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Quantum hydrodynamics of a single particle

Light(Science & Applications) 2020年第1期9卷 1199-1205页

作者： Daniel Gustavo Suarez-Forero Vincenzo Ardizzone Saimon Filipe Covre da Silva Marcus Reindl antonio Fieramosca Laura Polimeno Milena De Giorgi Lorenzo Dominici Loren N.Pfeiffer Giuseppe Gigli Dario Ballarini Fabrice Laussy Armando Rastelli daniele Sanvitto CNR NANOTEC Institute of NanotechnologyCampus EcotekneVia Monteroni73100 LecceItaly Dipartimento di Ingegneria dell’Innovazione Universita del SalentoCampus Ecoteknevia Monteroni73100 LecceItaly Institute of Semiconductor and Solid State Physics Johannes Kepler UniversityAltenbergerstr.69Linz 4040Austria Dipartimento di Matematica e Fisica E.De Giorgi Universita del SalentoCampus Ecoteknevia MonteroniLecce 73100Italy PRISM Princeton Institute for the Science and Technology of MaterialsPrinceton UniversityPrincetonNJ 08540USA Faculty of Science and Engineering University of WolverhamptonWulfruna StreetWolverhampton WV11LYUK Russian Quantum Center Novaya 100143025 SkolkovoMoscow RegionRussia

Semiconductor devices are strong competitors in the race for the development of quantum computational *** this work,we interface two semiconductor building blocks of different dimensionalities with complementary properties:(1)a quantum dot hosting a single exciton and acting as a nearly ideal single-photon emitter and(2)a quantum well in a 2D microcavity sustaining polaritons,which are known for their strong interactions and unique hydrodynamic properties,including ultrafast real-time monitoring of their propagation and phase *** the present experiment,we can thus observe how the injected single particles propagate and evolve inside the microcavity,giving rise to hydrodynamic features typical of macroscopic systems despite their genuine intrinsic quantum *** the presence of a structural defect,we observe the celebrated quantum interference of a single particle that produces fringes reminiscent of wave *** this behavior could be theoretically expected,our imaging of such an interference pattern,together with a measurement of antibunching,constitutes the first demonstration of spatial mapping of the self-interference of a single quantum particle impinging on an obstacle.

关键词： quantum particle hydrodynamic

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Hyper accuracy three-dimensional virtual anatomical rainbow model facilitates surgical planning and safe selective clamping during robot-assisted partial nephrectomy

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Asian Journal of Urology 2024年第4期11卷 660-665页

作者： Francesco Ditonno antonio Franco Celeste Manfredi daniele Amparore Enrico Checcucci Marco De Sio Alessandro Antonelli Cosimo De Nunzio Cristian Fiori Francesco Porpiglia Riccardo Autorino Department of Urology Rush UniversityChicagoILUSA Department of Urology Azienda Ospedaliera Universitaria Integrata VeronaUniversity of VeronaVeronaItaly Department of Urology Sant'Andrea HospitalSapienza UniversityRomeItaly Unit of Urology Department of WomanChild and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”NaplesItaly Division of Urology Department of OncologyUniversity of TurinSan Luigi Gonzaga HospitalOrbassanoTurinItaly

ObjectiveTo highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).MethodsA transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass(R.E.N.A.L nephrometry score 7A).An abnormal vasculature was observed,with a single renal vein and two right renal arteries originating superiorly to the vein and anterior,when dividing in their segmental *** to the hyper accuracy 3D(HA3D^(®))rainbow model(MEDICS Srl,Turin,Italy),one branch belonging to one of the segmental arteries was feeding the *** allowed for an accurate prediction of the area vascularized by each arterial *** 3D model was included in the intraoperative console view during the whole procedure,using the TilePro feature.A step-by-step explanation of the procedure is provided in the video attached to the present *** operative time was 90 min with a warm ischemia time on selective clamping of 13 *** blood loss was 180 *** intraoperative complication was encountered and no drain was placed at the end of the *** patient was discharged on postoperative Day 2,without any early postoperative *** final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical *** present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective *** shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps,and to safely adopt a“selective”clamping strategy that can translate in minimal functional impact.

