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Rhynchophorus ferrugineus attack affects a group of compounds rather than rearranging Phoenix canariensis metabolic pathways

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Journal of Integrative Plant Biology 2016年第4期58卷 388-396页

作者： antonio Giovino Federico Martinelli Sergio Saia Consiglio per la Ricerca in Agricoltura e l'analisi dell'economia agraria(CREA) Unita di ricerca per il recupero e la valorizzazione delle Specie Floricole Mediterranee(CREA-SFM)90011 Bagheria(PA)Italy Dipartimento di Scienze Agrarie e Forestali(SAF) University of PalermoViale delle ScienzeEdif.490128 PalermoItaly Istituto Euromediterraneo di Scienza e Tecnologia(IEMEST) Via E.Amari 12390139 PalermoItaly

The red palm weevil（RPW; Rhynchophorus ferrugineus） is spreading worldwide and severely harming many palm species. However, most studies on RPW focused on insect biology, and little information is available about the plant response to the attack. In the present experiment, we used metabolomics to study the alteration of the leaf metabolome of Phoenix canariensis at initial（1^（st） stage） or advanced（2^（nd） stage）attack by RPW compared with healthy（unattacked） *** leaf metabolome significantly varied among treatments. At the 1^（st） stage of attack, plants showed a reprogramming of carbohydrate and organic acid metabolism; in contrast, peptides and lipid metabolic pathways underwent more changes during the 2^（nd） than 1^（st） stage of attack. Enrichment metabolomics analysis indicated that RPW attack mostly affected a particular group of compounds rather than rearranging plant metabolic pathways. Some compounds selectively affected during the 1^（st） rather than 2^（nd） stage（e.g. phenylalanine; tryptophan; cellobiose;xylose; quinate; xylonite; idonate; and iso-threonate; cellobiotol and arbutine） are upstream events in the phenylpropanoid,terpenoid and alkaloid biosynthesis. These compounds could be designated as potential markers of initial RPW attack. However,further investigation is needed to determine efficient early screening methods of RPW attack based on the concentrations of these molecules.

关键词： Early detection Mediterranean environment metabolomics palms plant borer

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Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis

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World Journal of Gastroenterology 2006年第22期12卷 3471-3480页

作者： Marco Marzioni Giammarco Fava antonio Benedetti Department of Gastroenterology Universita Politecnica delle Marche via Tronto 1060020 AnconaItaly

Cholangiocytes, the epithelial cells lining the biliary ducts, are the target cells in several liver diseases. Cholangiopathies and cholangiocarcinoma generate interest in many scientists since the genesis. The developing mechanisms, and the therapeutic tools of these diseases are still undefined. Several studies demonstrate that many hormones, neuropeptides and neurotransmitters regulate malignant and non-malignant cholangiocyte pathophysiology in the course of chronic biliary diseases. The aim of this review is to present the findings of several studies published in the recent years that contributed to clarifying the role of nervous and neuroendocrine regulation of the pathophysiologic events associated with cholestasis and cholangiocarcinoma development. This manuscript is organized into two parts. The first part offers an overview of the innervation of the liver and the origin of neuroendocrine hormones, neurotransmitters and neuropeptides affecting cholangiocyte function and metabolism. The first section also reviews the effects played by several neuroendocrine hormones and nervous system on cholangiocyte growth, survival and functional activity in the course of cholestasis. In the second section, we summarize the results of some studies describing the role of nervous system and neuroendocrine hormones in the regulation of malignant cholangiocyte growth.

关键词： Cholangiocyte Neuroendocrine hormones Neurotransmitters Neuropeptides Cholestasis Nervous System Biliary carcinogenesis Pathophysiology Cholangiocarcinoma Proliferation

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Glial regenerative response in the imaginal discs of Drosophila melanogaster

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Neural Regeneration Research 2023年第1期18卷 109-110页

作者： Sergio B.Velarde antonio Baonza Centro de Biología Molecular“Severo Ochoa” CSIC/UAMMadridSpain

Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional *** response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior(Gallo and Deneen,2014;Kato et al.,2018).This glial regenerative response is associated with the repairing function of these cells and is found across species,suggesting that it may reflect a common underlying genetic mechanism(Kato et al.,2018).

关键词： damage migrate

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A solution to Tingley's problem for isometries between the unit spheres of compact C~*-algebras and JB~*-triples

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Science China Mathematics 2019年第3期62卷 553-568页

作者： antonio M.Peralta Ryotaro Tanaka Departamento de Ana'lisis Matem'atico Facultad de Ciencias Universidad de Granada Faculty of Mathematics Kyushu University

Let f : S(E) → S(B) be a surjective isometry between the unit spheres of two weakly compact JB*-triples not containing direct summands of rank less than or equal to 3. Suppose E has rank greater than or equal to 5. Applying techniques developed in JB*-triple theory, we prove that f admits an extension to a surjective real linear isometry T : E → B. Among the consequences, we show that every surjective isometry between the unit spheres of two compact C*-algebras A and B, without assuming any restriction on the rank of their direct summands(and in particular when A = K(H) and B = K(H′)), extends to a surjective real linear isometry from A into B. These results provide new examples of infinite-dimensional Banach spaces where Tingley's problem admits a positive answer.

