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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye Ming-Lin Pan Bo Hang Jian-Hua Mao antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

Hexavalent Chromium Cr (VI) Removal from Water by Mango Kernel Powder

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 84-103页

作者： Amadou Sarr Gning Cheikh Gaye antoine Blaise Kama Pape Abdoulaye Diaw Diène Diégane Thiare Modou Fall Laboratoire de Chimie Physique Organique et d’Analyses Environnementales (LCPOAE) Université Cheikh Anta Diop Dakar Sénégal Equipe Chimie des Matériaux Inorganique et Organique (ECMIO) Université Alioune Diop Bambey Sénégal Equipe des Matériaux Electrochimie et Photochimie Analytiques (EMEPA) Université Alioune Diop Bambey Sénégal Laboratoire de Photochimie et d’Analyse (LPA) Université Cheikh Anta Diop Dakar Sénégal

Metal trace elements (MTE) are among the most harmful micropollutants of natural waters. Eliminating them helps improve the quality and safety of drinking water and protect human health. In this work, we used mango kernel powder (MKP) as bioadsorbent material for removal of Cr (VI) from water. Uv-visible spectroscopy was used to monitor and quantify Cr (VI) during processing using the Beer-Lambert formula. Some parameters such as pH, mango powder, mass and contact time were optimized to determine adsorption capacity and chromium removal rate. Adsorption kinetics, equilibrium, isotherms and thermodynamic parameters such as ΔG˚, ΔH˚, and ΔS˚, as well as FTIR were studied to better understand the Cr (VI) removal process by MKP. The adsorption capacity reached 94.87 mg/g, for an optimal contact time of 30 min at 298 K. The obtained results are in accordance with a pseudo-second order Freundlich adsorption isotherm model. Finally FTIR was used to monitor the evolution of absorption bands, while Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS) were used to evaluate surface properties and morphology of the adsorbent.

关键词： Adsorption Chromium Mango Kernel Powder Spectroscopy Analysis Water Treatment

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纪念的责任诺曼底登陆日博物馆

室内设计与装修 2024年第8期 56-63页

作者： [法国]Projectiles antoine Cardi(摄影) coco(编译) Projectiles

阿罗曼切的诺曼底登陆日博物馆是第二次世界大战后第一座以此为主题的博物馆。2024年,随着由Projectiles设计的新建筑的开放,博物馆的历史翻开新的一页。项目主要的挑战是不光要重现记忆和传播那段历史,更要明确纪念的责任,其目的不仅... 详细信息

阿罗曼切的诺曼底登陆日博物馆是第二次世界大战后第一座以此为主题的博物馆。2024年,随着由Projectiles设计的新建筑的开放,博物馆的历史翻开新的一页。项目主要的挑战是不光要重现记忆和传播那段历史,更要明确纪念的责任,其目的不仅仅是要保存人工港口里那些会在不久的将来消失的遗迹。

关键词：诺曼底登陆博物馆纪念责任人工港口第二次世界大战

Prevalence and Factors Associated with Diabetes among City Hall Workers, Bohicon, Benin

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Open Journal of Epidemiology 2024年第2期14卷 366-377页

作者： Adjobimey Mênonli Djohoun Frimège Mama Cissé Ibrahim Mikponhoué Rose Gounongbé Fabien Ayélo Paul Hinson Vikkey antoine Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin Ecole de Mé decine Universit&#233 de Parakou Parakou Benin

Introduction: Living and working conditions are increasingly conducive to a sedentary lifestyle. Many administrative workers are exposed daily to long hours of work in a prolonged sitting position, which can favour the onset of diabetes. The aim of the study was to determine the prevalence and factors associated with diabetes among workers at a town hall in Benin in 2019. Methods: This was a descriptive cross-sectional study conducted from December 2018 to January 2019. Exhaustive recruitment was carried out. Data were collected during a face-to-face interview, using a standardized questionnaire including socio-professional factors, behavioral factors, anthropometric measurements, and blood glucose. Frequencies were calculated. Frequencies were compared using the chi-square and Fisher tests. The significance threshold was 5%. Results: A total of 85 workers were included. Their mean age was 41.55 ± 9.82 years, with a sex ratio of 6.1. = The prevalence of diabetes was estimated at 8.2% [95% CI: 3.38 - 16.23%] and 3 of the workers knew they had diabetes. A family history of diabetes was associated with diabetes (p = 0.032). Occupationally, 10.77% of permanent employees had diabetes, compared with 0.0% of non-permanent employees;12.50% of employees with at least 10 years’ seniority had diabetes, compared with 7.25% of those with less seniority;19.05% of employees who spent at least 6 hours a day sitting at work had diabetes, compared with 4.69% of those who spent less time sitting. Conclusion: Preventing chronic disease in the workplace is part of promoting workers’ health, and must take into account occupational factors such as prolonged sitting.

