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The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC

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Research 2024年第3期2023卷 273-283页

作者： Jiesi Wang Wei Zhang Hang Xu Bart ellenbroek Jiajie Dai Li Wang Chaogan Yan Weiwen Wang CAS Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing.China Department of Psychology University of Chinese Academy of SciencesBeijingChina School of Psychology Victoria University of WellingtonKelburnWellington 6012New Zealand CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijingChina.

Early-life stress can lead to sustained alterations in regional resting-state brain functions, but the underlying molecular mechanism remains unclear. Stress can also induce sustained changes in epigenetic modifications across brain regions, which are not limited to a few genes;rather, they often tend to produce global levels of change. The functional implication of these changes also remains to be elucidated. We hypothesize that global epigenetic changes may partly modulate the resting-state functions of brain regions to influence behavior. To test this hypothesis, we used an adolescent social stress (ASS) model in mice and examined the relationship between epigenetic modifications and regional resting-state brain activity using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that, compared to the control mice, the stressed mice showed increased anxiety and social avoidance behaviors and greater levels of dimethylation of histone H3 at lysine 9 (H3K9me2) in the medial prefrontal cortex (mPFC). In addition, the resting-state activity represented by the amplitude of low-frequency fluctuation (ALFF) was significantly lower in the mPFC of stressed mice. To verify the relationship of H3K9me2 and ALFF, the specific inhibition of H3Kme2 was performed by using the drug UNC0642, which reversed the anxiety behavior induced by ASS and significantly increase the ALFF value of mPFC in both normal and ASS animals. Our study is the first to report an association between histone modifications and rs-fMRI findings, providing a new perspective for understanding of the significance of regional brain epigenetic changes and a possible molecular explanation for rs-fMRI findings.

关键词： sustained mPFC alterations

Improved organs at risk segmentation based on modified U‐Net with self‐attention and consistency regularisation

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 850-865页

作者： Maksym Manko anton Popov Juan Manuel Gorriz Javier Ramirez Electronic Engineering Department Igor Sikorsky Kyiv Polytechnic InstituteKyivUkraine Department of Signal Theory Telematics and CommunicationsUniversity of GranadaGranadaSpain

Cancer is one of the leading causes of death in the world,with radiotherapy as one of the treatment *** planning starts with delineating the affected area from healthy organs,called organs at risk(OAR).A new approach to automatic OAR seg-mentation in the chest cavity in Computed Tomography(CT)images is *** proposed approach is based on the modified U‐Net architecture with the ResNet‐34 encoder,which is the baseline adopted in this *** new two‐branch CS‐SA U‐Net architecture is proposed,which consists of two parallel U‐Net models in which self‐attention blocks with cosine similarity as query‐key similarity function(CS‐SA)blocks are inserted between the encoder and decoder,which enabled the use of con-sistency *** proposed solution demonstrates state‐of‐the‐art performance for the problem of OAR segmentation in CT images on the publicly available SegTHOR benchmark dataset in terms of a Dice coefficient(oesophagus-0.8714,heart-0.9516,trachea-0.9286,aorta-0.9510)and Hausdorff distance(oesophagus-0.2541,heart-0.1514,trachea-0.1722,aorta-0.1114)and significantly outperforms the *** current approach is demonstrated to be viable for improving the quality of OAR segmentation for radiotherapy planning.

关键词： 3‐D computer vision deep learning deep neural networks image segmentation medical image processing object segmentation

Efficient cold atom source from a single-layer atom chip

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Chinese Optics Letters 2024年第6期22卷 103-108页

作者： Petr Skakunenko Darya Bykova anton Afanasiev Alexey Kalmykov Roman Kirtaev Victor Balykin Institute of Spectroscopy Russian Academy of Sciences Moscow 108840Russia Moscow Institute of Physics and Technology Moscow 141700Russia Skolkovo Institute of Science and Technology Moscow 121205Russia National Research University Higher School of Economics Moscow 101000Russia Present affiliation:Emerging Technologies Research Center XPANCEODubaiUnited Arab Emirates

We developed a new single-layer atom chip with an additional U-shaped current-carrying *** new U-shaped microwire creates optimized magnetic field distribution,which increases the trapping volume of a magneto-optical trap(MOT) near the *** approach allows one to localize more atoms,while a setup remains relatively simple (single-layer approach) and consumes low current (up to 10 A). The total number of trapped~(87)Rb atoms in our setup is 5×10~7.