关键词： Hyper accuracy three-dimensional rainbow model Augmented reality Clear cell renal cell carcinoma Robot-assisted partial nephrectomy Selective clamping

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Editorial article to:Animal experimental study on magnetic anchor technique-assisted endoscopic submucosal dissection of early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 51-54页

作者： Enrico Fiori Antonietta Lamazza daniele Crocetti antonio V Sterpetti Department of Surgery Sapienza University of RomeRome 00161Italy Department of Surgery University of Rome La SapienzaRome 00161Italy

In this editorial we comment on the article published in the recent issue of the World Journal of Gastrointestinal Endoscopy 2023;15(11):*** cancer(GC)remains the fifth most common malignancy and the fourth leading cause of cancer-related death *** overall prevalence of GC has declined,although that of proximal GC has increased over ***,a significant proportion of GC cases and deaths can be avoided if preventive interventions are *** GC(EGC)is defined as GC confined to the mucosa or *** resection is considered the most appropriate treatment for precancerous gastrointestinal lesions improving patient quality of life,with reduced rates of complications,shorter hospitalization period,and lower costs when compared to surgical *** mucosal resection(EMR)and endoscopic sub-mucosal dissection(ESD)are representative endoscopic treatments for EGC and precancerous gastric *** EMR implies injection of a saline solution into the sub-mucosal space,followed by excision of the lesion using a *** resection rates vary depending on the size and severity of the *** using conventional EMR methods for lesions less than 1 cm in size,the complete resection rate is approximately 60%,whereas for lesions larger than 2 cm,the complete resection rate is low(20%-30%).ESD can be used to remove tumors exceeding 2 cm in diameter and lesions associated with ulcers or submucosal *** with EMR,ESD has higher en bloc resection rates(90.2%vs 51.7%),higher complete resection rates(82.1 vs 42.2%),and lower recurrence rates(0.65%vs 6.05%).Thus,innovative techniques have been introduced.

关键词： Gastric cancer Early gastric cancer Endoscopic resection Endoscopic mucosal resection Endoscopic sub-mucosal dissection

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Hydroxytyrosol But Not Resveratrol Ingestion Induced an Acute Increment of Post Exercise Blood Flow in Brachial Artery

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Health 2016年第15期8卷 1766-1777页

作者： Giorgia Sarais antonio Crisafulli daniele Concu Andrea Fois Abdallah Raweh Alberto Concu Department of Life and Environmental Sciences University of Cagliari Cagliari Italy Laboratory of Sports Physiology University of Cagliari Cagliari Italy IIC Technologies Ltd. Cagliari Italy EventFeel Ltd. Cagliari Italy Medical Sciences Faculty The LUdeS Foundation Higher Education Institution Kalkara Malta

The aim of this study was to test if previous ingestion of compounds containing resveratrol or hydroxytyrosol, followed by an exhausting hand grip exercise, could induce an acute post-exercise increase in brachial blood flow. Six healthy subjects (three males and three females, 35 ± 7 years), 60 minutes after ingestion of a capsule containing 200 mg of resveratrol or 30 ml of extra virgin olive oil enriched with tyrosol, oleuropein and hydroxytyrosol, performed a hand grip exercise equal to half of their maximum strength until they were no longer able to express the same force (2-day interval between tests). The nonparametric Wilcoxon signed rank test was used for statistical evaluations. Brachial artery blood flow (Fba) and both blood velocity (Vba) and artery diameter (Dba) were assessed immediately after exercise cessation by means of colour Doppler ultrasound. After ingestion of the oil mixture the post-exercise value of Fba median was 2.4 times higher than that after ingestion of the resveratrol compound (P = 0.03), and also the Vba median concerning the hydroxytyrosol was 1.9 times higher than that of the resveratrol (P = 0.03). Both functional foods did not lead to a significant difference in the Dba medians. These results indicate that hydroxytyrosol, but not resveratrol, may be an effective adjuvant of recreational or agonistic, long-lasting sports performances, thanks to the powerful blood flow increment which can be obtained as soon as one hour from its oral intake.