关键词： Diabetes Prolonged Sitting Workers-Benin

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通用电气拆分记

商业周刊（中文版） 2024年第8期 56-63页

作者： Brooke Sutherland Ryan Been antoine Maillard(插画) 不详

在通用电气公司位于俄亥俄州比弗克里克市的厂,一间会议室里四周贴满了一张张大白纸。每张纸上都有记号笔写的潦草字迹,还覆盖着用各种彩色便利贴做的注释,里面总结了各种管子和导管的生产步骤,这些部件最后都会组装到某架喷气发动机上... 详细信息

在通用电气公司位于俄亥俄州比弗克里克市的厂,一间会议室里四周贴满了一张张大白纸。每张纸上都有记号笔写的潦草字迹,还覆盖着用各种彩色便利贴做的注释,里面总结了各种管子和导管的生产步骤,这些部件最后都会组装到某架喷气发动机上。这里的氛围更像是某所小学校的科学博览会,而不是在美国工业界的一家偶像级企业。但是简单明了正是其要点所在。确定比弗克里克工厂的布局是件很复杂的事:这家经过改造的工厂是去年投产的。

关键词：通用电气公司克里克记号笔美国工业界喷气发动机俄亥俄州生产步骤小学校

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 142-159页

作者： Adjobimey Mênonli Mikponhoué Rose Dégbey Cyriaque Hountohotègbé Esdras Guédou Alexandre Lawani Affousath Ayélo Paul Hinson antoine Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo-Phtisiologie Cotonou Benin Occupational Health Service at the Referral Hospital Construction Site Abomey-Calavi Benin Inter-Faculty Center for Environmental Training and Research for Sustainable Development (CIFRED) Abomey-Calavi Benin

Introduction: Work-related accidents are frequent and serious in the construction sector. The aim of the study was to determine the frequency and factors associated with occupational accidents on the construction site of a referral hospital in Benin. Methods: A cross-sectional study was carried out. The sample size was calculated using the Schwartz form adjusted for the number of workers on site and was 129 workers. Random sampling was used. The dependent variable was work-related accidents. The other variables were socio-demographic and occupational characteristics. Data were collected through a questionnaire survey. Medians and proportions were calculated. An association was sought using Chi-square and Fisher tests with a threshold of p Results: A total of 132 workers were included. Their median age was 30 years with an ITQ of [27 - 38];men were the most represented 126 (95.45%) with a level of education higher than or equal to high school in 101 (76.52%) and in the majority with a permanent status 85 (64.39%). Seniority of more than 5 years was observed in 92 (69.7%). Workers working more than 8 hours of overtime per week numbered 57 (43.18%). Exposure to vibrating objects was 49 (37.12%). In terms of psychosocial constraints, 82.58% had high psychological demands;79.53% low decision-making latitude;50.76% low social support. The frequency of work-related accidents was 6.82%, and the only associated factor was the type of worker (p = 0.016). On the other hand, there were 10.2% accidents among workers handling vibrating objects versus 4.98% among those not using them. With regard to psychosocial constraints, the following frequencies were recorded respectively: 6.42% among those with high psychological demand versus 8.7% among those with low psychological demand;7.62% among those with low decision-making latitude versus 3.7% among those with high decision-making latitude;8.96% among those with low social support versus 4.62% among those with high support. Conclusi

关键词： Occupational Injury Building and Civil Engineering Construction Environment

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安德烈·巴赞与作者策略

电影艺术 2024年第2期 112-118页

作者：安托万·德巴克蔡文晟(译) 巴黎高等师范学院湖北经济学院新媒体系

作为影史上最著名的批评概念之一的“作者策略”,始终会与特吕弗以及《电影手册》难解难分,但一个不容忽视却动辄被略去的事实是,巴赞对该策略的组成要素及其被践行的方式,态度向来游移不定,暧昧有余。不过,或许正是这一份与其助产士式... 详细信息

