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墨西哥两个水文封闭型高原湖泊沉积物记录到受人类活动影响的敏感度

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AMBIO－人类环境杂志 2005年第6期34卷 464-470页

作者： Sarah j.Davies Sarah E.Metcalfe Fernando Bernal-Brooks Arturo Chacón-Torres john G.Farmer A.B.MacKenzie anthony j.Newton 李四海 Aberystwyth威尔士大学地理和地球科学研究所第四纪环境变化科研小组诺丁汉大学地理学院 de Investigaciones Sobre Recursos Naturales研究所爱丁堡大学地球科学学院苏格兰大学环境研究中心

本文提供了墨西哥中部两个高原湖泊近期环境快速变化的证据。从济拉温湖(米却肯州)和胡安艾卡特兰湖(哈利斯科州)获得了多个沉积物钻芯,利用^(210)Pb和^(14)C,以及火山灰年代测定法确定年代,进行了硅藻组合、磁化率和金属含量分析。在... 详细信息

本文提供了墨西哥中部两个高原湖泊近期环境快速变化的证据。从济拉温湖(米却肯州)和胡安艾卡特兰湖(哈利斯科州)获得了多个沉积物钻芯,利用^(210)Pb和^(14)C,以及火山灰年代测定法确定年代,进行了硅藻组合、磁化率和金属含量分析。在殖民时期,两盆地内有汇水区被扰动的迹象,但这两个地方最显著的特征是,最近20年来硅藻种群组合特征的快速变化,这指示着富营养化的开始。尽管在胡安艾卡特兰湖还没获得这方面的任何数据,但济拉温湖的湖泊学数据支持这种解释。古湖泊学在跟踪近期变化过程,特别是在缺乏常规湖泊监测计划的情况下是一种强有力的工具。这些湖泊对汇水区的开发变化特别敏感,必须在将来的流域管理中予以考虑。

关键词：湖泊沉积物高原湖泊人类活动影响敏感度墨西哥封闭型水文 ^210Pb 快速变化硅藻组合

Utilization of Extracorporeal Membrane Oxygenation for Pulmonary Toxicity Caused by Inhaled Synthetic Cannabinoid. A Harbinger of Future Complications Associated with Inhaled Cannabinoid Products

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International journal of Clinical Medicine 2020年第2期11卷 53-61页

作者： Robert March Paul Guentert Elizabeth Kloska-Kearney David Kwak Cody Yerger Michael McBride j. R. Majewski Ross McCauley jordan Hatch jacob Speybroeck Allen Betts Mat Marsee Sufyan Zackariya Faisal Shariff Shivani Patel Ali Sualeh anthony Thomas Edward Evans Donald Westerhausen Mark Walsh Saint joseph Regional Medical Center Mishawaka IN USA Indiana University School of Medicine—South Bend South Bend IN USA Department of Pulmonary and Critical Care Medicine Methodist Hospital Indianapolis IN USA

There has been a dramatic increase in medical complications related to synthetic cannabinoid (SC) use either by water pipe or vaping. The legalization of marijuana in an increasing number of states has also resulted in an increase in a number of complications related not just to marijuana, but in particular, to SC. As a result, there have been recent increased reports of acute pulmonary injury related to inhaled SC products. We describe that rarely endotracheal intubation with mechanical ventilation has been required to treat the acute respiratory distress syndrome (ARDS) and the diffuse alveolar hemorrhage (DAH) associated with the acute toxicity of SC inhalation. We describe the second reported case of successful utilization of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) in order to treat acute pulmonary toxicity caused by SC inhalation by a water pipe. While the exact pathophysiology of these interesting and recent pulmonary complications is unknown, the recent increase in exposure to SC via water pipe systems and vaping suggests that there will be many more cases of patients that will require ECMO as a form of life-saving therapy.

