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Role of the receptor for advanced glycation end products in hepatic fibrosis

World Journal of Gastroenterology 2009年第46期15卷 5789-5798页

作者： Christina Lohwasser Daniel Neureiter Yury popov Michael Bauer Detlef Schuppan Department of Medicine Ⅰ University of Erlangen-NurembergErlangen-Nürnberg Institute of Pathology Paracelsus Private Medicine UniversitySalzburg Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBoston

AIM： To study the role of advanced glycation end products （AGE） and their specific receptor （RAGE） in the pathogenesis of liver fibrogenesis. METHODS： In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells （HSC） were measured after stimulation with the two RAGE ligands, advanced glycation end product-bovine serum albumin （AGE- BSA） and N＇-（carboxymethyl） lysine （CML）-BSA, or with tumor necrosis factor-α （TNF-α）. In vivo RAGE expression was examined in models of hepatic fibrosis induced by bile duct ligation or thioacetamide. The effects of AGE-BSA and CML-BSA on HSC proliferation, signal transduction and profibrogenic gene expression were studied in vitro. RESULTS： In hepatic fibrosis, RAGE expression was enhanced in activated HSC, and also in endothelial cells, inflammatory cells and activated bile duct epithelia. HSC expressed RAGE which was upregulated after stimulation with AGE-BSA, CML-BSA, and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation, apoptosis, fibrogenic signal transduction and fibrosis- or fibrolysis-related gene expression, except for marginal upregulation of procollagen α1（ I ） mRNA by AGE-BSA. CONCLUSION： Despite upregulation of RAGE in activated HSC, RAGE stimulation by AGE does not alter their fibrogenic activation. Therefore, RAGE does not contribute directly to hepatic fibrogenesis.

关键词： Advanced glycation end product Extracellularmatrix Hepatic stellate cell Matrix metalloproteinase Myofibroblast Receptor for advanced glycation endproducts Transforming growth factor β Tissue inhibitorof metalloproteinase Tumor necrosis factor α

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Integration of a field-effect-transistor terahertz detector with a diagonal horn antenna

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Chinese Physics B 2018年第6期27卷 539-542页

作者： Xiang Li Jian-dong Sun Zhi-peng Zhang V V popov Hua Qin School of Nano Technology and Nano Bionics University of Science and Technology of Chin Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-tech and Nano-bionics Chinese Academy of SciencesKotelnikov Institute of Radio Engineering and Electronics Saratov Branch Russian Academy of Science

Efficient coupling of terahertz electromagnetic wave with the active region in a terahertz detector is required to enhance the optical sensitivity. In this work, we demonstrate direct integration of a field-effect-transistor（FET） terahertz detector chip at the waveguide port of a horn antenna. Although the integration without a proper backshot is rather preliminary, the noise-equivalent power is greatly reduced from 2.7 nW/Hz^（1/2） for the bare detector chip to 76 pW/Hz^（1/2） at340 GHz. The enhancement factor of about 30 is confirmed by simulations revealing the effective increase in the energy flux density seen by the detector. The simulation further confirms the frequency response of the horn antenna and the onchip antennas. A design with the detector chip fully embedded within a waveguide cavity could be made to further enhance the coupling efficiency.

关键词： terahertz detector high electron mobility transistor diagonal horn

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Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation

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Integrative Zoology 2018年第2期13卷 180-193页

作者： Ivana MIRKOV Aleksandra popov ALEKSANDROV Vesna SUBOTA Dragan KATARANOVSKI Milena KATARANOVSKI Immunotoxicology Group Department of EcologyInstitute for Biological Research“Sinisa Stankovic”University of BelgradeBelgradeSerbia Institute for Medical Biochemistry Military Medical AcademyBelgradeSerbia Institute of Zoology Faculty of BiologyUniversity of BelgradeBelgradeSerbia Institute of Physiology and Biochemistry Faculty of BiologyUniversity of BelgradeBelgradeSerbia

