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Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms

World Journal of Gastroenterology 2008年第42期14卷 6481-6487页

作者： Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez antoine de mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud Institute of Health Research University of Costa Rica San José 2060 Costa Rica department of Statistics University of Costa Rica San José 2060 Costa Rica department of Pathology Calderón Guardia Hospital Costa Rica San José 2060 Costa Rica University Victor Segalen Bordeaux 2 146 rue Leo-Saignat Case 76 Bordeaux Cedex 33076 France departments of Medicine and Microbiology New York University School of Medicine NYU. Langone Medical Center 550 First Avenue New York 10016 United States

AIM： To determine the association of Helicobacter pylori （H pylorl） CagA^＋ infection and pro-inflammatory polymorphisms of the genes interleukin （IL）-IRN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS： Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay （ELISA）. Infection with H pylori CagA^＋ was determined by serology and polymerase chain reaction （PCR）. IL-1B and IL-1RN polymorphisms genotyping was performed by PCRrestriction fragment length polymorphism （PCR-RFIP）and PCR respectively. RESULTS： In this dyspeptic population, 86% were Hpylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis （AAG） was associated with CagA^＋ status [odd ratio （OR） = 4.1; P 〈 0.000] and fruit consumption （OR = 0.3; P 〈 0.00）. Atrophic body gastritis （ABG） was associated with pepsinogen PGI/PGII 〈 3.4 （OR = 4.9; P 〈 0.04） and alcohol consumption （OR = 7.3; P 〈 0.02）. Duodenal ulcer was associated with CagA^＋（OR = 2.9; P 〈 0.04） and smoking （OR = 2.4; P 〈 0.04）. PGI 〈 60 μg/L as well as PGI/PGII 〈 3.4 were associated with CagA^＋. CONCLUSION： In a dyspeptic population in Costa Rica, H pylori CagA^＋ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly- morphisms IL-1B ＋ 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population.

关键词： Atrophic gastritis Pepsinogen Pepticulcers Helicobacterpylori-CagA Interleukins

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A high-power electromagnetic source for disabling improvised explosive devices

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High Voltage 2024年第2期9卷 403-409页

作者： Laurent Ariztia Njomza Ibrahimi Alexey Zhabin antoine Silvestre de Ferron Marc Rivaletto Edson Martinod Valérie Bertrand Bucur Novac Laurent Pécastaing Universite de Pau et des Pays de l’Adour E2S UPPASIAMEPauFrance XLIM UMR CNRS BriveLimogesFrance CISTEME LimogesFrance Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK

Ultra-wideband(UWB)microwave sources driven by specialised pulsed power generators have experienced a considerable development in the last decade due to their wide domain of new applications such as defence or counter-terrorism *** authors present the main findings of a research dedicated to the development of a pulsed power-driven electromagnetic field source for disabling improvised explosive devices(IED).The pulsed power generator driving the source is a 13-stage compact Marx producing voltage pulses reaching an amplitude of 0.5 MV,with a pulse repetition frequency(PRF)of up to 100 *** generator is coupled to a bipolar pulse forming line,providing bipolar pulses with a dV/dt of around 1.6 MV/*** pulsed power system feeds an array composed of 16 Koshelev-type UWB antennas through an impedance matching *** resulting electromagnetic source is capable to produce pulsed electric fields(PEFs)having a figure-of-merit(FOM)of 1 ***,practical experiments were carried out to study the effects of the PEFs on *** targets used in the present study are M2B type flashbulbs,known to have the same susceptibility as the US army M6 *** configurations of wires(shielded,twisted,etc)with different lengths were used in connecting items inside these *** tests were performed by placing the flashbulbs at different distances to determine the essential parameters(i.e.,amplitude,duration,and frequency range)of the PEFs required to trigger *** overview of the experimental campaign and the main findings are also presented followed by conclusions.

关键词： power bipolar source

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Acetic acid additive in NaNO_(3)aqueous electrolyte for long-lifespan Mg-air batteries

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Journal of Magnesium and Alloys 2024年第2期12卷 825-839页

作者： Yaqing Zhou Fan Sun Gunahua Lin Sandrine Zanna antoine Seyeux Philippe Marcus Jolanta´Swiatowska Chimie ParisTech-CNRS PSL UniversityInstitut de Recherche de Chimie Paris11 rue Pierre et Marie CurieParis 75005France

Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environmental sustainability,and ***,the fast hydrogen evolution reaction(HER)in NaCl-based aqueous electrolytes impairs the performance of Mg-air batteries and leads to poor specific capacity,low energy density,and low ***,the conventionally used NaCl solute was proposed to be replaced by NaNO_(3)and acetic acid additive as a corrosion inhibitor,therefore an electrolyte engineering for long-life time Mg-air batteries is *** resulting Mg-air batteries based on this optimized electrolyte demonstrate an improved discharge voltage reaching~1.8 V for initial 5 h at a current density of 0.5 mA/cm^(2) and significantly prolonged cells'operational lifetime to over 360 h,in contrast to only~17 h observed in NaCl electrolyte.X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry were employed to analyse the composition of surface film and scanning electron microscopy combined with transmission electron microscopy to clarify the morphology changes of the surface layer as a function of acetic acid *** thorough studies of chemical composition and morphology of corrosion products have allowed us to elucidate the working mechanism of Mg anode in this optimized electrolyte for Mg-air batteries.