关键词： Tingley’s problem extension of isometries JB*-triples compact operators

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Antiviral therapy in hepatitis C virus cirrhotic patients in compensated and decompensated condition

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World Journal of Gastroenterology 2008年第42期14卷 6467-6472页

作者： Angelo Iacobellis antonio Ippolito Angelo Andriulli Division of Gastroenterology "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo 71013 Italy

The main goals of treating cirrhotic patients with antiviral therapy are to attain sustained viral clearance(SVR),halt disease progression,and prevent re-infection of the liver ***,while the medical need is great,the use of interferon and ribavirin might expose these patients to severe treated-related side effects as a large proportion of them have pre-existing hematological *** have reviewed potential benefits and risks associated with antiviral drugs in patients with liver cirrhosis,due to hepatitis C virus(HCV) *** cases presenting with bridging fibrosis or cirrhosis,current regimens of antiviral therapy have attained a 44%-48% rate of *** cirrhotic patients with portal hypertension,the SVR rate was 22% overall,12.5% in patients with genotype 1,and 66.7% in those with genotypes 2 and 3 following therapy with low doses of either Peg-IFN alpha-2b and of *** patients with decompensated cirrhosis,full dosages of Peg-IFN alpha-2b and of ribavirin produced a SVR rate of 35% overall,16% in patients with genotype 1 and 4,and 59% in those with genotype 2 and *** of hematological cytokines will either ensure full course of treatment to be accomplished with and prevent development of treatment-associated side *** benefits after HCV eradication were partial recovery of liver metabolic activity,prevention of hepatitis C recurrence after transplantation,and removal of some patients from the waiting list for liver *** observations highlighted that therapy is inadvisable for individuals with poor hepatic reserve(Child-Pugh-Turcotte score ≥ 10).Although SVR rates are low indecompensated cirrhotics due to hepatitis C,these patients have the most to gain as successful antiviral therapy is potentially lifesaving.

关键词： Hepatitis C virus Cirrhosis Peg-interferon Ribavirin Therapy

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Automorphism Groups of Pseudo-real Riemann Surfaces of Low Genus

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Acta Mathematica Sinica,English Series 2014年第1期30卷 11-22页

作者： Emilio BUJALANCE antonio F.COSTA Departamento de Matemáticas Fundamentales Facultad de CienciasUNEDSenda del rey928040 MadridSpain

A pseudo-real Riemann surface admits anticonformal automorphisms but no anticonformal *** obtain the classifcation of actions and groups of automorphisms of pseudo-real Riemann surfaces of genera 2,3 and *** instance the automorphism group of a pseudo-real Riemann surface of genus 4 is eitherC4orC8or the Fro¨benius group of order 20,and in the case ofC4there are exactly two possible topological *** MK P R,g be the set of surfaces in the moduli space MK g corresponding to pseudo-real Riemann *** obtain the equisymmetric stratifcation of MK P R,g for generag=2,3,4,and as a consequence we have that MK P R,gis connected forg=2,3 but MK P R,4has three connected components.

关键词： Riemann surface automorphism anticonformal automorphism moduli space

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Robust and fault-tolerant spacecraft attitude control based on an extended-observer design

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Control Theory and Technology 2022年第3期20卷 323-337页

作者： Alessandro Giuseppi Francesco Delli Priscoli antonio Pietrabissa Department of Computer Control and Management EngineeringLa SapienzaUniversity of RomeVia Ariosto 25Rome00185Italy

The aim of this work is to develop a robust control strategy able to drive the attitude of a spacecraft to a reference value,despite the presence of unknown but bounded uncertainties in the system parameters and external *** to the use of an extended observer design,the proposed control law is robust against all the uncertainties that affect the high-frequency gain matrix,which is shown to capture a broad spectrum of modelling issues,some of which are often neglected by traditional *** proposed controller then provides robustness against parametric uncertainties,as moment of inertia estimation,payload deformations,actuator faults and external disturbances,while maintaining its asymptotic properties.

