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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean O’Dowd antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Modeling West Nile Virus transmission in birds and humans:Advantages of using a cellular automata approach

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Infectious Disease Modelling 2024年第1期9卷 278-297页

作者： Baki Cissé David R.Lapen KChalvet-Monfray Nicholas H.Ogden antoinette Ludwig Public Health Sciences Division National Microbiology LaboratoryPublic Health Agency of CanadaSt-HyacintheCanada Groupe de Recherche enÉpidémiologie des Zoonoses et SantéPublique(GREZOSP) Facultéde Médecine VétérinaireUniversitéde MontréalSaint-HyacintheQuébecCanada Ottawa Research and Development Centre Science and Technology BranchAgriculture and Agri-Food CanadaOttawaK1A 0C6Canada Universitéde Lyon INRAEVetAgro SupUMR EPIAMarcy l’EtoileFrance UniversitéClermont Auvergne INRAEVetAgro SupUMR EPIASaint-Genès-ChampanelleFrance

In Canada,the periodic circulation of West Nile Virus(WNV)is difficult to predict and,beyond climatic factors,appears to be related to the migratory movements of infected birds from the southern United *** hypothesis has not yet been explored in a spatially distributed *** main objective of this work was to develop a spatially explicit dynamic model for the transmission of WNV in Canada,that allows us to explore non-climate related hypotheses associated with WNV transmission.A Cellular Automata(CA)approach for multiple hosts(birds and humans)is used for a test region in eastern Ontario,*** tool is designed to explore the role of host and vector spatial heterogeneity,host migration,and vector feeding *** developed a spatialized compartmental SEIRDS-SEI model for WNV transmission with a study region divided into 4 rectangular *** used 2010–2021 bird data from the eBird project and 2010–2019 mosquito data collected by Ontario Public Health to mimic bird and mosquito seasonal *** considered heterogeneous bird densities(high and low suitability areas)and homogeneous mosquito and human *** high suitability areas for birds,we identified 5 entry points for WNV-infected *** compared our simulations with pools of WNV-infected field collected *** and sensitivity analyses were performed using MATLAB *** results showed good correspondence between simulated and observed epidemics,supporting the validity of our model assumptions and *** analysis showed that a 5%increase or decrease in each parameter of our model except for the biting rate of bird by mosquito(c^(B,M)and mosquito natural mortality rate(d^(M)),had a very limited effect on the total number of cases(newly infected birds and humans),prevalence peak,or date of *** demonstrate the utility of the CA approach for studying WNV transmission in a heterogeneous landscape with multiple hosts.

关键词： Cellular automata Mosquito-borne diseases SEIRDS-SEI modeling West Nile Virus

Adverse Events following AstraZeneca COVID-19 Vaccination: A Case Study in Abidjan, Côte d’Ivoire

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Open Journal of Immunology 2024年第2期14卷 11-15页

作者： Chiayé Claire antoinette Yapo-Crezoit Samuel Boahene Mireille Dosso Immunity Biology Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Introduction: Pharmaceutical companies have boosted vaccine production following the global COVID-19 pandemic. In Côte d’Ivoire, the first vaccination campaign with the AstraZeneca vaccine began on March 1, 2021, as part of the Covax program. Despite the positive benefit/risk balance, the adverse effects of vaccination should not be minimized. Objective: To identify adverse events of AstraZeneca’s COVID-19 vaccination for better management. Materials and Methods: This is a case of a 57-year-old obese (BMI = 39 kg/m2) female health care worker who experienced adverse events in March 2021 after the second dose of AstraZeneca vaccine administered 4 weeks apart. These were subject to mandatory case reporting. Results: Major post-vaccination events occurred in a noisy systemic picture with parameters showing significant disturbances. Biological surveillance remains costly and makes the accountability of the vaccine complex. Conclusion: Vaccination remains the ultimate weapon in the fight against endemic diseases but should not overshadow the reporting of adverse events.

