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Key changes in denervated muscles and their impact on regeneration and reinnervation

Neural Regeneration Research 2014年第20期9卷 1796-1809页

作者： Peng Wu Aditya Chawla Robert j.Spinner Cong Yu Michael j.Yaszemski anthony j.Windebank Huan Wang Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Department of Hand Surgery Huashan HospitalFudan University Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of Medicine Department of Orthopedic Surgery Wake Forest School of MedicineWinston-SalemNCUSA Departments of Orthopedic Surgery and Biomedical Engineering Mayo ClinicRochesterMNUSA Department of Neurology Mayo ClinicRochesterMNUSA Shanghai Key Laboratory of Peripheral Nerve and Microsurgery

The neuromuscular junction becomes progressively less receptive to regenerating axons if nerve repair is delayed for a long period of time. It is difficult to ascertain the denervated muscle＇s residual receptivity by time alone. Other sensitive markers that closely correlate with the extent of denervation should be found. After a denervated muscle develops a fibrillation potential, muscle fiber conduction velocity, muscle fiber diameter, muscle wet weight, and maximal isometric force all decrease; remodeling increases neuromuscular junction fragmentation and plantar area, and expression of myogenesis-related genes is initially up-regulated and then down-regulated. All these changes correlate with both the time course and degree of denervation. The nature and time course of these denervation changes in muscle are reviewed from the literature to explore their roles in assessing both the degree of detrimental changes and the potential success of a nerve repair. Fibrillation potential amplitude, muscle fiber conduction velocity, muscle fiber diameter, mRNA expression levels of myogenic regulatory factors and nicotinic acetylcholine receptor could all reflect the severity and length of denervation and the receptiveness of denervated muscle to regenerating axons, which could possibly offer an important clue for surgical choices and predict the outcomes of delayed nerve repair.

关键词： nerve regeneration denervation reinnervation fibrillation potential muscle fiberconduction velocity muscle fiber diameter maximal isometric force neuromuscular junction geneexpression neural regeneration

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Compositionally restricted attention-based network for materials property predictions

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npj Computational Materials 2021年第1期7卷 684-693页

作者： anthony Yu-Tung Wang Steven K.Kauwe Ryan j.Murdock Taylor D.Sparks Fachgebiet Keramische Werkstoffe/Chair of Advanced Ceramic Materials Technische Universität BerlinBerlinGermany Department of Materials Science&Engineering University of UtahSalt Lake CityUTUSA

In this paper,we demonstrate an application of the Transformer self-attention mechanism in the context of materials *** network,the Compositionally Restricted Attention-Based network(CrabNet),explores the area of structure-agnostic materials property predictions when only a chemical formula is *** results show that CrabNet’s performance matches or exceeds current best-practice methods on nearly all of 28 total benchmark *** also demonstrate how CrabNet’s architecture lends itself towards model interpretability by showing different visualization approaches that are made possible by its *** feel confident that CrabNet and its attention-based framework will be of keen interest to future materials informatics researchers.

关键词： network property restricted

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Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?

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Neural Regeneration Research 2019年第10期14卷 1678-1683页

作者： anthony Davies Guido Wassink Laura Bennet Alistair j.Gunn joanne O.Davidson Department of Physiology The University of Auckland

Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and *** hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and *** guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic *** clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong *** are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic *** studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of *** this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes.

关键词： hypoxia-ischemia hypoxic-ischemic encephalopathy therapeutic hypothermia neuroprotection therapeutic strategies randomized controlled trials animal models fetal sheep piglets

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On the effects of landscape configuration on summer diurnal temperatures in urban residential areas: application in Phoenix, AZ

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Frontiers of Earth Science 2019年第3期13卷 445-463页

作者： Yiannis KAMARIANAKIS Xiaoxiao LI B. L. TURNER II anthony j. BRAZEL School of Mathematical and Statistical Sciences Arizona State UniversityTempe AZ 85287USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempe AZ 85298USA School of Sustainability Arizona State UniversityTempe AZ 85298USA Global Institute of Sustainability Arizona State UniversityTempe AZ 85287USA

The impacts of land-cover composition on urban temperatures, including temperature extremes, are well documented. Much less attention has been devoted to the consequences of land-cover configuration, most of which addresses land surface temperatures. This study explores the role of both composition and configuration—or land system architecture—of residential neighborhoods in the Phoenix metropolitan area, on near-surface air temperature. It addresses two-dimensional, spatial attributes of buildings, impervious surfaces, bare soil/ rock, vegetation and the “urbanscape” at large, from 50 m to 550 m at 100 m increments, for a representative 30-day high sun period. Linear mixed-effects models evaluate the significance of land system architecture metrics at different spatial aggregation levels. The results indicate that, controlling for land-cover composition and geographical variables, land-cover configuration, specifically the fractal dimension of buildings, is significantly associated with near-surface temperatures. In addition, statistically significant predictors related to composition and configuration appear to depend on the adopted level of spatial aggregation.

