检索结果-南通市图书馆

Prevalence and Determinants of Kidney markers among subjects with Hepatitis C Virus Infection

Open Journal of Nephrology 2020年第2期10卷 85-101页

作者： mathurin Pierre Kowo sylvain Raoul simeni Njonnou murielle sonia mehly Ngninzeko Firmin Ankouane Andoulo antonin ndjitoyap ndam.m.chelle tagny s.rtre Vicky Ama moor Jeanne Ngongang François Folefack Kaze Department of Internal medicine and specialty Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Yaounde University Teaching Hospital Yaoundé Cameroon Department of Internal medicine and specialty Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Higher Institute of Health sciences Université des Montagnes Bangangté Cameroon medical Centre “La Cathédrale” Yaoundé Cameroon Department of Physiological sciences and Biochemistry Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction: Hepatitis C virus (HCV) infection is a worldwide public health problem with multisystemic involvements including kidneys. We assessed the prevalence and determinants of kidney markers among HCV infected ... 详细信息

strong>Introduction:strong> Hepatitis C virus (HCV) infection is a worldwide public health problem with multisystemic involvements including kidneys. We assessed the prevalence and determinants of kidney markers among HCV infected subjects. strong>methods:strong> A cross-sectional study was conducted from march to July 2017 in two referral centers in Yaoundé. sociodemographic, clinical and paraclinical data were collected from patient’s records. Renal involvement was evaluated using estimated glomerular filtration rate (eGFR) by modification of Diet in Renal Disease’s (mDRD) equation, urine dipstick and albumin/creatinine ratio (ACR). An eGFR mL/min/1.73 msup>2sup> was defined as low and reduced respectively. Albuminuria was defined by an ACR > 30 mg/g and divided into A1 (mg/g), A2 (30 - 300 mg/g) and A3 (>300 mg/g). strong>Results:strong> We included 65 (41.5% males) HCV infected patients with a mean age of 56.8 ± 10.5 years. HCV infection was diagnosed for more than 5 years in 54 (83.1%) patients. HCV viral load and genotype were available in 40 (61.5%) patients;viral load was high (>5.9 logs/mL) in 20 (50%) of them and genotypes 4 (40%), 1 (32.5%) and 2 (27.5%) were found in this population. The mean eGFR was 112.9 ± 31.9 mL/min/1.73 msup>2sup> with 14 (21.5%) and 4 (6.2%) patients having reduced and low eGFR respectively. Albuminuria (80%), leukocyturia (24.6%) and hematuria (4.6%) were the observed dipstick abnormalities. median albuminuria (IQR) was 542.4 (238.7 - 961.5) mg/g, with 7 (11%), 12 (18%) and 46 (71%) patients in A1, A2 and A3 respectively. Reduced/low eGFR and albuminuria were observed in 58 (89.2%) patients while low eGFR and albuminuria were found in 55 (84.6%) patients. Advanced age, female gender, HCV genotype 1 and 4, and albuminuria (all p ssociated with eGFR reduction. strong>Conclusion:strong> Renal abnormalities are common in HCV infected patients leading by proteinuria and decr

关键词： Hepatitis C Virus Chronic Kidney Disease Prevalence sub-saharan Africa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：