关键词： Acetic acid additive in NaNO_(3)electrolyte Electrolyte engineering Corrosion surface film Surface characterization Hydrogen evolution

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Combining Thermochronology and Geochronology to Constrains Orogenic Processes in the Alps and Tibet

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Acta Geologica Sinica(English Edition) 2024年第S1期 41-43页

作者： Philippe Hervé LELOUP antoine MERCIER GE Chenglong Laboratoire de Géologie de Lyon: Terre Planètes et Environnement CNRS Key Laboratory of deep-Earth Dynamics of Ministry of Natural Resources Institute of Geology Chinese Academy of Geological Sciences

deciphering the kinematics of deformation is key to understand the crustal evolution. In the last decades several techniques have been developed to help constraining the timing of deformation. On one side geochronology techniques allow the dating of a wider range of minerals with higher spatial resolution. On the other side thermochronology, with the help of numerical simulations(PeCube, QTQt …), help to constrain the rock exhumation history that is often linked to the vertical component of deformation. In both cases the deformation timing can accurately be discussed only together with a serious structural analysis.

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PLCG2 Mutation in a Patient Presenting with Type 2 Autoimmune Hepatitis

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 685-687页

作者： antoine Gardin Léa Gaigne Aude Magérus Frédéric Rieux-Laucat Emmanuel Jacquemin Pediatric Hepatology and Liver Transplantation Unit National Reference Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune HepatitisFILFOIEERN RARE LIVERBicêtre HospitalAssistance Publique–Hôpitaux de ParisUniversity Paris-SaclayLe Kremlin-BicêtreFrance INSERM UMR 1193 HepatinovParis-Saclay UniversityOrsayFrance Laboratory of Immunogenetics of Pediatric Autoimmune Diseases INSERM UMR 1163Imagine InstituteParis CitéUniversityParisFrance

The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.

关键词： autoimmune Autoimmune immune

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Outcomes of intracranial hemorrhage in critically ill patients with acute leukemia: Results of a retrospective cohort study

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Journal of Intensive Medicine 2024年第4期4卷 508-514页

作者： antoine Herault Yannick Hourmant Etienne Lengliné antoine Lafarge Eric Mariotte1 2Michael Darmon12Sandrine Valade121 AP-HPHopital Saint-LouisMedical ICUParisFrance Universitéde Paris ParisFrance Hopital Charles Nicolle Medical ICURouenFrance AP-HP Hopital Saint LouisHematology DepartmentParisFrance

Background:Admission to the intensive care unit(ICU)is frequently required for patients with acute leukemia(AL)because of life-threatening complications such as intracranial hemorrhage(IH).In this study,we evaluated the impact of IH on survival and neurological outcomes in this ***:This was a single-center retrospective cohort study including adult patients with AL requiring ICU ad-mission and experiencing IH between 2002 and 2019 at Saint Louis *** type was determined according to the French-American-British *** imaging(either computed tomography or mag-netic resonance imaging)was available for all the *** primary endpoint of the study was to describe the clinical and biological characteristics and evaluate the mortality and neurological outcome of patients hospi-talized in the ICU with newly diagnosed AL and *** secondary endpoint was to identify predictive factors of IH in these ***:Thirty-five patients with AL were included,median age of the patients was 59.00(interquartile range[IQR]:36.00-66.00)***-nine patients(82.9%)had acute myeloid leukemia,including 12 patients with acute promyelocytic *** was constant,and 48.5% of patients had disseminated intravascular coagulation(DIC).At ICU admission,the median Sequential Organ Failure Assessment score was 5(IQR:3-9).The median time between AL onset and IH was 2.0(IQR:0.0-9.5)*** ICU and hospital mortality rates were 60.0%(n=21)and 65.7%(n=23),*** univariate analysis,mechanical ventilation and stupor were associated with mortality,but DIC and acute promyelocytic leukemia were *** multivariate analysis,stupor or coma was the only factor significantly associated with a poor outcome(odds ratio=8.56,95% confidence interval:2.40 to 30.46).Conclusion:IH is associated with a high mortality rate in AL patients,with stupor or coma at the onset of intracranial bleeding being independently associated with p

关键词： Acute leukemia Hematological malignancies Intracranial hemorrhage Intensive care unit Critical care

