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Probabilistic Quantitative Temporal Constraints:Representing,Reasoning,and Query Answering

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Journal of Electronic Science and Technology 2018年第1期16卷 1-10页

作者： Paolo Terenziani antonella Andolina Dipartimento di Scienze e Innovazione Tecnologica University of Eastern PiedmontAlessandria 15121 Istituto Tecnico Commerciale Sommeiller Torino 10129

In many applications and domains,temporal constraints between actions, and their probabilities play an important role. We propose the first approach in the literature coping with probabilistic quantitative constraints. To achieve such a challenging goal, we extend the widely used simple temporal problem(STP) framework to consider ***,we propose i) a formal representation of probabilistic quantitative constraints, ii) an algorithm,based on the operations of intersection and composition,for the propagation of such temporal constraints, and iii) facilities to support query answering on a set of such constraints. As a result, we provide users with the first homogeneous method supporting the treatment(representing,reasoning,and querying) of probabilistic quantitative constraints, as required by many applications and domains.

关键词： Artificial intelligence(AI) probabilities query answering quantitative temporal constraints temporal reasoning

The intricate debate on neurodegeneration and neuroinflammation in Parkinson’s disease:which came first?

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Neural Regeneration Research 2023年第1期18卷 125-126页

作者： antonella Cardinale Valeria Calabrese Experimental Neurophysiology Laboratory IRCCS San Raffaele RomaRomeItaly Department of Medicine Universitàdegli Studi di PerugiaPerugiaItaly

Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this *** principal hallmarks of PD are the loss of dopaminergic neurons in the substan... 详细信息

关键词： inflammation aggregation debate

Continuous dynamic monitoring of a centenary iron bridge for structural modification assessment

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 26-41页

作者： Carmelo GENTILE antonella SAISI Department of Architecture Built environment and Construction engineering (ABC) Piazza Leonardo da Vinci 32 Milan 20133Italy

A multi-channel continuous dynamic monitoring system has been installed in a centenary iron arch bridge on late November 2011. The historic infrastructure, completed in 1889 and crossing the Adda river about 50 km far from Milan, is the most important monument of XIX century iron architecture in Italy and is still used as roadway and railway bridge. The monitoring project follows a series of preliminary ambient vibration tests carried out on the bridge since June 2009. The paper describes the bridge structure and its dynamic characteristics identified from the experimental studies developed since 2009, the installed monitoring system and the software developed in LabVIEW for automatically processing the collected data. Subsequently, the tracking of automatically identified natural frequencies over a period of about 18 months is presented and discussed, highlighting the effects of environmental and operational conditions on the bridge dynamic characteristics as well as the detection of structural changes, mainly based on natural frequencies shifts.

关键词： automated modal identification continuous dynamic monitoring environmental/operational effects iron arch bridge structural health monitoring

100 years of high GEM concentration in the Central Italian Herbarium and Tropical Herbarium Studies Centre(Florence,Italy)

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Journal of Environmental Sciences 2020年第1期32卷 377-388页

作者： Jacopo Cabassi Valentina Rimondi Zhang Yeqing antonella Vacca Orlando Vaselli antonella Buccianti Pilario Costagliola Department of Earth Sciences University of FlorenceVia G.La Pira4-50121 FlorenceItaly CNR-Institute of Geosciences and Earth Resources Via G.La Pira4-50121 FlorenceItaly

Up to 1980 s,the most used preservative for herbaria specimens was HgCl2,sublimating at ambient air conditions;ionic Hg then reduces to Hg0(gaseous elemental mercury,GEM)and diffuses throughout poor ventilated *** GEM levels may indeed persist for decades,representing a health *** this study,we present new GEM data from the Central Italian Herbarium and Tropical Herbarium Studies Centre of the University of Florence(Italy).These herbaria host one of the largest collection of plants in the ***,HgCl2 was documented as plant preservative up to the 1920 *** surveys were conducted in July 2013 and July and December 2017,to account for temporal and seasonal *** show GEM concentrations well above those of external locations,with peak levels within specimen storage cabinets,exceeding 50,000 ng/*** concentrations up to^7800 ng/m3 were observed where the most ancient collections are stored and no ventilation systems were *** the contrary,lower GEM concentrations were observed at the first ***,lower and more homogeneously distributed GEM concentrations were measured in 2017 than in 2013 since the air-conditioning system was updated in *** concentrations were similar to other herbaria worldwide and lower than Italian permissible exposure limit of 20,000 ng/m3(8-hr working day).Our results indicate that after a century from the latest HgCl2 treatment GEM concentrations are still high,i.e.,the treatment itself is almost *** conditioning and renewing is probably the less expensive and more effective method for GEM lowering.

关键词： Gaseous elemental mercury(GEM) Mercuric chloride Herbaria Florence Health safety

Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： antonella Antonelli Carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

HOMOCLINIC SOLUTIONS OF NONLINEAR LAPLACIAN DIFFERENCE EQUATIONS WITHOUT AMBROSETTI-RABINOWITZ CONDITION

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Acta Mathematica Scientia 2021年第3期41卷 712-718页

作者： antonella NASTASI Stepan TERSIAN Calogero VETRO University of Palermo Department of Mathematics and Computer ScienceVia Archirafi 3490123PalermoItaly Institute of Mathematics and Informatics Bulgarian Academy of Sciences1113 SofiaBulgaria

The aim of this paper is to establish the existence of at least two non-zero homoclinic solutions for a nonlinear Laplacian difference equation without using AmbrosettiRabinowitz type-conditions. The main tools are mo... 详细信息

关键词： Difference equations homoclinic solutions non-zero solutions (p,q)-Laplacian operator

Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease?

