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Towards an understanding of Type Ia supernovae from a synthesis of theory and observations

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Frontiers of physics 2013年第2期8卷 116-143页

作者： W. Hillebrandt M. Kromer F. K. Ropke A. J. ruiter Max-Planck-Institut fiir Astrophysik Karl-Schwarzschild-Str. 1 D-85741 Garching Germany Institut fiir Theoretische Physik und Astrophysik Universit~it Wiirzburg Am Hubland D-97074 Wiirzburg Germany

Motivated by the fact that calibrated light curves of Type Ia supernovae （SNe Ia） have become a major tool to determine the expansion history of the Universe, considerable attention has been given to, both, observations and models of these events over the past 15 years. Here, we summarize new observational constraints, address recent progress in modeling Type Ia supernovae by means of three-dimensional hydrodynamic simulations, and discuss several of the still open questions. It will be be shown that the new models have considerable predictive power which allows us to study observable properties such as light curves and spectra without adjustable non-physical parameters. This is a necessary requisite to improve our understanding of the explosion mechanism and to settle the question of the applicability of SNe Ia as distance indicators for cosmology. We explore the capabilities of the models by comparing them be applied to study the origin of the diversity with observations and we show how such models can of SNe Ia.

关键词： supernovae nucleosynthesis stellar evolution binary and multiple stars nuclearreactions

Opportunistic screening for atrial fibrillation with a single lead device in geriatric patients

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Journal of Geriatric Cardiology 2020年第3期17卷 149-154,I0008页

作者： Lennaert AR Zwart Rene WMM Jansen Jacob H ruiter Tjeerd Germans Suat Simsek Martin EW Hemels department of Geriatric Medicine North West ClinicsWilhelminalaanAlkmaarthe Netherlands department of Geriatric Medicine Dijklander HospitalMaelsonstraatHoornthe Netherlands department of Cardiology North West ClinicsWilhelminalaanAlkmaarthe Netherlands department of Internal Medicine North West ClinicsWilhelminalaanAlkmaarthe Netherlands department of Cardiology Rijnstate HospitalArnhemthe Netherlands department of Cardiology Radboud University Medical CentreGeert Grooteplein ZuidNijmegenthe Netherlands

Objective To determine the diagnostic yield of repeated screening for atrial fibrillation(AF)among geriatric *** A pragmatic prospective cohort study into applying opportunistic screening for AF with a handheld single lead ECG device(SLD)in a geriatric *** patients of 65 years old and older visiting the geriatric outpatient clinic were eligible for inclusion.A 12 lead ECG was performed,followed by measurements with the SLD during every visit to the geriatric outpatient clinic.A frailty index was based on the accumulation of deficits *** 478 patients were *** were excluded if they did not give informed consent(17 patients),had a pacemaker or implantable cardioverter defibrillator(20 patients),or had incomplete medical files(two patients).After exclusion,439 patients participated in this *** mean age was 78 years(range 65 to 100 years),54%were *** was known in 89 patients(20%),first detected on the baseline ECG in four patients(1%)and first detected with the SLD in 20 patients(5%)during follow up *** of the SLD was 90.0%,specificity 99.0%,negative predictive value 99.7%,and positive predictive value 73.5%.Most patients(82%)with AF were frail and 53%were severely *** Repeated screening in geriatric patients has a five times higher diagnostic yield than usual *** was easily combined with usual *** of the positive predictive value of 73.5%,it remains necessary to confirm AF with a 12 lead ECG or 24-h Holter monitoring.

关键词： Atrial fibrillation Frailty Geriatric patients Opportunistic screening The elderly

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A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

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Frontiers in Biology 2016年第3期11卷 256-259页

作者： M. A. Bottelier A. Schrantee G. van Wingen H. G. Ruhe M. B. de ruiter L. Reneman department of Child-andAdolescentPsychiatry Triversum Alkmaar The Netherlands Brain Imaging Center Academic Medical Center University of Amsterdam Amsterdam The Netherlands department of Radiology Academic Medical Center Amsterdam The Netherlands department of Psychiatry Academic Medical Center Amsterdam The Netherlands Program for Mood and Anxiety Disorders Department of Psychiatry University Medical Center Groningen University of GroningenGroningen The Netherlands

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging （fMRI） is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine （NTR3103） in anxious and or depressed girls （12-14 years of age） we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are heeded to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.