关键词： Synthetic Cannabinoid Extracorporeal Membrane Oxygenation Mechanical Ventilation Water Pipe Vaping Pulmonary Toxicity

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk A.Martyn Ainsworth jean-Marc Moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana john Haight Thomas Læssøe Timothy j.Baroni józsef Geml Tsutomu Hattori Center for Forest Mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly Mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario Museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest Mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National Mycological Herbarium(DAOM) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia CBS Fungal Biodiversity Centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology

Sci Rep:科学家阐明线粒体的程序性细胞死亡过程

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现代生物医学进展 2016年第35期16卷 I0004-I0004页

作者： Ted D. Pham Phi Q. Pham jinfeng Li anthony G. Letai Douglas C. Wallace Peter j. Burke Department of Biomedical Engineering University of California Irvine CA USA Department of Chemical Engineering and Materials Science University of California Irvine CA USA Department of Chemical Engineering and Materials Science University of California Irvine CA USA Dana-Farber Cancer Institute Harvard University Boston MA USA Center for Mitochondrial and Epigenomic Medicine Children’s Hospital of Philadelphia and Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia PA USA Department of Biomedical Engineering University of California Irvine CA USA Department of Chemical Engineering and Materials Science University of California Irvine CA USA Department of Electrical Engineering and Computer Science University of California Irvine CA USA

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过... 详细信息

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过研究开发了一种监测线粒体改变的电子学方法，该方法能够指示出细胞进行自我毁灭的开始阶段，我们机体每个细胞中都有数百个、甚至数千个线粒体。每个线粒体都有着内膜和外膜结构；作为细胞的能量工厂，线粒体会对细胞中的碳水化合物和脂肪进行代谢产能以便细胞利用并且储存。但同时线粒体还有第二个角色，那就是调节细胞的生死通路。

关键词：死亡过程癌细胞线粒体程序性 Sci 科学家 Rep 加利福尼亚大学

Severe scrub typhus infection: Clinical features, diagnostic challenges and management

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World journal of Critical Care Medicine 2015年第3期4卷 244-250页

作者： john Victor Peter Thomas I Sudarsan john anthony j Prakash George M Varghese Medical Intensive Care Unit Christian Medical College Department of Microbiology Christian Medical College Department of Infectious Diseases Christian Medical College

Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%.

关键词： Rickettsia Diagnosis Management Outcome Multi-organ failure

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng jing Wang jiahuan Lu jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung anthony W.H.Chan Ka Fai To john Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong joseph j.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD ***,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

An international survey of classification and treatment choices for group D retinoblastoma

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International journal of Ophthalmology(English edition) 2017年第6期10卷 961-967页

作者： Christina Scelfo jasmine H Francis Vikas Khetan Thomas jenkins Brian Marr David H Abramson Carol L Shields jacob Pe’er Francis Munier jesse Berry j.William Harbour Andrey Yarovoy Evandro Lucena Timothy G Murray Pooja Bhagia Evelyn Paysse Samuray Tuncer Guillermo L Chantada Annette C Moll Tatiana Ushakova David A Plager Islamov Ziyovuddin Carlos A Leal Miguel A Materin Xun-Da ji jose W Cursino Rodrigo Polania Hayyam Kiratli Charlotta All-Ericsson Rejin Kebudi Santosh G Honavar Vicktoria Vishnevskia-Dai Sidnel Epelman anthony B Daniels jeanie D Ling Fousseyni Traore Marco A Ramirez-Ortiz Ophthalmic Oncology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York 10065 USA Department of Ophthalmology Weill-Cornell Medical Center New York 10065 USA Department of Vitreoretinal and Ocular Oncology Sankara Nathralaya Chennai 600066 India Ocular Ontology Service Wills Eye Hospital Thomas Jefferson University Pennsylvania 19107 USA Hadassah - Hebrew University Medical Center Jerusalem 91120 Israel jules-Gonin Eye Hospital Lausanne 1004 Switzerland USC Roski Eye Institute Children＇s Hospital of Los Angeles California 90033 USA Ocular Oncology Service Bascom Palmer Eye Institute University of Miami Miller School of Medicine Florida 33136 USA Ocular Oncology Department S.N. Fyodorov Eye Microsurgery Federal State Institution Moscow 127486 Russia Department of Ocular Oncology Instituto Nacional de Cancer Rio de Janeiro 1122 Brazil Murray Ocular Oncology and Retina Miami Children＇s Hospital Florida 33143 USA St. joseph＇s Children＇s Hospital New Jersey 07504 USA Department of Ophthalmology Baylor College of Medicine Texas 77030 USA Department of Ophthalmology Ocular Oncology Istanbul Medical Faculty Istanbul University Istanbul 34452 Turkey Oncology Department Hospital JP Garrahan Buenos Aires 1245 Argentina Department of Ophthalmology VU University Medical Center Amsterdam 1081 the Netherlands Department of Head and Neck Tumors Science Research Institute of Pediatric Oncology and Hematology N.N. Blokhin Russian Cancer Research Center Moscow 115478 Russia Pediatric Ophthalmology and Adult Strabismus Riley Hospital for Children Indiana University Medical Center Indiana 46202 USA National Oncology Center of Uzbekistan Tashkent 110508 Uzbekistan nstituto Nacional de Pediatria Coyoacan 04530 Mexico Department of Ophthalmology and Visual Science Smilow Cancer Hospital at Yale New Haven CT 06520 USA Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Ophthalmology Santa Casa Mi

