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Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters

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Journal of Genetics and Genomics 2023年第7期50卷 536-540页

作者： Alicia Coudert Caroline Cazin Amir Amiri-Yekta Selima Fourati Ben Mustapha Raoudha Zouari Julien Bessonat Abdelali Zoghmar antoine clergeau Catherine Metzler-Guillemain Chema Triki Herve Lejeune Nathalie Sermondade Eva Pipiras Nadia Prisant Isabelle Cedrin Leila Keskes Florence Lestrade Laetitia Hesters Nathalie Rives Beatrice Dorphin Agnes Guichet Catherine Patrat Emmanuel Dulioust Aur elie Feraille Franc ois Robert Eric Bieth Arthur Sorlin Jean-Pierre Siffroi Mariem Ben Khelifa Florence Boiterelle Sylvianne Hennebicq Veronique Satre Christophe Arnoult Charles Coutton Anne-Laure Barbotin Nicolas Thierry-Mieg Zine-Eddine Kherraf Pierre F.Ray Genetic Epigenetic and Therapies of Infertility Team Institute for Advanced BiosciencesInserm U 1209CNRS UMR 5309Universite Grenoble Alpes38000GrenobleFrance CHU Grenoble Alpes UM GI-DPI38000GrenobleFrance CHU Grenoble Alpes UM de Genetique Chromosomique38000GrenobleFrance Department of Genetics Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Polyclinique les Jasmins Centre d’Aide M edicale a la Procr eationCentre Urbain Nord1003TunisTunisia CHU Grenobles Alpes UF de Biologie de la Procr eation38000GrenobleFrance Reproduction Sciences and Surgery Clinique Ibn RochdConstantineAlgeria CHU Caen CECOS de CaenD epartement de BiologieUnit e de Biologie de la Reproduction14033CaenFrance APHM Hopital La-Conception P^ole Femmes-parents-enfantsCentre Clinico-biologique d’assistance M edicale a la Procr eation-CECOS13385 MarseilleFrance Aix-Marseille Univ InsermMMGU125113385 Marseille Medical Genetics13385 MarseilleFrance Clinique Hannibal Centre d’AMPLes Berges du Lac1053TunisTunisia Reproductive Medicine Department Hospices Civil de LyonLyonFrance Hopital Jean Verdier Universit e Sorbonne Paris NordParisFrance CHU de Pointe-a-Pitre/Abymes GuadeloupeFrance Service de Medecine de la Reproduction CHU Jean VerdierParisFrance Faculte de M edecine de Sfax SfaxTunisia CHR Metz-Thionville Service d’Assistance Medicale a la Procr eation57530Ars-LaquenexyFrance Unit of Reproductive Biology Antoine B ecl ere University HospitalUniversity Paris SudClamartParis-Sud UniversityLe Kremlin Bic^etreFrance Univ Rouen Normandie Inserm U1239NorDICAdrenal and Gonadal PathophysiologyReproductive Biology Laboratory-CECOSRouen University Hospital76031Rouen CedexFrance CHAL Centre Hospitalier Alpes Leman Centre AMP7474130Contamine-sur-ArveFrance CHU Angers Service de Gen etique49933AngersINSERM U1083France Service de Biologie de la Reproduction-CECOS Hopital Cochin 74014ParisFrance IRH Medicentre Clinique du Val d’Ouest39

Macrozoospermia,characterized by the presence of largeheaded spermatozoa usually carrying several flagella,is one of the most severe phenotypes of male *** in most cases,the gametes are chromosomally abnormal and cannot be used for assisted reproductive technologies(ART)(Ray et al.,2017).In 2007,subjects from consanguineous families were shown to carry the same homozygous deleterious AURKC variant(NM_001015878.2:c.144delC,later renamed c.145delC,***49TrpfsTer23),establishing AURKC as the first and main gene associated with macrozoospermia(Dieterich et al.,2007).Using flow cytometry,all spermatozoa from patients homozygous for the c.145delC variant were shown to be tetraploid,highlighting a cytokinesis blockage of the first meiotic divisions thus confirming that ART cannot be successful for these patients(Dieterich et al.,2009).

关键词： diagnosis establishing

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Hydraulic characteristics of an anaerobic baffled reactor as onsite wastewater treatment system

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Journal of Environmental Sciences 2010年第9期22卷 1319-1326页

作者： Yuttachai Sarathai Thammarat Koottatep antoine Morel School of Environment Resources and Development Asian Institute of Technology Eawag:Swiss Federal Institute for Aquatic Science & Technology Department for Water and Sanitation in Developing Countries(Sandec)