作为影史上最著名的批评概念之一的“作者策略”,始终会与特吕弗以及《电影手册》难解难分,但一个不容忽视却动辄被略去的事实是,巴赞对该策略的组成要素及其被践行的方式,态度向来游移不定,暧昧有余。不过,或许正是这一份与其助产士式的人格特质、处世之道、运思仪轨互为表里的暧昧和游移,让巴赞竭力揭橥的“脉络化的作者策略”最终有望化作抵御弥漫整个20世纪50年代的电影之死声浪的绝佳药方,进而催生出新浪潮电影这一“贫瘠的大写的艺术”。

关键词：安德烈·巴赞作者策略新浪潮迷影电影之死

Risk Factors for Cardiovascular Disease among Hotel Workers, Bohicon, Benin

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 130-141页

作者： Mênonli Adjobimey Rose Mikponhoué Eméline Gbaguidi Esdras Hountohotegbè Hélène Sacca Paul Ayélo Vikkey antoine Hinson Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin

Introduction: Non-communicable diseases (NCDs) are on the increase in several sectors of activity. The aim of the study was to determine the frequencies of cardiovascular risk factors (CVRF) and factors associated with hypertension among hotel workers in the city of Bohicon. Methods: This was a descriptive and analytical cross-sectional study conducted in the period from December 2018 to January 2019. The variables studied were sociodemographic, occupational, anthropometric and behavioral. Participant recruitment was exhaustive. A standardized questionnaire inspired by the STEPS-WHO questionnaire was used for data collection. After the descriptive analysis, a bivariate analysis was performed using Pearson’s Chi-square test or Fisher’s test at the 5% threshold. Results: A total of 101 workers, 53 (52.47%) of them male, participated in the study. The mean age was 30.60 ± 8.20 years, with extremes of 18 and 55 years. The frequencies of the main risk factors were: 68.32% sitting position > 6 hours/day;38.61% shift work;21.78% high psychological demand, 82.18% low decision latitude, 24.75% low social support, 21.78% occupational stress;7 (6.93%) harmful alcohol consumption;6.93% tobacco consumption;48.51% insufficient physical activity;98.02% insufficient fruit and vegetable consumption;59.41% overweight;14.85% HTA. Factors associated with hypertension were: sex, age and marital status. Conclusion: Occupational factors need to be taken into account when assessing CVRFs. NCD control programs are needed in all sectors of activity. A larger study is needed in the hotel sector.

关键词： FDRCV Occupational Factors Hypertension Hotels Benin

Sleep Disorders among Professional Oil Tanker Drivers in Ouagadougou Burkina Faso

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Occupational Diseases and Environmental Medicine 2024年第1期12卷 1-20页

作者： Guy Alain Ouédraogo Dofinihanou Dite Inessa Coulibaly Mênonli Adjobimey Abdoul Risgou Ouédraogo Rose Mikponhoue antoine Vikkey Hinson Health Sciences Training and Research Unit University of Ouahigouya Ouagadougou Burkina Faso Department of Pneumology Regional University Hospital of Ouahigouya Ouagadougou Burkina Faso Workers Health Office Ouagadougou Burkina Faso Occupational and Environmental Health Research Unit Faculty of Health Sciences Cotonou Republic of Benin Health Sciences Training and Research Unit Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: Sleep disorders among professional drivers are a major road safety problem. They cause fatigue and drowsiness at the wheel, which can lead to road traffic accidents and even accidents at work. The aim of this study was to assess sleep disorders among professional drivers of oil tankers in Ouagadougou, Burkina Faso. Methods: This was a descriptive and analytical cross-sectional study carried out from 11 April 2020 to 11 September 2020 in the national hydrocarbon company’s fuel depot. All the drivers present at the time were included and accomplished a questionnaire incorporating the commonly scales using to assess sleep disorders, sleep quality and sleep apnoea. Data analysis using R 3.6.1 software enabled to perform univariate and multivariate analyses to identify associated factors. Adjusted odd ratios were used to measure the strength of association. The significance level chosen was p ≤ 0.05. Results: All the 339 respondents were male. A proportion of 33.6% suffered from insomnia, including 12.7% with moderate to severe insomnia, and 18.58% were at risk of sleep apnoea. On the Epworth scale, 26.6% of drivers showed sleep debt and 4.1% excessive daytime sleepiness. The risk factors associated with insomnia were the use of psychostimulants. A history of diabetes and insomnia were risk factors associated with sleep apnoea syndrome. Conclusion: The prevalence of sleep disturbance and insomnia among the respondents were 52.2% and 33.6% respectively. Use of psychostimulants was the identified risk factor. The prevalence of SAS was 4.72%, with diabetes and insomnia as associated factors.

关键词： Sleep Disorders Sleep Apnoea Occupational Health Burkina