关键词： amygdala reactivity SSRI adverse effects anxiety depression

超声断层扫描数据压缩的时间窗构造及数据提取方法

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声学学报 2018年第2期43卷 189-201页

作者：秦博马晓川 Michael Zapf 鄢社锋 Nicole V.ruiter 中国电子科技集团公司电子科学研究院北京100041 中国科学院声学研究所水下航行器关键技术重点实验室北京100190 卡尔斯鲁厄理工学院数据处理和电子技术研究所德国卡尔斯鲁厄76021 中国科学院大学北京100049

介绍了一种针对三维超声断层扫描系统的数据压缩方法,该方法通过检测最早的目标反射重构目标表面位置;依据表面位置,计算目标回波信号的起止时间;以此为依据构造时间窗,标明成像算法所需数据在采样序列中存在的时间范围;最终提取有用数... 详细信息

介绍了一种针对三维超声断层扫描系统的数据压缩方法,该方法通过检测最早的目标反射重构目标表面位置;依据表面位置,计算目标回波信号的起止时间;以此为依据构造时间窗,标明成像算法所需数据在采样序列中存在的时间范围;最终提取有用数据,完成数据压缩。临床数据被用于算法的效果评价。结果表明,该方法可达到平均2.27的压缩率和0.21的压缩率标准差,以及2.25的数据传输加速比。较传统数据压缩方法,该方法只利用回波时域信息,可作为预压缩方法和传统方法结合使用以获得更高的压缩率。

关键词：时间窗发射器接收器波达时间数据压缩断层扫描

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Quality assurance and safety of hippocampal avoidance prophylactic cranial irradiation in the multicenter randomized phase III trial(NCT01780675)

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Journal of the National Cancer Center 2023年第2期3卷 135-140页

作者： Oscar Candiff JoséBelderbos Anne Lisa Wolf Eugène Damen Paul van Haaren Wouter Crijns Sandra Hol Leen Paelinck Zdenko van Kesteren Jaap Jaspers Geert de Kerf Wouter van Elmpt Fred Ubbels Sanne Schagen Dirk de Ruysscher Michiel de ruiter department of Radiation Oncology the Netherlands Cancer InstituteAmsterdamthe Netherlands department of Radiation Oncology Catharina HospitalEindhoventhe Netherlands department of Radiation Oncology/department of Oncology Laboratory of Experimental RadiotherapyKU LeuvenBelguimthe Netherlands department of Radiation Oncology Institute VerbeetenTilburgthe Netherlands department of Radiation Oncology Ghent University Hospital and Ghent UniversityGentBelgium department of Radiation Oncology Amsterdam UMC-Location University of AmsterdamAmsterdamthe Netherlands department of Radiation Oncology Erasmus Mc Cancer Institute-Erasmus Mc University Medical CenterRotterdamthe Netherlands department of Radiation Oncology Antwerp University and Antwerp University Hospital/Iridium NetwerkAntwerpBelgium department of Radiation Oncology University of Groningen-University Medical Center GroningenGroningenthe Netherlands Division of Psychosocial Research and Epidemiology the Netherlands Cancer InstituteAmsterdamthe Netherlands Radiation Oncology(Maastro) School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastrichtthe Netherlands

Objective:NCT01780675,a multicenter randomized phase III trial of prophylactic cranial irradiation(PCI)versus PCI with hippocampal sparing in small cell lung cancer(SCLC)investigated neurocognitive decline and *** part of quality assurance,we evaluated if hippocampal avoidance(HA)-PCI was performed according to the NCT01780675 trial protocol instructions,and performed a safety analysis to study the incidence and location of brain metastases for patients treated with ***:This retrospective analysis evaluated the quality of the irradiation given in the randomized controlled trial(RCT)comparing SCLC patients receiving PCI with or without hippocampal avoidance,using intensity mod-ulated radiotherapy(IMRT)or volumetric modulated arc therapy(VMAT).The dose distribution for each patient receiving HA-PCI was retrieved and analyzed to evaluate if the treatment dose constraints were met.A ques-tionnaire was sent out to all participating sites,and data on radiotherapy technique,pre-treatment dummy runs,phantom measurements and treatment electronic portal imaging device(EPID)dosimetry were collected and *** part of the safety analysis,the follow-up magnetic resonance imaging(MRI)or computerized to-mography(CT)scans on which cranial disease progression was first diagnosed were collected and matched to the radiotherapy planning dose *** matched scans were reviewed to analyze the location of the brain metastases in relation to the prescribed ***:A total of 168 patients were randomized in the NCT01780675 trial in 10 centers in the Netherlands and Belgium from April 2013 until March *** two patients receiving HA-PCI without evidence of brain metastases were *** patients were treated with 25 Gy in 10 *** runs and phantom measurements were performed in all institutions prior to enrolling patients into the *** radiotherapy(RT)plans showed a median mean bilateral hippocampal dose of 8.0 Gy,range 5.4-11.4(c

关键词： Hippocampus-avoidance profylactic cranial irradiation Small cell lung cancer Quality assurance NCT01780675 Neurocognition

鹿特丹WIJN AAN de KAde葡萄酒体验店

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现代装饰 2017年第4期 46-51页

作者： Rik de ruiter Luuk Stoltenborg STUDIO AAAN

将葡萄酒文化与室内设计相结合，会碰撞出怎样的火花？这是一家主体由2100块激光雕刻橡木面板打造的葡萄酒零售店，坐落在荷兰鹿特丹市中心一栋建于1896年的历史建筑内。整体空间一共为四层，包括底层、地面层、夹层和二楼。除了主要的... 详细信息

