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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Efficient Numerical Valuation of Continuous Installment Options

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Advances in Applied Mathematics and Mechanics 2011年第2期3卷 141-164页

作者： anton Mezentsev anton Pomelnikov Matthias Ehrhardt IdE Halmstad UniversityBox 82330118HalmstadSweden Lehrstuhl fur Angewandte Mathematik und Numerische Analysis Fachbereich C-Mathematik und NaturwissenschaftenBergische Universitat WuppertalGaußstr.2042119 WuppertalGermany

In this work we investigate the novel Kryzhnyi method for the numerical inverse Laplace transformation and apply it to the pricing problem of continuous installment *** compare the results with the one obtained using other classical methods for the inverse Laplace transformation,like the Euler summation method or the Gaver-Stehfest method.

关键词： Installment options Black-Scholes equation numerical inverse Laplace transform Gaver-Stehfest method Euler summation method optimal stopping problem non-monotonic stopping boundary

Investigating Energy Prosumer Behaviour in Crowd Energy Using an Interactive Model/diorama

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Journal of Electronic Science and Technology 2018年第4期16卷 341-350页

作者： Christian Ritzel anton Sentic the international institute of management in technology University of Fribourg Fribourg 1700Switzerland

Smart living labs such as the one located in Fribourg(Switzerland) focus on improving wellbeing and furthering knowledge related to building the district of the future on a technical and social level. Therefore, smart living labs represent an experimental platform/space where sustainable production and consumption strategies can be tested in a protected environment. A significant change in the socioeconomic production and consumption sphere can be expected by the rise of the so-called energy prosumer. Accordingly, this article presents an interactive model for the experimental investigation of energy prosumer behavior. In this context, two potential experiments on investment and trade decisions are briefly outlined. Since(behavioral and economic) experiments are usually conducted under controlled conditions in experimental labs involving mainly undergraduate students, the presented interactive model is flexible and mobile, providing the advantage to conduct experiments nearly everywhere involving everyday citizens.

关键词： Crowd energy decentralised energy systems experiments prosumers smart grid

EXPONENTIAL INTEGRATORS FOR STOCHASTIC SCHROdINGER EQUATIONS dRIVEN BY ITO NOISE

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Journal of Computational Mathematics 2018年第2期36卷 276-309页

作者： Rikard anton david Cohen department of Mathematics and Mathematical Statistics Umea University SE-901 87 Umea Sweden Department of Mathematics University of Innsbruck A 6020 Innsbruck Austria

We study an explicit exponential scheme for the time discretisation of stochastic SchrS- dinger Equations driven by additive or Multiplicative It6 Noise. The numerical scheme is shown to converge with strong order 1 if the noise is additive and with strong order 1/2 for multiplicative noise. In addition, if the noise is additive, we show that the exact solutions of the linear stochastic Sehr6dinger equations satisfy trace formulas for the expected mass, energy, and momentum （i. e., linear drifts in these quantities）. Furthermore, we inspect the behaviour of the numerical solutions with respect to these trace formulas. Several numerical simulations are presented and confirm our theoretical results.

关键词： Stochastic partial differential equations Stochastic SchrSdinger equations,Numerical methods Geometric numerical integration Stochastic exponential integrators,Strong convergence Trace formulas.

drosophila melanogaster brain invasion pathogenic Wolbachia in central nervous system of the fly

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Insect Science 2016年第2期23卷 253-264页

作者： anton Strunov Elena Kiseleva Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Prospekt Lavrentyeva 10 Novosibirsk 630090Russia

The pathogenic Wolbachia strain wMelPop rapidly over-replicates in the brain, muscles, and retina of drosophila melanogaster, causing severe tissue degeneration and premature death of the host. The unique features of this endosymbiont make it an excellent tool to be used for biological control of insects, pests, and vectors of human diseases. To follow the dynamics of bacterial morphology and titer in the nerve cells we used transmission electron microscopy of 3-d-old female brains. The neurons and glial cells from central brain of the fly had different Wolbachia titers ranging from single bacteria to large accumulations, tearing cell apart and invading extracellular space. The neuropile regions of the brain were free of wMelPop. Wolbaehia tightly interacted with host cell organelles and underwent several morphological changes in nerve cells. Based on different morphological types of bacteria described we propose for the first time a scheme of wMelPop dynamics within the somatic tissue of the host.

关键词： bacterial morphology dynamics brain drosophila melanogaster electronmicroscopy pathogenic endosymbiont Wolbachia strain wMelPop

Analyzing the energy intensity and greenhouse gas emission of Canadian oil sands crude upgrading through process modeling and simulation

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 212-218页

作者： anton ALVAREZ-MAJMUTOV Jinwen CHEN Natural Resources Canada CanmetENERGY One Oil Patch Drive Devon AB T9G 1A8 Canada