Studies of wild animals’immunity often use comparison with laboratory-raised *** such an approach,various data were obtained concerning wild Norway rat’s *** or higher potential of immune system cells to respond to activation stimuli were shown,because of analysis of disparate parameters and/or small number of analyzed *** differences between laboratory and wild rats were shown too,owing to great response variability in wild *** hypothesized that wild rats will express more intense immune activity compared to their laboratory counterparts which live in a less demanding *** test this,we analyzed the circulating levels of inflammatory cytokine interleukin-6(IL-6),a mediator which has a central role in host immune *** addition,we examined the activity of the central immune organ,the spleen,including cell proliferation and production of pro-inflammatory cytokines interferon-γ(IFN-γ)and interleukin-17(IL-17),which are major effectors of cellular adaptive immune *** order to obtain reasonable insight into the immunity of wild Norway rats,analysis was conducted on a much larger number of individuals compared to other *** levels of plasma IL-6,higher spleen mass,cellularity and basal IFN-γproduction concomitantly with lower basal production of anti-inflammatory cytokine interleukin-10(IL-10)revealed more intense immune activity in the wild compared to laboratory ***,lower responsiveness of their spleen cells’proinflammatory cytokine production to concanavalin A(ConA)stimulation,along with preserved capacity of IL-10 response,might be perceived as an indication of wild rats’reduced capability to cope with incoming environmental stimuli,but also as a means to limit tissue damage.

关键词： circulating interleukin-6 levels spleen cell cytokine production spleen cell proliferation

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New observations and transit solutions of the inflated exoplanets HAT-P-40b and HAT-P-51b

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Research in Astronomy and Astrophysics 2021年第2期21卷 157-160页

作者： Diana P.Kjurkchieva Nikola I.Petrov Velimir A.popov Department of Physics and Astronomy Shumen University115 Universitetska str.9700 ShumenBulgaria Institute of Astronomy and NAO Bulgarian Academy of SciencesTsarigradsko shossee 721784 SofiaBulgaria

We present high-precision photometric observations of the transiting exoplanets HAT-P-40 b and HAT-P-51 b by the Rozhen 2-m *** newly-observed transit of HAT-P-40 b is the first one with a complete *** orbital periods of the two targets were *** modeled the observed transits and found bigger stellar radii than those derived from the stellar *** planet radii of HATP-40 b and HAT-P-51 b obtained from our transit solutions are bigger than the values calculated by the empirical relations for Jupiter-mass and Saturn-mass planets *** values reveal the highlyinflated nature of the two targets,especially that of HAT-P-51 *** established that the best transit solutions correspond to a quadratic limb-darkening *** fitted limb-darkening coefficients of HAT-P-40 are close to the theoretical ones while those of HAT-P-51 are a little *** precise astrometric Gaia distances of the two targets are smaller by 6%–7%than the calculated values from the stellar *** propose the Gaia distances to be used for improvement of the stellar models as well as for more reliable calculation of the parameters of the known exoplanets.

关键词： (Stars )planetary systems-techniques photometric-Stars individual(HAT-P-40 and HAT-P-51)

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NSVS 2569022:a peculiar binary among W UMa stars with extremely small mass ratios

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Research in Astronomy and Astrophysics 2018年第10期18卷 123-130页

作者： Diana P.Kjurkchieva Velimir A.popov Nikola I.Petrov Department of Physics and Astronomy Shumen University Institute of Astronomy and NAO Bulgarian Academy of Sciences

Photometric observations of the W UMa binary NSVS 2569022 are presented. The light curve solution reveals that both components are of F spectral type （temperatures T1 = T2 = 6100 K）. NSVS 2569022 undergoes a total eclipse of W subtype and the mass ratio is well-determined. Its extremely small value of only 0.077 implies that the target will probably experience instability and a possible merger. This value ranks NSVS 2569022 in sixth place among binaries with the smallest mass ratio. Based on an empirical relation of ＂period - total mass＂ for low mass-ratio binaries, we estimate the global parameters of NSVS 2569022： masses M1 = 1.17 M⊙ and M2 = 0.09 M⊙; radii R1 = 1.19 R⊙ and R2 = 0.38 R⊙; luminosities L1 = 1.73 L⊙ and L2 = 0.17L⊙. An analysis of the characteristics of binaries with extremely low-mass ratios is made. NSVS 2569022 turns out to be a peculiar binary among W UMa stars with extremely small mass ratios due to its unexpectedly small fill-out factor of only 0.014 （slightly overcontact configuration）.