关键词： land system architecture urban heat island effect linear mixed-effects models near-surface air temperature land-cover configuration

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Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor

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Cellular & Molecular Immunology 2016年第5期13卷 651-657页

作者： jessy j. Alexander Lee D. Chaves anthony Chang Shruti Dighe Alexander jacob Richard j. Quigg Division of Nephrology Department of Medicine University at Buffalo School of Medicine and Health Sciences Buffalo NY USA Department of Pathology The University of Chicago Chicago IL USA Correspondence: Dr Jessy J. Alexander Division of Nephrology State University of New York at Buffalo Clinical and Translational Research Center 875 Ellicott Street 8-022 Buffalo NY 14203 USA

Activation of complement generates C5a which leads to signaling through C5aR 1. This is tightly controlled, including by the plasma proteins factor H （FH） and carboxypeptidase N. Here we studied a chronic serum sickness （CSS） model of glomerulonephritis （GN） in which there is an active humoral immune response, formation of glomerular immune complexes （ICs）, and resulting glomerular inflammation. The antibody response, glomerular IC deposition, the degree of GN, and consequent renal functional insufficiency in CSS were all worse in FH-/- mice compared to wild-type FH＋/＋ animals. This was ameliorated in the former by giving a C5aR1 antagonist for the final 3 weeks of the 5-week protocol. In contrast, blocking CP-mediated inactivation of C5a increased these disease measures. Thus, complement regulation by both plasma FH and CP to limit the quantity of active C5a is important in conditions where the humoral immune response is directed to a continuously present foreign antigen. Signaling through C5aR1 enhances the humoral immune response as well as the inflammatory response to ICs that have formed in glomeruli. Both effects are relevant even after disease has begun. Thus, pharmacological targeting of C5a in IC-mediated GN has potential clinical relevance.

关键词： C5a carboxypeptidase N factor H glomerulonephritis

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Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International journal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： Harry j.Carpenter Mergen H.Ghayesh anthony C.Zander Peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

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Potassium carbonate-based ternary transition temperature mixture(deep eutectic analogues)for CO_(2)absorption:Characterizations and DFT analysis

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Frontiers of Environmental Science & Engineering 2022年第7期16卷 113-124页

作者： Hosein Ghaedi Payam Kalhor Ming Zhao Peter T.Clough Edward j.anthony Paul S.Fennell School of Environment Tsinghua UniversityBeijing100084China Department of Chemistry Tsinghua UniversityBeijing100084China Energy and Power Theme Cranfield UniversityCranfieldBedfordshireMK430ALUK Department of Chemical Engineering Imperial College LondonSouth KensingtonLondonSW72AZUK

Is it possible to improve CO_(2)solubility in potassium carbonate(K_(2)CO_(3))-based transition temperature mixtures(TTMs)?To assess this possibility,a ternary transition-temperature mixture(TTTM)was prepared by using a hindered amine,2-amino-2-methyl-1,3-propanediol(AMPD).Fourier transform infrared spectroscopy(FT-IR)was employed to detect the functional groups including hydroxyl,amine,carbonate ion,and aliphatic functional groups in the prepared *** thermogravimetric analysis(TGA),it was found that the addition of AMPD to the binary mixture can increase the thermal stability of *** viscosity findings showed that TTTM has a higher viscosity than TTM while their difference was decreased by increasing *** addition,Eyring’s absolute rate theory was used to compute the activation parameters(∆G^(*),∆H^(*),and ∆S^(*)).The CO_(2)solubility in liquids was measured at a temperature of 303.15 K and pressures up to 1.8 *** results disclosed that the CO_(2)solubility of TTTM was improved by the addition of *** the pressure of about 1.8 MPa,the CO_(2)mole fractions of TTM and TTTM were 0.1697 and 0.2022,*** confirm the experimental data,density functional theory(DFT)was *** the DFT analysis,it was found that the TTTM+CO_(2)system has higher interaction energy(|∆E|)than the TTM+CO_(2)system indicating the higher CO_(2)affinity of the former *** study might help scientists to better understand and to improve CO_(2)solubility in these types of solvents by choosing a suitable amine as HBD and finding the best combination of HBA and HBD.