关键词： Adverse Events Post-Second Immunization AstraZeneca Vaccine Abidjan

The existence spectrum of Meta(K_4^((3))>K_4^((3))-e)

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Science China Mathematics 2010年第11期53卷 2865-2876页

作者： LO FARO Giovanni TRIPODI antoinette Department of Mathematics University of Messina

Let H and J1 be both t-uniform hypergraphs. Let J2 be a sub-hypergraph of J1. In this paper, the metamorphosis of a hypergraph decomposition is introduced, denoted by (H, J1 > J2)-design, which is a generalization of the concept of metamorphosis of a graph decomposition. Let Meta(J1>J2) denote the set of all integers v such that there exists a (Kv((3)), J1>J2)-design. We completely determine the set Meta(K4((3))>K4((3))-e).

关键词： hypergraph decomposition metamorphosis t-GDD group divisible (Γ t)-design candelabra (Γ t)-system

Family Literacy Programs: Where Have They Come from and Where Are They Going?

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Frontiers of Education in China 2012年第1期7卷 85-102页

作者： antoinette DOYLE Faculty of Education Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada

Family literacy programs in North America and the United Kingdom have enjoyed widespread public and political *** of initiatives following a variety of models currently operate under the spectrum of family literacy *** this paper,the influence of learning theories,the research on children’s early literacy development,and the sociopolitical context with gave rise to the intervention movement,will be reviewed with respect to their impact on current models of family literacy *** research on program evaluation is also considered,and is related to current practice and future directions in family literacy programming.

关键词： family literacy early literacy parent involvement early intervention

Leveraging Patient Loyalty for the Sustainability of Health Institutions in West Africa:The Role of Medical and Nonmedical Services

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Leveraging Patient Loyalty for the Sustainability of Health ...

作者： ASABEA ADDO antoinette 江苏大学

学位级别：硕士

近十年来,服务业竞争的加剧和环境的不利因素使得服务质量成为服务提供者和研究者关注的焦点。这方面的一个关键领域是如何确保顾客持续的惠顾（忠诚度）。在医疗领域,患者满意度被认为是卫生保健的首选结果之一,因为它直接关系到卫生... 详细信息

近十年来,服务业竞争的加剧和环境的不利因素使得服务质量成为服务提供者和研究者关注的焦点。这方面的一个关键领域是如何确保顾客持续的惠顾（忠诚度）。在医疗领域,患者满意度被认为是卫生保健的首选结果之一,因为它直接关系到卫生服务的再使用和卫生机构的成功。在许多研究中引用的解释变量中,关键是围绕服务提供的指标。然而,这一领域的研究还处于起步阶段,针对发展中国家的研究较少。事实上,发达国家和发展中国家的动态是不同的。因此,本文在一些选定的西非国家考察了医疗人员提供的服务质量和卫生设施的非医疗方面及其对患者满意度和忠诚度的影响。在方法上,本文采用了计量经济学模型和结构方程模型的原理进行分析。在结构方程模型中,本研究的实证结果显示,医务人员（医生、药师、实验室技术人员）的服务质量通过患者满意度的中介作用对患者忠诚度有正向影响。在计量经济学模型中,从DOLS和FMOLS估计推断,在FMOLS模型中,人力资源充足性、卫生设施基础设施、设备和资源增加1%,以及遵守卫生协议,分别导致患者忠诚度增加1.75%、3.03%、3.26%和1.16%。同样,DOLS模型表明,人力资源充足性、卫生设施基础设施、设备和资源以及卫生协议的遵守程度每增加1%,患者的忠诚度就分别增加1.54%、4.12%、3.47%和1.58%。因此,研究结果表明,卫生设施和基础设施、设备和资源、人力资源充足程度以及遵守卫生协议对任何卫生机构提供的服务质量都有积极和重大的影响。总之,应更加重视医务人员的服务和服务质量指标,以确保为患者提供优质服务和这些发展中国家卫生设施的可持续性。论文建议卫生机构定期对其工作人员进行在职培训,使他们了解当前的做法,以确保病人的满意度和忠诚度,并将行为良好的工作人员的激励方案制度化。同样,应遵循例行检查和维修计划,防止对医疗设备和资源造成损害。最后,卫生设施应遵守标准的卫生议定书,以确保提供高质量的保健。本论文的研究结果可能引起机构管理、决策者以及消费者满意度和忠诚度领域的研究人员的兴趣,特别是在卫生部门的相关人员。本研究将提供非传统的成本效益的方法,影响患者的满意度和忠诚度。

关键词：医疗服务西非卫生机构患者忠诚度

The Impact of Training and Development on Employee Performance Case of:Mobile Telephone Company Cameroon (MTN)

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The Impact of Training and Development on Employee Performan...

