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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural regeneration research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

应用CrISP清单,提升我国全科医学和基本医疗研究报告的质量

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中国全科医学 2025年第4期28卷 393-401页

作者：杨辉汪洋陈庆奇刘晨曦顾杰赵洋秦江梅曹新阳 Elizabeth Sturgiss William r.phillips 许岩丽 Monash大学公共卫生与预防医学学院澳大利亚墨尔本市VIC 3168 上海市全科医学与社区卫生发展研究中心 200090 同济大学附属杨浦医院全科医学科上海市200090 香港大学家庭医学及基层医疗学系中国香港特别行政区999077 华中科技大学同济医学院医药卫生管理学院湖北省武汉市430000 复旦大学附属中山医院全科医学科上海市200032 复旦大学附属中山医院国际医疗部上海市200032 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010 国家卫生健康委卫生发展研究中心北京市100044 《中国全科医学》杂志社有限公司北京市100053 School of Primary and Allied Health Care Monash UniversityMelbourneVictoriaAustraliaVIC 3168 University of Washington SeattleWashington98195

基本医疗(初级保健)研究报告内容的条目共识(CrISP)工作组于2023年提出了CrISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CrISP清单进行了中文翻译,并通过这篇述评,在回顾我国全... 详细信息

基本医疗(初级保健)研究报告内容的条目共识(CrISP)工作组于2023年提出了CrISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CrISP清单进行了中文翻译,并通过这篇述评,在回顾我国全科医学和基本医疗研究的内涵和发展现状的基础上,归纳了该领域的科研报告中目前存在的主要问题,如“以作者为中心”“过度重视塑造权威性”“盲目生搬国际经验”“缺乏对方法学的透明报告”“在论文中压入大量冗繁信息”以及“遮蔽关键信息”等。最后,编辑团队推荐和鼓励中国的全科医学和基本医疗服务研究的作者、编辑和学术评议专家尝试使用CrISP清单,在改善中国全科医学和基本医疗研究报告质量的同时,进一步完善该工具在学科发展研究、临床研究、卫生服务研究、卫生政策研究、教育和培训研究以及社区流行病学研究等亚领域中的应用。

关键词：全科医学基本医疗研究报告内容共识

Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly j rivenbark Timothy D phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

rare earth elements:Properties and applications to methanol synthesis catalysis via hydrogenation of carbon oxides

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journal of rare Earths 2018年第11期36卷 1127-1135页

作者： anthony r.richard Maohong Fan Department of Chemical Engineering University of WyomingLaramieWY 82071USA School of Energy resources University of WyomingLaramieWY 82071USA

Methanol （CH3OH） is an important industrial chemical with a wide variety of uses. Industrial methanol synthesis catalysts are typically composed of Cu, Zn, and AI, but the use of catalysts incorporating rare earth elements has been shown to improve the catalytic performance. Due to their unique chemical and physical properties, the use of rare earth elements （scandium, yttrium, and the lanthanides） in catalysis in general has continued to increase over the past few decades, while the use of rare earth in methanol synthesis catalysts has not, despite often improving pertbrmance. The ability of several of the rare earth elements （Pr, Ce, Eu, Tb, Yb） to easily switch between oxidation states makes them beneficial for many different types of catalysts. However, for methanol synthesis the surface basicity is an important property, and the basic nature of the rare earth elements can be used to tune the basicity of catalysts. A small number of correlations between rare earth properties and catalytic performance have been observed, but often do not apply to other catalysts. Properties such as strength of basic sites, ionic radius, and etec- tronegativity have been found to correlate with performance results such as activity or selectivity.