AIM： To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and geographic region. METHODS： An anonymized electronic survey was offered to 115 physicians at 39 retinoblastoma centers worldwide asking about IIRC classification schemes and treatment patterns used between 2008 and 2012. Participants were asked to record which version of the IIRC was used for classification, how many group D eyes were diagnosed, and how many eyes were treated with enucleation versus globe salvaging therapies. Averages of eyes per treatment modality were calculated and stratified by both IIRC version and geographic region. Statistical significance was determined by Chi-square, ANOVA and Kruskal-Wallis tests using Prism. RESULTS： The survey was completed by 29% of physicians invited to participate. Totally 1807 D eyes were diagnosed. Regarding IIRC system, 27% of centers used the Children＇s Hospital of Los Angeles （CHLA） version, 33% used the Children＇s Oncology Group （COG） version, 23% used the Philadelphia version, and 17% were unsure. The rate for primary enucleation varied between 0 and 100% and the mean was 29%. By IIRC version, primary enucleation rates were： Philadelphia, 8%; COG, 34%; and CHLA, 37%. By geographic region, primary enucleation rates were： Latin America, 57%; Asia, 40%; Europe, 36%; Africa, 10%, US, 8%; and Middle East, 8%. However, systemic chemoreduction was used more often than enucleation in all regions except Latin America with a mean of 57% per center （P〈0.0001）. CONCLUSION： Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, varied greatly with regards to IIRC version used and geographic r

关键词： retinoblastoma oncology retina enucleation chemotherapy intra-arterial chemotherapy ophthalmic arterychemosurgery cancer

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探讨智能医疗设备需求迅速崛起的原因

世界电子元器件 2011年第10期 38-38页

作者： anthony j.Kalaijakis Molex公司

医疗设备设计工程师一直面对开发病患护理的先进电子设备的挑战,在过去的十年左右,我们看到医疗设备市场出现了显著的进步,从易于使用的血压和血糖水平家庭监控装置,到医院手术室里使用的综合诊断成像设备、尖端机器人技术和激光外科设... 详细信息

医疗设备设计工程师一直面对开发病患护理的先进电子设备的挑战,在过去的十年左右,我们看到医疗设备市场出现了显著的进步,从易于使用的血压和血糖水平家庭监控装置,到医院手术室里使用的综合诊断成像设备、尖端机器人技术和激光外科设备都纷纷面世。医疗行业的一个重大发展趋势是逐渐采用与消费电子和通信行业相同的电子设计策略和组件,因而推动了这两个行业在最近几年实现快速增长。

关键词：医疗设备设备需求原因智能电子设备通信行业设计工程师医院手术室

南卡罗莱纳大学代勒摩尔商学院裁员后如何提升效率

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董事会 2009年第8期 98-98页

作者： anthony j.Nyberg

如果你的公司近期通过裁员缩小了规模，那么现在你所领导的正是那些经历裁员后的“幸存者”，但是在这种公司环境下，运气好并不与业绩佳挂钩，实际上你可能会面临严重的员工机能障碍。根据我们的研究，在以下几方面采取措施可以有效减... 详细信息

如果你的公司近期通过裁员缩小了规模，那么现在你所领导的正是那些经历裁员后的“幸存者”，但是在这种公司环境下，运气好并不与业绩佳挂钩，实际上你可能会面临严重的员工机能障碍。根据我们的研究，在以下几方面采取措施可以有效减少这种机能障碍带来的消极影响：

关键词：裁员商学院效率摩尔大学公司环境幸存者机能