关键词： Extended observer Spacecraft control Attitude stabilization

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Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity

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Neural Regeneration Research 2022年第2期17卷 292-299页

作者： Federica Ferrari antonio Moretti Roberto Federico Villa Department of Biology and Biotechnology Laboratory of Pharmacology and Molecular Medicine of Central Nervous SystemUniversity of PaviaVia FerrataPaviaItaly

Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke hyperglycemia is also present in a number of non-diabetic patients after acute ischemic stroke, presumably as a stress response. The aim of this review is to summarize the main effects of hyperglycemia when associated to ischemic injury in acute stroke patients, highlighting the clinical and neurological outcomes in these conditions and after the administration of the currently approved pharmacological treatment, i.e. insulin. The disappointing results of the clinical trials on insulin(including the hypoglycemic events) demand a change of strategy based on more focused therapies. Starting from the comprehensive evaluation of the physiopathological alterations occurring in the ischemic brain during hyperglycemic conditions, the effects of various classes of glucose-lowering drugs are reviewed, such as glucose-like peptide-1 receptor agonists, DPP-4 inhibitors and sodium glucose cotransporter 2 inhibitors, in the perspective of overcoming the up-to-date limitations and of evaluating the effectiveness of new potential therapeutic strategies.

关键词： acute ischemic stroke diabetes mellitus DPP-4 inhibitor glucose-like peptide-1 receptor agonist hyperglycemia hypoglycemia insulin physiopathology sodium glucose cotransporter 2 inhibitor

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SeSaMe:Metagenome Sequence Classification of Arbuscular Mycorrhizal Fungi-associated Microorganisms

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Genomics, Proteomics & Bioinformatics 2020年第5期18卷 601-612页

作者： Jee Eun Kang antonio Ciampi Mohamed Hijri Institut de Recherche en Biologie Vegetale Departement de Sciences BiologiquesUniversite de MontrealMontrealQC H1X 2B2Canada Department of Epidemiology Biostatistics and Occupational HealthMcGill UniversityMontrealQC H3A 1A2Canada Creative Research Initiatives Center for Molecular Biology of Translation School of Life SciencesKorea UniversitySeoul 02841Republic of Korea African Genome Center Agro BioSciencesMohammed Ⅵ Polytechnic University(UM6P)43150 Ben GuerirMorocco

Arbuscular mycorrhizal fungi(AMF)are plant root symbionts that play key roles in plant growth and soil *** are obligate biotrophic fungi that form coenocytic multinucleated hyphae and *** studies have shown that diverse microorganisms live on the surface of and inside their mycelia,resulting in a metagenome when whole-genome sequencing(WGS)data are obtained from sequencing AMF cultivated in *** metagenome contains not only the AMF sequences,but also those from associated *** this study,we introduce a novel bioinformatics program,Spore-associated Symbiotic Microbes(SeSaMe),designed for taxonomic classification of short sequences obtained by next-generation DNA sequencing.A genus-specific usage bias database was created based on amino acid usage and codon usage of a three consecutive codon DNA 9-mer encoding an amino acid trimer in a protein secondary *** program distinguishes between coding sequence(CDS)and non-CDS,and classifies a query sequence into a genus group out of 54 genera used as *** mean percentages of correct predictions of the CDS and the non-CDS test sets at the genus level were 71% and 50% for bacteria,68% and 73% for fungi(excluding AMF),and 49% and 72% for AMF(Rhizophagus irregularis),*** provides not only a means for estimating taxonomic diversity and abundance but also the gene reservoir of the reference taxonomic groups associated with ***,it enables users to study the symbiotic roles of associated *** can also be applicable to other microorganisms as well as soil *** is freely available at ***.

关键词： SeSaMe Spore-associated symbiotic microbes Arbuscular mycorrhizal fungi Taxonomic classification 3-codon DNA 9-mer

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Evaluation of the effectiveness of horizontal subsurface flow constructed wetlands for different media

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Journal of Environmental Sciences 2010年第6期22卷 820-825页

作者： antonio Albuquerque José Oliveira Sabrina Semitela Leonor Amaral Department of Civil Engineering and Architecture and C-MADE University of Beira Interior Municipality of Penamacor Department of Sciences and Environmental Engineering Faculty of Sciences and TechnologyNew University of Lisbon

Two media bed （gravel and Filtralite NR） were tested in a mesocosm to evaluate the removal of organic matter （as chemical oxygen demand （COD））, ammonia （NH4-N）, nitrite, nitrate and solid matter （as total suspended solids （TSS）） for a synthetic wastewater （acetate-based） and a domestic wastewater. The use of Filtralite allowed average removal rates （6--16.8 g COD/（m^2·day）, 0.8-1.1 g NH4-N/（m^2·day） and 3.1 g TSS/（m^2·day）） and removal efficiencies （65%-93%, 57%-85% and 78% for COD, NH4-N and TSS, respectively）, higher than that observed in the experiments with gravel. The applied loads of COD, ammonia, nitrate and TSS seem to influence the respective removal rates but only for the treatment of domestic wastewater with nigher correlation coefficients for Filtralite. Regardless the type of media bed and the type of wastewater, nitrate was completely removed for nitrogen loading rates up to 1.3 g NO3-N/（m^2·day）. There was no evidence of the influence of nitrate loads on the removal of organic matter.

关键词： media bed constructed wetlands pollutants removal rates

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