关键词： Methanol synthesis rare earth Lanthanides Catalysis Hydrogenation

Single-atom Pt on carbon nanotubes for selective electrocatalysis

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Carbon Energy 2024年第1期6卷 63-71页

作者： Samuel S.Hardisty Xiaoqian Lin anthony r.j.Kucernak David Zitoun Department of Chemistry Bar Ilan Institute of Nanotechnology and Advanced Materials(BINA)Bar Ilan UniversityRamat GanIsrael Department of Chemistry Molecular Science Research HubImperial College LondonLondonUK

Utilizing supported single atoms as catalysts presents an opportunity to reduce the usage of critical raw materials such as platinum,which are essential for electrochemical reactions such as hydrogen oxidation reaction(HOr).Herein,we describe the synthesis of a Pt single electrocatalyst inside single-walled carbon nanotubes(SWCNTs)via a redox *** via electron microscopy,X-ray photoelectron microscopy,and X-ray absorption spectroscopy show the single-atom nature of the *** electrochemical behavior of the sample to hydrogen and oxygen was investigated using the advanced floating electrode technique,which minimizes mass transport limitations and gives a thorough insight into the activity of the *** single-atom samples showed higher HOr activity than state-of-the-art 30%Pt/C while almost no oxygen reduction reaction activity in the proton exchange membrane fuel cell operating *** selective activity toward HOr arose as the main fingerprint of the catalyst confinement in the SWCNTs.

关键词： confinement electrocatalysis hydrogen platinum single atom catalysts

Placing old wine into new bottles:successful repurposing of bumetanide for treatment of autism spectrum disorder

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Science Bulletin 2021年第15期66卷 1491-1492,M0003页

作者： anthony G.phillips Department of Psychiatry Djavad Mowafaghian Centre for Brain HealthUniversity of British ColumbiaVancouver V6T 1Z4Canada

At a time of unprecedented need and despite significant advances in understanding brain function and related diseases,the drug pipeline for treatment of mental ill-health is failing[1,2].The reasons are many,including the unparalleled complexity of the central nervous system(CNS)itself,a lack of interdisciplinary research collaborations,increased drug development costs,and higher risk of clinical failure of CNS drugs compared with other areas of drug development[3–6].It is now widely recognized that individual dimensions of mental ill health arise from altered neural processes within specific brain circuits that may be shared across diagnostic categories[7,8].The inclusion of cognitive and social processes is particularly appropriate because cognitive dysfunction is of paramount importance to the understanding and treatment of many psychiatric disorders[9].This issue is further compounded by the lack of adequate medication to reverse cognitive and social *** respect to neurodevelopmental disorders that give rise to early onset of a spectrum of symptoms related to schizophrenia,attention deficit hyperactivity disorder,autism spectrum disorders(ASD)to name but a few,the need to discover effective treatment options is particularly urgent.

关键词：自闭症 drugs treatment

Steatotic livers are susceptible to normothermic ischemiareperfusion injury from mitochondrial Complex-Ⅰ?dysfunction

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World journal of Gastroenterology 2016年第19期22卷 4673-4684页

作者： Michael jj Chu rakesh Premkumar anthony jr Hickey Yannan jiang Brett Delahunt anthony rj phillips Adam Sjr Bartlett Department of Surgery University of Auckland School of Biological Sciences University of Auckland Maurice Wilkins Centre for Biodiscovery University of Auckland Department of Statistics University of Auckland Department of Pathology and Molecular Medicine Wellington School of Medicine University of Otago New Zealand Liver Transplant Unit Auckland City Hospital