关键词： binaries eclipsing - binaries close - stars fundamental parameters - stars individual(NSVS 2569022)

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Nitrogen and Carbon Isotope Data of Olenekian to Anisian Deposits from Kamenushka/South Primorye, Far-Eastern Russia and Their Palaeoenvironmental Significance

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Journal of Earth Science 2018年第4期29卷 837-853页

作者： Yuri D Zakharov Micha Horacek Alexander M popov Liana G Bondarenko Far Eastern Geological Institute of Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia BLT Wieselburg Research Center HBLFA Francisco-Josephinum Wieselburg 3250 Austria Institute of Lithospheric Research Vienna University Vienna 1090 Austria

The Kamenushka Formation, exposed in the northern part of South Primorye （Kamennshka-1 and Kamenushka-2 sections）, is one of the few localities in the world with richly fossiliferous Lower-Upper Olenekian sedimentary successions. Lower to Middle Triassic ammonoid-, brachiopod- and conodont-bearing silty-clayey deposits of the Kamenushka-1 and Kamenushka-2 sections have been isotope-geochemically investigated in detail. As a result, these sections, together with the previously investigated Abrek Section, exposed in the southern part of South Primorye, provide almost complete ^15Non- and ^13Corg- records for the Lower Triassic of this region. Nine N- isotope intervals and the five negative C-isotope excursions, reflecting, apparently, unstable climatic and hydrological conditions, have been distinguished in the Lower Triassic of South Primorye. On the basis of the new C-isotope data the Mesohedenstroemia bosphorensis Zone （upper part）, Shimanskyites shimanskyi and Neocolumbites insignis zones of South Primorye are correlated now with the Lower Smithian part of the Yinkeng Formation, the Upper Smithian part of the Helongshan Formation and the Middle Spathian part of the Nanlinghu Formation in South China, respectively, as has been observed in the Abrek, Kamenushka-2, West Pingdingshan and Majiashan sections.

关键词： Triassic N- and C-isotopes palaeoclimatology bio- and chemostratigraphy Pri- morye Russia.

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Photometric observations and light curve solutions of the W UMa stars NSVS 2244206,NSVS 908513,CSS J004004.7+385531 and VSX J062624.4+570907

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Research in Astronomy and Astrophysics 2016年第9期16卷 15-22页

作者： Diana Petrova Kiurkchieva Velimir Angelov popov Doroteya Lyubenova Vasileva Nikola Ivanov Petrov Department of Physics Shumen University115Universitetska Str.1712 ShumenBulgaria IRIDA Observatory 17A Prof.Asen Zlatarov Str.SofiaBulgaria Institute of Astronomy and National Astronomical Observatory Bulgarian Academy of Sciences72Tsarigradsko Shose Blvd.1784 SofiaBulgaria

Photometric observations in Sloan 9＇ and i＇ bands of four W UMa stars, NSVS 2244206, NSVS 908513, CSS J004004.7＋385531 and VSX J062624.4＋570907, are presented. The light curve solutions reveal that all targets have overcontact configurations with fillout factors within 0.15-0.26. Their components are G-K spectral types and are almost in thermal contact. They are also relatively close in size and luminosity： the radius ratios r2/r1 are within 0.75-0.90; the luminosity ratios 12/11 are within 0.53-0.63. The results of the light curve solution of CSS J004004.7＋385531 imply the weak limb-darkening effect of its primary component and possible presence of additional absorbing features in the system.

关键词： methods data analysis -- stars fundamental parameters -- stars binaries eclipsing individ-ual (NSVS 2244206, NSVS 908513, CSS J004004.7+385531, VSX J062624.4+570907)

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Dimethylammonium iodide stabilized bismuth halide perovskite photocatalyst for hydrogen evolution

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Nano Research 2021年第4期14卷 1116-1125页

作者： He Zhao Kalyani Chordiya Petri Leukkunen Alexey popov Mousumi Upadhyay Kahaly Krisztian Kordas Satu Ojala Environmental and Chemical Engineering Research Unit University of OuluP.O.Box 4300FI-90014 OuluFinland ELI-ALPS ELI-HU Non-Profit Ltd.Dugonicster 136720 SzegedHungary Institute of Physics University of Szegedf D6m ter 9H-6720 Szeged Hungary Nano and Molecular Systems Research Unit University of OuluP.O.Box 3000FI-90014 OuluFinland Optoelectronics and Measurement Techniques Unit University of OuluFI-90570 OuluFinland Microelectronics Research Unit University of OuluP.O.Box 4500FI-90014 OuluFinland VTT Technical Research Centre of Finland FI-90590 OuluFinland