关键词： Functional Foods Hydroxytyrosol Resveratrol Hand Grip Blood Flow

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Impact of neoadjuvant multimodal therapy in the setting of locally advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第28期30卷 3452-3455页

作者： daniele Ferraro Federica Falaschi Luca Nazzaro Giovanni Vennarecci Hepato-biliary and Liver Transplant Centre Department of General Surgery and Woman’s HealthAORN Antonio CardarelliNaples 80131Italy

Immunotherapy and the implementation of more aggressive treatment schemes for locally advanced hepatocellular carcinomas have expanded the boundaries of curative *** of these advancements,patients who were once consid... 详细信息

关键词： Hepatocellular carcinoma Immunotherapy Radioembolization Chemoembolization Liver transplantation Liver resection

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Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis:A prospective study

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World Journal of Gastroenterology 2021年第30期27卷 5112-5125页

作者： Mar Riveiro-Barciela Cristina Marcos-Fosch Fernando Martinez-Valle Fabrizio Bronte Olimpia Orozco Isidro Sanz-Pérez daniele Torres Maria-Teresa Salcedo Salvatore Petta Rafael Esteban antonio Craxi Maria Buti Department of Medicine of the UAB Hospital Universitari Vall d’HebronBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos IIIMadrid 28029Spain Systemic Autoimmune Diseases Unit Internal Medicine DepartmentHospital Universitari Vall d'HebronBarcelona 08035Spain Sezione di Gastroenterologia Di.Bi.M.I.SUniversity of PalermoPalermo 90133Italy Pathology Department Hospital Universitari Vall d'HebronBarcelona 08035Spain

BACKGROUND There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus,but there is scarce data on hepatitis B virus *** hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen(HBeAg)negative *** To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy *** Prospective case-control collaborative study conducted in two tertiary *** hundred and two subjects prospectively recruited at the outpatient clinic were included from May 2016 to April 2017:201 naïve HBeAg-negative hepatitis B virus-infected[49 chronic hepatitis B(CHB)and 152 inactive carriers(ICs)]and 201 healthy *** and metabolic measures,liver stiffness and carotid Doppler ultrasound were *** atherosclerosis was established on an intima-media thickness increase of≥1.2 mm and/or the presence of carotid *** distributed quantitative variables were compared with the Student t test and those with a non-normal distribution with the Mann-Whitney U *** variables were compared between groups using theχ2 or Fisher exact *** Carotid plaques were found more often in CHB(32.7%)than ICs(17.1%)or controls(18.4%)(P=0.048).Subclinical atherosclerosis was also increased in CHB(40.8%)vsICs(19.1%)or controls(19.4%)(P=0.003).No differences in the risk of atherosclerosis were observed between controls and *** factors independently associated with the presence of carotid plaques were age[odds ratio(OR)1.43,P<0.001]and CHB(OR 1.18,P=0.004)and for subclinical atherosclerosis,age(OR 1.45,P<0.001),CHB(OR 1.23,P<0.001)and diabetes(OR 1.13,P=0.028).In the subset of young subjects(<50 years),carotid plaques(12.5%vs 1.1%,P=0.027)and subclinical atherosclerosis(12.5%vs 2.2%,P=0.058

关键词： Hepatitis B virus Carotid plaques Subclinical atherosclerosis Cardiovascular risk Endothelial dysfunction Intima-media thickness

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Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

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Health 2013年第7期5卷 1-6页

作者： Flavio RRomero Luis GDucati Marco AZanini daniele CCataneo antonio JMCataneo Roberto CGabarra Neurosurgeon at Hospital das Clínicas de Botucatu-UNESP BotucatuBrazil Neurosurgery at Sao Paulo State University Medical School BotucatuBrazil Thoracic Surgery at Sao Paulo State University Medical School BotucatuBrazil

