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Algorithms to Compute the Largest Invariant Set Contained in an Algebraic Set for Continuous-Time and Discrete-Time Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 57-69页

作者： Laura Menini Corrado Possieri antonio tornambè Dipartimento di Ingegneria Industriale Universitàdi Roma Tor VergataRoma 00133Italy Istituto di Analisi dei Sistemi ed Informatica“A.Ruberti ”Consiglio Nazionale delle Ricerche(IASI-CNR)Roma 00185Italy Dipartimento di Ingegneria Civile e Ingegneria Informatica Universitàdi Roma Tor VergataRoma 00133Italy

In this paper, some computational tools are proposed to determine the largest invariant set, with respect to either a continuous-time or a discrete-time system, that is contained in an algebraic set. In particular, it is shown that if the vector field governing the dynamics of the system is polynomial and the considered analytic set is a variety, then algorithms from algebraic geometry can be used to solve the considered problem. Examples of applications of the method(spanning from the characterization of the stability to the computation of the zero dynamics) are given all throughout the paper.

关键词： Asymptotic stability discrete-time systems invariance nonlinear systems

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Experimental Study of Selective Batch Bio-Adsorption for the Removal of Dyes in Industrial Textile Effluents

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Journal of Renewable Materials 2025年第1期13卷 127-146页

作者： Zakaria Laggoun Amel Khalfaoui Kerroum Derbal Amira Fadia Ghomrani Abderrezzaq Benalia antonio Pizzi Laboratory of Environmental Process Engineering(LIPE) Department of Environmental EngineeringFaculty of Engineering ProcessUniversity Salah Boubnider-Constantine 3New City Ali MendjeliConstantine25000Algeria Laboratory of Process Engineering for Sustainable Development and Health Products(GPDDPS) Department of Process EngineeringNational Polytechnic School of ConstantineConstantine25000Algeria Physics of Matter and Radiation Laboratory(LPMR) Department of Process EngineeringFaculty of Science and TechnologyUniversity Mohamed Cherif MessaadiaSouk Ahras41000Algeria Higher Normal School of Constantine Ali Mendjeli Nouvelle VilleConstantine25000Algeria Laboratoire d’Etude et Recherche sur le Matériau Bois(LERMAB) Ecole Nationale Supérieure des Technologies et Industries du Bois(ENSTIB)University of LorraineEpinal88000France

This research aims to study the bio-adsorption process of two dyes,Cibacron Green H3G(CG-H3G)and Terasil Red(TR),in a single system and to bring them closer to the industrial textile discharge by a binary mixture of two dyes(TR+CG-H3G).The Cockle Shell(CS)was used as a natural *** characterizations of CS were investigated by Fourier transform infrared(FTIR),X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDX)and Brunauer–Emmett–Teller(BET).The adsorption potential of Cockle Shells was tested in two cases(single and binary system)and determined by:contact time(0–60 min),bio-adsorption dose(3–15 g/L),initial concentration(10–300 mg/L),temperature(22–61°C)and pH solution(2–12).The study of bio-adsorption(equilibrium and kinetics)was conducted at 22°*** kinetic studies demon-strated that a pseudo-second-order adsorption mechanism had a good correlation coefﬁcient(R2≥0.999).The Langmuir isotherm modeling provided a well-deﬁned description of TR and CG-H3G bio-adsorption on cockle shells,exhibiting maximum capacities of 29.41 and 3.69 mg/g respectively at 22°*** thermodynamic study shows that the reaction between the TR,CG-H3G dyes molecules and the bio-adsorbent is exothermic,spontaneous in the range of 22–31°C with the aleatory character decrease at the solid-liquid *** study of selectivity in single and binary systems has been performed under optimal operating conditions using the industrial textile rejection pH(pH=6.04).CG-H3G dye is found to have a higher selectivity than TR in single(0–60 min)and binary systems with a range of 6–45 min,as shown by the selectivity *** was discovered that CS has the capability to remove both CG-H3G and TR dyes in both simple and binary systems,making it a superior bio-adsorbent.

关键词： Cockle shells bio-adsorption binary system dyes cibacron green terasil red selectivity

Role of Helicobacter pylori infection and the risk of cholelithiasis

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World Journal of Gastroenterology 2025年第8期31卷 152-154页

作者： Nicolò Fabbri Salvatore Greco antonio Pesce Francesco Virgilio Danila Romeo Carlo V Feo Unit of General Surgery Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Internal Medicine Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Department of Morphology Surgeryand Experimental MedicineUniversity of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Hepato-Biliary Surgery IRCCS San Raffaele HospitalMilan 20132LombardyItaly Local Health Agency of Ferrara Ferrara 44100Emilia-RomagnaItaly