This paper presents an evaluation of the energy intensity and related greenhouse gas/CO2 emissions of integrated oil sands crude upgrading processes. Two major oil sands crude upgrading schemes currently used in Canadian oil sands operations were investigated： cokingbased and hydroconversion-based. The analysis, which was based on a robust process model of the entire process, was constructed in Aspen HYSYS and calibrated with representative data. Simulations were conducted for the two upgrading schemes in order to generate a detailed inventory of the required energy and utility inputs： process fuel, steam, hydrogen and power. It was concluded that while hydroconversion-based scheme yields considerably higher amount of synthetic crude oil （SCO） than the cokerbased scheme （94 wt-% vs. 76 wt-%）, it consumes more energy and is therefore more CO2-intensive （413.2kg CO2/m3sco vs. 216.4kg CO2/m^3sco）. This substantial difference results from the large amount of hydrogen consumed in the ebullated-bed hydroconverter in the hydroconversion-based scheme, as hydrogen production through conventional methane steam reforming is highly energy-intensive and therefore the major source of CO2 emission. Further simulations indicated that optimization of hydroconverter operating variables had only a minor effect on the overall CO2 emission due to the complex trade-off effect between energy inputs.

关键词： Oil sands crude upgrading hydroconversion,process modeling greenhouse gas emissions

Trajectory correction for lunar flyby transfers to libration point orbits using continuous thrust

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Astrodynamics 2022年第3期6卷 285-300页

作者： Yi Qi anton de Ruiter School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China department of Aerospace Engineering Ryerson UniversityTorontoON M5B 2K3Canada

Trajectory corrections for lunar flyby transfers to Sun–Earth/Moon libration point orbits(LPOs)with continuous thrusts are investigated using an ephemeris *** lunar flyby transfer has special geometrical and dynamical structures;therefore,its trajectory correction strategy is considerably different from that of previous studies and should be specifically *** this paper,we first propose a control strategy based on the backstepping technique with a dead-band scheme using an ephemeris *** initial error caused by the launch time error is *** the perturbed transfers significantly diverge from the reference transfers after the spacecraft passes by the Moon,we adopt two sets of control parameters in two portions before and after the lunar flyby,***,practical constraints owing to the navigation and propellant systems are introduced in the dynamical model of the trajectory *** a prograde type 2 orbit as an example,numerical simulations show that our control strategy can efficiently address trajectory corrections for lunar flyby transfers with different practical *** addition,we analyze the effects of the navigation intervals and dead-band scheme on trajectory ***,trajectory corrections for different lunar flyby transfers are depicted and compared.

关键词： libration point orbit trajectory correction Earth-Moon system continuous thrust backstepping technique

Analysis of the Water Film Behavior and its Breakup on Profile using Experimental and Numerical Methods

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Journal of Thermal Science 2014年第4期23卷 325-331页

作者： Tomas MUZIK Pavel SAFARIK antonín TUCEK TechSoft Engineering Na Pankraci 2614000 PragueCzech Republic CTU in Prague Department of Fluid Dynamics and ThermodynamicsTechnicka 416607 PragueCzech Republic

This paper deals with the description of water film behaviour on the airfoil NACA0012 using experimental and numerical methods. Properties of the water film on the profile and its breakup into droplets behind the profile are investigated in the aerodynamic tunnel and using CFd methods. The characteristic parameters of the water film, like its thickness and shape for different flow modes are described. Hereafter are described droplets drifted by the air, which water film is broken behind the profile.

关键词： NACA0012 profile water film droplets breakup CFd

Exact Computation of the Topology and Geometric Invariants of the Voronoi diagram of Spheres in 3d

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Journal of Computer Science & Technology 2013年第2期28卷 255-266页

作者： Franois anton darka Mioc Marcelo Santos Research division of Geodesy National Space Institute Technical University of Denmark department of Geodesy and Geomatics Engineering University of New Brunswick

In this paper, we are addressing the exact the Voronoi diagram of spheres using Wu＇s algorithm. computation of the delaunay graph （or quasi-triangulation） and Our main contributions are first a methodology for automated derivation of invariants of the delaunay empty circumsphere predicate for spheres and the Voronoi vertex of four spheres, then the application of this methodology to get all geometrical invariants that intervene in this problem and the exact computation of the delaunay graph and the Voronoi diagram of spheres. To the best of our knowledge, there does not exist a comprehensive treatment of the exact computation with geometrical invariants of the delaunay graph and the Voronoi diagram of spheres. Starting from the system of equations defining the zero-dimensional algebraic set of the problem, we are applying Wu＇s algorithm to transform the initial system into an equivalent Wu characteristic （triangular） set. In the corresponding system of algebraic equations, in each polynomial （except the first one）, the variable with higher order from the preceding polynomial has been eliminated （by pseudo-remainder computations） and the last polynomial we obtain is a polynomial of a single variable. By regrouping all the formal coefficients for each monomial in each polynomial, we get polynomials that are invariants for the given problem. We rewrite the original system by replacing the invariant polynomials by new formal coefficients. We repeat the process until all the algebraic relationships （syzygies） between the invariants have been found by applying Wu＇s algorithm on the invariants. Finally, we present an incremental algorithm for the construction of Voronoi diagrams and delaunay graphs of spheres in 3d and its application to Geodesy.

关键词： Voronoi diagram of spheres delaunay graph of spheres Wu's method invariant characteristic set