AIM: To assess the effects of ischemic preconditioning(IPC, 10-min ischemia/10-min reperfusion) on steatotic liver mitochondrial function after normothermic ischemia-reperfusion injury(IrI).METHODS: Sixty male Sprague-Dawley rats were fed8-wk with either control chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IrI group underwent 60 min partial hepatic ischemia and 4 h reperfusion;(2) the IPC group underwent IPC prior to same standard IrI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I r I o r I P C. H e p a t i c mitochondrial function was analyzed by oxygraphs. Mitochondrial Complex-Ⅰ, Complex-Ⅱ enzyme activity, serum alanine aminotransferase(ALT), and histological injury were ***: Steatotic-IrI livers had a greater increase in ALT(2476 ± 166 vs 1457 ± 103 IU/L, P jury following IrI compared to the lean liver group. Steatotic-IrI demonstrated lower Complex-Ⅰ?activity at baseline [78.4 ± 2.5 vs 116.4 ± 6.0 nmol/(*** protein), P rI [28.0 ± 6.2 vs 104.3 ± 12.6 nmol/(*** protein), P rI also demonstrated impaired Complex-Ⅰ?function post-IrI compared to the lean liver IrI group. Complex-Ⅱ activity was unaffected by hepatic steatosis or IrI. Lean liver mitochondrial function was unchanged following IrI. IPC normalized ALT and histological injury in steatotic livers but had no effect on overall steatotic liver mitochondrial function or individual mitochondrial complex enzyme activities. CONCLUSION: Warm IrI impairs steatotic liver Complex-Ⅰ?activity and function. The protective effects of IPC in steatotic livers may not be mediated through mitochondria.

关键词： Mitochondrial respiration Fatty liver Liver ischemia Oxidative phosphorylation Liver injury Hepatic steatosis Ischemic preconditioning

reflections on the past, present and future of condensed matter physics

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Science Bulletin 2018年第16期63卷 1019-1022页

作者： anthony j. Leggett Department of Physics University of lUinois at Urbana-Champaign Urbana IL 61801-3003 USA Shanghai Center for Complex Physics Shanghai Jiao Tong University Shanghai 200240 China

I will not go into the history of how I come to be giving a talk with this preposterously pretentious ***,a couple of general comments before I start:first,I am a‘‘pure"rather than an applied physicist,and I am afraid that my talk will give rather short shrift to the applied side of condensed matter physics(CMP),which of course has been hugely important over the

关键词：物理学家压缩礼品试验性应用

An improved culturing method for opiine fruit fly parasitoids and its application to parasitoid monitoring in the field

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Insect Science 2018年第1期25卷 99-108页

作者： Ayad Masry Michael j. Furlong anthony r. Clarke john Paul Cunningham School of Earth Environmental and Biological Sciences School Queensland University of Technology (QUT) Brisbane Queensland Australia School of Biological Sciences the University of Queensland St Lucia Queensland Australia plant Biosecurity Cooperative research Centre Bruce ACT Australia Department of Economic Development Jobs Transport and Resources AgriBio Centre La Trobe University Bundoora Victoria Australia

Good culturing methods play an important role in the study of insect behavior and its application to pest management. Here, we describe and validate a new method for rearing the parasitoid wasp, Diachasmirnorpha kraussii, which attacks some of the world＇s worst fruit fly pests and is an internationally used biological control agent. Our method differs from standard culturing approaches by presenting adult wasps with host- infested artificial media within a ＂culturing bag,＂ which mimics a natural （fruit） oviposition substrate. In laboratory trials using wild collected D. kraussii, the culturing bag method was compared to the use of host-infested nectarines, and a commonly used laboratory method of presenting host-infested artificial media within Petri dishes. The culturing bag method proved to be a significant improvement on both methods, combining the advantages of high host survival in artificial media with parasitism levels that were the equivalent to those recorded using host-infested fruits. In our field study, culturing bags infested with the Queensland fruit fly, Bactrocera tryoni, and hung in a mixed peach and nectarine orchard proved to be effective ＂artificial fruits＂ attracting wild D. kraussii for oviposition. Significantly more adult wasps were reared from the culturing bags compared to field collected fruits. This was shown to be due to higher fruit fly larval density in the bags, as similar percentage parasitism rates were found between the culturing bags and ripe fruits. We discuss how this cheap, time-efficient method could be applied to collecting and monitoring wild D. kraussii populations in orchards, and assist in maintaining genetic variability in parasitoid laboratory cultures.

关键词： Bactrocera biological control fruit fly mass rearing natural enemies Tephritidae wasp