This article aims to deepen the understanding of the role of Helicobacter pylori(***)infection in the development of cholelithiasis,initiated by the article by Yao et al,who investigated the potential link between *** infection and the development of cholelithiasis through a multicenter retrospective study on an Asian population of over 70000 *** also performed a compre-hensive analysis of previously published studies on *** and cholelithiasis,finding a positive association therein[odds ratio(OR)=1.103,P=0.049].Patients positive for *** also had lower levels of total and direct bilirubin,but higher levels of total cholesterol and low-density lipoprotein cholesterol compared to uninfected patients(P<0.05).Cohort studies have confirmed that *** is a risk factor for cholelithiasis(P<0.0001),and aggregate analyses of case-control and cross-sectional studies have shown a positive association between *** and cholelithiasis in Asia(OR=1.599,P=0.034),but not in Europe(OR=1.277,P=0.246).Moreover,*** appears to be related to a higher ratio of choledocho-lithiasis/cholecystolithiasis(OR=3.321,P=0.033).The authors conclude that *** infection is positively correlated with cholelithiasis,particularly with the choledocholithiasis phenotype,especially in Asia,and it is potentially related to bilirubin and cholesterol metabolism.

关键词： Helicobacter pylori Helicobacter pylori infection Cholelithiasis Proton pump inhibitors Choledocholithiasis

Advanced hepatocellular carcinoma treatment strategies:Are transarterial approaches leading the way?

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 22-27页

作者： Stefan Patauner Giovanni Scotton Francesca Notte antonio Frena Department of General and Pediatric Surgery Bolzano Central Hospital-SABESBolzano 39100Trentino-Alto AdigeItaly

Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality worldwide,with advanced stages posing significant treatment ***-though hepatic arterial infusion chemotherapy(HAIC)has emerged as a promising modality for treating advanced HCC,particularly in Asian clinical practice,its adoption in Western medicine remains limited due to a lack of large-scale randomized controlled *** editorial reviews and comments on the meta-analysis conducted by Zhou et al,which evaluates the efficacy and safety of HAIC and its combination strategies for advanced *** authors performed a comprehensive meta-analysis of various clinical trials and cohort studies comparing HAIC and its combinations to other first-line treatments,such as sorafenib and transarterial chemoembolization(TACE).In this work,HAIC showed significantly better results regarding overall survival and progression-free survival compared to sorafenib or TACE alone and their *** in combination with lenvatinib,ablation,programmed cell death 1 inhibitors,and radiotherapy further enhanced patient outcomes,indicating a synergistic *** editorial focuses on the critical role of multimodal treatment strategies in managing advanced *** advocates for a paradigm shift towards integrated treatment approaches to enhance survival rates and improve the quality of life in patients with advanced HCC.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Transarterial chemoembolization Sorafenib Combined therapy

Diagnostic accuracy and cost-effectiveness of the CAR-OLT score in predicting cardiac risk for liver transplantation

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World Journal of Transplantation 2025年第2期15卷 138-148页

作者： Marco Biolato Luca Miele Alfonso W Avolio Giuseppe Marrone antonio Liguori Francesco Galati Anna Petti Lidia Tomasello Daniela Pedicino Antonella Lombardo Alessia D'Aiello Maurizio Pompili Salvatore Agnes antonio Gasbarrini antonio Grieco Department of Medical and Surgical Sciences Centro Malattie Apparato Digerente(CEMAD)Fondazione Policlinico Universitario Agostino GemelliIstituto di Ricerca e Cura a Carattere Scientifico(IRCCS)Rome 00168LazioItaly Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168LazioItaly General Surgery and Liver Transplantation Unit Fondazione Policlinico Universitario Agostino GemelliIstituto di Ricerca e Cura a Carattere Scientifico(IRCCS)Rome 00168LazioItaly Department of Cardiovascular Sciences Fondazione Policlinico Universitario Agostino GemelliIstituto di Ricerca e Cura a Carattere Scientifico(IRCCS)Rome 00168LazioItaly

BACKGROUND The CAR-OLT score predicts major adverse cardiovascular events 1 year after liver transplant(LT).AIM To test the hypothesis that the CAR-OLT score may help avoid cardiac stress tests in LT *** This retrospective single-center cohort study included all adult patients undergoing elective evaluation for first cadaveric donor orthotopic LT for liver cirrhosis with or without hepatocellular carcinoma at Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricerca e Cura a Carattere Scientifico in Rome,*** contraindications for LT listing were defined after a center-specific cardiac workup,which included cardiac stress tests for most *** diagnostic accuracy of the CAR-OLT score was evaluated using the area under the receiver operating characteristic(AUROC)*** A total of 342 LT candidates were evaluated between 2015 and 2019,with a moderate cardiovascular risk profile(37%diabetes,34%hypertension,22%obesity).Of these,80(23%)candidates underwent coronary ***-one(6%)candidates were given cardiac contraindications to LT listing,48%of which were due to coronary artery *** CAR-OLT score predicted cardiac contraindications to LT listing with an AUROC of *** optimal cut-off for sensitivity was a CAR-OLT score≤23,which showed a 99%negative predictive value for cardiac contraindications to LT listing.A total of 84(25%)LT candidates with a CAR-OLT score≤23 underwent 87 non-invasive cardiac tests and 13 coronary angiographies pre-listing,with estimated costs of approximately 48000€.The estimated savings per patient was€574.70 for the Italian National Health *** A CAR-OLT score≤23 can identify LT candidates who can be safely listed without the need for cardiac stress tests,providing time and cost *** findings require external validation.