关键词： atom chip cold atoms laser cooling magneto-optical trap U-MOT

Task Offloading in Edge Computing Using GNNs and DQN

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2649-2671页

作者： Asier Garmendia-Orbegozo Jose David Nunez-Gonzalez Miguel Angel anton Department of Applied Mathematics University of the Basque Country UPV/EHUEibar20600Spain TECNALIA Basque Research and Technology Alliance(BRTA)San Sebastian20009Spain

In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task *** many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing *** this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud *** different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the *** the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not *** study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round *** showed that variants offer a slight improvement in task success rate and workload *** terms of energy efficiency,they provided similar ***,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is *** novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant *** download score defined in this research is a crucial feature for determining the quality of a download path

关键词： Edge computing edge offloading fog computing task offloading

Technological parameters of thin-film pulsed laser scribing for perovskite photovoltaics

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CLEAN ENERGY 2024年第3期8卷 127-135页

作者： Ishteev, Rustam Gostishchev, Pavel Tiukhova, Mariia Sorokin, anton Ishteev, Arthur Kondratenko, Vladimir RTU MIREA Inst Adv Technol & Ind Programming Dept Nanoelect Lab Precis Machining Mat Moscow Russia Res & Pract Clin Ctr Diagnost & Telemed Technol Moscow Hlth Care Dept Moscow Russia Natl Univ Sci & Technol MISIS Lab Adv Solar Energy LASE 4 Leninsky St Moscow Russia Russian Acad Sci RAS Semenov Fed Res Ctr Chem Phys 4 Kosygina Str Moscow Russia

Over the past decade, the power conversion efficiency of halide perovskite solar cells has shown a rapid increase to 26.1%. The significant efficiency growth and the relative simplification of the technology for obtaining thin-film solar cells due to liquid printing methods determine the high potential for the low-cost perovskite solar cells manufacturing. However, efficient use of cell geometry is comparable to the size of standard crystalline-Si wafers (156:156 mm and more). Therefore, modular geometry similar to amorphous-Si solar cell approaches is used to scale perovskite solar cells. Serial electrical connection of thin-film cells requires precise processing of the conductive layers that form the device p-i-n structure. The subject of research is the development of a full pulsed laser scribing cycle for inverted perovskite solar cells. In this work, we propose a study of a laser-patterning technology In2O3:SnO2 (ITO) conductive layer and a photoactive perovskite layer Cs0,2(CH(NH2)2)0,8PbI3. Process regimes of transparent conducting electrodes based on ITO and halide perovskite layer Cs0,2(CH(NH2)2)0,8PbI3 laser patterning were obtained. The optimal parameters for the multipass mode processing of ITO and perovskite layer were determined. The cell was electrically isolated at a scribe line width of 30 mu m. A full pulsed-laser scribing cycle for inverted perovskite solar cells is developed and applied to laser-patterning of an indium-tin oxide (ITO) conductive layer and a photoactive perovskite layer. The optimal parameters for the multipass mode processing of ITO and perovskite layers are determined. Graphical Abstract

关键词： patterning perovskite solar cell perovskite solar cell photovoltaics scribing SOLAR MODULES CELLS

Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

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World Journal of Stem Cells 2024年第9期16卷 827-831页

作者： Vera V Voinova Daria V Vasina anton P Bonartsev Faculty of Biology MV Lomonosov Moscow State UniversityMoscow 119234Russia NF Gamaleya National Research Centre for Epidemiology and Microbiology Ministry of Health of the Russian FederationMoscow 123098Russia

Bibliographic analysis is still very rarely used in experimental basic study *** comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of valuable information for writing reviews and experimental papers in this *** experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectives in this *** is due to the fact that these studies have addressed a great variety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselves and their various products:Sponges,hydrogels,exosomes,and genetic *** a wide variety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be provided by bibliometric ***,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for every basic study manuscripts,primarily for the“Introduction”section,and review.