关键词： Ternary transition-temperature mixture FT-IR and thermal stability analysis Viscosity and correlation study Eyring’s absolute rate theory CO_(2)solubility Density functional theory(DFT)

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A probabilistic approach for predictive congestion control in wireless sensor networks

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journal of Zhejiang University-Science C(Computers and Electronics) 2014年第3期15卷 187-199页

作者： R.ANNIE UTHRA S.V.KASMIR RAjA A.jEYASEKAR anthony j.LATTANZE Department of Computer Science and Engineering SRM University Department of Software Engineering Carnegie Mellon University

Any node in a wireless sensor network is a resource constrained device in terms of memory, bandwidth, and energy, which leads to a large number of packet drops, low throughput, and significant waste of energy due to retransmission. This paper presents a new approach for predicting congestion using a probabilistic method and controlling congestion using new rate control methods. The probabilistic approach used for prediction of the occurrence of congestion in a node is developed using data traffic and buffer occupancy. The rate control method uses a back-off selection scheme and also rate allocation schemes, namely rate regulation(RRG) and split protocol(SP), to improve throughput and reduce packet drop. A back-off interval selection scheme is introduced in combination with rate reduction(RR) and RRG. The back-off interval selection scheme considers channel state and collision-free transmission to prevent congestion. Simulations were conducted and the results were compared with those of decentralized predictive congestion control(DPCC) and adaptive duty-cycle based congestion control(ADCC). The results showed that the proposed method reduces congestion and improves performance.

关键词： Congestion Rate allocation Congestion control Packet loss Back-off interval Rate control

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Low-intensity extracorporeal shock wave therapy for Peyronie’s disease:a single-center experience

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Asian journal of Andrology 2022年第1期24卷 45-49页

作者： Maher Abdessater William Akakpo anthony Kanbar jérome Parra Thomas Seisen Emmanuel Chartier-Kastler Sarah j Drouin Morgan Roupret APHP-Sorbonne University PitiéSalpêtrièreAcademic Urology Unit83 bvd HopitalParis 75013France

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy(LiESWT)protocol for the treatment of Peyronie’s disease(PD).Patients treated for PD were prospectively recorded,and data were retrospectively ***,characteristics of fibrous plaques,concomitant treatments,International Index of Erectile Function(IIEF-5),Lue score,and pain score on Likert scale were *** in acute phase of PD and an angulation of<40°were *** protocol consisted of 6 weekly sessions of 4000 pulses each,applied from different directions,with a maximal power of 20 W and 8 Hz *** included 39 patients(median age:56.8 years,interquartile range[IQR]:35.8–62.2 years).The median number of sessions received per patient was *** treatment,the median Lue score decreased from 6.8 initially to 3.3(P=0.003),the median Likert pain score dropped from 1.8 to 0.7(P=0.004),the median plaque size was reduced from 2 cm to 1.2 cm(P=0.08),and the median penile curvature diminished from 31°to 17°(P=0.07).On univariate and multivariate analysis,the only predictors of success were younger age(odds ratio[OR]=0.95,P=0.03 and OR=0.91,P=0.04,respectively)and concomitant use of phosphodiesterase-5 inhibitors(PDE5i;OR=0.92,P=0.02 and OR=0.93,P=0.01,respectively).LiESWT had a favorable impact on Lue score and notably penile pain,curvature,plaque size,and erectile function in patients treated for PD during the early inflammatory phase,with no side *** age and concomitant use of PDE5i were the only success predictors.

关键词： erectile dysfunction extracorporeal shock wave therapy Peyronie’s disease piezoelectric waves

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Cleft foot: A case report and review of literature

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World journal of Orthopedics 2020年第2期11卷 129-136页

作者： Sergey S Leonchuk Andrey S Neretin anthony j Blanchard 6^th and 5^th Orthopedic Departments Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopedics 6Kurgan 640014Russia Department of Surgery University of CincinnatiCollege of MedicineCincinnatiOH 45219United States

BACKGROUND Cleft foot is a very rare congenital anomaly,which is characterized by central rays deficiency of the *** is also known as split foot or ectrodactyly of the foot,and it is very often combined with splitting of the *** defect develops due to insufficient activity of the median apical ectodermal ridge,which leads to an increase in cell death or a decrease in cell *** to the rarity of the pathology,there are few papers on the surgical treatment of this congenital foot disease,and publications to date concern the treatment of *** SUMMARY We present a clinical case of congenital splitting of the feet and hands in a 31-year-old woman and a long-term result of foot treatment using the minimal arrangement of the Ilizarov *** patient had paternal inheritance of the *** the surgical treatment,cosmetic view and functional condition of the foot were improved and persisted two years after *** were no complications in the treatment *** The possibility of dosed control and stable fixation of the foot rays made it possible to create favorable conditions for the healing of the central wound and the closure of the segment splitting without *** long-term outcome of the treatment of foot congenital splitting using the proposed Ilizarov apparatus arrangement has shown its *** approach should be considered as an option of treatment in similar cases.

关键词： Cleft foot Split foot Ectrodactyly Congenital malformation Ilizarov Case report

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