关键词： Transplantation Coronary artery disease Pharmacoeconomic Listing Major adverse cardiovascular events

Clinical benefits and controversies of jejunostomy feeding in patients undergoing gastrectomy for gastric cancer

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 422-426页

作者： Martino Munini Margot Fodor Alessio Corradi antonio Frena Department of General and Pediatric Surgery Bolzano Central HospitalBolzano 39100Trentino-Alto AdigeItaly

Globally,gastric cancer ranks as the fifth most common malignancy and the third leading cause of cancer-related *** combined with periop-erative chemotherapy is currently the standard of care in locally advanced stages,but the completion rate of multimodal approach is influenced also by patient related *** is a well-known risk factor associated with poor oncological *** perioperative supplementation could lead to an im-provement of the nutritional *** article reviews and comments the retro-spective study conducted by Jaquet et al,which evaluates the impact of enteral nutrition by jejunostomy feeding in patients undergoing gastrectomy for *** authors included 172 patients,35%of whom received *** with optimized biological nutritional parameters(body mass index,albumin,prealbumin)showed reduced major complications(>III),according to the Dindo-Clavien classification,0(0%)vs 8(4.7%)(P=0.05).In the era of multimodal treatment,optimization of nutritional and performance status is integral part of the therapeutic strategy.

Recent Developments in Bioadhesives and Binders

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Journal of Renewable Materials 2025年第2期13卷 199-249页

作者： Hong Lei Xiaojian Zhou antonio Pizzi Guanben Du Xuedong Xi College of Chemistry and Material Engineering Zhejiang A&F UniversityHangzhou311300China Yunnan Key Laboratory ofWood Adhesives and Glued Products College of Material Science and EngineeringSouthwest Forestry UniversityKunming650224China Laboratoire d’Etude et de Recherche sur le MAteriau Bois(LERMAB) University of LorraineBlvd.des AiguillettesNancy54000France

This review is composed of three main parts each of which is written by well-known top specialists that have been,in a way or other,also the main participants of the majority of the developments ***,after a general part covering the grand lines and more in-depth views of more recent tannin,lignin,carbohydrate and soy bioadhesives,somemix of the other bio raw materials with soy protein and soy flour and some other differently sourced bioadhesives for wood,this review presents a more in-depth part on starch-based wood adhesives and a more indepth part covering plant protein-based *** must be kept in mind that the review is focused on completely or almost completely biosourced adhesives,the fashionable adhesives derived from mixes of biosourced materials with synthetic resins having been intentionally *** choice was made as the latter constitute only an intermediate interval,possibly temporary if even for a somewhat long times,towards a final full bioeconomy of scale in this *** review also focuses on more recent results,mainly obtained in the last 10–20 years,thus on adhesive formulations really innovative and sometimes even *** all these fields there is still a lot of possibility of innovation for relevant formulation as this field is still in rapid growth.

关键词： Adhesives wood wood bioadhesives binders oxidized renewable materials carbohydrates starch cellulose lignin tannin vegetal proteins non-isocyanate polyurethanes(NIPU)

Hepatic abscess and hydatid liver cyst:European infectious disease point of view

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World Journal of Hepatology 2025年第2期17卷 310-315页

作者： antonio Giorgio Emanuela Ciracì Massimo De Luca Giuseppe Stella Valentina Giorgio Liver Unit Athena Clinical CenterPiedimonte 81016CasertaItaly Ospedale Civile di Ostuni(BR) Medicina InternaOstuni 72017BrindisiItaly Liver Unit Cardarelli HospitalNaples 80131Italy Department of Pediatric and Women Children and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica Del Sacro CuoreRome 00168Italy

This manuscript is based on a recent study by Pillay et al that was published in *** abscesses can be caused by rare potentially life-threatening infections of either bacterial or parasitic *** incidence rate in Europe is lower than in developing countries,but it is a major complication with high morbidity,particularly in immunocompromised *** are most frequently caused by Enterobacterales infections,but hypervirulent Klebsiella strains are an emerging problem in Western *** has been a public health problem in Europe,primarily imported from other endemic *** the same time,this infection is becoming an emerging disease,as the number of infected patients who have not traveled to endemic areas is *** options for hydatid liver cyst include chemotherapy,open or laparoscopic surgery,percutaneous treatment(percutaneous aspiration,re-aspiration and injection and its modification)and“wait and watch”*** hydatid liver cyst patients in Pillay et al’s study received surgical treatment,but several studies have confirmed the safety and efficacy of percutaneous aspiration,re-aspiration and injection.

关键词： Hepatic abscess Liver cystic echinococcosis Ultrasound-guided intervention Klebsiella pneumoniae Percutaneous aspiration Amoebic liver abscess Hypervirulent pathogens