The feasibility of using anaerobic baffled reactor （ABR） as onsite wastewater treatment system was discussed. The ABR consisted of one sedimentation chamber and three up-flow chambers in series was experimented under different peak flow factors （PFF of 1 to 6）, superficial gas velocities （between 0.6 and 3.1 cm/hr） and hydraulic retention times （HRT）（24, 36 and 48 hr）. Residence time distribution （RTD） analyses were carded out to investigate the hydraulic characteristics of the ABR. It was found that the PFF resulted in hydraulic dead space. The dead space did not exceed 13% at PFF of 1, 2 and 4 while there was 2-fold increase （26%） at PFF of 6. Superficial gas velocities did not result in more （biological） dead space. The mixing pattern of ABR tended to be a completely- mixed reactor when PFF increased. Superficial gas velocities did not affect mixing pattern. The effects of PFF on mixing pattern could be minimized by higher HRT （48 hr）. The tank-in-series （TIS） model （N = 4） was suitable to describe the hydraulic behaviour of the studied system. The HRT of 48 hr was able to maintain the mixing pattern under different flow patterns, introducing satisfactory hydraulic efficiency. Chemical oxygen demand （COD） and total suspended solids （TSS） removals under all flow patterns were achieved more than 85% and 90%, respectively. The standard deviation of effluent COD and TSS concentration did not exceed 15 mg/L.

关键词： anaerobic baffled reactor dead space hydraulic characteristics onsite system peak flow factor

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Liquid metal thermal hydraulics R&D at European scale:achievements and prospects

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Frontiers in Energy 2021年第4期15卷 842-853页

作者： Ferry ROELOFS antoine GERSCHENFELD Katrien Van TICHELEN Nuclear Research and Consultancy Group(NRG) Westerduinweg 31755 LEPettenThe Netherlands CEA DES UniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance SCK CEN Boeretang 2002400 MolBelgium

A significant role for a future nuclear carbonfree energy production is attributed to fast reactors,mostly employing a liquid metal as a *** paper summarizes the efforts that have been undertaken in collaborative projects sponsored by the European Commission in the past 20 years in the fields of liquid-metal heat transfer modeling,fuel assembly and core thermal hydraulics,pool and system thermal hydraulics,and establishment of best practice guidelines and verification,validation,and uncertainty quantification(UQ).The achievements in these fields will be presented along with the prospects on topics which will be studied collaboratively in Europe in the years to *** prospects include further development of heat transfer models for applied computational fluid dynamics(CFD),further analysis of the consequences of fuel assembly blockages on coolant flow and temperature,analysis of the thermal hydraulic effects in deformed fuel assemblies,extended validation of three-dimensional pool thermal hydraulic CFD models,and further development and validation of multi-scale system thermal hydraulic methods.

关键词： liquid metal thermal hydraulics Europe

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Stop-and-go waves induced by correlated noise in pedestrian models without inertia

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 52-60页

作者： antoine Tordeux Andreas Schadschneider Sylvain Lassarre School of Mechanical Engineering and Safety Engineering University of WuppertalWuppertal 42119Germany Institute for Theoretical Physics University of CologneCologne 50937Germany Engineering of Surface Transportation Networks and Advanced Computing Laboratory French Institute of Science and Technology for TransportDevelopment and NetworksMarne La Vallee E-77447France

Stop-and-go waves are commonly observed in traffic and pedestrian *** most microscopic traffic models,they occur through a phase transition and instability of the homogeneous solution after fine tuning of *** effects are believed to play an important role in this *** this article,we present a novel explanation for stop-and-go waves based on stochastic effects in the absence of *** model used is a first order optimal velocity(OV)model including an additive stochastic noise.A power spectral analysis for single-file pedestrian trajectories highlights the existence of Brownian speed *** use the Ornstein-Uhlenbeck process to describe such a correlated *** introduction of this specific colored noise in the first order OV model allows describing realistic stop-and-go behavior without requiring instabilities or phase transitions,the homogeneous configurations being systematically stochastically *** compare the stochastic model to deterministic unstable OV models and analyze individual speed autocorrelation to describe the nature of the waves in stationary *** apply the approach to pedestrian single-file motion and compare simulation results to real pedestrian *** simulation results are quantitatively very similar to the real *** discuss plausible values for the model parameters and their meaning.

关键词： Transportation engineering Pedestrian single-file motion Stop-and-go dynamics First order microscopic model Brownian noise Simulation

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Zinc-mediated reactions on salicylaldehyde for Botrytis cinerea control

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Chinese Chemical Letters 2020年第3期31卷 706-710页

作者： antoine Franche Claire Imbs antoine Fayeulle Franck Merlier Muriel Billamboz Estelle Léonard Sorbonne University Universitéde technologie de CompiègneESCOMEA TIMR 4297Centre de recherche de RoyallieuCS 6031960203 Compiègne cedexFrance ESCOM UTCEA TIMR 42971 allée du Réseau Jean-Marie Buckmaster60200 CompiègneFrance Sorbonne Universités Universitéde Technologie de CompiègneGénie Enzymatique et Cellulaire(GEC)UMR-CNRS 7025CS 6031960203 Compiègne CedexFrance Laboratoire de chimie durable et santé Yncrea Hauts-de-FranceHEI13 rue de Toul59046 Lille CedexFrance

Botrytis cinerea is a necrotrophic fungusth at a ffects various plant *** control is an ecessity and as much as possible,eco-friendly conditions and bioresources to obtain these chemicals should be *** this context,a series of products w as obtained from salicylaldehyde using zinc as a powerful reagent and tested for antifungal activity against Botrytis cinerea.