将葡萄酒文化与室内设计相结合，会碰撞出怎样的火花？这是一家主体由2100块激光雕刻橡木面板打造的葡萄酒零售店，坐落在荷兰鹿特丹市中心一栋建于1896年的历史建筑内。整体空间一共为四层，包括底层、地面层、夹层和二楼。除了主要的零售空间，这里另设有一个小型酒吧、厨房、品酒室和酒窖，成就了其个性所在。

关键词：葡萄酒文化鹿特丹酒体整体空间室内设计激光雕刻历史建筑市中心

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Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid

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World Journal of Transplantation 2018年第5期8卷 156-166页

作者： Petra E de ruiter Yashna Gadjradj Robert J de Knegt Herold J Metselaar Jan NM Ijzermans Luc JW van der Laan department of Surgery Erasmus MC-University Medical Center department of Gastroenterology and Hepatology Erasmus MC-University Medical Center

AIM To investigate the specific effects of immunosuppressants on the antiviral action of daclatasvir and *** The antiviral activity of daclatasvir(DCV) and asunaprevir(ASV) combined with immunosuppressants was tested using two in vitro models for hepatitis C virus(HCV) *** Tacrolimus, rapamycin and cyclosporine did not negatively affect the antiviral action of DCV or ASV. Mycophenolic acid(MPA) showed additive antiviral effects combined with these direct acting antivirals(DAAs). MPA induces interferon-stimulated genes(ISGs) and is a potent GTP synthesis inhibitor. DCV or ASV did not induce ISGs expression nor affected ISG induction by MPA. Rather, the combined antiviral effect of MPA with DCV and ASV was partly mediated via inhibition of GTP *** Immunosuppressants do not negatively affect the antiviral activity of DAAs. MPA has additive effect on the antiviral action of DCV and ASV. This combined benefit needs to be confirmed in prospective clinical trials.

关键词： Immunosuppressant Hepatitis C Daclatasvir Asunaprevir Liver Transplantation

黑斑羚粪便中碳同位素揭示的食性变化(英文)

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动物学报 2006年第6期52卷 1015-1025页

作者： Daryl CODRON Jacqui CODRON Julia A. LEE-THORP Matt SPONHEIMER Darryl de ruiter JAMES S. BRINK department of Archaeology University of Cape Town Private Bag Rondebosch 7701 RSA Florisbad Quaternary Research National Museum PO Box 266 Bloemfontein 9300 RSA department of Archaeology University of Cape Town Private Bag Rondebosch 7701 RSA department of Archaeological Sciences Bradford University Bradford BD7 1DP UK department of Anthropology University of Colorado at Boulder Boulder CO 80309 USA department of Anthropology University of Colorado at Boulder Boulder CO 80309 USA Department of Anthropology Texas A&M University College Station TX 77843 USA Florisbad Quaternary Research National Museum PO Box 266 Bloemfontein 9300 RSA Centre for Environmental Management Faculty of Natural and Agricultural Science University of the Free State Bloemfontein 9300 RSA

利用稳定碳同位素数据(δ13C)分析了南非克鲁格国家公园混食性黑斑羚(Aepyceros melampus)时间和空间尺度上的食性变化,验证了两个假说,即有蹄类食性变化是由生境中木本植物与草本植物的相对配比导致;降雨控制有蹄类生态。结果表明:黑... 详细信息

利用稳定碳同位素数据(δ13C)分析了南非克鲁格国家公园混食性黑斑羚(Aepyceros melampus)时间和空间尺度上的食性变化,验证了两个假说,即有蹄类食性变化是由生境中木本植物与草本植物的相对配比导致;降雨控制有蹄类生态。结果表明:黑斑羚的食性涵盖了精食者-粗食者采食谱系,且食性中木本与草本比例在不同月间、季节、年度和区域间存在很大变化。栖息于开放性热带稀树草原和草原中的黑斑羚通常采食比生境中更高比例的草本,但在时间尺度上并不恒定。在克鲁格北部的一个区域(Punda Maria) ,黑斑羚采食的草本比克鲁格国家公园中其它任何区域都多。与其它生境相比,在河边的黑斑羚采食草本数量更少,尤其是在食性空间变化更为明显的旱季。因此,我们的数据不支持有蹄类食性组成变化是由生境中木本与草本比例不同造成的假说,食性与降雨量间也无明显的关系。我们的结果支持草本中蛋白含量增加引起黑斑羚采食比例的增加这一模型。粪便中氮含量在时间和空间上的变化很小,揭示在可利用食物中,无论木本还是草本,黑斑羚进行选择采食以保证最好的食物质量。基于这些结果,我们认为更具体的食物选择和可利用性最适采食理论能够更好地解释这种生态学变化。

关键词：黑斑羚木本草本食草动物克鲁格公园

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PATTERNS IN SOIL FOOD WEB REPSONSES TO NATURAL AND ANTHROPOGENIC DISTRUBANCES

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PATTERNS IN SOIL FOOD WEB REPSONSES TO NATURAL AND ANTHROPOG...