Rio Grande do Sul Rio Grande do SulBrazil METAMAT(Mato Grosso State Geological Survey) CuiabaBrazil

The volcanic rocks of the Colíder and Roosevelt formations are extensively exposed in the south-central portion of the Amazonian Craton where effusive and pyroclastic rocks have been *** units,topped by chemical sediments and oceanic facies as rhyolite and andesite lavas,rhyodacite,and porphyritic dacite,with frequent intercalations of pyroclastic and epiclastic ***-rock geochemistry for 55 samples of rhyolitic to andesitic composition suggests the involvement of fertile mantle-derived components with E-MORB to OIB *** analyzed rocks display calc-alkaline to shoshonitic affinity consistent with generation related to an active continental *** whole-rock Sm-Nd isotope data from selected felsic volcanic rocks of the Colíder and Roosevelt formations yield negative initial eNd values between–3 and–9,indicating the predominantly crustal nature of the parental magmas with early Archean to late Paleoproterozoic(ca.2.5–2.0 Ga)depleted mantle model ages.

关键词： Amazonian craton Geochemistry Sm-Nd isotopes Paleoproterozoic Volcanism

Brent *** Texas Intermediate in the US petro derivatives price formation

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Petroleum Science 2024年第1期21卷 729-739页

作者： Alejandro almeida antonio A.Golpe Juan Manuel Martín-Alvarez Jose carlos Vides Universidad Internacional de La Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over *** the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the refined ***,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate ***,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined *** results possess important considerations to policymakers and the market participants and the price formation.

关键词： Crude oil prices Spatial panel model Refined products Price formation

Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de almeida Fernandes Guilherme de Freitas Camoes Diana Ferreira Carolina Queijo carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia antonio department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;Pder(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

A numerical assessment of two geometries for reducing elbow erosion

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Particuology 2020年第2期18卷 117-133页

作者： carlos antonio Ribeiro Duarte Francisco Joséde Souza Diego Nei Venturi Martin Sommerfeld department of Engineering Federal University of Goiás-Regional Catal(a)oAv.Dr.Lamartine Pinto de Avelar1120Catal(a)oGoiásBrazil School of Mechanical Engineering Federal University of Uberl(a)ndiaAv.Joāo Naves de(A)vila2121 Bloco 5PUberl(a)ndiaMinas GeraisBrazil Multiphase Flow Systems(MPS) Otto-von-Guericke-University MagdeburgZeppelinstraβe 1D-06130 Halle(Saale)Germany

Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed *** are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged *** option,although less commonly used,is the vortex-chamber *** both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating *** present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged *** are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion *** analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe *** general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of *** the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading ***,the advantages and disadvantages of each fitting are highlighted.

关键词： Relative erosion Plugged tee Erosion reduction Pipe fitting Computational fluid dynamics

Stability analysis of the fluttering and autorotation of flow-induced rotation of a hinged flat plate

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Journal of Hydrodynamics 2013年第5期25卷 755-762页

作者： MIRZAEISEFAT Sina FERNANdeS antonio carlos department of Naval Architecture and Marine Engineering University of Michigan COPPE/UFRJ Federal University of Rio de Janeiro

This work describes investigations performed on the interaction of uniform current and freely rotating plate about a fixed vertical axis. Fluttering and autorotation are two different motions that may occur during the flow induced rotation. The dimensional analysis proves that the motion in flow induced rotation motion is governed essentially by the dimensionless moment of inertia and Reynolds number. Certain combinations define the stability boundaries between fluttering and autorotation. Fluttering is oscillation of body about a vertical axis and the autorotation is a name given to the case when the body turns continuously about the vertical axis First, the loads and moment coefficients are calculated by experiments and streamline theory for different angles of attack for a fixed fiat plate. Then for dynamic case, a bifurcation diagram is presented based on experiments to classify different motion states of flow induced rotation. Finally, a dynamical model is proposed for stability analysis of flow induced rotation of a flat plate.

关键词： flow-induced rotation autorotation fluttering stability analysis

Phenomenological model for torsional galloping of an elastic flat plate due to hydrodynamic loads

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Journal of Hydrodynamics 2014年第1期26卷 57-65页

作者： FERNANdeS antonio carlos ARMANdeI Mohammadmehdi department of Naval and Ocean Engineering COPPE/UFRJ

This study investigates the torsional galloping phenomenon, an instability type flow-induced oscillation, in an elastic stru-cture due to hydrodynamic loads into the water current. The structure applied here is a rectangular flat plate with an elastic axis in its mid-chord length. The elasticity is provided by torsion spring. The flat plate has only one degree of freedom which is rotation in pure yaw about its axis. It is observed that as the current speed is higher than a critical velocity, the flat plate becomes unstable. The instability leads to torsional galloping occurrence, as a result of which the flat plate begins to yaw about the elastic axis. By testing two different chord lengths each with several torsion spring rates, the flat plate behavior is investigated and three different responses are recognized. Then, a phenomenological model is developed with the original kernel in the form of the van der Pol-Duffing equa-tion. The model explains these three responses observed experimentally.

关键词： torsional galloping flow-induced oscillation phenomenological model van der Pol-Duffing equation