关键词： Salicylaldehyde Zinc-mediated reactions Green solvents Alkoxymethylphenol PEG-cresol Botrytis cinerea control

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Sleep to Survive Predators

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Neuroscience Bulletin 2022年第9期38卷 1114-1116页

作者： Mattia Aime antoine R.Adamantidis Department of Neurology Zentrum für Experimentelle NeurologieInselspital University Hospital Bern3010BernSwitzerland Department of Biomedical Research University of Bern3010BernSwitzerland

Sleep is a reversible behavioral state characterized by a higher arousal threshold and transient disconnection from the external ***,sleeping organisms show lowered behavioral responsiveness to sensory stimuli(such as sound,touch,and smell)in the experimental environment[1]that contrastswithheightenedauditory-evokedneuronal responses recorded in the cortex in rodents and non-human primates[2,3].These reports support the hypothesis of sensory gating,as found during sleep spindles,that ultimately preserves sleep from external ***,this strongly contrasts to the high vulnerability to predation associated with sleep states in the natural environment.

关键词： evoked auditory cortex

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A review of modified and hybrid anaerobic baffled reactors for industrial wastewater treatment

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Water Science and Engineering 2022年第3期15卷 247-256页

作者： Poh Lin Lau antoine P.Trzcinski Department of Civil Engineering School of Engineering and TechnologyUniversity of Technology SarawakSibuSarawak 96000Malaysia School of Agriculture and Environmental Science University of Southern QueenslandWest StreetQueensland 4350Australia

This review discusses high-strength wastewater treatment using anaerobic baffled reactors(ABRs)and modified *** research findings and applications of ABRs in treating various types of high strength wastewater generated from food companies,livestock,and industries were summarized and *** parameters affecting the performance of ABRs are briefly *** state-of-the-art laboratory studies are compiled and critically *** challenges and suggestions for future investigation are also addressed.

关键词： Anaerobic baffled reactor Industrial food wastewater Livestock wastewater High-strength wastewater Anaerobic digestion

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Farmers' contributions to the conservation of tree diversity in the Groundnut Basin,Senegal

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Journal of Forestry Research 2017年第5期28卷 1083-1096页

作者： antoine Sambou Bienvenu Sambou Anders R?bild Department of Geosciences and Natural Resource Management Faculty of ScienceUniversity of Copenhagen Institut des Sciences de l'Environnement (ISE) Facultdes Sciences et TechniqueUniversitCheikh Anta Diop(UCAD)

Tree diversity in West Africa is threatened by intensified land uses and salinization, and farmers’ role in conservation of tree species is unclear. We hypothesized that farmers contribute to conservation of tree diversity through protection of trees in their agroforestry landscapes and compared the diversity and structure of the tree vegetation across landscape classes. Inventories were carried out in three villages in the Groundnut Basin in Senegal, assessing tree diversity, density and crown cover. Tree diversity as assessed by species accumulation curves was high in forests, but cultivated landscapes had comparable or almost comparable diversity, especially in the cases where the forest was planted or was affected by charcoal production. However, the occurrence of exotic species was higher in cultivated parts of the landscape, and although many species were in common, ordination plots indicated that forests and cultivated landscapes to some degree had different species composition. Salinity had a strong influence on vegetation, not only in the tans (salt marshes) but also across the other landscape classes. In conclusion, agroforestry landscapes in the three villages harbor considerable tree diversity, but insufficient to fully conserve the tree species. We argue that informing and including farmers in tree management in the region will contribute to overall conservation of tree genetic resources.

关键词： Tree diversity Conservation-landscape classes Environmental factors Groundnut Basin

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Vibrations induced by tunnel boring machine in urban areas: In situ measurements and methodology of analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第1期15卷 130-145页

作者： antoine Rallu Nicolas Berthoz Simon Charlemagne Denis Branque University of Lyon ENTPELTDS-UMR CNRS 5513CeLyAVaulx-en-VelinFrance French Centre for Tunnel Studies(CETU) BronFrance

Excavation with tunnel boring machine(TBM)can generate vibrations,causing damages to neighbouring buildings and disturbing the residents or the *** problem is particularly challenging in urban areas,where TBMs are increasingly large in diameter and shallow in *** response to this problem,four experimental campaigns were carried out in different geotechnical contexts in *** vibration measurements were acquired on the surface and inside the *** measurements are also complemented by few data in the *** original methodology of signal processing is pro-posed to characterize the amplitude of the particle velocities,as well as the frequency content of the signals to highlight the most energetic *** levels of vibrations are also compared with the thresholds existing in various European regulations concerning the impact on neighbouring structures and the disturbance to local residents.

关键词： Ground-borne vibrations Tunnel boring machine(TBM) In situ measurement Dynamic characterization Vibration levels Site spectrum

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Celebrating the 95th birthday of Professor Karl *** Part 3-Memory lane

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Computer Modeling in Engineering & Sciences 2021年第12期129卷 1487-1488页

作者： de Saint-Exupéry, antoine

There are four items in Part 3,which begins with the section“On friendship:Our secret regret of growing old”,an excerpt from the 1939 novel titled“Wind,Sand and Stars”by the well-known French fighter-pilot literar... 详细信息

关键词： antoine birthday literary

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