Aim: The interest of inflammatory marker increased in the last years, even in preventing clinical outcome after subarachnoid hemorrhage (SAH). Our objective was to study the relationships between C-reactive protein levels and clinical outcome and the development of cerebral vasospasm after aneurismal SAH. Methods: One hundred adult patients with aneurismal SAH were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, transcranial doppler (TCD) and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on daily between admission and 10th days. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to predict outcome. Results: A progressive increase in the CRP levels from the admission to the 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS and mRS scores on discharge and CRP levels. Conclusion: Increased CRP levels were strongly associated with poor clinical outcome. CRP levels can predict cerebral vasospasm and delayed ischemic deficits with higher statistic significance. There are relationships between hemodynamic chances in TCD and higher CRP levels.

关键词： Intracranial Vasospasm Subarachnoid Hemorrhage C Protein Intracranial Aneurism

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World Journal of Clinical Cases 2022年第19期10卷 6370-6384页

作者： Daniela Chieffo Carla Avallone Annamaria Serio Georgios Demetrios Kotzalidis Marta Balocchi Ilaria De Luca daniele Hirsch Angela Gonsalez del Castillo Pierluigi Lanzotti Giuseppe Marano Lucio Rinaldi antonio Lanzone Eugenio Mercuri Marianna Mazza Gabriele Sani Service of Clinical Psychology Catholic University of Sacred HeartRome 00168Italy Department of Neurosciences Catholic University of Sacred HeartRome 00168Italy Department of Obstetrics and Gynaecology Catholic University of Sacred HeartRome 00168Italy Paediatric Neurology Unit Catholic University of Sacred HeartRome 00168Italy Department of Geriatrics Neuroscience and OrthopedicsFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic impacted in a still undefined way pregnant women’s mental *** are reports of mood and affect changes in the general population and the suggestion that similar changes occur also in the pregnant *** greater vulnerability of women during the COVID-19 restriction period may translate into a greater risk for mental disorders in the gestational *** hypothesised that pregnant women in the prepandemic period would have less psychopathology and more psychological support than pregnant women during the pandemic restriction *** To compare pregnant women for anxiety,prenatal depression,psychopathology,and social support before and after the awareness of the *** administered to women willing to participate in their 2nd-3rd trimesters of pregnancy theEdinburgh Postnatal Depression Scale(EPDS),the State-Trait Anxiety Inventory Form Y(STAI-Y),and the Symptom CheckList-90-Revised(SCL-90R);we further collected sociodemographicvariables and explored women’s social *** comparison was *** firstsample was termed nonCOVID-19 because data were gathered before the COVID-19 outbreak(January 2020-February 2020)was declared,and the second sample termed COVID-19 becauseparticipants were already subjected to the COVID-19-related restrictive measures(January 2021-February 2021).Since normal distribution was not met(Shapiro-Wilk test applied),we appliednonparametric Mann-Whitney’s U-test to compare psychometric *** standards were *** nonCOVID-19 group reported higher support from partners only,while the COVID-19 groupreported multiple support(χ^(2)=9.7181;P=0.021);the nonCOVID-19 group scored higher than theCOVID-19 group only on state anxiety among psychometric scales[STAI-Y1,nonCOVID-19median=39(95%CI:39.19-51.10)vs COVID-19 median=32(95%CI:30.83-38.90);Mann-Whitney’sU=117.5,P=0.00596].Other measures did not differ meaningfully between the two gr

关键词： COVID-19 pandemic Pregnancy Social Support Anxiety Depression Psychopathology

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The duration of the conventional chemoembolization for hepatocellular carcinoma:factors affecting the procedural time

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Hepatoma Research 2022年第1期8卷 313-326页

作者： Matteo Renzulli Mattia Gentilini Giovanni Marasco Nicolo Brandi Alessandro Granito Silvia Lo Monaco Anna Maria Ierardi antonio De Cinque Francesco Tovoli Laura Bartalena daniele Spinelli Fabio Piscaglia Rita Golfieri Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Internal Medicine and Digestive Physiopathology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Division of Internal Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Diagnostic and Interventional Radiology Department Fondazione IRCCS CàGranda Ospedale Maggiore PoliclinicoUniversitàdegli Studi di Milano MilanMilan 20122Italy