Metal halide perovskites have emerged as novel and promising photocatalysts for hydrogen ***,their stability in water is a vital and urgent research *** this paper a novel approach to stabilize a bismuth halide perovskite[(CH_(3))_(2)NH_(2)]_(3)[Bil_(6)](DA_(3)Bil_(6))in water using dimethylammonium iodide(DAI)without the assistance of acids or coatings is *** DA3Bil6 powder exhibits good stability in DAI solutions for at least two *** concentration of DAI is found as a critical parameter,where the I^(-)ions play the key role in the *** stability of DA3Bil6 in water is realized via a surface dissolution-recrystallization *** DA3Bil6 demonstrates constant photocatalytic properties for visible light-induced photo-oxidation of I^(-)ions and with PtCI4 as a co-catalyst(Pt-DA_(3)Bil_(6)),photocatalytic H2 evolution with a rate of 5.7μmol·h^(-1)from HI in DAI solution,obtaining an apparent quantum efficiency of 0.83%at 535 *** study provides new insights on the stabilization of metal halide perovskites for photocatalysis in aqueous solution.

关键词： bismuth halide perovskite dimethylammonium iodide photocatalysis hydrogen evolution

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Correlation of microstructure and magnetic properties in Sm(Co_(bal)Fe_(0.1)Cu_(0.1)Zr_(0.033))_(6.93) magnets solution-treated at different temperatures

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Rare Metals 2019年第1期38卷 20-28页

作者： Cheng Xu Hui Wang Tian-Li Zhang Alexander popov Raghavan Gopalan Cheng-Bao Jiang School of Materials Science and Engineering Beihang University M.N. Miheev Institute of Metal Physics Ural Branch of Russian Academy of Sciences International Advanced Research Centre for Powder Metallurgy and New Materials(ARCI) IITM Research Park

The correlation of microstructure and magnetic properties in Sm(Co_(bal)Fe_(0.1)Cu_(0.1)Zr_(0.033))_(6.93) magnets solution-treated at different temperatures was systematically investigated. It is found that the magnets solution-treated at 1219℃ possess a single 1:7 H phase, exhibiting the homogeneous cellular structure during further aging treatment, leading to the optimum magnetic properties. However, for the magnets solution-treated at 1211 and 1223℃,2:17 H or 1:5 H secondary phase will also form besides 1:7 H main phase, which cannot transform into cellular structure,thus deteriorating the magnetic properties greatly. The irreversible magnetization investigations with recoil loops also propose a non-uniform pinning in the magnets induced by the secondary precipitates. At proper solution temperature, Zr is supposed to occupy the Fe-Fe dumbbell sites in the form of Zr-vacancy pairs, leading to the minimum c/a ratio and thus stabilizing the 1:7 H phase. Finally,Sm(Co_(bal)Fe_(0.1)Cu_(0.1)Zr_(0.033))_(6.93) magnets with the maximum energy product and intrinsic coercivity at 550℃ up to 60.73 kJ·m^(-3) and 553.88 kA·m^(-1) were prepared by powder metallurgy method.

关键词： Sm2Co17 Solution treatment Phase constitution Demagnetization curve squareness

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Observations and light curve solutions of a selection of middle-contact W UMa binaries

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Research in Astronomy and Astrophysics 2018年第4期18卷 105-114页

作者： Diana Petrova Kjurkchieva Velimir Angelov popov Doroteya Lyubenova Vasileva Nikola Ivanov Petrov Department of Physics Shumen University IRIDA Observatory Rozhen NAO Institute of Astronomy and NAO Bulgarian Academy of Sciences

Photometric observations in Sloan g′and i′ bands of W UMa binaries NSVS 4340949,T-Dra0–00959,GSC 03950–00707,NSVS 4665041,NSVS 4803568,MM Peg,MM Com and NSVS4751449 are *** light curve solutions revealed that the components of each target are of G and K spectral *** binaries of the sample have middle-contact configurations whose fillout factors are within the range 0.2–*** only exception is NSVS 4751449 which is in deeper contact（fillout factor of 0.55）.It precisely obeys the relation between mass ratio and fillout factor for deep,low mass ratio overcontact *** of the eclipses of almost all targets（except MM Peg）is an occultation and their photometric mass ratios and solutions could be accepted with *** found that the target components have almost equal temperatures but differ considerably in size and *** components of the partially-eclipsed MM Peg have close *** solutions reveal that NSVS 4340949,T-Dra0–00959,NSVS 4803568 and MM Com are of W subtype while GSC 03950–00707,NSVS 4665041,MM Peg and NSVS 4751449 are of A *** subclassification is well-determined for all totallyeclipsed *** targets confirm the trends in which W-subtype systems have smaller periods and lower temperatures than A subtype binaries.

关键词： binaries close — binaries eclipsing — stars fundamental parameters — stars late-type

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