作者： AKOTUMI MARIA antoinette 南昌大学

学位级别：硕士

The quality of human resource is an asset to any organisation and as a result training has become an issue that has to be faced by every *** amount,and quality of training carried out varies enormously from organisation to organisation due to factors such as the degree of external change for instance,new markets or new processes,the adaptability of existing workforce and importantly the extent to which the organisation supports the idea of internal career *** organisation meet their needs for training in an ad-hoc and haphazard way while others set about identifying their training needs,then design training activities in a rational manner and finally assess the results of *** study therefore sought to determine the impact of training on employees with emphasis on the lower,middle level staff and the administrators of MTN *** research questions were to find out how MTN Cameroon develops its training and development schemes,what necessitates the formulation of these schemes,what effect does training and development have on workers performance and *** study accessed the training and development process of MTN Cameroon and whether training has improved employees performance and *** accomplish the purpose of the research,related theories and empirical literature were sufficiently *** compiling data for the research the sample used of workers of MTN Cameroon all over *** data were obtained through questionnaires,field observations and *** compiling data for the research the convenient sampling method was used to select the respondents for the *** effect 133 respondents were *** data were obtained through questionnaires,field observations and interviews while secondary data was collected from Fundamental books on customer’s services and Fundamental books on *** gathered was analysed using statiscal package for social sciences（SPSS version 21 and

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Promising Effects of an Intervention: Young Children’s Literacy Gains and Changes in Their Home Literacy Activities from a Bilingual Family Literacy Program in Canada

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Frontiers of Education in China 2010年第3期5卷 409-429页

作者： Jing Zhang Janette Pelletier antoinette Doyle Department of Elementary Education and Reading Buffalo State College of State University of New YorkNY 14222USA Institute of Child Study Ontario Institute for Studies in Education of the University of TorontoToronto M5R 2X2Canada Faculty of Education Memorial University of NewfoundlandNewfoundland A1B 3X8Canada

The goal of this paper was to examine promising effects of a bilingual family literacy program: to track the changes of families’ literacy activities through a bilingual family literacy intervention, and to examine the children literacy gains in both Chinese and English across socioeconomic sub-groups. The intervention was an eight-week, two hours per week, literacy program in three Chinese communities in Toronto. Parents, with their children, participated in the program. The extremely high attendance rate provided evidence that families enjoyed the family literacy intervention and felt that the sessions were worthwhile. For their families’ literacy activities, the three sites followed the same trend: reaching the peak of activity at week four, slightly dropping down at weeks five and six, and then increasing to a second peak at week seven or week eight. Results also showed that across the three groups, children of mothers with lower education levels made fewer gains in their English expressive vocabularies and their Chinese expressive vocabularies, than children whose mothers had a higher level of education.

关键词： family literacy bilingual literacy gains parenting

Epidemiologic and socioeconomic factors impacting hepatitis B virus and related hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第29期28卷 3793-3802页

作者： Bipul Gnyawali antoinette Pusateri Ashley Nickerson Sajid Jalil Khalid Mumtaz Department of Medicine Kettering Medical CenterDaytonOH 45342United States Department of Medicine The Ohio State UniversityColumbusOH 43210United States

Chronic Hepatitis B is a highly prevalent disease worldwide and is estimated to cause more than 800000 annual deaths from complications such as cirrhosis and hepatocellular carcinoma(HCC).Although universal hepatitis B vaccination programs may have reduced the incidence and prevalence of chronic hepatitis B and related HCC,the disease still imposes a significant healthcare burden in many endemic regions such as Africa and the Asia-Pacific *** is especially concerning given the global underdiagnosis of hepatitis B and the limited availability of vaccination,screening,and treatment in low-resource *** including male gender,older age,ethnicity,and geographic location as well as low socioeconomic status are more heavily impacted by chronic hepatitis B and related *** to mitigate this impact include increasing screening in high-risk groups according to national guidelines,increasing awareness and health literacy in vulnerable populations,and developing more robust vaccination programs in under-served regions.

关键词： Hepatitis B Epidemiology Hepatocellular carcinoma Socioeconomic status Healthcare disparity Hepatitis B vaccine