Aim:The present study evaluated the duration of chemoembolization in patients with hepatocellular carcinoma,analyzing possible factors affecting the procedural ***:In total,175 patients who underwent chemoembolization have been prospectively *** procedural length was considered the time between the insertion and the removal of the angiographic *** features related to the tumor burden and angiographic procedures,which could be related to the procedural time,were ***:The chemoembolization time resulted in a mean of 58.1 *** longer procedural time was associated with a number of nodules treated per patient≥2(P<0.001),a number of segments with nodules≥2(P<0.001),the presence of more than 1 nodule in the same segment(P<0.001),the location of the tumor in the left lobe(P=0.001),the exclusion from the Milan criteria(P<0.001),and a number of segments treated≥2(P<0.001).Only the number of nodules treated per patient resulted significantly in multivariate analysis(OR 2.927,95%CI:2.015-4.251,P<0.001).Conclusion:The factors related to longer procedural time are the number of nodules treated≥2,the number of segments with nodules≥2,the involvement of the left lobe,the tumor burden outside the Milan criteria,and the number of segments treated≥*** these characteristics,known in the pre-procedural phase,represent useful tools for a correct planning of the angiographic room’s workflow during the pandemic era as well as in the future to reduce downtime and increase productivity.

关键词： Chemoembolization hepatocellular carcinoma procedural time angiographic room management

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Effects of Unsaturated Fatty Acid Esters of Testosterone on Neuronal, Behavioral and Hormonal Parameters in Male Rats Subjected to the Formalin Test

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Open Journal of Endocrine and Metabolic Diseases 2014年第6期4卷 167-179页

作者： Anna Petroni Paolo Fiorenzani Valentina Tomei antonio Garofalo Francesca Aiello daniele Della Seta antonio Giordano Stella Vodo Ilaria Ceccarelli Anna Maria Aloisi Department of Medicine Surgery and Neuroscience University of Siena Siena Italy Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy Department of Pharmacy and Health Nutrition Sciences University of Calabria Rende Italy

Chronic diseases are often accompanied by inflammatory and degenerative processes. Estrogens have repeatedly been found to be involved in these processes. Testosterone (T) is the main precursor of estrogen in the brain and T replacement in chronic diseases has become important in recent years, prompting research on new T-conjugated molecules. We recently synthesized three new molecules including unsaturated fatty acid esters: T-linoleate (TL), T-oleate (TO) and T-eicosapentanoate (TEPA). These substances were s.c. administered for 7 days to intact male rats subjected to the formalin test (FT). Three other groups were included as comparisons: NAIVE, receiving no substance, OIL, treated with almond oil (vehicle), and TN, treated with T-undecanoate, a?saturated?fatty acid. Spontaneous behaviors and pain-induced responses were determined during the FT, hormones (T and dihydrotestosterone, DHT) were determined in blood, while estrogen receptors (ERα?and?β) were detected at the genomic and proteomic levels in the hippocampus, hypothalamus and spinal cord. In the hippocampus, ERα?and ERβ?mRNA levels were increased respectively by TN and TL treatments with respect to OIL, whereas the hypothalamus TO and TL caused a decrease of ERα?mRNA levels. At the proteomic level, TO, TL and TEPA decreased the levels of ERα?in the hypothalamus, whereas TEPA decreased ERβ?in the spinal cord, hippocampus and hypothalamus. There was no effect of treatment on the spontaneous behaviors, while the TO and TL groups showed lower pain-induced behaviors (paw jerk frequency and licking duration) than the OIL group. TN increased paw jerk frequency and decreased licking duration with respect to OIL. The treatments had no effect on T and DHT plasma levels. These results clearly indicate the possibility of pain and ER modulation by T-esters.

关键词： Testosterone CNS Fatty Acids Pain Estrogen Receptors

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