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安德烈·巴赞与作者策略

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电影艺术 2024年第2期 112-118页

作者：安托万·德巴克蔡文晟(译) 巴黎高等师范学院湖北经济学院新媒体系

作为影史上最著名的批评概念之一的“作者策略”,始终会与特吕弗以及《电影手册》难解难分,但一个不容忽视却动辄被略去的事实是,巴赞对该策略的组成要素及其被践行的方式,态度向来游移不定,暧昧有余。不过,或许正是这一份与其助产士式... 详细信息

作为影史上最著名的批评概念之一的“作者策略”,始终会与特吕弗以及《电影手册》难解难分,但一个不容忽视却动辄被略去的事实是,巴赞对该策略的组成要素及其被践行的方式,态度向来游移不定,暧昧有余。不过,或许正是这一份与其助产士式的人格特质、处世之道、运思仪轨互为表里的暧昧和游移,让巴赞竭力揭橥的“脉络化的作者策略”最终有望化作抵御弥漫整个20世纪50年代的电影之死声浪的绝佳药方,进而催生出新浪潮电影这一“贫瘠的大写的艺术”。

关键词：安德烈·巴赞作者策略新浪潮迷影电影之死

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Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： antoine Henry Dario A.Fioretto Lorenzo M.Procopio Stéphane Monfray Frédéric Boeuf Laurent Vivien Eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCITélécom ParisPalaiseauFrance Université Paris-Saclay CNRSCentre for Nanosciences and NanotechnologyUMR 9001PalaiseauFrance Weizmann Institute of Science RehovotIsrael STMicroelectronics SAS CrollesFrance

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability,noise resilience,parallelization,and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave ***,state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation,and efficient photon pair *** have developed silicon ring resonators with a footprint below 0.05 mm^(2)providing more than 70 frequency channels separated by 21 *** exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic *** fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state *** demonstrate for the first time,we believe,a fully connected five-user quantum network in the frequency *** results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology,for applications in quantum computing and secure communications.

关键词： integrated photonics frequency domain quantum gates quantum networks

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戈达尔的离世教给我们的那些事

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电影艺术 2024年第3期 3-8页

作者： [法]安托万·德巴克蔡文晟(译) 巴黎高等师范学院湖北经济学院新媒体系

为什么让-吕克·戈达尔在其91岁高龄之际选择协助自杀这件事与我们每一个人有关?因为,戈达尔就是历史。诚然,身为一个难以归类的创作者,戈达尔一生都活在一种绝对的孤立中,但这并非一种唯我、自恋式的状态,反之,充斥其间的各式群像,早... 详细信息

为什么让-吕克·戈达尔在其91岁高龄之际选择协助自杀这件事与我们每一个人有关?因为,戈达尔就是历史。诚然,身为一个难以归类的创作者,戈达尔一生都活在一种绝对的孤立中,但这并非一种唯我、自恋式的状态,反之,充斥其间的各式群像,早已成为世界的映照,言下之意,要说戈达尔其人其思最终何以泽被四方,其主因无非在此,而这个与赋形存在深层联结的关键现象,最后亦将成为他在面对生命乃至死亡时的极致解法:要走,就要走得无亏无欠。

关键词：让-吕克 ·戈达尔历史赋形死亡协助自杀

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置身巴黎大街上的实拍:好莱坞与新浪潮

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上海师范大学学报（哲学社会科学版） 2024年第4期53卷 93-99页

作者： [法]安托万·德巴克蔡文晟(译) 巴黎高等师范学院湖北经济学院新媒体系

没有比较,就没有历史,没有历史,就没有故事,更遑论叙事,亦即一个攸关人及其视角的艺术行动。诚然,20世纪50年代盛极一时的好莱坞大举移师巴黎实拍的风气,与战后美法间一系列经济政策关系匪浅,但,若少了那几个以《电影手册》为策反据点... 详细信息

没有比较,就没有历史,没有历史,就没有故事,更遑论叙事,亦即一个攸关人及其视角的艺术行动。诚然,20世纪50年代盛极一时的好莱坞大举移师巴黎实拍的风气,与战后美法间一系列经济政策关系匪浅,但,若少了那几个以《电影手册》为策反据点、以场面调度为电影之真的终极圭臬的“新浪潮五虎将”的积极介入,“就地取材”,最终也只能流于最片面意义的写实主义,并至多引来批评家的阵阵奚落。从某种程度上来说,得是引领日后新浪潮的那几个年轻影评人,才让好莱坞到巴黎大街上实拍这件事具备了绝对意义上的创造性,不仅先行催生出法国本地影坛的突变,继又受惠于此:外部环境之变虽能左右影史走势,但唯有一种迷影式的目光,该历史才得以无限生成。

关键词：好莱坞新浪潮巴黎实拍迷影比较电影

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