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Role of brain-derived neurotrophic factor during the regenerative response after traumatic brain injury in adult zebrafish

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Neural Regeneration Research 2018年第6期13卷 941-944页

作者： Pietro Cacialli antonio palladino Carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Several mammalian animal models of traumatic brain injury have been used, mostly rodents. However, reparative mechanisms in mammalian brain are very limited, and newly formed neurons do not survive for long time. The brain of adult zebrafish, a teleost fish widely used as vertebrate model, possesses high regenerative properties after injury due to the presence of numerous stem cells niches. The ventricular lining of the zebrafish dorsal telencephalon is the most studied neuronal stem cell niche because its dorso-lateral zone is considered the equivalent to the hippocampus of mammals which contains one of the two constitutive neurogenic niches of mammals. To mimic TBI, stab wound in the dorso-lateral telencephalon of zebrafish was used in studies devoted to fish regenerative properties. Brain-derived neurotrophic factor, which is known to play key roles in the repair process after traumatic brain lesions, persists around the lesioned area of injured telencephalon of adult zebrafish. These results are extensively compared to reparative processes in rodent brain. Considering the complete repair of the damaged area in fish, it could be tempting to consider brain-derived neurotrophic factor as a factor contributing to create a permissive environment that enables the establishment of new neuronal population in damaged brain.

关键词： brain-derived neurotrophic factor neurotrophins neurotrophic factors brain telencephalon teleost fish traumatic brain injury lesion neurons

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Quality of bowel preparation in patients with inflammatory bowel disease undergoing colonoscopy:What factors to consider?

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World Journal of Gastrointestinal Endoscopy 2023年第3期15卷 133-145页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Mario Romeo Giovanna palladino Marina Cipullo Giorgia Iadanza Simone Olivieri Giuseppe Zagaria Nicola De Gennaro antonio Santonastaso Marco Romano Alessandro Federico Department of Precision Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy

An adequate bowel preparation in patients with inflammatory bowel disease(IBD)is a prerequisite for successful colonoscopy for screening,diagnosis,and *** bowel preparation formulations are available,both high-and low-volume based on polyethylene ***,low-volume formulations are also based on several compounds such as magnesium citrate preparations with sodium picosulphate,oral sulphate solution,and oral sodium phosphatebased *** studies on the quality of bowel preparation prior to colonoscopy in the IBD population are still required,with current evidence from existing studies being *** frontiers are also moving towards the use of alternatives to anterograde ones,using preparations based on retrograde colonic lavage.

关键词： Bowel preparation Colonoscopy Inflammatory bowel disease Crohn’s disease Ulcerative colitis Artificial intelligence

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