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World Journal of Gastroenterology 2014年第28期20卷 9217-9228页

作者： antonella Scalerar Giovanni Tarantino Department of Clinical Medicine and Surgery Federico Ⅱ University Medical School of Naples National Cancer Institute "Pascale Foundation"IRCS

It was estimated that from 2002 to 2008 the risk of developing cancer increased a quarter-fold in men and two-fold in women due to excessive BMI. Obesity, metabolic syndrome and type 2 diabetes mellitus are strictly related and are key pathogenetic factors of non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease worldwide. The most important consequence of the “metabolic epidemics” is the probable rise in the incidence of hepatocarcinoma (HCC), and NAFLD is the major causative factor. Adipose tissue is not merely a storage organ where lipids are preserved as an energy source. It is an active organ with important endocrine, paracrine, and autocrine actions in addition to immune functions. Adipocytes produce a wide range of hormones, cytokines, and growth factors that can act locally in the adipose tissue microenvironment and systemically. In this article, the main roles of insulin growth factor (IGF)-1 and IGF-2 are discussed. The role of IGF-2 is not only confined to HCC, but it may also act in early hepato-carcinogenesis, as pre-neoplastic lesions express IGF-2 mRNA. IGF-1 and IGF-2 interact with specific receptors (IGF-1R and IGF-2R). IGF-1R is over-expressed in in vitro and in animal models of HCC and it was demonstrated that IGF ligands exerted their effects on HCC cells through IGF-1R and that it was involved in the degeneration of pre-neoplastic lesions via an increase in their mitotic activity. Both IGF-2R and TGF β, a growth inhibitor, levels are reduced in human HCC compared with adjacent normal liver tissues. Another key mechanism involves peroxisome proliferator-activated receptor (PPAR)γ. In in vitro studies, PPARγ inhibited various carcinomas including HCC, most probably by regulating apoptosis via the p21, p53 and p27 pathways. Finally, as a clinical consequence, to improve survival, efforts to achieve a “healthier diet” should be promoted by physicians and politicians.

关键词： Hepatocarcinoma Non-alcoholic fatty liver disease Insulin growth factor Peroxisome proliferatoractivated receptor γ Adipokines

Growing and aging of hematopoietic stem cells

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World Journal of Stem Cells 2021年第6期13卷 594-604页

作者： Ion Udroiu antonella Sgura Department of Science Roma Tre UniversityRome 00146Italy

In the hematopoietic system, a small number of stem cells produce a progeny ofseveral distinct lineages. During ontogeny, they arise in the aorta-gonadmesonephrosregion of the embryo and the placenta, afterwards colonise the liverand finally the bone marrow. After this fetal phase of rapid expansion, thenumber of hematopoietic stem cells continues to grow, in order to sustain theincreasing blood volume of the developing newborn, and eventually reaches asteady-state. The kinetics of this growth are mirrored by the rates of telomereshortening in leukocytes. During adulthood, hematopoietic stem cells undergo avery small number of cell divisions. Nonetheless, they are subjected to aging,eventually reducing their potential to produce differentiated progeny. The causalrelationships between telomere shortening, DNA damage, epigenetic changes,and aging have still to be elucidated.

关键词： Bone marrow Fetus Growth and development Hematopoietic stem cells Leukemia Liver

The coexistence of fast and slow diffusion processes in the life cycle of Aedes aegypti mosquitoes

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International Journal of Biomathematics 2021年第1期14卷 73-103页

作者： antonella Lupica Annunziata Palumbo Engineering School DEIm DepartmentUniversity of TusciaLargo dell’Università01100 ViterboItaly

A new model that describes the life cycle of mosquitoes of the species Aedes aegypti,main carriers of vector-borne diseases,is *** novelty is to include in the model the coexistence of two independent diffusion processes,one fast which obeys the constitutive Fick’s law,the other slow which satisfies the Cattaneo evolution *** analysis of the corresponding ODE model shows the overall stability of the Mosquitoes-Free Equilibrium(MFE),together with the local stability of the other equilibrium point admitted by the *** wave type solutions have been investigated,providing an estimate of the minimal speed for which there are monotone waves that connect the homogeneous equilibria allowed by the system.A special section is dedicated to the analysis of the hyperbolic model obtained neglecting the fast diffusive *** particular case is suitable to describe the biological process as it overcomes the paradox of infinite speed propagation,typical of parabolic *** numerical simulations compare the existing models in the literature with those presented in this discussion,showing that although the generalized model is parabolic,the associated wave velocity admits upper bound represented by the speed of the waves linked to the classic parabolic model present in the published literature,so the presence of a slow flux together with a fast one slows down the speed with which a population spreads.

关键词： Population growth reaction-diffusion equation stability traveling wave