关键词： Bibliometric analysis Mesenchymal stem cells Wound healing Tissue engineering Dressing Hydrogels Matrix Exosomes

An Underwater Biomimetic Robot that can Swim,Bipedal Walk and Grasp

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Journal of Bionic Engineering 2024年第3期21卷 1223-1237页

作者： Qiuxuan Wu Liwei Pan FuLin Du ZhaoSheng Wu XiaoNi Chi FaRong Gao Jian Wang anton A.Zhilenkov School of Automation Hangzhou Dianzi UniversityHangzhou310018China International Joint Research Laboratory for Autonomous Robotic Systems Hangzhou310018China GEELY Automotive Institute Hangzhou Vocational and Technical CollegeHangzhou310018China Institute of Hydrodynamics and Control Processes Sankt-Petersburg Saint Petersburg State Marine Technical UniversitySankt-PetersburgRussia

In developing and exploring extreme and harsh underwater environments,underwater robots can effectively replace humans to complete *** meet the requirements of underwater flexible motion and comprehensive subsea operation,a novel octopus-inspired robot with eight soft limbs was designed and *** robot possesses the capabilities of underwater bipedal walking,multi-arm swimming,and grasping *** closely interact with the underwater seabed environment and minimize disturbance,the robot employs a cable-driven flexible arm for its walking in underwater floor through a bipedal walking *** multi-arm swimming offers a means of three-dimensional spatial movement,allowing the robot to swiftly explore and navigate over large areas,thereby enhancing its ***,the robot’s walking arm enables it to grasp and transport objects underwater,thereby enhancing its practicality in underwater environments.A simplified motion models and gait generation strategies were proposed for two modes of robot locomotion:swimming and walking,inspired by the movement characteristics of octopus-inspired multi-arm swimming and bipedal *** experimental verification,the robot’s average speed of underwater bipedal walking reaches 7.26 cm/s,while the horizontal movement speed for multi-arm swimming is 8.6 cm/s.

关键词： Underwater soft robots Underwater bipedal walking Multi-arm swimming Cable drive

Virtual Transmission Solution Based on Battery Energy Storage Systems to Boost Transmission Capacity

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 466-474页

作者： Matías Agüero Jaime Peralta Eugenio Quintana Victor Velar anton Stepanov Hossein Ashourian Jean Mahseredjian Roberto Cárdenas Coordinador Eléctrico Nacional SantiagoChile PGSTech Montreal Canada Ecole Polytechnique de Montréal Montréal Canada University of Chile Santiago Chile IEEE

The increasing penetration of variable renewable energy(VRE)generation along with the decommissioning of conventional power plants in Chile,has raised several operational challenges in the Chilean National Power Grid(NPG),including transmission congestion and VRE *** mitigate these limitations,an innovative virtual transmission solution based on battery energy storage systems(BESSs),known as grid booster(GB),has been proposed to increase the capacity of the main 500 kV corridor of the *** paper analyzes the dynamic performance of the GB using a wide-area electromagnetic transient(EMT)model of the *** GB project,composed of two 500 MVA BESS units at each extreme of the 500 kV corridor,allows increasing the transmission capacity for 15 min during N-1 contingencies,overcoming transmission limitations under normal operation conditions while maintaining system stability during *** dynamic behavior of the GB is also analyzed to control power flow as well as voltage *** results show that the GB is an effective solution to allow greater penetration of VRE generation while maintaining system stability in the NPG.

关键词： Battery energy storage system(BESS) grid booster transient stability voltage stability electromagnetic transient(EMT)

Aspirin interruption before neurosurgical interventions:A controversial problem

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World Journal of Cardiology 2024年第4期16卷 191-198页

作者： Alexander Kulikov anton Konovalov Pier Paolo Pugnaloni Federico Bilotta Department of Anesthesiology Burdenko National Medical Research Center of NeurosurgeryMoscow 125047Russia Department of Vascular Neurosurgery Burdenko National Medical Research Center of NeurosurgeryMoscow 125047Russia Department of Anesthesiology Critical Care and Pain MedicineUniversity of Rome“Sapienza”Rome 00161Italy

Aspirin is widely used for primary or secondary prevention of ischemic *** the same time,chronic aspirin consumption can affect blood clot formation during surgical intervention and increase intraoperative blood *** is especially important for high-risk surgery,including *** European Society of Cardiology guidelines recommend aspirin interruption for at least 7 d before neurosurgical intervention,but this suggestion is not supported by clinical *** narrative review presents evidence that challenges the necessity for aspirin interruption in neurosurgical patients,describes options for aspirin effect monitoring and the clinical implication of these methods,and summarizes current clinical data on bleeding risk associated with chronic aspirin therapy in neurosurgical patients,including brain tumor surgery,cerebrovascular procedures,and spinal surgery.

关键词： Aspirin Neurosurgery Postoperative complications Bleeding risk Brain tumor surgery Cerebrovascular surgery Spinal surgery